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1. 发明申请

US20120203199A1 Method and apparatus for providing access to an internal body organ 审中-公开
标题翻译：提供进入内部器官的方法和装置
公开(公告)号：US20120203199A1
公开(公告)日：2012-08-09
申请号：US13373787
申请日：2011-11-30
申请人： Alfred E. Mann , Gregory M. Harbers , Kelly A. Chapman , Abram D. Janis
发明人： Alfred E. Mann , Gregory M. Harbers , Kelly A. Chapman , Abram D. Janis
IPC分类号： A61M5/00 , A61M29/00 , A61B17/34 , A61M25/01
CPC分类号： A61M25/04 , A61M25/0017 , A61M25/0068 , A61M25/0606 , A61M25/0643 , A61M29/00 , A61M39/0208 , A61M39/0247 , A61M2039/0223 , A61M2039/0261
摘要： Catheter systems and methods for facilitating the delivery of a therapeutic agent directly to the interior of a body organ, and/or the extraction of material from said organ. The catheter distal end is placed within the body organ to be treated. The catheter may carry a fixation device near the catheter distal end. When implanted, the fixation device retains the catheter distal end in the organ despite normal patient activity. The fixation device may include porous material to promote soft tissue ingrowth for anchoring the catheter distal end within the organ.
摘要翻译：用于促进将治疗剂直接递送到身体器官内部的导管系统和方法，和/或从所述器官提取材料。将导管远端放置在待治疗的身体器官内。导管可以在导管远端附近携带固定装置。当植入时，尽管正常的患者活动，但是固定装置将导管远端保持在器官中。固定装置可以包括多孔材料以促进软组织向内生长以将导管远端锚定在器官内。

2. 发明授权

US08641778B2 Prosthesis attachment method and apparatus with soft tissue integrating seal 有权
标题翻译：假体附着方法和软组织集成密封装置
公开(公告)号：US08641778B2
公开(公告)日：2014-02-04
申请号：US12735452
申请日：2009-01-21
申请人： Alfred E. Mann , Byron L. Moran , Abram D. Janis , Paul Kaluzniak
发明人： Alfred E. Mann , Byron L. Moran , Abram D. Janis , Paul Kaluzniak
IPC分类号： A61F2/78
CPC分类号： A61B17/8625 , A61B17/60 , A61F2/2814 , A61F2/30749 , A61F2/78 , A61F2002/0086 , A61F2002/30013 , A61F2002/30029 , A61F2002/30434 , A61F2002/30448 , A61F2002/30451 , A61F2002/3093 , A61F2002/7887 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2250/0024 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00149
摘要： A method and apparatus for reducing the incident of infection proximate to an exit site where a prosthesis fastener, e.g., a bone screw, percutaneously penetrates a patient's skin/soft tissue. Infection reduction is achieved in accordance with the invention by growing a tissue integrating seal around the fastener proximate to the exit site.
摘要翻译：用于减少接近出口部位的感染事件的方法和装置，其中假体紧固件（例如骨螺钉）经皮穿透患者的皮肤/软组织。根据本发明通过在邻近出口部位附近围绕紧固件生长组织集成密封来实现感染减少。

3. 发明授权

US08655455B2 Neural stimulator with percutaneous connectivity 有权
标题翻译：具有经皮连接的神经刺激器
公开(公告)号：US08655455B2
公开(公告)日：2014-02-18
申请号：US13500731
申请日：2010-09-30
申请人： Alfred E. Mann , Tom Xiaohai He
发明人： Alfred E. Mann , Tom Xiaohai He
IPC分类号： A61N1/00
CPC分类号： A61N1/0539 , A61M39/0247 , A61M2039/0261 , A61M2039/0267 , A61N1/0536 , A61N1/36017 , A61N1/36128
摘要： An implantable neurostimulation system includes both implantable and external components. Electrical connectivity between the external and implanted components is achieved through a plurality of feedthrough pins located within an insulative wall of a percutaneous port embedded in the skin. The percutaneous port has the general shape and appearance of a small thimble, embedded in the skin with its open end facing outwardly from the skin surface, and with its closed end located below the skin surface, thereby forming a cavity or dimple in the skin. Various plugs or cartridges can be removably inserted into the cavity of the percutaneous port, in various orientations, to facilitate appropriate connectivity between the external and implanted components of the system through selected ones of the feedthrough pins. A mesh edging secured around the periphery wall of the port promotes tissue ingrowth and vascularization, thereby forming a percutaneous seal around the port that prevents infection.
摘要翻译：植入式神经刺激系统包括可植入和外部组件。外部和植入部件之间的电连接通过位于皮肤内的经皮端口的绝缘壁内的多个穿通针来实现。经皮端口具有嵌入皮肤中的小套管的一般形状和外观，其开口端从皮肤表面向外，并且其封闭端位于皮肤表面下方，从而在皮肤中形成空腔或凹坑。可以以各种取向将各种插头或药筒可移除地插入到经皮端口的空腔中，以通过选定的馈通针来促进系统的外部部件和植入部件之间的适当连接。围绕端口的周围壁固定的网状边缘促进组织向内生长和血管形成，从而在端口周围形成防止感染的经皮密封。

4. 发明授权

US08202260B2 Partially implantable medical devices with cartridge movement sensor and associated methods 有权
标题翻译：部分可植入医疗设备，带有盒式移动传感器和相关方法
公开(公告)号：US08202260B2
公开(公告)日：2012-06-19
申请号：US12390430
申请日：2009-02-21
申请人： Alfred E. Mann , Tom Xiaohai He
发明人： Alfred E. Mann , Tom Xiaohai He
IPC分类号： A61M31/00
CPC分类号： A61M5/14244 , A61M5/14276 , A61M5/16854 , A61M39/0247 , A61M39/04 , A61M2205/12 , A61M2205/50 , A61M2205/6054 , A61M2205/8206
摘要： An apparatus for use with a fluid cartridge is disclosed. The apparatus includes a percutaneous port including an interior configured to receive the fluid cartridge, an implantable operative portion operably connected to the percutaneous port, a cartridge sensor configured to sense movement of the fluid cartridge relative to the percutaneous port, and a controller.
摘要翻译：公开了一种与流体盒一起使用的装置。该装置包括经皮端口，其包括构造成接收流体盒的内部，可操作地连接到经皮端口的可植入操作部分，配置成感测流体盒相对于经皮端口的运动的盒传感器，以及控制器。

5. 发明授权

US08175714B2 Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress 有权
标题翻译：植入式视网膜电极阵列配置，用于最小的视网膜损伤和减少视网膜应力的方法
公开(公告)号：US08175714B2
公开(公告)日：2012-05-08
申请号：US13044825
申请日：2011-03-10
申请人： Robert J. Greenberg , Alfred E. Mann , James S. Little , Karl-Heinz Ihrig , Brian V. Mech , Neil H. Talbot , DaoMin Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , James S. Little , Karl-Heinz Ihrig , Brian V. Mech , Neil H. Talbot , DaoMin Zhou
IPC分类号： A61N1/375
CPC分类号： A61N1/0543
摘要： This invention is a retinal electrode array assembly and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means and with innovations that reduce actual and potential damage to the retina and the surrounding tissue.
摘要翻译：本发明是一种视网膜电极阵列组件及其使用方法，其通过向操作外科医生提供视觉参考和抓握装置以及减少对视网膜和周围组织的实际和潜在损伤的创新来促进手术植入程序。

6. 发明申请

US20100217239A1 PARTIALLY IMPLANTABLE MEDICAL DEVICES AND METHODS 有权
标题翻译：部分植入式医疗器械及方法
公开(公告)号：US20100217239A1
公开(公告)日：2010-08-26
申请号：US12390425
申请日：2009-02-21
申请人： Alfred E. Mann , Tom Xiaohai He
发明人： Alfred E. Mann , Tom Xiaohai He
IPC分类号： A61M5/142
CPC分类号： A61M5/14244 , A61M5/14276 , A61M5/16854 , A61M39/0247 , A61M39/04 , A61M2205/12 , A61M2205/50 , A61M2205/6054 , A61M2205/8206
摘要： Partially implantable medical devices and methods associated with partially implantable medical devices.
摘要翻译：部分可植入的医疗设备和与部分可植入医疗设备相关的方法。

7. 发明授权

US07684858B2 Methods and systems for placing an implanted stimulator for stimulating tissue 失效
标题翻译：放置刺激器刺激组织的方法和系统
公开(公告)号：US07684858B2
公开(公告)日：2010-03-23
申请号：US11232540
申请日：2005-09-21
申请人： Tom Xiaohai He , Todd K. Whitehurst , Alfred E. Mann , Peter K. Johnson
发明人： Tom Xiaohai He , Todd K. Whitehurst , Alfred E. Mann , Peter K. Johnson
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/37205
摘要： Systems for providing stimulation with an implantable system control unit and for optimally positioning that system control unit include a system control unit configured to provide a stimulus to a patient with a member attached to the system control unit for pulling the system control unit into position within the patient. Methods of optimally positioning the implantable system control unit within a patient such that the system control unit is proximal to target tissue that is to be stimulated by the system control unit include threading a member through a patient's body using a needle, the member passing proximal to the target tissue and being attached to the system control unit, and pulling the system control unit into place with the member.
摘要翻译：用于用可植入系统控制单元提供刺激并且用于最佳地定位该系统控制单元的系统包括系统控制单元，该系统控制单元被配置为向患者提供具有连接到系统控制单元的构件的刺激，用于将系统控制单元牵引到患者。将可植入系统控制单元最佳地定位在患者体内的方法，使得系统控制单元靠近要由系统控制单元刺激的目标组织包括使用针穿过患者身体的部件，所述构件通过近端到目标组织并附接到系统控制单元，并且将系统控制单元拉到构件的适当位置。

8. 发明申请

US20080147004A1 External Infusion Device With Remote Programming, Bolus Estimator and/or Vibration Alarm Capabilities 有权
标题翻译：外部输液设备，具有远程编程，螺栓估计和/或振动报警功能
公开(公告)号：US20080147004A1
公开(公告)日：2008-06-19
申请号：US11670387
申请日：2007-02-01
申请人： Alfred E. Mann , James D. Causey , Alan Haubach , Luis J. Malave , John Livingston , Cliff Hague , Chad Srisathapat , Jay Yonemoto , Deborah Ruppert , Dennis P. Bishop , Adrian Gut , Bob Murtfeldt
发明人： Alfred E. Mann , James D. Causey , Alan Haubach , Luis J. Malave , John Livingston , Cliff Hague , Chad Srisathapat , Jay Yonemoto , Deborah Ruppert , Dennis P. Bishop , Adrian Gut , Bob Murtfeldt
IPC分类号： A61M37/00 , A61K9/22 , A61M31/00 , G06F17/00
CPC分类号： A61M5/1723 , A61M5/14244 , A61M5/172 , A61M5/36 , A61M2005/1402 , A61M2005/1403 , A61M2205/18 , A61M2205/3561 , A61M2205/3592 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2209/01 , A61M2230/201 , G06F19/00 , G06F19/3468 , Y02A90/22 , Y02A90/26 , Y10S128/903
摘要： An infusion system for infusing a liquid into a body includes an external infusion device and a remote commander. The external infusion device includes a housing, a receiver, a processor and an indication device. The receiver is coupled to the housing and for receiving remotely generated commands. The processor is coupled to the housing and the receiver to receive remotely generated commands and to control the external infusion device in accordance with the commands. The indication device indicates when a command has been received and indicates when the command is being utilized to control the external infusion device so that the external infusion device is capable of being concealed from view when being remotely commanded. The remote commander includes a commander housing, a keypad for transmitting commands, and a transmitter for transmitting commands to the receiver of the external infusion device.
摘要翻译：用于将液体注入身体的输注系统包括外部输注装置和远程指挥器。外部输注装置包括壳体，接收器，处理器和指示装置。接收器耦合到壳体并用于接收远程产生的命令。处理器耦合到壳体和接收器以接收远程产生的命令并根据命令控制外部输注装置。指示装置指示何时已经接收到命令，并且指示何时正在利用命令来控制外部输注装置，使得外部输注装置能够在远程命令时被隐藏。遥控器包括指挥器壳体，用于发送命令的键盘和用于向外部输注装置的接收器发送命令的发射器。

9. 发明授权

US07324012B2 Telemetered characteristic monitor system and method of using the same 有权
标题翻译：遥测特征监测系统及其使用方法
公开(公告)号：US07324012B2
公开(公告)日：2008-01-29
申请号：US11225790
申请日：2005-09-12
申请人： Alfred E. Mann , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
发明人： Alfred E. Mann , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B5/6849 , A61B2560/0214 , A61B2560/0223 , A61M2005/1726 , G06F19/00
摘要： A telemetered characteristic monitor system includes a remotely located data receiving device, a sensor for producing signal indicative of a characteristic of a user, and a transmitter device. The transmitter device includes a housing, a sensor connector, a processor, and a transmitter. The transmitter receives the signals from the sensor and wirelessly transmits the processed signals to the remotely located data receiving device. The processor coupled to the sensor processes the signals from the sensor for transmission to the remotely located data receiving device. The data receiving device may be a characteristic monitor, a data receiver that provides data to another device, an RF programmer for a medical device, a medication delivery device (such as an infusion pump), or the like.
摘要翻译：遥测特征监视器系统包括远程定位的数据接收装置，用于产生指示用户特征的信号的传感器和发射机装置。发射器装置包括壳体，传感器连接器，处理器和发射器。发射机接收来自传感器的信号，并将经处理的信号无线发送到位于远程的数据接收装置。耦合到传感器的处理器处理来自传感器的信号以传输到位于远程的数据接收装置。数据接收装置可以是特征监视器，向另一设备提供数据的数据接收器，用于医疗装置的RF编程器，药物输送装置（例如输液泵）等。

10. 发明授权

US07098803B2 Telemetered characteristic monitor system and method of using the same 有权
标题翻译：遥测特征监测系统及其使用方法
公开(公告)号：US07098803B2
公开(公告)日：2006-08-29
申请号：US10898589
申请日：2004-07-23
申请人： Alfred E. Mann , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
发明人： Alfred E. Mann , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
IPC分类号： A61B1/00
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B5/6849 , A61B2560/0214 , A61B2560/0223 , A61M2005/1726 , G06F19/00
摘要： A telemetered characteristic monitor system includes a remotely located data receiving device, a sensor for producing signal indicative of a characteristic of a user, and a transmitter device. The transmitter device includes a housing, a sensor connector, a processor, and a transmitter. The transmitter receives the signals from the sensor and Tirelessly transmits the processed signals to the remotely located data receiving device. The processor coupled to the sensor processes the signals from the sensor for transmission to the remotely located data receiving device. The data receiving device may be a characteristic monitor, a data receiver that provides data to another device, an RF programmer for a medical device, a medication delivery device (such as an infusion pump), or the like.
摘要翻译：遥测特征监视器系统包括远程定位的数据接收装置，用于产生指示用户特征的信号的传感器和发射机装置。发射器装置包括壳体，传感器连接器，处理器和发射器。发射机接收来自传感器的信号，并将处理后的信号无条件地发送到位于远程的数据接收装置。耦合到传感器的处理器处理来自传感器的信号以传输到位于远程的数据接收装置。数据接收装置可以是特征监视器，向另一设备提供数据的数据接收器，用于医疗装置的RF编程器，药物输送装置（例如输液泵）等。

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