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1. 发明授权

US07727768B2 Method for a nanocalorimeter for detecting chemical reactions 失效
标题翻译：用于检测化学反应的纳米光度计的方法
公开(公告)号：US07727768B2
公开(公告)日：2010-06-01
申请号：US11149632
申请日：2005-06-10
申请人： Alan G. Bell , Richard H. Bruce , Scott A. Elrod , Eric Peeters , Francisco E. Torres
发明人： Alan G. Bell , Richard H. Bruce , Scott A. Elrod , Eric Peeters , Francisco E. Torres
IPC分类号： G01N33/00
CPC分类号： B82Y15/00 , G01N25/4846 , G01N25/4866 , Y10S977/957 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.
摘要翻译：用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米光度计。热测量设备连接到检测电子设备。该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。然后用检测电子元件测量在合并溶液中发生的热变化。

2. 发明授权

US07141210B2 Apparatus and method for a nanocalorimeter for detecting chemical reactions 有权
公开(公告)号：US07141210B2
公开(公告)日：2006-11-28
申请号：US10114611
申请日：2002-04-01
申请人： Alan G. Bell , Richard H. Bruce , Scott A. Elrod , Eric Peeters , Francisco E. Torres
发明人： Alan G. Bell , Richard H. Bruce , Scott A. Elrod , Eric Peeters , Francisco E. Torres
IPC分类号： G01N31/00
CPC分类号： B82Y15/00 , G01N25/4846 , G01N25/4866 , Y10S977/957 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A nanocalorimeter array for detecting chemical reactions includes at least one thermal isolation region residing on a substrate. Each thermal isolation region includes at least one thermal equilibration region, within which resides a thermal measurement device connected to detection electronics.

3. 发明授权

US07147763B2 Apparatus and method for using electrostatic force to cause fluid movement 有权
公开(公告)号：US07147763B2
公开(公告)日：2006-12-12
申请号：US10115336
申请日：2002-04-01
申请人： Scott A. Elrod , Eric Peeters , Francisco E. Torres , David K. Biegelsen , John L. Dunec , Alan G. Bell
发明人： Scott A. Elrod , Eric Peeters , Francisco E. Torres , David K. Biegelsen , John L. Dunec , Alan G. Bell
IPC分类号： G01N27/26
CPC分类号： B01F13/0071 , B01F5/0085 , B01F13/0076 , B01J2219/0036 , B01J2219/00527 , B01J2219/00653 , B01L3/502792 , B01L2300/089 , B01L2400/0415 , B01L2400/0427 , C40B60/14 , G02B26/005
摘要： A device for effecting motion of liquid droplets on a surface through the use of electrostatic field force includes a single substrate on which are disposed a plurality of spaced-apart electrodes. A dielectric material surrounds the electrodes on the substrate. The surface on which the liquid droplets are deposited is fabricated from a material that facilitates motion of the liquid droplets.

4. 发明授权

US07416897B2 Method for high-throughput screening assay sample preparation and analysis 有权
标题翻译：高通量筛选测定方法样品制备和分析方法
公开(公告)号：US07416897B2
公开(公告)日：2008-08-26
申请号：US10719961
申请日：2003-11-21
申请人： Richard H. Bruce , Francisco E. Torres , Alan G. Bell , Eric Peeters
发明人： Richard H. Bruce , Francisco E. Torres , Alan G. Bell , Eric Peeters
IPC分类号： G01K17/00 , G01K17/20 , G01N35/00 , G01N25/20
CPC分类号： G01N25/4866 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.
摘要翻译：公开了用于高通量筛选测定样品制备和用于鉴定药物靶标和文库化合物之间的结合的测试的方法，用于测量结合反应焓的量热器件。该方法包括将文库化合物与指定溶剂混合，并将目标化合物溶液与第二指定溶剂混合在量热装置上。文库化合物/溶剂与目标化合物/溶剂溶液合并，文库化合物/溶剂溶液也与量热装置上的第三溶剂溶液合并。对于两个合并的溶液检测反应热，并进行比较。

5. 发明授权

US07914735B2 Use of physical barriers to minimize evaporative heat losses 有权
标题翻译：使用物理障碍来减少蒸发热损失
公开(公告)号：US07914735B2
公开(公告)日：2011-03-29
申请号：US11037666
申请日：2005-01-18
申请人： Francisco E. Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory B. Anderson , Alan G. Bell , Richard H. Bruce
发明人： Francisco E. Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory B. Anderson , Alan G. Bell , Richard H. Bruce
IPC分类号： G01N33/00
CPC分类号： G01N25/482 , G01K17/006
摘要： A detection system includes a detection device and an anti-evaporation device. The detection device comprises a region configured to merge at least two small drops and to detect a potential transient signal generated by the merger of the drops. The an anti-evaporation is configured to enclose the region and limit evaporation from the region. A method for detecting a signal includes the following steps: depositing drops of potentially reactive chemical solutions on a detection device within a drop-merging region; placing an anti-evaporation device over the drop-merging region to form a seal around the drop-merging region; merging the drops of potentially reactive chemical solutions; and measuring a signal occurring within the merged solution drops.
摘要翻译：检测系统包括检测装置和防蒸发装置。检测装置包括被配置为合并至少两个小液滴并且检测由液滴的合并产生的潜在瞬态信号的区域。防蒸发被配置为包围该区域并限制该区域的蒸发。一种用于检测信号的方法包括以下步骤：在滴合并区域内的检测装置上沉积潜在的反应性化学溶液滴; 将防蒸发装置放置在熔融合并区域上以形成围绕滴合并区域的密封; 合并潜在的活性化学溶液滴; 并且测量在合并溶液中发生的信号下降。

6. 发明授权

US07632008B2 Ranking fragment types with calorimetry 有权
标题翻译：用量热法排列片段类型
公开(公告)号：US07632008B2
公开(公告)日：2009-12-15
申请号：US11760236
申请日：2007-06-08
申请人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
发明人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
IPC分类号： G01K17/00
CPC分类号： G01N25/48
摘要： Test and reference groups of samples can be provided and concurrently combined and output signals can be provided. Each sample can have a volume not exceeding approximately 100 microliters, and each group can be provided in a region, such as in a cell of an array calorimeter. Each test group can include at least one fragment sample and one target sample, and its reference group can include similar samples. The output signals can include information about heat of reaction due to combining the fragment and target samples. For each target type, the output signals can be used to rank fragment types. For example, a subset of fragment types that react with the target type can be identified; an equilibrium constant or ligand efficiency can be obtained for each such fragment type; or a rank ordering can be obtained of such fragment types.
摘要翻译：样品的测试和参考组可以提供并同时组合，并且可以提供输出信号。每个样品可以具有不超过约100微升的体积，并且每个组可以设置在诸如阵列量热计的单元格的区域中。每个测试组可以包括至少一个片段样品和一个目标样品，其参考组可以包括相似的样品。输出信号可以包括由于组合片段和目标样品而引起的反应热的信息。对于每种目标类型，输出信号可用于对片段类型进行排序。例如，可以识别与目标类型反应的片段类型的子集; 可以获得每种这样的片段类型的平衡常数或配体效率; 或者可以获得这样的片段类型的等级排序。

7. 发明申请

US20080304541A1 Ranking Fragment Types with Calorimetry 有权
标题翻译：使用量热法排列片段类型
公开(公告)号：US20080304541A1
公开(公告)日：2008-12-11
申请号：US11760236
申请日：2007-06-08
申请人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
发明人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
IPC分类号： G01K17/00
CPC分类号： G01N25/48
摘要： Test and reference groups of samples can be provided and concurrently combined and output signals can be provided. Each sample can have a volume not exceeding approximately 100 microliters, and each group can be provided in a region, such as in a cell of an array calorimeter. Each test group can include at least one fragment sample and one target sample, and its reference group can include similar samples. The output signals can include information about heat of reaction due to combining the fragment and target samples. For each target type, the output signals can be used to rank fragment types. For example, a subset of fragment types that react with the target type can be identified; an equilibrium constant or ligand efficiency can be obtained for each such fragment type; or a rank ordering can be obtained of such fragment types.
摘要翻译：样品的测试和参考组可以提供并同时组合，并且可以提供输出信号。每个样品可以具有不超过约100微升的体积，并且每个组可以设置在诸如阵列量热计的单元格的区域中。每个测试组可以包括至少一个片段样品和一个目标样品，其参考组可以包括相似的样品。输出信号可以包括由于组合片段和目标样品而引起的反应热的信息。对于每种目标类型，输出信号可用于对片段类型进行排序。例如，可以识别与目标类型反应的片段类型的子集; 可以获得每种这样的片段类型的平衡常数或配体效率; 或者可以获得这样的片段类型的等级排序。

8. 发明授权

US08617899B2 Enhanced drop mixing using magnetic actuation 有权
标题翻译：使用磁力驱动增强液滴混合
公开(公告)号：US08617899B2
公开(公告)日：2013-12-31
申请号：US12031519
申请日：2008-02-14
申请人： Dirk De Bruyker , Ali Asgar Saleem Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
发明人： Dirk De Bruyker , Ali Asgar Saleem Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
IPC分类号： G01N25/20 , G01N27/00 , G01N25/00 , C12M1/02
CPC分类号： B01F13/0818 , B01F13/0071 , B01F13/0076 , B01F13/0077 , B01F2015/0221 , G01N25/48 , Y10T137/0318 , Y10T137/87652 , Y10T436/25 , Y10T436/2575
摘要： A method and device for merging and mixing at least two separate and distinct fluid drops on a substrate, includes a drop merging area on the surface, where a first magnetic material is placed at a first location. A first drop of fluid is then placed at the first location on the surface, resulting in the first magnetic material being at least partially positioned within the first drop of fluid. A second drop of fluid is then placed at a second location on the surface of the drop merging area. A magnetic field is applied by a varying magnetic field generator to at least a portion of the drop merge area of the substrate, which includes at least the first location on the substrate. The varying magnetic field will act on the first magnetic material to move the first magnetic material within the first drop of fluid, causing a stirring of the fluid. A drop merging force from a drop merging mechanism is applied to at least one of the first drop of fluid and the second drop of fluid within the drop merge area. This causes at least one of the first drop of fluid and the second drop of fluid to move toward the other and make contact. The internal stirring of the fluid in the first drop of fluid by the movement of the magnetic material enhances the mixing of the constituents of the first drop of fluid and the constituents of the second drop of fluid.
摘要翻译：用于在衬底上合并和混合至少两个独立且不同的液滴的方法和装置包括在表面上的液滴合并区域，其中第一磁性材料放置在第一位置。然后将第一滴流体放置在表面上的第一位置处，导致第一磁性材料至少部分地定位在第一液滴内。然后将第二滴流体放置在滴液合并区域的表面上的第二位置。通过变化的磁场发生器将磁场施加到衬底的下落合并区域的至少一部分，其至少包括衬底上的第一位置。变化的磁场将作用在第一磁性材料上以使第一磁性材料在第一液滴内移动，引起流体的搅拌。来自液滴合并机构的液滴合并力被施加到液滴合并区域中的第一液体流体和第二液体流中的至少一个。这使得第一液体流体和第二液体液滴中的至少一个朝向另一个流体移动并进行接触。通过磁性材料的运动在第一滴流体中内部流体的内部搅拌增强了第一滴流体的组分与第二滴流体的组分的混合。

9. 发明申请

US20110263464A1 ENHANCED DROP MIXING USING MAGNETIC ACTUATION 有权
标题翻译：使用磁力驱动的增强液压混合
公开(公告)号：US20110263464A1
公开(公告)日：2011-10-27
申请号：US12031519
申请日：2008-02-14
申请人： Dirk De Bruyker , Ali Asgar Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
发明人： Dirk De Bruyker , Ali Asgar Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
IPC分类号： C40B60/14 , F15D1/00
CPC分类号： B01F13/0818 , B01F13/0071 , B01F13/0076 , B01F13/0077 , B01F2015/0221 , G01N25/48 , Y10T137/0318 , Y10T137/87652 , Y10T436/25 , Y10T436/2575
摘要： A method and device for merging and mixing at least two separate and distinct fluid drops on a substrate, includes a drop merging area on the surface, where a first magnetic material is placed at a first location. A first drop of fluid is then placed at the first location on the surface, resulting in the first magnetic material being at least partially positioned within the first drop of fluid. A second drop of fluid is then placed at a second location on the surface of the drop merging area. A magnetic field is applied by a varying magnetic field generator to at least a portion of the drop merge area of the substrate, which includes at least the first location on the substrate. The varying magnetic field will act on the first magnetic material to move the first magnetic material within the first drop of fluid, causing a stirring of the fluid. A drop merging force from a drop merging mechanism is applied to at least one of the first drop of fluid and the second drop of fluid within the drop merge area. This causes at least one of the first drop of fluid and the second drop of fluid to move toward the other and make contact. The internal stirring of the fluid in the first drop of fluid by the movement of the magnetic material enhances the mixing of the constituents of the first drop of fluid and the constituents of the second drop of fluid.
摘要翻译：用于在衬底上合并和混合至少两个独立且不同的液滴的方法和装置包括在表面上的液滴合并区域，其中第一磁性材料放置在第一位置。然后将第一滴流体放置在表面上的第一位置处，导致第一磁性材料至少部分地定位在第一液滴内。然后将第二滴流体放置在滴液合并区域的表面上的第二位置。通过变化的磁场发生器将磁场施加到衬底的下落合并区域的至少一部分，其至少包括衬底上的第一位置。变化的磁场将作用在第一磁性材料上，以使第一磁性材料在第一液滴内移动，引起流体的搅拌。来自液滴合并机构的液滴合并力被施加到液滴合并区域中的第一液体流体和第二液体流中的至少一个。这使得第一液体流体和第二液体液滴中的至少一个朝向另一个流体移动并进行接触。通过磁性材料的运动在第一滴流体中内部流体的内部搅拌增强了第一滴流体的组分与第二滴流体的组分的混合。

10. 发明授权

US5883895A Arbitration ring with automatic sizing for a partially populated switching network 失效
标题翻译：具有部分填充交换网络的自动调整大小的仲裁环
公开(公告)号：US5883895A
公开(公告)日：1999-03-16
申请号：US754688
申请日：1996-11-21
申请人： Helen M. Davis , Daniel H. Greene , Alan G. Bell
发明人： Helen M. Davis , Daniel H. Greene , Alan G. Bell
IPC分类号： H04L12/56 , H04L12/403 , H04J3/02
CPC分类号： H04L49/508 , H04L49/102 , H04L49/1553 , H04L49/201 , H04L49/25 , H04L49/30 , H04L49/3081 , H04L2012/5679 , H04L2012/5681 , H04L49/103 , H04L49/15 , H04L49/20
摘要： Access to a switching network of an ATM (Asynchronous Transfer Mode) switch is scheduled with a reservation ring that automatically determines the number of channels populating the switching network during a switch cycle. The reservation ring is a distributed arbiter that resolves conflicts arising among a plurality of input channels for access to a plurality of output channels of the switching network. Each input channel populating the switching network is coupled to an arbitration unit of the reservation ring. The arbitration units on the ring determine when an arbitration cycle is complete for each of the arbitration units populating the ring. This enables the number of channels populating the switching network to increase or decrease without having to reconfigure the reservation ring.
摘要翻译： ATM（异步传输模式）交换机的交换网络的访问通过预留环进行调度，自动确定在切换周期期间填充交换网络的信道数量。预留环是分布式仲裁器，其解决在用于访问交换网络的多个输出信道的多个输入信道之间产生的冲突。填充交换网络的每个输入信道被耦合到预留环的仲裁单元。环上的仲裁单元确定每个填充环的仲裁单元何时完成仲裁周期。这使得填充交换网络的信道的数量增加或减少，而不必重新配置保留环。

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