专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050131015A1 Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase 失效
标题翻译：杂环酰胺衍生物作为糖原磷酸化酶的抑制剂
公开(公告)号：US20050131015A1
公开(公告)日：2005-06-16
申请号：US10506741
申请日：2003-03-04
申请人： Alan Birch , Andrew Morley , Andrew Stocker , Paul Whittamore
发明人： Alan Birch , Andrew Morley , Andrew Stocker , Paul Whittamore
IPC分类号： A61K31/4375 , A61K31/4709 , A61K31/519 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P43/00 , C07D495/04 , C07D519/00 , C07D498/02
CPC分类号： C07D495/04
摘要： Heterocyclic amides of formula (1) wherein: X is N or CH; R4 and R5 together are either —S—C(R6)═C(R7)— or —C(R7)═C(R6)—S—; R6 and R7 are independently selected from, for example hydrogen, halo and Cl-4alkyl; A is phenylene or heteroarylene; n is 0, 1 or 2; R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; R2 is hydrogen, hydroxy or carboxy; R3 is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C1-4alkyl(optionally substituted by 1 or 2 R8 groups); R8 is selected from for example hydroxy, —COCOOR9, —C(O)N(R9)(R10), —NHC(O)R9, (R9)(R10)N— and —COOR9; R9 and R10 are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13); R13 is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy; or a pharmaceutically acceptable salt or pro-drug thereof; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
摘要翻译：式（1）的杂环酰胺其中：X是N或CH; R 4和R 5一起是-SC（R 6）-C（R 7） - 或 -C（R 7）C（R 6）-S-; R 6和R 7独立地选自，例如氢，卤素和C 1-4烷基; A是亚苯基或亚杂芳基; n为0,1或2; R 1选自例如卤素，硝基，氰基，羟基，羧基; R 2是氢，羟基或羧基; R 3选自例如氢，羟基，芳基，杂环基和C 1-4烷基（任选被1或2个R 8取代）组）; R 8选自例如羟基，-COCOOR 9，-C（O）N（R 9）（R 10）），-NHC（O）R 9，（R 9）（R 10）N - 和-COOR ^{9 ; R 9和R 10选自例如氢，羟基，C 1-4烷基（任选被1或2个R SUP取代 > 13 ）; R 13选自羟基，卤素，三卤代甲基和C 1-4烷氧基; 或其药学上可接受的盐或前体药物; 具有糖原磷酸化酶抑制活性，因此具有与增加的糖原磷酸化酶活性相关的疾病状态的治疗价值。描述了制备所述杂环酰胺衍生物和含有它们的药物组合物的方法。}

2. 发明申请

US20070043069A1 HETEROCYCLIC AMIDE DERIVATIVES AS INHIBITORS OF GLYCOGEN PHOSPHORYLASE 失效
标题翻译：作为GLYCOGEN PHOSPHORYLASE的抑制剂的杂环酰胺衍生物
公开(公告)号：US20070043069A1
公开(公告)日：2007-02-22
申请号：US11463144
申请日：2006-08-08
申请人： Alan Birch , Andrew Morley , Andrew Stocker , Paul Whittamore
发明人： Alan Birch , Andrew Morley , Andrew Stocker , Paul Whittamore
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D495/04
摘要： Heterocyclic amides of formula (1) wherein: X is N or CH; R4 and R5 together are either —S—C(R6)═C(R7)— or —C(R7)═C(R6)—S—; R6 and R7 are independently selected from, for example hydrogen, halo and C1-4alkyl; A is phenylene or heteroarylene; n is 0, 1 or 2; R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; R2 is hydrogen, hydroxy or carboxy; R3 is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C1-4alkyl(optionally substituted by 1 or 2 R8 groups); R8 is selected from for example hydroxy, —COCOOR9, —C(O)N(R9)(R10), —NHC(O)R9, (R9)(R10)N— and —COOR9; R9 and R10 are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13); R13 is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy; or a pharmaceutically acceptable salt or pro-drug thereof, possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
摘要翻译：式（1）的杂环酰胺其中：X是N或CH; R 4和R 5一起是-SC（R 6）-C（R 7） - 或 -C（R 7）C（R 6）-S-; R 6和R 7独立地选自，例如氢，卤素和C 1-4烷基; A是亚苯基或亚杂芳基; n为0,1或2; R 1选自例如卤素，硝基，氰基，羟基，羧基; R 2是氢，羟基或羧基; R 3选自例如氢，羟基，芳基，杂环基和C 1-4烷基（任选被1或2个R 8取代）组）; R 8选自例如羟基，-COCOOR 9，-C（O）N（R 9）（R 10）），-NHC（O）R 9，（R 9）（R 10）N - 和-COOR ^{9 ; R 9和R 10选自例如氢，羟基，C 1-4烷基（任选被1或2个R SUP取代 > 13 ）; R 13选自羟基，卤素，三卤代甲基和C 1-4烷氧基; 或其药学上可接受的盐或前药具有糖原磷酸化酶抑制活性，因此在治疗与增加的糖原磷酸化酶活性相关的疾病状态方面具有价值。描述了制备所述杂环酰胺衍生物和含有它们的药物组合物的方法。}

3. 发明申请

US20050131016A1 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US20050131016A1
公开(公告)日：2005-06-16
申请号：US10506748
申请日：2003-03-04
申请人： Alan Birch , Andrew Morley
发明人： Alan Birch , Andrew Morley
IPC分类号： A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61P3/04 , A61P3/10 , A61P7/00 , A61P9/10 , A61P43/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14 , C07D43/02
CPC分类号： C07D401/12 , C07D401/14 , C07D417/14
摘要： Heterocyclic amides of formula (1) wherein: is a single or double bond; A is phenylene or heteroarylene; m is 0, 1 or 2; n is 0, 1 or 2; R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; R2 is hydrogen, hydroxy or carboxy; R3 is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C1-4alkyl(optionally substituted by 1 or 2 R8 groups); R4 is independently selected from for example hydrogen, halo, nitro, cyano, hydroxy, C1-4alkyl, and C1-4alkanoyl; R8 is selected from for example hydroxy, —COCOOR9, —C(O)N(R9)(R10), —NHC(O)R9, (R9)(R10)N— and —COOR9; R9 and R10 are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13); R13 is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy; or a pharmaceutically acceptable salt or pro-drug thereof; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
摘要翻译：式（1）的杂环酰胺其中：是单键或双键; A是亚苯基或亚杂芳基; m为0,1或2; n为0,1或2; R 1选自例如卤素，硝基，氰基，羟基，羧基; R 2是氢，羟基或羧基; R 3选自例如氢，羟基，芳基，杂环基和C 1-4烷基（任选被1或2个R 8取代）组）; R 4独立地选自例如氢，卤素，硝基，氰基，羟基，C 1-4烷基和C 1-4烷基。烷酰基; R 8选自例如羟基，-COCOOR 9，-C（O）N（R 9）（R 10）），-NHC（O）R 9，（R 9）（R 10）N - 和-COOR ^{9 ; R 9和R 10选自例如氢，羟基，C 1-4烷基（任选被1或2个R SUP取代 > 13 ）; R 13选自羟基，卤素，三卤代甲基和C 1-4烷氧基; 或其药学上可接受的盐或前体药物; 具有糖原磷酸化酶抑制活性，因此具有与增加的糖原磷酸化酶活性相关的疾病状态的治疗价值。描述了制备所述杂环酰胺衍生物和含有它们的药物组合物的方法。}

4. 发明授权

US6124343A Substituted phenyl compounds with a substituent having a thienyl ring 失效
标题翻译：具有噻吩基环的取代基的取代苯基化合物
公开(公告)号：US6124343A
公开(公告)日：2000-09-26
申请号：US898547
申请日：1997-07-22
申请人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
发明人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
IPC分类号： C07C255/54 , C07D213/30 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12 , A61K31/381
CPC分类号： C07D213/30 , C07C255/54 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12
摘要： This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1是CN，CH2CN，CH = CHCN，CHO或CH = CHCO2H; R 2是芳基低级烷氧基，杂芳基低级烷氧基，芳基低级烷硫基或杂芳基低级烷硫基，其中芳基和杂芳基部分中的每一个任选被取代; R3是卤素; R 4是任选取代的芳基或任选取代的杂芳基; R5是羧基或酸等isostere; X是氧或硫; n为0或1; 或其N-氧化物，其前体药物溶剂化物或其药学上可接受的盐，该化合物具有内皮素拮抗剂活性。本发明还涉及制备式I化合物及其药物用途的方法。

5. 发明申请

US20060014756A1 Benzimidazoles 有权
标题翻译：苯并咪唑
公开(公告)号：US20060014756A1
公开(公告)日：2006-01-19
申请号：US11029064
申请日：2005-01-04
申请人： Michael Edwards , Paul Cox , Shelley Amendola , Stephanie Deprets , Timothy Gillespy , Christopher Edlin , Andrew Morley , Charles Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir Majid , John Reader , Lloyd Payne , Nawaz Khan , Michael Cherry
发明人： Michael Edwards , Paul Cox , Shelley Amendola , Stephanie Deprets , Timothy Gillespy , Christopher Edlin , Andrew Morley , Charles Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir Majid , John Reader , Lloyd Payne , Nawaz Khan , Michael Cherry
IPC分类号： A61K31/496 , A61K31/4184 , C07D43/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译：本发明涉及通式（Ix）的生理活性化合物和含有这些化合物及其前药以及这些化合物及其前药的药学上可接受的盐和溶剂合物的组合物，以及式（Ix）范围内的新化合物 Ix），以及它们的制备过程。这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

6. 发明授权

US06048893A Substituted phenyl compounds with a substituent having A 1,3-benzodioxole ring 有权
标题翻译：具有取代基的取代苯基化合物具有1,3-苯并间二氧杂环戊烯环
公开(公告)号：US06048893A
公开(公告)日：2000-04-11
申请号：US330288
申请日：1999-06-11
申请人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
发明人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
IPC分类号： C07C255/54 , C07D213/30 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12 , A61K31/335 , C07D317/60
CPC分类号： C07D213/30 , C07C255/54 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12
摘要： This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1是CN，CH2CN，CH = CHCN，CHO或CH = CHCO2H; R 2是芳基低级烷氧基，杂芳基低级烷氧基，芳基低级烷硫基或杂芳基低级烷硫基，其中芳基和杂芳基部分中的每一个任选被取代; R3是卤素; R 4是任选取代的芳基或任选取代的杂芳基; R5是羧基或酸等isostere; X是氧或硫; n为0或1; 或其N-氧化物，其前体药物溶剂化物或其药学上可接受的盐，该化合物具有内皮素拮抗剂活性。本发明还涉及制备式I化合物及其药物用途的方法。

7. 发明授权

US08250987B1 Frangible kinetic energy projectile for air defense 有权
标题翻译：用于防空的易碎动能弹丸
公开(公告)号：US08250987B1
公开(公告)日：2012-08-28
申请号：US12502307
申请日：2009-07-14
申请人： Andrew Morley , Mohan J. Palathingal , Leon Manole , Ernest L. Logsdon, Jr.
发明人： Andrew Morley , Mohan J. Palathingal , Leon Manole , Ernest L. Logsdon, Jr.
IPC分类号： F42B12/56
CPC分类号： F42B12/56 , F42B10/48 , F42B12/06
摘要： A Kinetic Energy penetrator round is shown effective in neutralizing incoming air borne threat munitions such as rockets, artillery, or mortars for instance, without posing a threat in urban environments to harm bystanders on the ground. There are also no hazards or expense with this round of cleaning up unexploded ordnance, which might have occurred with other types of rounds due to unreliability of self destruct mechanisms. Shown herein is a kinetic energy penetrator for air defense that merely self destructs beyond its operational range into fragments that are not lethal to personnel on ground; no pyrotechnic or energetic materials means are used to activate this self destruct process. A full bore projectile structure is shown that is composed of plural axi-symmetric circular disks stacked on each other and tied by a shape memory metal wire of Nitinol. While operational as a joined group, the disks are a formidable round to kill an incoming air target. After the self destruct phase however, each disk is separated from adjacent disks on either side by a spring mechanism that enables separation after the process is initiated in flight when the Nitinol wire deforms due to heating from air drag. Each disk then proceeds alone with low enough terminal kinetic energy on the ground to be less than lethal.
摘要翻译：动能穿透轮显示出有效地中和进入的空中威胁弹药，如火箭弹，火炮或迫击炮，而不会在城市环境中造成威胁，以对地面旁边的旁观者造成伤害。这轮清理未爆弹药也不会有任何危险或费用，由于自毁机制不可靠，其他类型的轮次可能发生。这里显示的是一种用于防空的动能穿透器，其仅在自己的作战范围内自我毁灭成为对地面人员不致死的碎片; 没有使用烟火或高能材料来激活这种自毁过程。显示了一个完整的射弹结构，由多个相互堆叠的轴对称圆盘组成，并由Nitinol的形状记忆金属线捆绑。在作为联合组进行操作时，磁盘是一个强大的一轮，可以杀死进入的空中目标。然而，在自毁阶段之后，通过弹簧机构将每个盘与相邻的盘分开，当弹簧机构在由于空气阻力的加热而导致镍钛诺线变形时，在飞行中启动过程之后能够分离。然后，每个盘单独运行，在地面上的足够低的末端动能小于致命的。

8. 发明申请

US20060058522A1 Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 失效
标题翻译：噻吩 - 甲酰胺衍生物及其作为酶ikk-2的抑制剂的用途
公开(公告)号：US20060058522A1
公开(公告)日：2006-03-16
申请号：US10542326
申请日：2004-01-13
申请人： Alan Faull , Craig Johnstone , Andrew Morley , Jeffrey Poyser
发明人： Alan Faull , Craig Johnstone , Andrew Morley , Jeffrey Poyser
IPC分类号： C07D417/02 , C07D413/02 , C07D409/02
CPC分类号： C07D409/12 , C07D333/38 , C07D333/44 , C07D413/12
摘要： The invention relates to thiophene carboxamides of formula (I), wherein A, R1, R2, R3, R4, R5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及式（I）的噻吩甲酰胺，其中A，R 1，R 2，R 3，R 4， R 5和X如说明书中所定义，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途

9. 发明申请

US20050267304A1 Azaindoles 失效
标题翻译：楝树
公开(公告)号：US20050267304A1
公开(公告)日：2005-12-01
申请号：US10995103
申请日：2004-11-23
申请人： Paul Cox , Tahir Majid , Justine Lai , Andrew Morley , Shelley Amendola , Stephanie Deprets , Christopher Edlin , Charles Gardner , Dorothea Kominos , Brian Pedgrift , Frank Halley , Timothy Gillespy , Michael Edwards , Francois Clerc , Conception Nemecek , Olivier Houille , Dominique Damour , Herve Bouchard , Daniel Bezard , Chantal Carrez
发明人： Paul Cox , Tahir Majid , Justine Lai , Andrew Morley , Shelley Amendola , Stephanie Deprets , Christopher Edlin , Charles Gardner , Dorothea Kominos , Brian Pedgrift , Frank Halley , Timothy Gillespy , Michael Edwards , Francois Clerc , Conception Nemecek , Olivier Houille , Dominique Damour , Herve Bouchard , Daniel Bezard , Chantal Carrez
IPC分类号： A61K20060101 , A61K31/437 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61P20060101 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D20060101 , C07D209/00 , C07D221/00 , C07D241/00 , C07D471/04 , C07D487/04 , C07D519/00 , C07D487/02 , A61K31/4745 , A61K31/498 , C07D471/02
CPC分类号： C07D519/00 , C07D471/04 , C07D487/04
摘要： The invention is directed to physiologically active compounds of general formula (I):— and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译：本发明涉及通式（I）的生理活性化合物： - 和含有这些化合物的组合物; 及其前药，以及这些化合物及其前药的药学上可接受的盐和溶剂合物，以及式（I）范围内的新化合物。这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

10. 发明申请

US20050159472A1 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US20050159472A1
公开(公告)日：2005-07-21
申请号：US10506592
申请日：2003-03-04
申请人： Andrew Morley
发明人： Andrew Morley
IPC分类号： A61K31/404 , A61P3/04 , A61P3/08 , A61P3/10 , A61P5/50 , A61P9/10 , A61P43/00 , C07D209/42 , A61K31/405 , C07D45/02
CPC分类号： C07D209/42
摘要： Heterocyclic amides of formula (1) wherein: R1 is independently selected from, for example, C1-6alkyl, C5-7cycloalkyl, C5-7cycloalkylC1-3alkyl, C1-6alkoxy, C5-7cycloalkoxy, C5-7cycloalkylC1-3alkoxy, heterocyclyl, heterocyclylC1-3alkyl, heterocyclyloxy or heterocyclylC1-3alkoxy, R2 is phenyl or heteroaryl; R3 is independently selected from hydrogen, halo, nitro, cyano, hydroxy, carboxy, carbamoyl, C1-4alkyl, C2-4alkenyl, C2-4alkyl, C1-4alkoxy, C1-4alkanoyl, fluoromethyl, difluoromethyl trifluoromethyl and trifluoromethoxy; or a pharmaceutically acceptable salt or pro-drug thereof; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
摘要翻译：式（1）的杂环酰胺其中：R 1独立地选自C 1-6烷基，C 5-7烷基，环烷基，C 5-7环烷基C 1-3烷基，C 1-6烷氧基，C 5-7 环烷氧基，C 5-7环烷基C 1-3烷氧基，杂环基，杂环基C 1-3烷基，杂环氧基或杂环基C 1-3 烷氧基，R 2是苯基或杂芳基; R 3独立地选自氢，卤素，硝基，氰基，羟基，羧基，氨基甲酰基，C 1-4烷基，C 2-4 烯基，C 2-4烷基，C 1-4烷氧基，C 1-4烷酰基，氟甲基，二氟甲基三氟甲基和三氟甲氧基; 或其药学上可接受的盐或前体药物; 具有糖原磷酸化酶抑制活性，因此具有与增加的糖原磷酸化酶活性相关的疾病状态的治疗价值。描述了制备所述杂环酰胺衍生物和含有它们的药物组合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式