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1. 发明授权

US08658093B2 Devices and methods for the detection of analytes 有权
标题翻译：用于检测分析物的装置和方法
公开(公告)号：US08658093B2
公开(公告)日：2014-02-25
申请号：US12167292
申请日：2008-07-03
申请人： Aldrich N. K. Lau , Robert G. Eason , Kristian M. Scaboo , Handong Li
发明人： Aldrich N. K. Lau , Robert G. Eason , Kristian M. Scaboo , Handong Li
IPC分类号： G01N1/26
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , G01N33/54326 , G01N2400/00
摘要： System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
摘要翻译：描述了用于检测分析物如致病细胞的系统和方法。这些方法允许直接测量分析物如病原体，而不需要样品制备和/或PCR。这些装置可以单独用作食品和农产品中的空气传播病原体和其他致病生物的使用点传感器。

2. 发明申请

US20090142772A1 Devices and Methods for the Detection of Analytes 有权
标题翻译：用于检测分析物的装置和方法
公开(公告)号：US20090142772A1
公开(公告)日：2009-06-04
申请号：US12167292
申请日：2008-07-03
申请人： Aldrich N.K. Lau , Robert G. Eason , Kristian M. Scaboo , Handong Li
发明人： Aldrich N.K. Lau , Robert G. Eason , Kristian M. Scaboo , Handong Li
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , G01N33/54326 , G01N2400/00
摘要： System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products.
摘要翻译：描述了用于检测分析物如致病细胞的系统和方法。这些方法允许直接测量分析物如病原体，而不需要样品制备和/或PCR。这些装置可以单独用作食品和农产品中的空气传播病原体和其他致病生物的使用点传感器。

3. 发明申请

US20160245774A1 HIGHLY SELECTIVE COATED-ELECTRODE NANOGAP TRANSDUCERS FOR THE DETECTION OF REDOX MOLECULES 审中-公开
标题翻译：用于检测氧化还原分子的高选择性涂覆电极纳米粒子转移体
公开(公告)号：US20160245774A1
公开(公告)日：2016-08-25
申请号：US15144591
申请日：2016-05-02
申请人： Noureddine Tayebi , Xing Su , Handong Li
发明人： Noureddine Tayebi , Xing Su , Handong Li
IPC分类号： G01N27/327 , C23C16/00
CPC分类号： G01N27/3278 , C23C16/00
摘要： Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
摘要翻译：描述了用于检测氧化还原分子的高选择性涂层电极纳米胶片转换器。在一个示例中，分析物检测系统包括具有用于分析物检测的表面的一个或多个换能器电极。表面包括抑制分析物与一个或多个换能器电极的表面的直接接触的涂层。

4. 发明授权

US08742522B2 Method of making a semiconductor radiation detector 有权
标题翻译：制造半导体辐射探测器的方法
公开(公告)号：US08742522B2
公开(公告)日：2014-06-03
申请号：US13442957
申请日：2012-04-10
申请人： Handong Li , Michael Prokesch , John F. Eger
发明人： Handong Li , Michael Prokesch , John F. Eger
IPC分类号： H01L27/14
CPC分类号： H01L31/022408 , H01L27/14676 , H01L27/14696 , H01L31/085 , H01L31/1828 , Y02E10/543
摘要： A method of making a semiconductor radiation detector wherein the metal layers which serve as the cathode and anode electrodes are recessed from the designated prospective dice lines which define the total upper and lower surface areas for each detector such that the dicing blade will not directly engage the metal during dicing and therefore prevent metal from intruding upon (smearing) the vertical side walls of the detector substrate.
摘要翻译：一种制造半导体辐射检测器的方法，其中用作阴极和阳极电极的金属层从指定的预期骰子线凹下，其限定每个检测器的总上表面积和下表面积，使得切割刀片不会直接接合金属，因此防止金属侵入（污染）检测器基板的垂直侧壁。

5. 发明授权

US08647821B2 Method and apparatus for combined electrochemical synthesis and detection of analytes 有权
标题翻译：用于组合电化学合成和分析物检测的方法和装置
公开(公告)号：US08647821B2
公开(公告)日：2014-02-11
申请号：US13726062
申请日：2012-12-22
申请人： Hernan A. Castro , Gordon D. Holt , Brandon C. Barnett , Handong Li , Narayanan Sundararajan , Wei Wang
发明人： Hernan A. Castro , Gordon D. Holt , Brandon C. Barnett , Handong Li , Narayanan Sundararajan , Wei Wang
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C25B15/02 , G01R27/26 , H01G4/35 , G01N27/00 , C07H21/00
CPC分类号： C25B3/00 , G01N27/226 , H01M14/00
摘要： Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.
摘要翻译：描述了用于检测电极表面上的结合的装置和方法。此外，描述了用于电化学合成聚合物的装置和方法以及用于合成和检测在共同的集成器件表面上与聚合物结合的方法。

6. 发明申请

US20140001055A1 HIGH THROUGHPUT BIOCHEMICAL DETECTION USING SINGLE MOLECULE FINGERPRINTING ARRAYS 有权
标题翻译：使用单分子指纹阵列进行高通量生物化学检测
公开(公告)号：US20140001055A1
公开(公告)日：2014-01-02
申请号：US13538346
申请日：2012-06-29
申请人： Oguz H. Elibol , Grace M. Credo , Xing Su , Madoo Varma , Jonathan S. Daniels , Drew Hall , Handong Li , Noureddine Tayebi , Kai Wu
发明人： Oguz H. Elibol , Grace M. Credo , Xing Su , Madoo Varma , Jonathan S. Daniels , Drew Hall , Handong Li , Noureddine Tayebi , Kai Wu
IPC分类号： G01N27/26 , B82Y5/00 , B82Y30/00
CPC分类号： G01N27/3277 , B01J19/0046 , B01J2219/00608 , B01J2219/00653 , B01J2219/00722 , B81B7/04 , B81B2201/0214 , B81B2201/058 , B82Y15/00 , C40B20/04 , C40B50/16 , G01N27/3278 , G01N27/4145 , G01N27/4146 , G01N27/4148
摘要： Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.
摘要翻译：各种实施方案提供使用换能器阵列进行高通量生物分子检测的装置，方法和系统。在一个实施例中，由换能器元件组成的换能器阵列可用于检测涉及氧化还原基因标签的化学反应的副产物。每个换能器元件可以至少包括反应室和指纹区域，其被配置为使来自反应室的流体通过指纹区域流动。反应室可以包括分子附着区域，并且指纹区域可以包括由纳米间隙分开的至少一组电极，用于进行氧化还原循环反应。在实施方案中，通过使反应室中潜氧氧化还原标记的探针分子，催化剂和靶分子的反应通过指纹区域流动所述腔室内容物，可以检测氧化还原循环反应以鉴定氧化还原标记的生物分子。

7. 发明授权

US08294025B2 Lateral collection photovoltaics 有权
标题翻译：横向收集光伏
公开(公告)号：US08294025B2
公开(公告)日：2012-10-23
申请号：US11972491
申请日：2008-01-10
申请人： Stephen J. Fonash , Handong Li , David Stone
发明人： Stephen J. Fonash , Handong Li , David Stone
IPC分类号： H01L31/02224
CPC分类号： H01L31/035281 , B82Y20/00 , H01L31/022425 , H01L31/022433 , H01L31/03529 , H01L31/18 , H01L51/445 , H01L51/447 , Y02E10/549 , Y10T428/24174
摘要： Lateral collection photovoltaic (LCP) structures based on micro- and nano-collecting elements are used to collect photogenerated carriers. In one set of embodiments, the collecting elements are arrayed on a conducting substrate. In certain versions, the collecting elements are substantially perpendicular to the conductor. In another set of embodiments, the micro- or nano-scale collecting elements do not have direct physical and electrical contact to any conducting substrate. In one version, both anode and cathode electrodes are laterally arrayed. In another version, the collecting elements of one electrode are a composite wherein a conductor is separated by an insulator, which is part of each collector element, from the opposing electrode residing on the substrate. In still another version, the collection of one electrode structure is a composite containing both the anode and the cathode collecting elements for collection. An active material is positioned among the collector elements.
摘要翻译：使用基于微纳米收集元件的侧向收集光伏（LCP）结构来收集光生载流子。在一组实施例中，集合元件排列在导电衬底上。在某些形式中，收集元件基本上垂直于导体。在另一组实施例中，微尺度或纳米级收集元件不具有与任何导电衬底的直接物理和电接触。在一个版本中，阳极和阴极电极都是横向排列的。在另一个版本中，一个电极的收集元件是复合材料，其中导体由驻留在基底上的相对电极的绝缘体分隔开，绝缘体是每个集电器元件的一部分。在另一个版本中，一个电极结构的集合是包含阳极和阴极收集元件用于收集的复合物。活性物质位于收集器元件之间。

8. 发明申请

US20080257109A1 High Vacuum In-Situ Refining Method for High-Purity Materials and an Apparatus Thereof 失效
标题翻译：高纯度材料的真空原位精炼方法及其设备
公开(公告)号：US20080257109A1
公开(公告)日：2008-10-23
申请号：US12067835
申请日：2006-04-11
申请人： Xiaolong Du , Zhaoquan Zeng , Hongtao Yuan , Handong Li , Qikun Xue , Jinfeng Jia
发明人： Xiaolong Du , Zhaoquan Zeng , Hongtao Yuan , Handong Li , Qikun Xue , Jinfeng Jia
IPC分类号： C21C5/30 , C21B7/24
CPC分类号： C22B9/02 , C22B9/04 , C22B9/14 , C22B19/12 , C22B19/18 , F27B14/04 , F27B14/20 , Y02P10/234
摘要： The present invention concerns a high vacuum in-situ refining method for high-purity and superhigh-purity materials and the apparatus thereof, characterized in heating the upper part and lower part of crucible separately using double-heating-wires diffusion furnace under vacuum, thereby forming the temperature profile which is high at upper part and low at lower part of crucible, or in reverse during different stages; then heating the crucible in two steps to remove impurities with high saturation vapor pressure and low saturation vapor pressure respectively in efficiency; and obtaining high-purity materials eventually. The whole procedure is isolated from atmosphere, reducing contamination upon stuff remarkably. The present invention could provide products with high-quality and high production capacity, which are stable in performance, therefore is reliable and free from contamination. The present invention is appropriate for manufacture of high-purity and superhigh-purity materials, particularly for manufacture of high-activity high-purity materials.
摘要翻译：本发明涉及一种用于高纯度和超高纯度材料的高真空原位精制方法及其装置，其特征在于使用双重加热丝扩散炉在真空下分别加热坩埚的上部和下部，由此形成坩埚上部和下部较高的温度分布，或在不同阶段形成相反的温度分布; 然后分两步加热坩埚以分别以高饱和蒸气压和低饱和蒸气压去除杂质; 并最终获得高纯度材料。整个过程与大气隔离，减少了污染物的显着。本发明可以提供具有高质量和高生产能力的产品，性能稳定，因此可靠，无污染。本发明适用于制造高纯度和超高纯度材料，特别是用于制造高活性高纯度材料。

9. 发明授权

US07354720B2 Label free analysis of nucleic acids 有权
标题翻译：无标签分析核酸
公开(公告)号：US07354720B2
公开(公告)日：2008-04-08
申请号：US11313874
申请日：2005-12-20
申请人： Andrea Cuppoletti , Handong Li
发明人： Andrea Cuppoletti , Handong Li
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6816 , C12Q1/6834 , C12Q2565/107 , C12Q2563/107
摘要： A method is provided for label free analysis of nucleic acid materials. In accordance with the present invention, a fluorescent material is provided having a certain fluorescence emission without nucleic acids attached thereto. The fluorescent material of the present invention, has a greater emission upon the binding of a single stranded nucleic acid and an even greater emission upon the binding of a double stranded nucleic acid allowing detection of double stranded binding without using a label attached to the DNA.
摘要翻译：提供了一种用于无标记分析核酸材料的方法。根据本发明，提供具有一定荧光发射的荧光材料，而不附加核酸。本发明的荧光材料在单链核酸结合时具有更大的发射，并且在双链核酸的结合时具有甚至更大的发射，从而允许检测双链结合而不使用与DNA连接的标记。

10. 发明申请

US20080081782A1 Method for the selective enrichment and labeling of phosphorproteins 有权
标题翻译：磷蛋白选择性富集和标记方法
公开(公告)号：US20080081782A1
公开(公告)日：2008-04-03
申请号：US11529541
申请日：2006-09-29
申请人： Handong Li , Narayan Sundararajan
发明人： Handong Li , Narayan Sundararajan
IPC分类号： A61K38/16 , C07K14/475
CPC分类号： C07K1/13 , C07K7/08
摘要： The embodiments of the invention relate to a method for the introduction of a labeling structure such as a fluorescent molecules or a Raman tags to a compound. Imidazole functionalized resins or polymers are used to selectively immobilize phosphocompounds without protecting the carboxylic groups. Relying on the pKa difference between amines and hydrazides and carrying out the reaction in a slightly acidic buffer, all of the amines are protected by protonation while the hydrazides react with the phosphate imidazolide to form a phosphoramidate bond.
摘要翻译：本发明的实施方案涉及将化合物引入诸如荧光分子或拉曼标签的标记结构的方法。咪唑官能化树脂或聚合物用于选择性地固定磷酸化合物而不保护羧基。依赖于胺和酰肼之间的pKα差异并在微酸性缓冲液中进行反应，所有的胺都被质子化保护，而酰肼与磷酸咪唑化物反应形成氨基磷酸酯键。

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