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1. 发明申请

US20140220606A1 MICROFLUIDIC ASSAY DEVICES AND METHODS 审中-公开
标题翻译：微流感测定装置及方法
公开(公告)号：US20140220606A1
公开(公告)日：2014-08-07
申请号：US13981825
申请日：2012-01-28
申请人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Jungyoup Han
发明人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Jungyoup Han
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/54393 , B01L3/5025 , B01L3/502715 , B01L3/5085 , B01L3/50857 , B01L2200/0642 , B01L2300/0636 , B01L2300/0829 , B01L2300/0851 , B01L2300/088 , B01L2300/0893 , G01N33/6866 , G01N33/6869
摘要： Microfluidic microplate devices and methods for assay systems such as immunoassays, to achieve improvements particularly of higher sensitivity and more repeatable performance, are disclosed. In preferred embodiments, also disclosed are the use of a range of coating buffers for the capture antibody and the use of coating buffers with specific formulations within very narrow ranges to achieve optimal results in the use of the devices and methods.
摘要翻译：公开了微流控微板装置和用于诸如免疫测定的测定系统的方法，以实现特别是更高灵敏度和更可重复性能的改进。在优选的实施方案中，还公开了一系列用于捕获抗体的包衣缓冲液的使用以及在非常窄的范围内使用具有特定制剂的包衣缓冲液以在使用该装置和方法中实现最佳结果。

2. 发明授权

US09919311B2 Microfluidic assay platforms 有权
公开(公告)号：US09919311B2
公开(公告)日：2018-03-20
申请号：US13384963
申请日：2010-07-20
申请人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
发明人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
IPC分类号： G01N1/28 , B01L3/00
CPC分类号： B01L3/5025 , B01L3/50273 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0851 , B01L2300/0861 , B01L2300/088 , B01L2300/0883 , B01L2300/161 , B01L2400/0406
摘要： This invention discloses novel improvements to conventional microtiter plates, involving integrating microfluidic channels with such microtiter plates to simplify the assay operation, Increase operational speed and reduce reagent consumption. The present invention can be used in place of a conventional microliter plate and can be easily substituted without any changes to the existing instrumentation systems designed for microtiter plates. The invention also discloses a microfluidic device integrated with sample loading wells wherein the entire flow process is capillary driven.

3. 发明申请

US20120328488A1 MICROFLUIDIC ASSAY PLATFORMS 有权
标题翻译：微流感测定平台
公开(公告)号：US20120328488A1
公开(公告)日：2012-12-27
申请号：US13384963
申请日：2010-07-20
申请人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
发明人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
IPC分类号： G01N1/28
CPC分类号： B01L3/5025 , B01L3/50273 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0851 , B01L2300/0861 , B01L2300/088 , B01L2300/0883 , B01L2300/161 , B01L2400/0406
摘要： This invention discloses novel improvements to conventional microtiter plates, involving integrating microfluidic channels with such microtiter plates to simplify the assay operation, Increase operational speed and reduce reagent consumption. The present invention can be used in place of a conventional microliter plate and can be easily substituted without any changes to the existing instrumentation systems designed for microtiter plates. The invention also discloses a microfluidic device integrated with sample loading wells wherein the entire flow process is capillary driven.
摘要翻译：本发明公开了对常规微量滴定板的新颖改进，涉及将微流体通道与这种微量滴定板结合，以简化测定操作，提高操作速度和减少试剂消耗。本发明可以用于代替传统的微升板，并且可以容易地替代，而不会改变设计用于微量滴定板的现有仪器系统。本发明还公开了一种与样品加载井集成的微流体装置，其中整个流动过程是毛细管驱动的。

4. 发明授权

US07601269B2 On-chip sample preparation for whole blood analysis 失效
公开(公告)号：US07601269B2
公开(公告)日：2009-10-13
申请号：US12327204
申请日：2008-12-03
申请人： Chong H. Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
发明人： Chong H. Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
IPC分类号： B01D37/00 , B01L11/00
CPC分类号： B01D45/00 , B01D21/283 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/0668 , B01L2200/146 , B01L2300/0816 , B01L2300/0861 , B01L2400/0487 , B01L2400/084 , B01L2400/086 , G01N33/491
摘要： A novel filter-less separation technique for separating suspended particles from a solution is disclosed. More specifically, an on-chip bioparticle separator is disclosed, which relies on the differential force exerted by application of a series of high magnitude, short duration pressure pulses on bioparticles in suspension within microchannels, resulting in separation of suspended bioparticles. The filter-less separation technique is inherently suited to μTAS (Micro Total Analysis System) since it exploits uniquely microscale phenomena to achieve separation. The on-chip bioparticle separator can be easily integrated with a disposable biochip, can be fabricated using low-cost, rapid manufacturing techniques, and can provide high performance for separation of bioparticles without the use of specialized or expensive equipment. Embodiments of the present invention address a significant challenge in the development of disposable microfluidic biochips, specifically, providing a reliable solution for separating bioparticles in a microfluidic system that may be immediately applied for a variety of microfluidic biochip applications.

5. 发明申请

US20050069459A1 On-chip sample preparation for whole blood analysis 失效
标题翻译：全血分析片上样品制备
公开(公告)号：US20050069459A1
公开(公告)日：2005-03-31
申请号：US10946685
申请日：2004-09-22
申请人： Chong Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
发明人： Chong Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
IPC分类号： B01L99/00 , B01L11/00
CPC分类号： B01D45/00 , B01D21/283 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/0668 , B01L2200/146 , B01L2300/0816 , B01L2300/0861 , B01L2400/0487 , B01L2400/084 , B01L2400/086 , G01N33/491
摘要： A novel filter-less separation technique for separating suspended particles from a solution is disclosed. More specifically, an on-chip bioparticle separator is disclosed, which relies on the differential force exerted by application of a series of high magnitude, short duration pressure pulses on bioparticles in suspension within microchannels, resulting in separation of suspended bioparticles. The filter-less separation technique is inherently suited to μTAS (Micro Total Analysis System) since it exploits uniquely microscale phenomena to achieve separation. The on-chip bioparticle separator can be easily integrated with a disposable biochip, can be fabricated using low-cost, rapid manufacturing techniques, and can provide high performance for separation of bioparticles without the use of specialized or expensive equipment. Embodiments of the present invention address a significant challenge in the development of disposable microfluidic biochips, specifically, providing a reliable solution for separating bioparticles in a microfluidic system that may be immediately applied for a variety of microfluidic biochip applications.
摘要翻译：公开了一种用于从溶液中分离悬浮颗粒的新型无滤膜分离技术。更具体地，公开了片上生物颗粒分离器，其依赖于通过在微通道内的悬浮液中的生物颗粒上施加一系列高幅度，短持续时间的压力脉冲而施加的差分力，导致悬浮的生物颗粒的分离。无过滤器分离技术固有地适用于muTAS（微总体分析系统），因为它利用独特的微观现象来实现分离。片上生物颗粒分离器可以容易地与一次性生物芯片集成，可以使用低成本，快速的制造技术制造，并且可以提供高性能用于分离生物颗粒而不使用专门的或昂贵的设备。本发明的实施方案解决了一次性微流体生物芯片开发中的重大挑战，具体地说，为微流体系统中分离生物颗粒提供了可靠的解决方案，微流体系统可立即应用于各种微流体生物芯片应用。

6. 发明申请

US20090152215A1 ON-CHIP SAMPLE PREPARATION FOR WHOLE BLOOD ANALYSIS 失效
标题翻译：用于全血分析的片上样品制备
公开(公告)号：US20090152215A1
公开(公告)日：2009-06-18
申请号：US12327204
申请日：2008-12-03
申请人： Chong H. Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
发明人： Chong H. Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
IPC分类号： B01D45/00
CPC分类号： B01D45/00 , B01D21/283 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/0668 , B01L2200/146 , B01L2300/0816 , B01L2300/0861 , B01L2400/0487 , B01L2400/084 , B01L2400/086 , G01N33/491
摘要： A novel filter-less separation technique for separating suspended particles from a solution is disclosed. More specifically, an on-chip bioparticle separator is disclosed, which relies on the differential force exerted by application of a series of high magnitude, short duration pressure pulses on bioparticles in suspension within microchannels, resulting in separation of suspended bioparticles. The filter-less separation technique is inherently suited to μTAS (Micro Total Analysis System) since it exploits uniquely microscale phenomena to achieve separation. The on-chip bioparticle separator can be easily integrated with a disposable biochip, can be fabricated using low-cost, rapid manufacturing techniques, and can provide high performance for separation of bioparticles without the use of specialized or expensive equipment. Embodiments of the present invention address a significant challenge in the development of disposable microfluidic biochips, specifically, providing a reliable solution for separating bioparticles in a microfluidic system that may be immediately applied for a variety of microfluidic biochip applications.
摘要翻译：公开了一种用于从溶液中分离悬浮颗粒的新型无滤膜分离技术。更具体地，公开了片上生物颗粒分离器，其依赖于通过在微通道内的悬浮液中的生物颗粒上施加一系列高幅度，短持续时间的压力脉冲而施加的差分力，导致悬浮的生物颗粒的分离。无过滤器分离技术固有地适用于muTAS（微总体分析系统），因为它利用独特的微观现象来实现分离。片上生物颗粒分离器可以容易地与一次性生物芯片集成，可以使用低成本，快速的制造技术制造，并且可以提供高性能用于分离生物颗粒而不使用专门的或昂贵的设备。本发明的实施方案解决了一次性微流体生物芯片开发中的重大挑战，具体地说，为微流体系统中分离生物颗粒提供了可靠的解决方案，微流体系统可立即应用于各种微流体生物芯片应用。

7. 发明授权

US07476326B2 On-chip sample preparation for whole blood analysis 失效
标题翻译：全血分析片上样品制备
公开(公告)号：US07476326B2
公开(公告)日：2009-01-13
申请号：US10946685
申请日：2004-09-22
申请人： Chong H. Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
发明人： Chong H. Ahn , Aniruddha Puntambekar , Alok Jain , Jungyoup Han
IPC分类号： B01D37/00 , B01L11/00
CPC分类号： B01D45/00 , B01D21/283 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/0668 , B01L2200/146 , B01L2300/0816 , B01L2300/0861 , B01L2400/0487 , B01L2400/084 , B01L2400/086 , G01N33/491
摘要： A novel filter-less separation technique for separating suspended particles from a solution is disclosed. More specifically, an on-chip bioparticle separator is disclosed, which relies on the differential force exerted by application of a series of high magnitude, short duration pressure pulses on bioparticles in suspension within microchannels, resulting in separation of suspended bioparticles. The filter-less separation technique is inherently suited to μTAS (Micro Total Analysis System) since it exploits uniquely microscale phenomena to achieve separation. The on-chip bioparticle separator can be easily integrated with a disposable biochip, can be fabricated using low-cost, rapid manufacturing techniques, and can provide high performance for separation of bioparticles without the use of specialized or expensive equipment. Embodiments of the present invention address a significant challenge in the development of disposable microfluidic biochips, specifically, providing a reliable solution for separating bioparticles in a microfluidic system that may be immediately applied for a variety of microfluidic biochip applications.
摘要翻译：公开了一种用于从溶液中分离悬浮颗粒的新型无滤膜分离技术。更具体地，公开了片上生物颗粒分离器，其依赖于通过在微通道内的悬浮液中的生物颗粒上施加一系列高幅度，短持续时间的压力脉冲而施加的差分力，导致悬浮的生物颗粒的分离。无过滤器分离技术固有地适用于muTAS（微总体分析系统），因为它利用独特的微观现象来实现分离。片上生物颗粒分离器可以容易地与一次性生物芯片集成，可以使用低成本，快速的制造技术制造，并且可以提供高性能用于分离生物颗粒而不使用专门的或昂贵的设备。本发明的实施方案解决了一次性微流体生物芯片开发中的重大挑战，具体地说，为微流体系统中分离生物颗粒提供了可靠的解决方案，微流体系统可立即应用于各种微流体生物芯片应用。

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