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1. 发明授权

US09630294B2 Machine tools and methods of operation thereof 有权
公开(公告)号：US09630294B2
公开(公告)日：2017-04-25
申请号：US12863786
申请日：2009-01-21
申请人： Mark Andrew Stocker
发明人： Mark Andrew Stocker
IPC分类号： B24B49/00 , B24B47/22 , B23Q1/25 , B24B41/00 , B24B47/20 , B23Q1/54 , B23Q1/48
CPC分类号： B24B47/22 , B23Q1/25 , B23Q1/4804 , B23Q1/5425 , B24B41/005 , B24B47/20 , B24B49/00
摘要： A machine tool is provided which comprises a machine base (10), a first support (20,100) mounted on a first rotational machine axis on the base, and a second support (22,102) mounted on a second rotational machine axis on the base. The second rotational axis is parallel to and spaced laterally from the first rotational axis and carries a mount (38,112) moveable relative to the second support along a first linear machine axis orthogonal to the second rotational axis. A control arrangement is operable to control the orientation of the first support on the first rotational axis, and the orientation of the mount relative to the second rotational axis and its location along the linear axis, so as to govern the position and orientation of the first support and the mount relative to each other. Existing machine tools often use long linear guide rails and stacked orthogonal axes which introduce alignment and offset errors. The present invention avoids the need for and/or reduces the number of these structures in machine tools.

2. 发明授权

US07918954B2 Method and apparatus for sealing a glass package 有权
公开(公告)号：US07918954B2
公开(公告)日：2011-04-05
申请号：US12245832
申请日：2008-10-06
申请人： Jeffrey Michael Amsden , James Joseph Bernas , John Joseph Costello, III , Margaret Helen Gentile , Mark Andrew Stocker , Lu Zhang
发明人： Jeffrey Michael Amsden , James Joseph Bernas , John Joseph Costello, III , Margaret Helen Gentile , Mark Andrew Stocker , Lu Zhang
IPC分类号： C03C27/00 , C03C27/06 , B32B17/00 , B32B37/00 , B32B37/10
CPC分类号： H05B33/04 , C03C23/001 , C03C23/002 , C03C23/0025 , C03C27/06 , C09J5/00 , C09J2205/31 , C09J2400/143 , H01L51/5246 , H05B33/10 , Y10T156/1066 , Y10T156/1374
摘要： An apparatus for sealing a substrate assembly by applying a force to the assembly while simultaneously exposing the substrate assembly, and in particular a sealing material disposed between two substrates of the substrate assembly, to an irradiating beam of electromagnetic energy. The beam heats, cures and/or melts the sealing material, depending upon the sealing material to form the seal. The force is applied by directing a flow of fluid against the substrate assembly, and beneficially improves contact between the substrates of the substrate assembly and the sealing material during the sealing process, therefore assisting in achieving a hermetic seal between the substrates.

3. 发明申请

US20110073259A1 METHOD AND APPARATUS FOR SEALING A GLASS PACKAGE 有权
标题翻译：密封玻璃包装的方法和装置
公开(公告)号：US20110073259A1
公开(公告)日：2011-03-31
申请号：US12958640
申请日：2010-12-02
申请人： Jeffrey Michael Amsden , James Joseph Bernas , John Joseph Costello, III , Margaret Helen Gentile , Mark Andrew Stocker , Lu Zhang
发明人： Jeffrey Michael Amsden , James Joseph Bernas , John Joseph Costello, III , Margaret Helen Gentile , Mark Andrew Stocker , Lu Zhang
IPC分类号： B29C65/14
CPC分类号： H05B33/04 , C03C23/001 , C03C23/002 , C03C23/0025 , C03C27/06 , C09J5/00 , C09J2205/31 , C09J2400/143 , H01L51/5246 , H05B33/10 , Y10T156/1066 , Y10T156/1374
摘要： An apparatus for sealing a substrate assembly by applying a force to the assembly while simultaneously exposing the substrate assembly, and in particular a sealing material disposed between two substrates of the substrate assembly, to an irradiating beam of electromagnetic energy. The beam heats, cures and/or melts the sealing material, depending upon the sealing material to form the seal. The force is applied by directing a flow of fluid against the substrate assembly, and beneficially improves contact between the substrates of the substrate assembly and the sealing material during the sealing process, therefore assisting in achieving a hermetic seal between the substrates.
摘要翻译：一种用于通过向组件施加力同时将衬底组件，特别是设置在衬底组件的两个衬底之间的密封材料同时暴露于电磁能的照射束来密封衬底组件的装置。梁根据密封材料加热，固化和/或熔化密封材料以形成密封。通过将流体流引导到衬底组件来施加力，并且有利地改善在密封过程期间衬底组件的衬底与密封材料之间的接触，从而有助于实现衬底之间的气密密封。

4. 发明申请

US20110060022A1 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic Acid - 465 审中-公开
标题翻译： 4- [4-（2-金刚烷基氨基甲酰基）-5-叔丁基 - 吡唑-1-基]苯甲酸465
公开(公告)号：US20110060022A1
公开(公告)日：2011-03-10
申请号：US12741589
申请日：2008-11-05
申请人： Martin Packer , James Stewart Scott , Andrew Stocker , Paul Robert Owen Whittamore
发明人： Martin Packer , James Stewart Scott , Andrew Stocker , Paul Robert Owen Whittamore
IPC分类号： A61K31/415 , C07D231/14 , A61P3/10 , A61P3/04
CPC分类号： C07D231/14
摘要： 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid and pharmaceutically-acceptable salts thereof and a particular crystalline form of the Agent (Form 1); their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译： 4- [4-（2-金刚烷基氨基甲酰基）-5-叔丁基 - 吡唑-1-基]苯甲酸及其药学上可接受的盐和特定结晶形式的试剂（形式1）; 还描述了它们在抑制11β和HSD1中的用途，其制备方法和包含它们的药物组合物。

5. 发明授权

US07816391B2 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US07816391B2
公开(公告)日：2010-10-19
申请号：US12259562
申请日：2008-10-28
申请人： Martin John Packer , James Stewart Scott , Andrew Stocker , Paul Robert Owen Whittamore
发明人： Martin John Packer , James Stewart Scott , Andrew Stocker , Paul Robert Owen Whittamore
IPC分类号： A01N43/56 , C07D231/02 , C07D231/54
CPC分类号： C07D231/18 , C07D231/14 , C07D403/06 , C07D405/12
摘要： A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.
摘要翻译：式（I）的化合物及其药学上可接受的盐，其中所述可变基团定义在其内; 还描述了它们在抑制11β和HSD1中的用途，其制备方法和包含它们的药物组合物。

6. 发明授权

US07276517B2 Heterocyclic amide derivatives as inhibitors of glycogen phosphorylase 失效
标题翻译：杂环酰胺衍生物作为糖原磷酸化酶的抑制剂
公开(公告)号：US07276517B2
公开(公告)日：2007-10-02
申请号：US11463144
申请日：2006-08-08
申请人： Alan Martin Birch , Andrew David Morley , Andrew Stocker , Paul Robert Owen Whittamore
发明人： Alan Martin Birch , Andrew David Morley , Andrew Stocker , Paul Robert Owen Whittamore
IPC分类号： A61K31/4375 , C07D471/04
CPC分类号： C07D495/04
摘要： Heterocyclic amides of formula (1) wherein: X is N or CH; R4 and R5 together are either —S—C(R6)═C(R7)— or —C(R7)═C(R6)—S—; R6 and R7 are independently selected from, for example hydrogen, halo and C1-4alkyl; A is phenylene or heteroarylene; n is 0, 1 or 2; R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; R2 is hydrogen, hydroxy or carboxy; R3 is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C1-4alkyl(optionally substituted by 1 or 2 R8 groups); R8 is selected from for example hydroxy, —COCOOR9, —C(O)N(R9)(R10), —NHC(O)R9, (R9)(R10)N— and —COOR9; R9 and R10 are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13); R13 is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy; or a pharmaceutically acceptable salt or pro-drug thereof, possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
摘要翻译：式（1）的杂环酰胺其中：X是N或CH; R 4和R 5一起是-SC（R 6）-C（R 7） - 或 -C（R 7）C（R 6）-S-; R 6和R 7独立地选自，例如氢，卤素和C 1-4烷基; A是亚苯基或亚杂芳基; n为0,1或2; R 1选自例如卤素，硝基，氰基，羟基，羧基; R 2是氢，羟基或羧基; R 3选自例如氢，羟基，芳基，杂环基和C 1-4烷基（任选被1或2个R 8取代）组）; R 8选自例如羟基，-COCOOR 9，-C（O）N（R 9）（R 10）），-NHC（O）R 9，（R 9）（R 10）N - 和-COOR ^{9 ; R 9和R 10选自例如氢，羟基，C 1-4烷基（任选被1或2个R SUP取代 > 13 ）; R 13选自羟基，卤素，三卤代甲基和C 1-4烷氧基; 或其药学上可接受的盐或前药具有糖原磷酸化酶抑制活性，因此在治疗与增加的糖原磷酸化酶活性相关的疾病状态方面具有价值。描述了制备所述杂环酰胺衍生物和含有它们的药物组合物的方法。}

7. 发明申请

US20060035953A1 Process and intermediates for the preparation of the thienopyrrole derivatives 失效
标题翻译：制备噻吩并吡咯衍生物的方法和中间体
公开(公告)号：US20060035953A1
公开(公告)日：2006-02-16
申请号：US10528974
申请日：2003-09-29
申请人： Paul Murray , Jeremy Parker , Paul Schofield , Andrew Stocker
发明人： Paul Murray , Jeremy Parker , Paul Schofield , Andrew Stocker
IPC分类号： A61K31/407 , C07D498/02
CPC分类号： C07D495/04 , C07D333/36 , Y02P20/55
摘要： A process for preparing a compound of formula (I) where R4 and R5 are as defined in the specification; and R6 is hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R4, R5 and R6 are as defined in relation to formula (I), and R7 is nitrogen-protecting group, and removing the group R7—, and thereafter if desired or necessary, removing any protecting group R6 to obtain the corresponding carboxylic acid. Novel intermediates and the use of the products in the preparation of pharmaceutical compounds is also described and claimed.
摘要翻译：制备其中R 4和R 5的式（I）化合物的方法如说明书中所定义; 和R 6是氢或保护基，该方法包括使式（II）的化合物环化，其中R 4，R 5和 R 6如关于式（I）所定义，R 7为氮保护基，除去R 7 - ，然后如果需要或必要的话，除去任何保护基团R 6以获得相应的羧酸。还描述和要求保护新型中间体和制备药物化合物中产物的用途。

8. 发明申请

US20050130963A1 Indole-amid derivatives which possess glycogen phosphorylase inhibitory activity 失效
公开(公告)号：US20050130963A1
公开(公告)日：2005-06-16
申请号：US10506729
申请日：2003-03-04
申请人： Andrew Stocker , Paul Robert Whittamore
发明人： Andrew Stocker , Paul Robert Whittamore
IPC分类号： A61K31/422 , A61P3/04 , A61P3/10 , A61P9/10 , A61P43/00 , C07D209/42 , C07D413/12 , A61K31/5377 , A61K31/405 , A61K31/4178 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497
CPC分类号： C07D413/12 , C07D209/42
摘要： Heterocyclic amides of formula (1) wherein: m is 0, 1 or 2; n is 0, 1 or 2; B is phenyl or heterocyclyl; R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; R2 and R3 are independently selected from, for example, C5-7cycloalkyl, cyano(C1-4)alkyl, C1-4alkyl (optionally substituted with 1 or 2 R8 groups), OR8 and R8; R4 is independently selected from for example hydrogen, halo, nitro, cyano, hydroxy, C1-4alkyl, and C1-4alkanoyl; R8 is selected from for example hydroxy, heterocyclyl, aryl, —COCOOR9, —C(O)N(R9)(R10), (R9)(R10)N— and —COOR9; R9 and R10 are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13); R13 is selected from for example, hydroxy, C1-4alkoxy, heterocyclyl and C1-4alkanoyl; R14 is selected from for example, hydrogen, halo, C1-4alkyl, C5-7cycloalkyl, C1-4alkoxy, cyano, cyano(C1-4)alkyl, —COR3, (R2)(R3)NCO—, and (R2)(R3)NSO2—; or a pharmaceutically acceptable salt or pro-drug thereof; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.

9. 发明授权

US06300330B1 Heterocycle derivatives which inhibit factor Xa 失效
标题翻译：抑制因子Xa的杂环衍生物
公开(公告)号：US06300330B1
公开(公告)日：2001-10-09
申请号：US09297768
申请日：1999-05-07
申请人： Andrew Stocker , John Preston , John Wall Rayner , Michael James Smithers , Paul Turner
发明人： Andrew Stocker , John Preston , John Wall Rayner , Michael James Smithers , Paul Turner
IPC分类号： A61K31496
CPC分类号： C07D213/73 , A61K31/44 , A61K31/505 , C07D213/56 , C07D213/61 , C07D213/84 , C07D213/89 , C07D237/08 , C07D239/26
摘要： The invention relates to heterocyclic derivatives of the formula (I): A—B—X1—T1(R2)—L1—T2(R3)—X2—Q or pharmaceutically acceptable salts thereof, which possess antithrombotic and anticoagulant properties due to their inhibition of Factor Xa and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.
摘要翻译：本发明涉及式（I）的杂环衍生物：AB-X1-T1（R2）-L1-T2（R3）-X2-Q或其药学上可接受的盐，由于它们抑制因子而具有抗血栓形成和抗凝血性质因此，可用于治疗人或动物的方法。本发明还涉及制备杂环衍生物的方法，含有它们的药物组合物及其在制备用于产生抗血栓形成或抗凝血作用的药物中的用途。

10. 发明授权

US06220938B1 Grinding machines 失效
标题翻译：磨床
公开(公告)号：US06220938B1
公开(公告)日：2001-04-24
申请号：US09273058
申请日：1999-03-19
申请人： Mark Andrew Stocker , Matthew James Ball , Dermot Robert Falkner , Peter Vaughan Mawer , Paul Martin Howard Morantz
发明人： Mark Andrew Stocker , Matthew James Ball , Dermot Robert Falkner , Peter Vaughan Mawer , Paul Martin Howard Morantz
IPC分类号： B24B908
CPC分类号： B24B9/065 , B24D5/02 , B24D5/066
摘要： A grinding pin (53) for notch grinding is provided. The grinding pin comprises a cylindrical region of formable grinding material and in which is formed a groove (18) for forming a notch. The length of the cylindrical region is such that further grooves (20) can be formed therein as each groove becomes too worn to form a notch.
摘要翻译：提供了一种用于切口研磨的研磨销（53）。研磨销包括可成形研磨材料的圆柱形区域，并且其中形成有用于形成凹口的凹槽（18）。圆柱形区域的长度使得当每个凹槽变得太磨损以形成切口时，可以在其中形成另外的凹槽（20）。

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