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1. 发明授权

US06762313B2 Processes for preparing linoleic acid raw materials for subsequent conjugation 有权
标题翻译：制备亚油酸原料用于后续共轭的方法
公开(公告)号：US06762313B2
公开(公告)日：2004-07-13
申请号：US10380564
申请日：2003-03-13
申请人： Albert Strube , Uwe Hoemmerich , Bernhard Gutsche
发明人： Albert Strube , Uwe Hoemmerich , Bernhard Gutsche
IPC分类号： C11C100
CPC分类号： C11C3/04 , C11B3/12 , C11C3/10
摘要： Processes for preparing linoleic acid raw materials are described wherein the processes comprise: (a) transesterifying a triglyceride component with an alcohol having from 1 to 4 carbon atoms, at a temperature of from 80 to 120° C., to form a transesterification mixture comprising linoleic acid esters and one or more by-products selected from the group consisting of glycerides, free glycerol, and soaps, wherein the triglyceride component is comprised of at least 60% by weight linoleic acid; and (b) removing the one or more by-products from the transesterification mixture.
摘要翻译：描述了制备亚油酸原料的方法，其中所述方法包括：（a）在80至120℃的温度下将甘油三酯组分与具有1至4个碳原子的醇进行酯交换以形成酯交换混合物，其包含亚油酸酯和选自甘油酯，游离甘油和皂的一种或多种副产物，其中甘油三酯组分由至少60重量％的亚油酸组成; 和（b）从酯交换混合物中除去一种或多种副产物。

2. 发明申请

US20080033191A1 Process for producing glycerol having low aldehyde and ketone content and improved storage stability 审中-公开
标题翻译：具有低醛和酮含量的甘油的生产方法和储存稳定性得到改善
公开(公告)号：US20080033191A1
公开(公告)日：2008-02-07
申请号：US11880928
申请日：2007-07-25
申请人： Ulrich Schoerken , David Melchior , Jochen Seifert , Carolin Meyer , Valerie Eychenne , Christiane Richard-Elsner , Horst Josten , Jean Rigal , Bernhard Gutsche , Albert Strube
发明人： Ulrich Schoerken , David Melchior , Jochen Seifert , Carolin Meyer , Valerie Eychenne , Christiane Richard-Elsner , Horst Josten , Jean Rigal , Bernhard Gutsche , Albert Strube
IPC分类号： C07C51/00
CPC分类号： C07C29/88 , A61K47/10 , C07C31/225
摘要： The invention describes a process for the production of glycerol of providing a vegetable oil or fat as starting material, obtaining crude glycerol from the vegetable oil or fat, and treating the crude glycerol with a reducing agent. The present invention also describes a process for the production of a medicament or pharmaceutical composition, the medicament or composition formed by combining glycerol and at least one pharmaceutically active ingredient. The present invention also describes a pharmaceutical composition or medicament composed of glycerol obtained by way of the invention and a pharmaceutically active ingredient, which compositions forms very little glyceraldehyde and dihydroxyacetone during storage.
摘要翻译：本发明描述了一种生产以植物油或脂肪为原料的甘油的制备方法，从植物油或脂肪中获得粗甘油，并用还原剂处理粗甘油。本发明还描述了制备药物或药物组合物的方法，所述药物或组合物通过将甘油与至少一种药物活性成分组合而形成。本发明还描述了由通过本发明获得的甘油和药物活性成分组成的药物组合物或药物，该组合物在储存期间形成非常少的甘油醛和二羟基丙酮。

3. 发明申请

US20060233986A1 Composition for controlled tempering by means of phase change, production and use thereof 审中-公开
标题翻译：通过相变，生产和使用控制回火的组成
公开(公告)号：US20060233986A1
公开(公告)日：2006-10-19
申请号：US10544023
申请日：2003-12-19
申请人： Bernhard Gutsche , Gerhard Wollmann , Albert Strube , Eike Mahnke
发明人： Bernhard Gutsche , Gerhard Wollmann , Albert Strube , Eike Mahnke
IPC分类号： B32B27/32
CPC分类号： C09K5/063 , A61F2007/0292 , F28D20/02 , F28D2020/0008 , Y02E60/145 , Y02E60/147 , Y10T428/1334
摘要： This disclosure relates to a heat or cold storage composition comprising at least one continuous and at least one discontinuous phase, the continuous phase being liquid or at least plastic at a temperature of −10 to 50° C. and the discontinuous phase—present in the continuous phase—being particulate and containing as phase change material (PCM) at least 10% by weight of an organic compound with a melting point of 0 to 50° C. and at least one structuring polymeric compound. It also relates to the use of a composition according to the invention for controlled heating/cooling by phase change and to a device for the controlled heating/cooling of an object by phase change at least comprising a container for holding a composition according to the invention.
摘要翻译：本公开涉及包含至少一个连续和至少一个不连续相的热或冷储存组合物，所述连续相是液体或在-10至50℃的温度下至少是塑料，并且所述不连续相存在于连续相分散的颗粒并含有至少10重量％的熔点为0至50℃的有机化合物和至少一种结构化聚合化合物作为相变材料（PCM）。它还涉及根据本发明的组合物用于通过相变的受控加热/冷却以及通过相变的用于受控加热/冷却物体的装置的用途，所述相变至少包括用于保持根据本发明的组合物的容器。

4. 发明授权

US08580986B2 Process for the production of fatty acid alkyl esters 失效
标题翻译：生产脂肪酸烷基酯的方法
公开(公告)号：US08580986B2
公开(公告)日：2013-11-12
申请号：US12304078
申请日：2007-05-16
申请人： Eric Dubreucq , Albrecht Weiss , Bernhard Gutsche , Bernd Fabry , Guy Moulin
发明人： Eric Dubreucq , Albrecht Weiss , Bernhard Gutsche , Bernd Fabry , Guy Moulin
IPC分类号： C11C3/00 , C12P7/64
CPC分类号： C12P7/649 , A23K10/10 , C10L1/026 , C11C3/003 , Y02E50/13 , Y02E50/17
摘要： Disclosed is an improved process for the production of fatty acid lower alkyl esters according to formula (I) R1CO—OR2 (I) in which R1CO represents a linear or branched acyl moiety having from about 6 to about 22 carbon atoms and 0 to 6 double bonds and wherein R2 is a linear or branched alkyl moiety having 1 to 6 carbon atoms, by transesterification of triglycerides or fatty acid esters using C1-C6 aliphatic alcohols, which includes the steps of (a) providing an aqueous mixture of aliphatic C1-C6 alcohol by fermenting in a first reactor a carbon source comprising carbohydrates and/or glycerol produce a fermentation broth comprising said aliphatic C1-C6 alcohol, (b) providing in a second reactor a triglyceride and/or an ester of a fatty acid, together with a biocatalyst capable of effecting a transesterification reaction, (c) transferring said aqueous aliphatic C1-C6 alcohol mixture obtained from said first reactor into said second reactor to provide a two-phase system, and (d) effecting the transesterification reaction to produce said fatty acid lower alkyl ester and a glycerol- or alcohol-containing aqueous phase. The products thus obtained are particularly useful as components of the fuel known as biodiesel.
摘要翻译：公开了一种改进的式（I）R1CO-OR2（I）的脂肪酸低级烷基酯的制备方法，其中R 1 CO表示具有约6至约22个碳原子且0至6个双键的直链或支链酰基部分并且其中R 2是具有1至6个碳原子的直链或支链烷基部分，通过使用C 1 -C 6脂族醇进行甘油三酯或脂肪酸酯的酯交换反应，其包括以下步骤：（a）提供脂族C 1 -C 6 醇通过在第一反应器中发酵包含碳水化合物和/或甘油的碳源产生包含所述脂族C 1 -C 6醇的发酵液，（b）在第二反应器中提供甘油三酯和/或脂肪酸酯，以及能够进行酯交换反应的生物催化剂，（c）将从所述第一反应器获得的脂族C 1 -C 6醇混合物混合物转移到所述第二反应器中以提供两相体系，和（d） g的酯交换反应以产生所述脂肪酸低级烷基酯和含甘油或醇的水相。这样得到的产物特别适用于称为生物柴油的燃料的组分。

5. 发明申请

US20110089370A1 Lipophilic Preparations 审中-公开
标题翻译：亲脂性制剂
公开(公告)号：US20110089370A1
公开(公告)日：2011-04-21
申请号：US12672705
申请日：2008-08-01
申请人： Bernhard Gutsche , Ulrich Schörken , Albrecht Weiss , Bernd Fabry
发明人： Bernhard Gutsche , Ulrich Schörken , Albrecht Weiss , Bernd Fabry
IPC分类号： C12P7/64 , C09K3/00
CPC分类号： C12P7/6463 , C11C3/003
摘要： Disclosed are novel lipophilic preparations comprising (a) from 20 to 40% by weight of myristic acid or esters thereof, (b) from 20 to 40% by weight of palmitic acid or esters thereof, (c) from 0.1 to 5% by weight of aliphatic and/or cycloaliphatic hydrocarbons and (d) less than 20% by weight of carboxylic acids or esters thereof having 12 and fewer carbons in the acyl moiety and (e) less than 20% by weight of carboxylic acids or esters thereof having 16 and more carbons in the acyl moiety, with the proviso that all percentages add up to 100% by weight.
摘要翻译：公开了新的亲脂性制剂，其包含（a）20至40重量％的肉豆蔻酸或其酯，（b）20至40重量％的棕榈酸或其酯，（c）0.1至5重量％的脂族和/或脂环族烃和（d）少于20重量％的在酰基部分中具有12个或更少碳原子的羧酸或其酯，和（e）少于20重量％的具有16个碳原子的羧酸或其酯和酰基部分中的更多碳，条件是所有百分比加起来为100重量％。

6. 发明申请

US20090253944A1 Process for Preparing Alkylene Oxides 有权
标题翻译：制备环氧烷的方法
公开(公告)号：US20090253944A1
公开(公告)日：2009-10-08
申请号：US12295679
申请日：2007-03-23
申请人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
发明人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
IPC分类号： C07C29/04
CPC分类号： C07D301/12 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , C07D301/14
摘要： The invention provides a process for preparing ethylene oxide and/or propylene oxide by contacting ethylene and/or propylene with an oxidizing agent, wherein (i) the reaction takes place in a microreaction system (p-reactor) and (ii) the oxidizing agent used is a peroxo compound.
摘要翻译：本发明提供了通过使乙烯和/或丙烯与氧化剂接触来制备环氧乙烷和/或环氧丙烷的方法，其中（i）反应在微反应系统（p反应器）中进行，和（ii）氧化剂使用过氧化合物。

7. 发明申请

US20070196893A1 Process for obtaining lutein from algae 失效
标题翻译：从藻类中获得叶黄素的方法
公开(公告)号：US20070196893A1
公开(公告)日：2007-08-23
申请号：US11651792
申请日：2007-01-10
申请人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
发明人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
IPC分类号： C07C35/18 , C12P23/00
CPC分类号： C12P23/00 , A23K20/179 , A23L5/46 , A23L33/105 , A61K8/9706 , A61K2800/522 , A61Q19/00
摘要： A process of obtaining lutein in a high yield from green algae is described. Lutein and lutein-enriched products obtained by the process, which are suitable for use as dietary supplements and/or food additives, or cosmetic or pharmaceutical raw materials, are also described.
摘要翻译：描述了从绿藻中获得高产量的叶黄素的方法。还描述了通过该方法获得的适合用作膳食补充剂和/或食品添加剂的化妆品或药物原料的叶黄素和富含叶黄素的产品。

8. 发明授权

US07244856B2 Processes for recovering phytosterols via crystallization 有权
标题翻译：通过结晶回收植物甾醇的方法
公开(公告)号：US07244856B2
公开(公告)日：2007-07-17
申请号：US10896486
申请日：2004-07-22
申请人： Christophe Sicre , Rene Armengaud , Joerg Schwarzer , Bernhard Gutsche , Markus Musholt , Volkmar Jordan
发明人： Christophe Sicre , Rene Armengaud , Joerg Schwarzer , Bernhard Gutsche , Markus Musholt , Volkmar Jordan
IPC分类号： C07J9/00
CPC分类号： C07J9/00
摘要： Processes for recovering phytosterols are described. The processes comprise: (a) providing a liquid mixture containing a phytosterol, methanol, and one or more additional compounds, wherein the methanol is present in an amount of from 25 to 75% by weight, based on the phytosterol; (b) cooling the mixture to form phytosterol crystals; and (c) separating the phytosterol crystals from the remainder of the mixture.
摘要翻译：描述了恢复植物甾醇的方法。所述方法包括：（a）提供含有植物甾醇，甲醇和一种或多种另外的化合物的液体混合物，其中所述甲醇以基于植物甾醇的25至75重量％的量存在; （b）冷却混合物以形成植物甾醇晶体; 和（c）将植物甾醇晶体与混合物的其余部分分离。

9. 发明授权

US07091012B2 Processes for obtaining sterols and polar lipids from vegetable oil lecithin fractions 失效
$Processes for obtaining sterols and polar lipids from vegetable oil lecithin fractions$
标题翻译：从植物油卵磷脂级分获得固醇和极性脂质的方法
公开(公告)号：US07091012B2
公开(公告)日：2006-08-15
申请号：US10988743
申请日：2004-11-15
申请人： Sabine Both , Teresa Alexandre , Bernhard Gutsche , Juergen Kray , Carsten Beverungen , Rainer Eickenberg
发明人： Sabine Both , Teresa Alexandre , Bernhard Gutsche , Juergen Kray , Carsten Beverungen , Rainer Eickenberg
IPC分类号： C12P7/40
CPC分类号： B01D61/145 , B01D61/142 , C11B1/00 , C11B1/025 , C11B1/10 , C11B3/008 , C12P33/00
摘要： Processes for the simultaneous production of sterols and polar lipids, in which preparations of vegetable oil lecithin fractions are subjected to ultrafiltration and, on the one hand, the sterols in the permeate and, on the other hand, the polar lipids in the retentate are enriched. The permeate and retentate can subsequently be worked up by methods known per se.
摘要翻译：用于同时生产甾醇和极性脂质的方法，其中植物油卵磷脂级分的制备物经过超滤，一方面是渗透物中的固醇，另一方面，渗余物中的极性脂质富集。渗透物和渗余物随后可以通过本身已知的方法来处理。

10. 发明申请

US20060052619A1 Method for producing linear or branched fatty acid esters by means of heterogeneously catalysed reactive rectification with an upstream reactor 有权
标题翻译：通过用上游反应器进行非均相催化的反应性精馏生产直链或支链脂肪酸酯的方法
公开(公告)号：US20060052619A1
公开(公告)日：2006-03-09
申请号：US10537973
申请日：2003-12-02
申请人： Bernhard Gutsche , Magnus Topphoff , Harald Robler , Erich Reuter
发明人： Bernhard Gutsche , Magnus Topphoff , Harald Robler , Erich Reuter
IPC分类号： C07C69/02
CPC分类号： C07C67/08 , C07C67/54 , Y02P20/127 , C07C69/003 , C07C69/22 , C07C69/18
摘要： The disclosed invention relates to a countercurrent process for the continuous esterification of C1-22 (fatty) acids with C1-10 monoalkanols, C2-5 di- or trialkanols or mixtures thereof in the liquid phase in the presence of heterogeneous catalysts in a preliminary reactor (1) and in a reaction column (3), characterized in that the reaction column (3) is preceded by the preliminary reactor (1) and a separation unit (2) for the purpose of reducing the viscosity of the reaction mixture and removing the water of reaction from the system via a separation unit (2) to displace the reaction equilibrium before the reaction column (3). A further aspect of the invention concerns feeding nitrogen in at the lowermost plate of the reaction column (3) in order to increase the vapour load in the lower part of the reaction column.
摘要翻译：所公开的本发明涉及用C 1〜12个单烷醇（C 2-5）连续酯化C 1-22（脂肪酸）的逆流方法，在反应器（1）和反应塔（3）中的非均相催化剂存在下，液相中的二 - 或三烷醇或其混合物或其混合物，其特征在于反应塔（3）之前是预备反应器（1）和分离单元（2），用于降低反应混合物的粘度并通过分离单元（2）从体系中除去反应水以置换反应塔（3）之前的反应平衡，。本发明的另一方面涉及在反应塔（3）的最下面的塔板上加入氮气，以增加反应塔下部的蒸气负荷。

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