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1. 发明授权

US5098377A Multimodal displacement pump and dissolution system for same 失效
标题翻译：多模式位移泵和溶解系统相同
公开(公告)号：US5098377A
公开(公告)日：1992-03-24
申请号：US559124
申请日：1990-07-26
申请人： Alexander Borsanyi , Richard Harp , Robert Lebo , Scott L. Pool , Joseph Rondinone , John T. Sorensen , Roxanne Wall , Albert L. Stone
发明人： Alexander Borsanyi , Richard Harp , Robert Lebo , Scott L. Pool , Joseph Rondinone , John T. Sorensen , Roxanne Wall , Albert L. Stone
IPC分类号： A61M1/00
CPC分类号： A61M1/0062 , A61M1/0072
摘要： Disclosed is a pneumatically-driven volume controlled bellows pump apparatus for oscillating liquid into a localized area of the human body, preferably methyl-tertiary butyl ether or another solvent, into the gallbladder. The pump includes a fluid reservoir in the form of an inverted syringe attached via a stopcock to the bellows. The bellows is attached via a second stopcock to a catheter also attached to a priming syringe. An inlet pinch valve is disposed between the bellows and the fluid reservoir and an outlet pinch valve between the bellows and the fluid receiver.To use the pump, a pigtail catheter with outlets in the pigtail is inserted into the desired area of the body, preferably a receptacle such as the gallbladder, to introduce a selected volume of liquid for gallstone dissolution. Liquid is infused into the receptacle by decompression of the bellows with the inlet but not the outlet valve open and then by compression of the bellows with the outlet but not the inlet valve open. Repeated infusion and aspiration is automatically accomplished by decompression and compression of the bellows with the inlet valve closed and the outlet valve open, or by compression and decompression of the bellows while the inlet valve is open and the outlet valve is closed alternated with compression and decompression while the inlet valve is closed and the outlet valve is open. Complete aspiration is accomplished by the use of a vacuum pump attached to the fluid reservoir. Also disclosed are syringe units and a transfer cap for use with the pump, together with a method for dissolving gallstones.
摘要翻译：公开了一种气动驱动的体积控制的波纹管泵装置，用于将液体振荡到人体的局部区域，优选甲基叔丁基醚或另一种溶剂进入胆囊。该泵包括呈倒置的注射器形式的流体储存器，其通过旋塞连接到波纹管。波纹管通过第二个旋塞连接到也连接到灌注注射器的导管上。入口夹管阀设置在波纹管和流体储存器之间，以及在波纹管和流体接收器之间的出口压紧阀。为了使用该泵，将在尾纤中具有出口的猪尾导管插入身体的所需区域，优选地插入诸如胆囊的容器中，以引入选定体积的用于胆结石溶解的液体。通过用入口减压波纹管而不是出口阀打开，然后通过带有出口的波纹管压缩而不是入口阀打开，将液体注入到容器中。重复输注和抽吸通过减压和压缩波纹管自动完成，入口阀关闭，出口阀打开，或通过压缩和减压波纹管，同时入口阀打开，出口阀关闭，与压缩和减压交替而入口阀关闭，出口阀打开。完全抽吸是通过使用连接到流体储存器的真空泵来实现的。还公开了用于泵的注射器单元和转移盖，以及用于溶解胆结石的方法。

2. 发明授权

US06506176B1 Methods, apparatus and system for removal of lenses from mammalian eyes 有权
标题翻译：用于从哺乳动物眼睛去除镜片的方法，装置和系统
公开(公告)号：US06506176B1
公开(公告)日：2003-01-14
申请号：US09505098
申请日：2000-02-16
申请人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi , James B. Gerg , John I. Muri , Roger F. Etherington , John A. Ripley
发明人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi , James B. Gerg , John I. Muri , Roger F. Etherington , John A. Ripley
IPC分类号： A61F900
CPC分类号： A61F9/00763 , A61F9/013
摘要： A system for removing the lens from an eye of a mammal, including a lens-removal device having a probe for penetrating the lens capsule. The probe includes a sheath that shields a rotating impeller at all times, with the impeller being pneumatically actuated to advance to a lens removal position within the sheath. The impeller is pneumatically rotated using a turbine mechanism within a handle for the probe. Irrigation and aspiration are provided to facilitate removal of the lens tissue. The turbine is driven with pulsed air to prevent stiction. A purge/protection cap helps remove air bubbles from the system prior to use and protects the delicate impeller during transport. An operating system is also provided with a foot pedal actuator.
摘要翻译：一种用于从哺乳动物的眼睛移除透镜的系统，包括具有用于穿透透镜胶囊的探针的透镜去除装置。探头包括一个护罩，其一直屏蔽旋转的叶轮，其中叶轮被气动地驱动以前进到护套内的透镜去除位置。叶轮在用于探针的手柄内使用涡轮机构气动旋转。提供灌溉和抽吸以便于去除透镜组织。涡轮机用脉冲空气驱动以防止静摩擦。吹扫/保护帽有助于在使用前清除系统中的气泡，并在运输过程中保护细密的叶轮。操作系统还设置有脚踏板致动器。

3. 外观设计

USD434149S Cataract removal device 失效
公开(公告)号：USD434149S
公开(公告)日：2000-11-21
申请号：US100749
申请日：1999-02-17
申请人： Soheila Mirhashemi , Michael Mittelstein , John T. Sorensen
设计人： Soheila Mirhashemi , Michael Mittelstein , John T. Sorensen

4. 发明授权

US5437678A Ophthalmic lens removal method and apparatus 失效
标题翻译：眼科镜片去除方法及装置
公开(公告)号：US5437678A
公开(公告)日：1995-08-01
申请号：US984229
申请日：1992-11-30
申请人： John T. Sorensen
发明人： John T. Sorensen
IPC分类号： A61B17/00 , A61F9/00 , A61F9/007 , A61F9/013
CPC分类号： A61F9/00763 , A61B2017/00685
摘要： Apparatus for reducing the size of an object disposed in a generally closed fluid medium includes a handpiece having an axis extending from a housing at a proximal end to a probe at an opposing distal end. A reducer at the distal end of the probe is adapted for insertion into the fluid medium where it is rotatable to reduce in size the object. The reducer is configured to create a fluid flow in the fluid medium so that the handpiece can be maintained laterally and axially stationary while the object is moved by the fluid flow into contact with the reducer. An associated method includes the steps of rotating the rotary member at a speed sufficient to reduce the size of the object, and in a manner to produce a flow of the fluid sufficient to move the object into the rotary member.
摘要翻译：用于减小设置在通常封闭的流体介质中的物体的尺寸的装置包括具有从近端处的壳体延伸到在相对的远端处的探针的轴的手持件。在探头的远端处的减速器适于插入流体介质中，其中其可旋转以减小物体的尺寸。减速器构造成在流体介质中产生流体流动，使得当物体被流体流移动以与减速器接触时，手持件可以被侧向和轴向地保持固定。相关联的方法包括以足以减小物体的尺寸的速度旋转旋转构件的步骤，以及产生足以将物体移动到旋转构件中的流体流的方式。

5. 发明授权

US4994025A Method of dissolving cholesterol-rich calculi with short chain halogenated organic solvents and cosolvents 失效
标题翻译：用短链卤代有机溶剂和共溶剂溶解富含胆固醇的结石的方法
公开(公告)号：US4994025A
公开(公告)日：1991-02-19
申请号：US400212
申请日：1989-08-29
申请人： Paul DeAntonio , Kenneth G. Mayhan , John T. Sorensen
发明人： Paul DeAntonio , Kenneth G. Mayhan , John T. Sorensen
IPC分类号： A61B17/22 , A61K31/02 , A61P1/16
CPC分类号： A61K31/02 , A61B2017/22084
摘要： Disclosed is a method for dissolving cholesterol-rich calculi, most preferably gallstones in vivo, comprising contacting the calculus with a fluid compound of the formula R-X, R having 2 to 4 carbon atoms with substituents consisting of hydrogen of halogen, X being halogen, and wherein if X is fluorine, at least one substituent is selected from the group consisting of hydrogen, chlorine, bromine, or iodine. Usually R-X is 2-bromo-2-chloro-1,1,1-trifluoroethane (also referred to as Halothane.) Other compounds of particular interest are 2-chloro-1,2,-dibromo-1,1,2-trifluoroethane, 1-bromo-2-chloro-1,1,2-trifluoroethane, 2,3-dibromo-1,1,1-trifluoropropane, 2-iodo-1,1,1-trifluoroethane, 1,2-dichloro-1,1-difluoroethane, 1,1,2-trichloro-2,3,3-trifluorocyclobutane, hexafluoro-1,1,3,4,-tetrachlorobutane, 1,1,1-trichlorotrifluoroethane, and 1,2-dibromo-tetrafluoroethane. Furthermore, Halothane and MtBE in combination effectively dissolve cholesterol-rich calculi.Finally, dissolution can be enhanced by adding to the dissolution solvent up to about 50 percent by volume of a lower alcohol. Usually the lower alcohol is ethanol in the amount of about 5 to 40, usually 10 to 30 and preferably about 10 percent by volume. Most preferably in this case, R-X is Halothane or 1,1,1-trichlorotrifluoroethane. Dissolution using previously known solvents such as MtBE is also enhanced by such addition of lower alcohols. In addition, the practical use of MtBE for dissolution can be improved by the addition of the compounds described above as R-X, particularly Halothane, and usually at levels of about 5 to 50 volume percent Halothane.
摘要翻译：公开了一种在体内溶解富胆固醇结石，最优选胆结石的方法，包括使结石与式RX的流体化合物，具有2至4个碳原子的R和R的卤素取代基组成的取代基，X是卤素，和其中如果X是氟，则至少一个取代基选自氢，氯，溴或碘。通常RX是2-溴-2-氯-1,1,1-三氟乙烷（也称为氟烷）。其它特别令人感兴趣的化合物是2-氯-1,2,2-二溴-1,1,2-三氟乙烷，1-溴-2-氯-1,1,2-三氟乙烷，2,3-二溴-1,1,1-三氟丙烷，2-碘-1,1,1-三氟乙烷，1,2-二氯-1 ，1,2-二氟乙烷，1,1,2-三氯-2,3,3-三氟环丁烷，六氟-1,1,3,4， - 四氯丁烷，1,1,1-三氯三氟乙烷和1,2-二溴 - 四氟乙烷。此外，氟烷和MtBE组合有效地溶解富含胆固醇的结石。最后，通过向溶解溶剂中加入高达约50体积％的低级醇可以提高溶解度。通常，低级醇是乙醇，其量为约5至40，通常为10至30，优选约10体积％。最优选在这种情况下，R-X是氟烷或1,1,1-三氯三氟乙烷。使用先前已知的溶剂如MtBE的溶解也通过这样加入低级醇来增强。另外，通过加入上述作为R-X，特别是氟烷的化合物，可以提高MtBE用于溶解的实际用途，通常为约5〜50体积％的卤代烷的水平。

6. 发明授权

US07445436B2 Peristaltic pump with a moveable pump head 有权
标题翻译：蠕动泵具有可移动的泵头
公开(公告)号：US07445436B2
公开(公告)日：2008-11-04
申请号：US10673296
申请日：2003-09-29
申请人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi , James Gerg , Robert Schauer
发明人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi , James Gerg , Robert Schauer
IPC分类号： F04B43/08 , F04B43/12
CPC分类号： F04B43/1253 , F04B43/1276
摘要： A peristaltic pump 10 for use in ophthalmic surgery includes a housing 12, a pump head 14 having plurality of rollers 16 held within the housing 12, and a backing plate 18 attached to the housing 12. The pump head 14 moves relative to the housing 12 and backing plate 18.
摘要翻译：用于眼科手术的蠕动泵10包括壳体12，具有保持在壳体12内的多个辊16的泵头14和附接到壳体12的背板18。泵头14相对于壳体12和背板18移动。

7. 发明授权

US06852289B2 Methods and apparatus for determining analytes in various matrices 失效
标题翻译：用于确定各种基质中分析物的方法和装置
公开(公告)号：US06852289B2
公开(公告)日：2005-02-08
申请号：US09817446
申请日：2001-03-26
申请人： Virginia C. Gordon , Bennett W. Root, Jr. , Barbara J. Peasley , John F. Elias , John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
发明人： Virginia C. Gordon , Bennett W. Root, Jr. , Barbara J. Peasley , John F. Elias , John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
IPC分类号： B01L3/00 , G01N33/52 , G01N33/543 , B01L11/00 , B01D24/00 , C12M3/00
CPC分类号： B01L3/5025 , B01L3/50255 , G01N33/52 , G01N33/54366 , Y10T436/173845 , Y10T436/18
摘要： Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at detectable concentration.
摘要翻译：用于定性或定量测定诸如食品，生物流体等的基质中的一种或多种分析物的方法和装置。用于测定单个分析物的实施方案包括样品接收容器，第一膜和含有试剂的孔。制备的样品通过第一膜，除去外来物质，并且滤液进入含试剂的孔中以提供可以从其中测定分析物的滤液 - 试剂混合物。用于测定多个分析物的实施方案包括与第一膜串联的一个或多个另外的膜，每个这样的附加膜可操作以捕获一种或多种分析物。然后可以将每种附加分析物从其已被捕获的膜上洗脱出来，以分离含有试剂的孔，以提供洗脱剂 - 试剂混合物，从中可以确定每种所需的分析物。还包括制剂添加剂的配方。此外，提供了上述发明的一个实施方案，用于测定在低（例如，亚可检测）水平下存在于基质中的分析物，其中该装置的过滤器用于捕获和浓缩分析物，以提供滤液 - 试剂混合物，其中分析物以可检测的浓度存在。

8. 发明授权

US06655934B2 Inverted peristaltic pumps and related methods 有权
公开(公告)号：US06655934B2
公开(公告)日：2003-12-02
申请号：US10102608
申请日：2002-03-20
申请人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi
发明人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi
IPC分类号： F04B4308
CPC分类号： F04B43/1261
摘要： Inverted peristaltic pumps and related apparatus/methods wherein one or more compressible pump tubes are formed or mounted on a core member and one or more tube compressing members move about the core member so as to compress the tube(s) and propel a fluid through the tube(s). The core member may be removable and the pump tube(s) may be pre-mounted on the core member to form a disposable or reusable tubing cartridge. The core member or tubing cartridge may be easily inserted into and removed from the pump. In some embodiments troughs or grooves may be formed on the core member and the tube(s) may be disposed in such troughs or grooves.

9. 发明授权

US07959641B2 Tubular cutter device and methods for cutting and removing strips of tissue from the body of a patient 有权
标题翻译：管状刀具装置以及从患者体内切割和去除组织条的方法
公开(公告)号：US07959641B2
公开(公告)日：2011-06-14
申请号：US10560267
申请日：2004-06-10
申请人： John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
发明人： John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
IPC分类号： A61B17/32
CPC分类号： A61F9/00781 , A61B17/320016 , A61B18/1482 , A61B2017/320064 , A61B2018/00083 , A61B2018/1497 , A61F9/007 , A61F9/00736 , A61F9/0079
摘要： Methods and devices for cutting strips of tissue from masses of tissue inside or outside of the bodies of human or animal subjects. The device generally comprises a) an elongate cutting tube that has a distal end and a lumen that opens through an opening in the distal end and b) first and second cutting edges formed on generally opposite edges of the distal end of the cutting tube and separated by a distance D. The device is advanced through tissue to cut a strip of tissue of approximate width W. Width W is approximately equal to distance D.
摘要翻译：用于从人体或动物体内或体外的组织块切割组织条的方法和装置。该装置通常包括：a）细长切割管，其具有远端和通过远端中的开口打开的内腔，以及b）形成在切割管的远端的大致相对的边缘上的第一和第二切割边缘，距离D.设备通过组织前进以切割近似宽度W的组织条。宽度W近似等于距离D.

10. 发明授权

US07842034B2 Electrosurgical devices and methods for selective cutting of tissue 有权
标题翻译：用于选择性切割组织的电外科手术装置和方法
公开(公告)号：US07842034B2
公开(公告)日：2010-11-30
申请号：US10560265
申请日：2004-06-10
申请人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi , James B. Gerg
发明人： Michael Mittelstein , John T. Sorensen , Soheila Mirhashemi , James B. Gerg
IPC分类号： A61B18/14
CPC分类号： A61B18/1482 , A61B2018/00083 , A61B2018/1497 , A61F9/007 , A61F9/0079
摘要： Methods and devices for cutting or coagulating. A device comprises a) an elongate member having a distal end, b) at least one foot member extending from the distal end of the elongate member, said foot member having a upper surface and a lower surface, c) an electrically and thermally insulating covering formed on at least the lower surface of the foot member and d) at least one electrode on the upper surface of the foot member. In operation, the at least one electrode is energized so as to cause cutting or coagulation of tissue located above the upper surface(s) of the foot member(s) while not causing substantial damage to tissue located below the lower surface(s) of the foot member(s).
摘要翻译：切割或凝结的方法和装置。一种装置包括：a）具有远端的细长构件，b）从所述细长构件的远端延伸的至少一个脚构件，所述脚构件具有上表面和下表面，c）电绝热覆盖物形成在所述脚部件的至少所述下表面上，以及d）所述脚部件的上表面上的至少一个电极。在操作中，所述至少一个电极被通电，以便使得位于所述足部件的上表面上方的组织切割或凝结，同时不会对位于所述下部表面的下表面下方的组织造成实质损伤足部成员。

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