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1. 发明申请

US20160202254A1 NANOSTRUCTURED DEVICES FOR DETECTING AND ANALYZING BIOMOLECULES 有权
标题翻译：用于检测和分析生物分子的纳米结构设备
公开(公告)号：US20160202254A1
公开(公告)日：2016-07-14
申请号：US11947834
申请日：2007-11-30
申请人： An-Ping Zhang , Anthony John Murray , Rui Chen
发明人： An-Ping Zhang , Anthony John Murray , Rui Chen
IPC分类号： G01N33/543 , G01N27/414
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y40/00 , G01N27/327 , G01N27/4145 , G01N27/4146 , G01N33/545
摘要： A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.
摘要翻译：一种生物传感FET器件，包括多个纳米结构SOI沟道，其适于在具有高离子强度的溶液中操作并且提供灵敏度和检测。通常，生物传感装置包括下面的基底层，绝缘体和半导体层，以及半导体层中的多个通道，其在通道中包括多个整体或部分形成的纳米孔。

2. 发明授权

US09409769B2 Nanostructured devices for detecting and analyzing biomolecules 有权
标题翻译：用于检测和分析生物分子的纳米结构设备
公开(公告)号：US09409769B2
公开(公告)日：2016-08-09
申请号：US11947834
申请日：2007-11-30
申请人： An-Ping Zhang , Anthony John Murray , Rui Chen
发明人： An-Ping Zhang , Anthony John Murray , Rui Chen
IPC分类号： G01N27/327 , B82Y15/00 , G01N27/30
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y40/00 , G01N27/327 , G01N27/4145 , G01N27/4146 , G01N33/545
摘要： A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.
摘要翻译：一种生物传感FET器件，包括多个纳米结构SOI沟道，其适于在具有高离子强度的溶液中操作并且提供灵敏度和检测。通常，生物传感装置包括下面的基底层，绝缘体和半导体层，以及半导体层中的多个通道，其在通道中包括多个整体或部分形成的纳米孔。

3. 发明授权

US08622223B2 Membrane assemblies and methods of making and using the same 失效
标题翻译：膜组件及其制造和使用方法
公开(公告)号：US08622223B2
公开(公告)日：2014-01-07
申请号：US12337164
申请日：2008-12-17
申请人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
发明人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
IPC分类号： B01D71/02 , B01D69/12 , B01D63/08
CPC分类号： C23C26/00 , B01D67/0065 , C23C28/00 , C23C28/04 , C25D11/02 , C25D11/045 , C25D11/32 , Y10T428/249953 , Y10T428/249967 , Y10T428/249969
摘要： A method of making a membrane assembly is provided. The method comprises forming an inorganic membrane layer disposed on a substrate, and forming a plurality of macropores in the substrate at least in part using anodization. Further, a membrane assembly is provided. The membrane assembly comprises a filtering membrane that is coupled to an anodized substrate comprising a plurality of macropores.
摘要翻译：提供制造膜组件的方法。该方法包括形成设置在基板上的无机膜层，并且至少部分地使用阳极氧化在基板中形成多个大孔。此外，提供了膜组件。膜组件包括过滤膜，其与包括多个大孔的阳极化底物耦合。

4. 发明申请

US20100159572A1 DEVICE AND ASSOCIATED METHOD 审中-公开
标题翻译：装置和相关方法
公开(公告)号：US20100159572A1
公开(公告)日：2010-06-24
申请号：US12340789
申请日：2008-12-22
申请人： Rui Chen , Anping Zhang , Anup Sood , Anthony John Murray
发明人： Rui Chen , Anping Zhang , Anup Sood , Anthony John Murray
IPC分类号： C12M1/34 , B01J19/00 , B05D3/02
CPC分类号： B01J19/0046 , B01J2219/00536 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , G01N33/54353 , G01N33/552
摘要： A microfluidic device for detecting one or more molecules of interest comprising: a non-conductive substrate; wherein the non-conductive substrate is provided with a plurality of thermally active elements is provided. A method for selectively functionalizing a plurality of thermally active elements is also provided.
摘要翻译：一种用于检测一个或多个感兴趣分子的微流体装置，包括：非导电衬底; 其中所述非导电基板设置有多个热活性元件。还提供了一种用于选择性地功能化多个热活性元件的方法。

5. 发明申请

US20100300882A1 DEVICES AND METHODS FOR IN-LINE SAMPLE PREPARATION OF MATERIALS 审中-公开
标题翻译：用于材料的在线样品制备的装置和方法
公开(公告)号：US20100300882A1
公开(公告)日：2010-12-02
申请号：US12471519
申请日：2009-05-26
申请人： Anping Zhang , Anthony John Murray , Rui Chen , Wei Yuan
发明人： Anping Zhang , Anthony John Murray , Rui Chen , Wei Yuan
IPC分类号： C25B7/00 , B01D61/42 , C07K1/26
CPC分类号： C07K1/34 , B01D63/087 , B01D2325/028 , B01L3/502753 , B01L2200/0631 , B01L2300/0681 , C07K1/16
摘要： A microfluidic device for in-line sample preparation of one or more materials. The microfludic device comprises an in-line tangential flow component. The in-line tangential flow component comprises a first channel through which the sample flows; and one or more additional channels. The first channel and the one ore more channels are separated by a membrane; and wherein a differential is present between the first channel and additional channel that is separated by the membrane.
摘要翻译：用于在线样品制备一种或多种材料的微流体装置。微流体装置包括直线切向流分量。在线切向流分量包括样品流过的第一通道; 和一个或多个附加信道。第一个通道和一个以上的通道被隔膜隔开; 并且其中在所述第一通道和由所述隔膜分离的附加通道之间存在差速器。

6. 发明申请

US20110042299A1 COMPOSITE MEMBRANE ASSEMBLIES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：复合膜组件及其制造方法和使用方法
公开(公告)号：US20110042299A1
公开(公告)日：2011-02-24
申请号：US12544660
申请日：2009-08-20
申请人： Anping Zhang , Rui Chen , Anthony John Murray
发明人： Anping Zhang , Rui Chen , Anthony John Murray
IPC分类号： B01D71/06 , B01D71/00 , B01D71/12 , B01D71/10 , B01D69/12 , B01D67/00 , B05D5/00 , C23C28/00
CPC分类号： B01D65/003 , B01D69/10 , B01D69/125
摘要： A composite membrane assembly is provided. The composite membrane assembly comprises a porous substrate, a filtering membrane at least partially coupled to the porous substrate, a polymer membrane at least partially coupled to the filtering membrane, and an interface material at least partially disposed between the filtering membrane and the polymer membrane.
摘要翻译：提供复合膜组件。复合膜组件包括多孔基底，至少部分耦合到多孔基底的过滤膜，至少部分耦合到过滤膜的聚合物膜，以及至少部分地设置在过滤膜和聚合物膜之间的界面材料。

7. 发明申请

US20100147762A1 MEMBRANE ASSEMBLIES AND METHODS OF MAKING AND USING THE SAME 失效
标题翻译：膜组件及其制造和使用方法
公开(公告)号：US20100147762A1
公开(公告)日：2010-06-17
申请号：US12337164
申请日：2008-12-17
申请人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
发明人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
IPC分类号： B01D69/12 , B01D67/00 , B44C1/22 , C23C28/04 , C25D11/02
CPC分类号： C23C26/00 , B01D67/0065 , C23C28/00 , C23C28/04 , C25D11/02 , C25D11/045 , C25D11/32 , Y10T428/249953 , Y10T428/249967 , Y10T428/249969
摘要： A method of making a membrane assembly is provided. The method comprises forming an inorganic membrane layer disposed on a substrate, and forming a plurality of macropores in the substrate at least in part using anodization. Further, a membrane assembly is provided. The membrane assembly comprises a filtering membrane that is coupled to an anodized substrate comprising a plurality of macropores.
摘要翻译：提供制造膜组件的方法。该方法包括形成设置在基板上的无机膜层，并且至少部分地使用阳极氧化在基板中形成多个大孔。此外，提供了膜组件。膜组件包括过滤膜，其与包括多个大孔的阳极化底物耦合。

8. 发明申请

US20090142825A1 COMPOSITE DETECTION DEVICES HAVING IN-LINE DESALTING AND METHODS OF MAKING THE SAME 有权
标题翻译：具有在线脱盐剂的复合物检测装置及其制备方法
公开(公告)号：US20090142825A1
公开(公告)日：2009-06-04
申请号：US11947224
申请日：2007-11-29
申请人： Anthony John Murray , Anping Zhang , Rui Chen
发明人： Anthony John Murray , Anping Zhang , Rui Chen
IPC分类号： C12M1/34 , G03C5/60
CPC分类号： G01N33/54373 , B01L3/5027 , B01L3/502753 , Y10S977/904 , Y10S977/92 , Y10S977/958
摘要： A composite detection device having in-line desalting is provided. The composite detection device comprises a membrane configured for desalting at least a portion of an analyte stream, and a nanostructure for detecting a bio-molecule or a bio-molecule interaction, wherein the nanostructure and the membrane are arranged such that an analyte stream desalted at least in part by the membrane is detected by the nanostructure. A bio-sending detection system having the composite detection device and method of fabrication of the composite detection device are also provided.
摘要翻译：提供具有直列脱盐的复合检测装置。复合检测装置包括被配置用于对分析物流的至少一部分进行脱盐的膜和用于检测生物分子或生物分子相互作用的纳米结构，其中纳米结构和膜被布置成使得分析物流在至少部分由膜被纳米结构检测。还提供了具有复合检测装置和复合检测装置的制造方法的生物发送检测系统。

9. 发明授权

US08940521B2 Composite detection devices having in-line desalting and methods of making the same 有权
标题翻译：具有在线脱盐的复合检测装置及其制造方法
公开(公告)号：US08940521B2
公开(公告)日：2015-01-27
申请号：US11947224
申请日：2007-11-29
申请人： Anthony John Murray , Anping Zhang , Rui Chen
发明人： Anthony John Murray , Anping Zhang , Rui Chen
IPC分类号： B01D63/08 , B01D69/10 , B01D71/02 , B01D71/04 , B01D71/06 , B82Y5/00 , G01N33/543 , B01L3/00
CPC分类号： G01N33/54373 , B01L3/5027 , B01L3/502753 , Y10S977/904 , Y10S977/92 , Y10S977/958
摘要： A composite detection device having in-line desalting is provided. The composite detection device comprises a membrane configured for desalting at least a portion of an analyte stream, and a nanostructure for detecting a bio-molecule or a bio-molecule interaction, wherein the nanostructure and the membrane are arranged such that an analyte stream desalted at least in part by the membrane is detected by the nanostructure. A bio-sending detection system having the composite detection device and method of fabrication of the composite detection device are also provided.
摘要翻译：提供具有直列脱盐的复合检测装置。复合检测装置包括被配置用于对分析物流的至少一部分进行脱盐的膜和用于检测生物分子或生物分子相互作用的纳米结构，其中纳米结构和膜被布置成使得分析物流在至少部分由膜被纳米结构检测。还提供了具有复合检测装置和复合检测装置的制造方法的生物发送检测系统。

10. 发明授权

US07740748B2 Electrophoresis system and method 失效
标题翻译：电泳系统及方法
公开(公告)号：US07740748B2
公开(公告)日：2010-06-22
申请号：US12258657
申请日：2008-10-27
申请人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
发明人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , B01L3/502715 , G01N27/44743
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis device comprises a loading channel, an injection channel, and a separation channel. The loading channel is in fluid communication with a first and second sample port. The injection channel is connected to the loading channel to form a first intersection. The separation channel is connected to the injection channel to form a second intersection and in fluid communication with a first and second reservoir, and wherein the injection channel is in fluid communication with a third reservoir. The electrophoresis system further comprises electrodes coupled to the first sample port and the third reservoir, and the first reservoir and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the third reservoir and form a sample plug in the second intersection, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳装置包括装载通道，注射通道和分离通道。装载通道与第一和第二采样端口流体连通。注入通道连接到装载通道以形成第一交叉。分离通道连接到注入通道以形成第二交叉并且与第一和第二储存器流体连通，并且其中注入通道与第三储存器流体连通。电泳系统还包括分别耦合到第一样品端口和第三储存器的电极，以及分别适于将样品移动到装载通道中的第一储存器和第二储存器，以朝向第三储存器形成样品塞并且将样品塞进一步朝向第二储存器移动到分离通道中。

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