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1. 发明申请

US20080033191A1 Process for producing glycerol having low aldehyde and ketone content and improved storage stability 审中-公开
标题翻译：具有低醛和酮含量的甘油的生产方法和储存稳定性得到改善
公开(公告)号：US20080033191A1
公开(公告)日：2008-02-07
申请号：US11880928
申请日：2007-07-25
申请人： Ulrich Schoerken , David Melchior , Jochen Seifert , Carolin Meyer , Valerie Eychenne , Christiane Richard-Elsner , Horst Josten , Jean Rigal , Bernhard Gutsche , Albert Strube
发明人： Ulrich Schoerken , David Melchior , Jochen Seifert , Carolin Meyer , Valerie Eychenne , Christiane Richard-Elsner , Horst Josten , Jean Rigal , Bernhard Gutsche , Albert Strube
IPC分类号： C07C51/00
CPC分类号： C07C29/88 , A61K47/10 , C07C31/225
摘要： The invention describes a process for the production of glycerol of providing a vegetable oil or fat as starting material, obtaining crude glycerol from the vegetable oil or fat, and treating the crude glycerol with a reducing agent. The present invention also describes a process for the production of a medicament or pharmaceutical composition, the medicament or composition formed by combining glycerol and at least one pharmaceutically active ingredient. The present invention also describes a pharmaceutical composition or medicament composed of glycerol obtained by way of the invention and a pharmaceutically active ingredient, which compositions forms very little glyceraldehyde and dihydroxyacetone during storage.
摘要翻译：本发明描述了一种生产以植物油或脂肪为原料的甘油的制备方法，从植物油或脂肪中获得粗甘油，并用还原剂处理粗甘油。本发明还描述了制备药物或药物组合物的方法，所述药物或组合物通过将甘油与至少一种药物活性成分组合而形成。本发明还描述了由通过本发明获得的甘油和药物活性成分组成的药物组合物或药物，该组合物在储存期间形成非常少的甘油醛和二羟基丙酮。

2. 发明申请

US20050255570A1 Method for producing conjugated linoleic acid 失效
标题翻译：共轭亚油酸的制备方法
公开(公告)号：US20050255570A1
公开(公告)日：2005-11-17
申请号：US10516987
申请日：2003-05-28
申请人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
发明人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
IPC分类号： C12P7/64 , C12R1/05
CPC分类号： C12P7/6427
摘要： Processes for preparing conjugated linoleic acid are described wherein a conjugated linoleic acid lower alkyl ester is subjected to hydrolysis in the presence of an enzyme to form a hydrolyzate comprising a conjugated linoleic acid and a lower alkanol, wherein at least a portion of the lower alkanol is continuously removed; the hydrolyzate is separated into an organic phase and an aqueous/alcoholic phase; and the conjugated linoleic acid is separated from the organic phase.
摘要翻译：描述制备共轭亚油酸的方法，其中共轭亚油酸低级烷基酯在酶存在下进行水解以形成包含共轭亚油酸和低级链烷醇的水解产物，其中至少一部分低级烷醇为连续删除将水解产物分离成有机相和水相/醇相; 共轭亚油酸与有机相分离。

3. 发明申请

US20070148746A1 PROCESS FOR THE ENZYMATIC SYNTHESIS OF TRIGLYCERIDES 审中-公开
标题翻译：合成酶的合成方法
公开(公告)号：US20070148746A1
公开(公告)日：2007-06-28
申请号：US11565696
申请日：2006-12-01
申请人： ULRICH SCHOERKEN , Carolin Meyer , Peter Horlacher , Sabine Both
发明人： ULRICH SCHOERKEN , Carolin Meyer , Peter Horlacher , Sabine Both
IPC分类号： C12P7/64 , C07C57/02
CPC分类号： C12P7/6472 , C12P7/6454
摘要： The invention relates to a process for the enzymatic synthesis of esters of polyunsaturated, short-chain or sensitive fatty acids with a high triglyceride content, which is made up of an enzymatic synthesis of the mixture of triglycerides and partial glycerides starting from free fatty acid, methyl or ethyl esters and glycerol, a subsequent selective enzymatic back-hydrolysis of the partial glycerides to fatty acid and glycerol and distillation-based separation of the triglycerides, and to the triglyceride-rich ester mixtures obtainable by this process. The process is preferably carried out as a one-pot process in the same reactor and in the presence of the same enzyme.
摘要翻译：本发明涉及一种用于酶促合成具有高甘油三酯含量的多不饱和，短链或敏感脂肪酸酯的方法，其由甘油三酯和偏甘油酯从游离脂肪酸开始的混合物的酶合成，甲基或乙酯和甘油，随后将部分甘油酯选择性酶促回水解成脂肪酸和甘油，并且基于蒸馏的甘油三酸酯分离，以及通过该方法可获得的富含甘油三酯的酯混合物。该方法优选在同一反应器中和在相同酶存在下作为一锅法进行。

4. 发明授权

US07138256B2 Processes for preparing conjugated linoleic acid from conjugated linoleic acid esters 失效
标题翻译：从共轭亚油酸酯制备共轭亚油酸的方法
公开(公告)号：US07138256B2
公开(公告)日：2006-11-21
申请号：US10516987
申请日：2003-05-28
申请人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
发明人： Lars Zander , Stefan Busch , Carolin Meyer , Sabine Both , Ulrich Schoerken
IPC分类号： C12P7/64
CPC分类号： C12P7/6427
摘要： Processes for preparing conjugated linoleic acid are described wherein a conjugated linoleic acid lower alkyl ester is subjected to hydrolysis in the presence of an enzyme to form a hydrolyzate comprising a conjugated linoleic acid and a lower alkanol, wherein at least a portion of the lower alkanol is continuously removed; the hydrolyzate is separated into an organic phase and an aqueous/alcoholic phase; and the conjugated linoleic acid is separated from the organic phase.
摘要翻译：描述制备共轭亚油酸的方法，其中共轭亚油酸低级烷基酯在酶存在下进行水解以形成包含共轭亚油酸和低级链烷醇的水解产物，其中至少一部分低级烷醇为连续删除将水解产物分离成有机相和水相/醇相; 共轭亚油酸与有机相分离。

5. 发明申请

US20050233426A1 Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes 审中-公开
标题翻译：在酶存在下生产不饱和脂肪酸甘油三酸酯的方法
公开(公告)号：US20050233426A1
公开(公告)日：2005-10-20
申请号：US11093410
申请日：2005-03-30
申请人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
发明人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
IPC分类号： C11C3/06 , C11C3/10 , C12P7/64
CPC分类号： C12P7/6472
摘要： Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form their triglycerides is accelerated by addition of an additive from the group of weakly basic salts, complexing agents and ion exchangers and/or addition of a weakly basic salt and/or addition of an entraining agent in the form of a solvent or a gas and/or addition of glycerol-binding adsorbers and/or heat treatment of the partial glyceride intermediate product, (b) the immobilized enzymes are removed from the triglyceride by separation or filtration and (c) the remaining fatty acids and/or C1-4 alkyl esters thereof are removed from the triglyceride by distillation, refining or extraction.
摘要翻译：使用多不饱和脂肪酸酶催化生产甘油三酸酯的方法，其中（a）多不饱和脂肪酸和/或其中C 1-4烷基酯与甘油在真空中的存在下反应，通过从弱碱性盐，络合剂和离子交换剂组中加入添加剂和/或加入弱碱性盐和/或以溶剂形式加入夹带剂来加速形成它们的甘油三酯的固定化酶或甘油结合吸附剂的气体和/或加成物和/或热处理部分甘油酯中间产物，（b）通过分离或过滤从甘油三酯中除去固定化的酶，和（c）剩余的脂肪酸和/或通过蒸馏，精制或萃取，从甘油三酯中除去C 1-4烷基酯。

6. 发明授权

US07981641B2 Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes 有权
标题翻译：在酶存在下生产不饱和脂肪酸甘油三酸酯的方法
公开(公告)号：US07981641B2
公开(公告)日：2011-07-19
申请号：US12061005
申请日：2008-04-02
申请人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
发明人： Ulrich Schoerken , Sabine Both , Carolin Meyer , Peter Horlacher
IPC分类号： C12P7/64 , C08L91/00
CPC分类号： C12P7/6472
摘要： Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form their triglycerides is accelerated by addition of an additive from the group of weakly basic salts, complexing agents and ion exchangers and/or addition of a weakly basic salt and/or addition of an entraining agent in the form of a solvent or a gas and/or addition of glycerol-binding adsorbers and/or heat treatment of the partial glyceride intermediate product, (b) the immobilized enzymes are removed from the triglyceride by separation or filtration and (c) the remaining fatty acids and/or C1-4 alkyl esters thereof are removed from the triglyceride by distillation, refining or extraction.
摘要翻译：使用多不饱和脂肪酸进行酶催化生产甘油三酸酯的方法，其中（a）在固定化酶存在下，多不饱和脂肪酸和/或其中C 1-4烷基酯与甘油在真空中反应形成其甘油三酸酯的方法是通过加入来自弱碱性盐，络合剂和离子交换剂的添加剂和/或加入弱碱性盐和/或以溶剂或气体的形式加入夹带剂和/或添加甘油结合吸附剂和/或热处理部分甘油酯中间产物，（b）通过分离或过滤从甘油三酯中除去固定化的酶，和（c）除去剩余的脂肪酸和/或其中的C 1-4烷基酯从甘油三酯通过蒸馏，精制或提取。

7. 发明授权

US07604966B2 Process for the production of structured lipid mixtures 有权
标题翻译：生产结构化脂质混合物的方法
公开(公告)号：US07604966B2
公开(公告)日：2009-10-20
申请号：US11554799
申请日：2006-10-31
申请人： Ulrich Schoerken , Doris Bell , Peter Horlacher , Diana Stuhlmann , Carolin Meyer
发明人： Ulrich Schoerken , Doris Bell , Peter Horlacher , Diana Stuhlmann , Carolin Meyer
IPC分类号： C12P7/64
CPC分类号： C11C3/10 , A21D2/165 , A23D9/00 , A23K20/158 , A23L33/115 , A23L33/12
摘要： The invention relates to structured lipid mixtures corresponding to formula (I): characterized in that R1CO, R2CO and R3CO independently of one another represent (i) linear saturated acyl groups containing 6 to 12 carbon atoms or (ii) the acyl group of conjugated linoleic acid (CLA) and/or an omega-3 or omega-6 fatty acid (OF), with the proviso that the quantity of CLA acyl groups amounts to 3 to 50 mol- % and the quantity of OF acyl groups to 5 to 25 mol- %, based on the quantity of acyl groups. The mixtures are preferably made by subjecting a mixture of component (a) a medium-chain triglyceride; and component (b) a CLA, an (OF), a TG-CLA (TG-OF) or a mixture thereof to enzymatic transesterification in the presence of a vegetable, marine or microbial oil.
摘要翻译：本发明涉及对应于式（I）的结构化脂质混合物：其特征在于R1CO，R2CO和R3CO彼此独立地表示（i）含有6至12个碳原子的直链饱和酰基或（ii）共轭亚油酸的酰基酸（CLA）和/或ω-3或ω-6脂肪酸（OF），条件是CLA酰基的量为3〜50摩尔％，酰基的量为5〜25 mol％，基于酰基的数量。混合物优选通过将组分（a），中链甘油三酯的混合物，和（b）CLA，（OF），TG-CLA（TG-OF）或其混合物在植物，海洋或微生物油的存在下进行酶促酯交换反应。

8. 发明申请

US20080182304A1 PROCESSES FOR THE PRODUCTION OF TRIGLYCERIDES OF UNSATURATED FATTY ACIDS IN THE PRESENCE OF ENZYMES 有权
标题翻译：在酶的存在下生产不饱和脂肪酸的三聚氰胺的方法
公开(公告)号：US20080182304A1
公开(公告)日：2008-07-31
申请号：US12061005
申请日：2008-04-02
申请人： ULRICH SCHOERKEN , Sabine Both , Carolin Meyer , Peter Horlacher
发明人： ULRICH SCHOERKEN , Sabine Both , Carolin Meyer , Peter Horlacher
IPC分类号： C12P7/64
CPC分类号： C12P7/6472
摘要： Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form heir triglycerides is accelerated by addition of an additive from the group of weakly basic salts, complexing agents and ion exchangers and/or addition of a weakly basic salt and/or addition of an entraining agent in the form of a solvent or a gas and/or addition of glycerol-binding adsorbers and/or heat treatment of the partial glyceride intermediate product, (b) the immobilized enzymes are removed from the triglyceride by separation or filtration and (c) the remaining fatty acids and/or C1-4 alkyl esters thereof are removed from the triglyceride by distillation, refining or extraction.
摘要翻译：使用多不饱和脂肪酸酶催化生产甘油三酸酯的方法，其中（a）多不饱和脂肪酸和/或其中C 1-4烷基酯与甘油在真空中的存在下反应，通过从弱碱性盐，络合剂和离子交换剂组中加入添加剂和/或加入弱碱性盐和/或加入溶剂形式的夹带剂来加速形成继承甘油三酯的固定化酶或甘油结合吸附剂的气体和/或加成物和/或热处理部分甘油酯中间产物，（b）通过分离或过滤从甘油三酯中除去固定化的酶，和（c）剩余的脂肪酸和/或通过蒸馏，精制或萃取，从甘油三酯中除去C 1-4烷基酯。

9. 发明申请

US20070111292A1 STRUCTURED LIPID MIXTURES 有权
标题翻译：结构脂肪混合物
公开(公告)号：US20070111292A1
公开(公告)日：2007-05-17
申请号：US11554799
申请日：2006-10-31
申请人： Ulrich Schoerken , Doris Bell , Peter Horlacher , Diana Stuhlmann , Carolin Meyer
发明人： Ulrich Schoerken , Doris Bell , Peter Horlacher , Diana Stuhlmann , Carolin Meyer
IPC分类号： A61K31/22 , C12P7/64
CPC分类号： C11C3/10 , A21D2/165 , A23D9/00 , A23K20/158 , A23L33/115 , A23L33/12
摘要： The invention relates to structured lipid mixtures corresponding to formula (I): characterized in that R1CO, R2CO and R3CO independently of one another represent (i) linear saturated acyl groups containing 6 to 12 carbon atoms or (ii) the acyl group of conjugated linoleic acid (CLA) and/or an omega-3 or omega-6 fatty acid (OF), with the proviso that the quantity of CLA acyl groups amounts to 3 to 50 mol-% and the quantity of OF acyl groups to 5 to 25 mol-%, based on the quantity of acyl groups. The mixtures are preferably made by subjecting a mixture of component (a) a medium-chain triglyceride; and component (b) a CLA, an (OF), a TG-CLA (TG-OF) or a mixture thereof to enzymatic transesterification in the presence of a vegetable, marine or microbial oil.
摘要翻译：本发明涉及对应于式（I）的结构化脂质混合物：其特征在于R 1 CO，R 2 CO和R 3 CO独立地彼此表示（i）含有6至12个碳原子的直链饱和酰基或（ii）共轭亚油酸（CLA）和/或ω-3或ω-6脂肪酸（OF）的酰基，其中条件是基于酰基的量，CLA酰基的量为3至50摩尔％，酰基的量为5至25摩尔％。混合物优选通过将组分（a），中链甘油三酯的混合物，和（b）CLA，（OF），TG-CLA（TG-OF）或其混合物在植物，海洋或微生物油的存在下进行酶促酯交换反应。

10. 发明申请

US20060057689A1 Method for producing c4-c12 fatty acids 审中-公开
标题翻译：生产c4-c12脂肪酸的方法
公开(公告)号：US20060057689A1
公开(公告)日：2006-03-16
申请号：US10513812
申请日：2003-04-29
申请人： Ralf Otto , Georg Fieg , Sabine Both , Ulrich Schoerken , Levent Yueksel , Ingomar Mrozek , Carolin Meyer , Norbert Klein , Albrecht Weiss
发明人： Ralf Otto , Georg Fieg , Sabine Both , Ulrich Schoerken , Levent Yueksel , Ingomar Mrozek , Carolin Meyer , Norbert Klein , Albrecht Weiss
IPC分类号： C12P7/64 , C12P7/40
CPC分类号： C12P7/6418 , C12P7/40
摘要： Processes for preparing fatty acids are described wherein a C4-C12 fatty acid methyl ester is subjected to hydrolysis in the presence of an enzyme to form an organic phase comprising a C4-C12 fatty acid and an aqueous phase comprising methanol, wherein at least a portion of the methanol is continuously removed; and the organic phase is subsequently separated from the aqueous phase, and optionally, where the organic phase further comprises an unhydrolyzed portion of the C4-C12 fatty acid methyl ester, the unhydrolyzed portion of the C4-C12 fatty acid methyl ester is separated from the C4-C12 fatty acid.
摘要翻译：描述了制备脂肪酸的方法，其中在酶的存在下使C 4 -C 12脂肪酸甲酯进行水解以形成包含C 脂肪酸和包含甲醇的水相，其中至少部分甲醇被连续除去; 随后将有机相与水相分离，任选地，当有机相进一步包含C 6-14脂肪酸甲酯的未水解部分时，将C 4 -C 12脂肪酸甲酯的未水解部分与C 4 -C 12脂肪酸甲酯分离 >脂肪酸。

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