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1. 发明授权

US09919311B2 Microfluidic assay platforms 有权
公开(公告)号：US09919311B2
公开(公告)日：2018-03-20
申请号：US13384963
申请日：2010-07-20
申请人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
发明人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
IPC分类号： G01N1/28 , B01L3/00
CPC分类号： B01L3/5025 , B01L3/50273 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0851 , B01L2300/0861 , B01L2300/088 , B01L2300/0883 , B01L2300/161 , B01L2400/0406
摘要： This invention discloses novel improvements to conventional microtiter plates, involving integrating microfluidic channels with such microtiter plates to simplify the assay operation, Increase operational speed and reduce reagent consumption. The present invention can be used in place of a conventional microliter plate and can be easily substituted without any changes to the existing instrumentation systems designed for microtiter plates. The invention also discloses a microfluidic device integrated with sample loading wells wherein the entire flow process is capillary driven.

2. 发明申请

US20140220606A1 MICROFLUIDIC ASSAY DEVICES AND METHODS 审中-公开
标题翻译：微流感测定装置及方法
公开(公告)号：US20140220606A1
公开(公告)日：2014-08-07
申请号：US13981825
申请日：2012-01-28
申请人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Jungyoup Han
发明人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Jungyoup Han
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/54393 , B01L3/5025 , B01L3/502715 , B01L3/5085 , B01L3/50857 , B01L2200/0642 , B01L2300/0636 , B01L2300/0829 , B01L2300/0851 , B01L2300/088 , B01L2300/0893 , G01N33/6866 , G01N33/6869
摘要： Microfluidic microplate devices and methods for assay systems such as immunoassays, to achieve improvements particularly of higher sensitivity and more repeatable performance, are disclosed. In preferred embodiments, also disclosed are the use of a range of coating buffers for the capture antibody and the use of coating buffers with specific formulations within very narrow ranges to achieve optimal results in the use of the devices and methods.
摘要翻译：公开了微流控微板装置和用于诸如免疫测定的测定系统的方法，以实现特别是更高灵敏度和更可重复性能的改进。在优选的实施方案中，还公开了一系列用于捕获抗体的包衣缓冲液的使用以及在非常窄的范围内使用具有特定制剂的包衣缓冲液以在使用该装置和方法中实现最佳结果。

3. 发明申请

US20050130226A1 Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation 审中-公开
标题翻译：完全集成的蛋白质实验室芯片与智能微流体阵列生成
公开(公告)号：US20050130226A1
公开(公告)日：2005-06-16
申请号：US10947576
申请日：2004-09-22
申请人： Chong Ahn , Junhai Kai , Young-Soo Sohn
发明人： Chong Ahn , Junhai Kai , Young-Soo Sohn
IPC分类号： C12M1/34 , G01N33/53 , G01N33/537 , G01N33/543 , H01L21/00
CPC分类号： B81C1/00206 , B81B2201/051 , G01N33/54353 , G01N33/54393
摘要： Techniques for the fabrication of fully-integrated lab-on-a-chips (or biochips) specifically oriented towards point-of-care detection of biomolecules using immunoassay based detection techniques are disclosed. A primary task for the development of such biochips is the development of techniques to precisely deposit and localize the capture antibody on pre-determined locations over the biochip. The use of selective surface modification, specifically control over the surface energy, to achieve localized adsorption of the capture antibody is disclosed. Another approach, also disclosed, describes the use of smart passive microfluidics to confine the flow of the capture antibody along certain paths of the biochip and thereby control the locations over which the capture antibody is adsorbed. Furthermore, the use of an integrated microlens array as means of enhancing the detection sensitivity of the biochip is also disclosed.
摘要翻译：公开了使用基于免疫测定的检测技术来制造专门针对生物分子的护理点检测的完全整合的芯片上实验室（或生物芯片）的技术。开发这样的生物芯片的主要任务是开发在生物芯片上的预定位置上精确沉积和定位捕获抗体的技术。公开了使用选择性表面改性，特别是控制表面能来实现捕获抗体的局部吸附。还公开了另一种方法，描述了使用智能被动微流体将捕获抗体的流动限制在生物芯片的某些路径上，从而控制捕获抗体吸附的位置。此外，还公开了使用集成微透镜阵列作为增强生物芯片的检测灵敏度的手段。

4. 发明申请

US20120328488A1 MICROFLUIDIC ASSAY PLATFORMS 有权
标题翻译：微流感测定平台
公开(公告)号：US20120328488A1
公开(公告)日：2012-12-27
申请号：US13384963
申请日：2010-07-20
申请人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
发明人： Aniruddha Puntambekar , Junhai Kai , Se Hwan Lee , Chong Ahn
IPC分类号： G01N1/28
CPC分类号： B01L3/5025 , B01L3/50273 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0851 , B01L2300/0861 , B01L2300/088 , B01L2300/0883 , B01L2300/161 , B01L2400/0406
摘要： This invention discloses novel improvements to conventional microtiter plates, involving integrating microfluidic channels with such microtiter plates to simplify the assay operation, Increase operational speed and reduce reagent consumption. The present invention can be used in place of a conventional microliter plate and can be easily substituted without any changes to the existing instrumentation systems designed for microtiter plates. The invention also discloses a microfluidic device integrated with sample loading wells wherein the entire flow process is capillary driven.
摘要翻译：本发明公开了对常规微量滴定板的新颖改进，涉及将微流体通道与这种微量滴定板结合，以简化测定操作，提高操作速度和减少试剂消耗。本发明可以用于代替传统的微升板，并且可以容易地替代，而不会改变设计用于微量滴定板的现有仪器系统。本发明还公开了一种与样品加载井集成的微流体装置，其中整个流动过程是毛细管驱动的。

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