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1. 发明授权

US06048893A Substituted phenyl compounds with a substituent having A 1,3-benzodioxole ring 有权
标题翻译：具有取代基的取代苯基化合物具有1,3-苯并间二氧杂环戊烯环
公开(公告)号：US06048893A
公开(公告)日：2000-04-11
申请号：US330288
申请日：1999-06-11
申请人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
发明人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
IPC分类号： C07C255/54 , C07D213/30 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12 , A61K31/335 , C07D317/60
CPC分类号： C07D213/30 , C07C255/54 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12
摘要： This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1是CN，CH2CN，CH = CHCN，CHO或CH = CHCO2H; R 2是芳基低级烷氧基，杂芳基低级烷氧基，芳基低级烷硫基或杂芳基低级烷硫基，其中芳基和杂芳基部分中的每一个任选被取代; R3是卤素; R 4是任选取代的芳基或任选取代的杂芳基; R5是羧基或酸等isostere; X是氧或硫; n为0或1; 或其N-氧化物，其前体药物溶剂化物或其药学上可接受的盐，该化合物具有内皮素拮抗剂活性。本发明还涉及制备式I化合物及其药物用途的方法。

2. 发明授权

US6124343A Substituted phenyl compounds with a substituent having a thienyl ring 失效
标题翻译：具有噻吩基环的取代基的取代苯基化合物
公开(公告)号：US6124343A
公开(公告)日：2000-09-26
申请号：US898547
申请日：1997-07-22
申请人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
发明人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
IPC分类号： C07C255/54 , C07D213/30 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12 , A61K31/381
CPC分类号： C07D213/30 , C07C255/54 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12
摘要： This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1是CN，CH2CN，CH = CHCN，CHO或CH = CHCO2H; R 2是芳基低级烷氧基，杂芳基低级烷氧基，芳基低级烷硫基或杂芳基低级烷硫基，其中芳基和杂芳基部分中的每一个任选被取代; R3是卤素; R 4是任选取代的芳基或任选取代的杂芳基; R5是羧基或酸等isostere; X是氧或硫; n为0或1; 或其N-氧化物，其前体药物溶剂化物或其药学上可接受的盐，该化合物具有内皮素拮抗剂活性。本发明还涉及制备式I化合物及其药物用途的方法。

3. 发明申请

US20060122234A1 Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors 审中-公开
标题翻译：取代的噻吩基 - 异羟肟酸作为组蛋白脱乙酰酶抑制剂
公开(公告)号：US20060122234A1
公开(公告)日：2006-06-08
申请号：US10522873
申请日：2003-07-24
申请人： Janet Archer , Walter Bordogna , Richard Bull , David Clark , Hazel Dyke , Matthew Gill , Neil Harris , Marco Van Den Heuvel , Stephen Price
发明人： Janet Archer , Walter Bordogna , Richard Bull , David Clark , Hazel Dyke , Matthew Gill , Neil Harris , Marco Van Den Heuvel , Stephen Price
IPC分类号： A61K31/4436 , A61K31/433 , A61K31/4245 , A61K31/4178 , A61K31/416 , C07D409/02
CPC分类号： C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： A compound of formula (I): which can be used in the treatment of diseases associated with histone deacetylase enzymatic activity.
摘要翻译：式（I）化合物：其可用于治疗与组蛋白脱乙酰酶酶活性相关的疾病。

4. 发明申请

US20060029240A1 Loudspeakers 审中-公开
标题翻译：扬声器
公开(公告)号：US20060029240A1
公开(公告)日：2006-02-09
申请号：US11244230
申请日：2005-10-06
申请人： Graham Bank , Neil Harris , Denis Morecroft
发明人： Graham Bank , Neil Harris , Denis Morecroft
IPC分类号： H04R25/00
CPC分类号： H04R9/025 , H04R1/227 , H04R7/045 , H04R9/06 , H04R9/066 , H04R17/00 , H04R2440/05 , H04R2499/15
摘要： A loudspeaker comprising a resonant panel-form member adapted to produce an acoustic output and a vibration exciting system on the panel-form member and adapted to apply bending wave energy thereto, characterised in that the vibration exciting system is adapted to apply a bending couple to the panel-form member.
摘要翻译：一种扬声器，包括适于在所述面板构件上产生声输出和振动激励系统的谐振板形构件，并且适于向其施加弯曲波能，其特征在于，所述振动激励系统适于将弯曲耦合施加到面板成员。

5. 发明申请

US20050176791A1 5-HT2B receptor antagonists 审中-公开
标题翻译： 5-HT2B受体拮抗剂
公开(公告)号：US20050176791A1
公开(公告)日：2005-08-11
申请号：US10640476
申请日：2003-08-14
申请人： Alexander Oxford , Richard Borman , Robert Coleman , Kenneth Clark , George Hynd , Janet Archer , Amanda Aley , Neil Harris , Andrew Goulter
发明人： Alexander Oxford , Richard Borman , Robert Coleman , Kenneth Clark , George Hynd , Janet Archer , Amanda Aley , Neil Harris , Andrew Goulter
IPC分类号： A61K31/421 , A61P9/04 , C07D263/48 , C07D413/04
CPC分类号： C07D263/48 , A61K31/421 , C07D413/04
摘要： The present invention relates to compounds which include compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R′, SO2R, C(═O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R′ is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group. The compounds are useful in the treatment of conditions including conditions which can be alleviated by antagonism of a 5-HT2B receptor such as GI disorders and congestive heart failure.
摘要翻译：本发明涉及包括式I化合物或其药学上可接受的盐的化合物，其中R 1和R 4中的一个选自由以下组成的组： H和任选取代的C 1-6烷基，C 3-7环烷基，C 3-7环烷基-C 1〜 4烷基和苯基-C 1-4烷基; R 1和R 4中的另一个是任选取代的C 9-14芳基; R 2和R 3是：（i）独立地选自H，R，R'，SO 2 R，C（-O ）R，（CH 2）2 NR 6，其中n为1至4，R H和R 6独立地选自H和R，其中R是任选取代的C 1-4烷基，R'任选被取代苯基-C 1-4烷基，或（ii）与它们所连接的氮原子一起形成任选取代的C 5-7杂环基。所述化合物可用于治疗包括可通过拮抗5-HT 2B受体如GI病症和充血性心力衰竭而缓解的病症的病症。

6. 发明授权

US06389935B1 Acoustic display screen 失效
标题翻译：声屏显示
公开(公告)号：US06389935B1
公开(公告)日：2002-05-21
申请号：US09029056
申请日：1998-07-08
申请人： Henry Azima , Martin Colloms , Neil Harris
发明人： Henry Azima , Martin Colloms , Neil Harris
IPC分类号： H04R2500
CPC分类号： H04R7/06 , G07F9/02 , H04R5/02 , H04R7/045 , H04R2307/029 , H04R2499/15
摘要： A display screen (32), e.g., a projection screen comprising a panel having a light reflective surface, characterised in that the screen is a distributed mode acoustic radiator loudspeaker having a transducer (9) mounted wholly and exclusively thereon to vibrate the radiator to cause it to resonate to provide an acoustic output.
摘要翻译：显示屏（32），例如包括具有光反射表面的面板的投影屏幕，其特征在于，所述屏幕是分布式模式声辐射扬声器，其具有完全和专门地安装在其上的振动器（9），以使散热器振动，它共鸣提供声输出。

7. 发明授权

US06320967B1 Passenger vehicles incorporating loudspeakers comprising panel-form acoustic radiating elements 有权
标题翻译：包括扬声器的乘用车包括面板式声辐射元件
公开(公告)号：US06320967B1
公开(公告)日：2001-11-20
申请号：US09029349
申请日：1998-08-24
申请人： Henry Azima , Martin Colloms , Neil Harris
发明人： Henry Azima , Martin Colloms , Neil Harris
IPC分类号： H04R2500
CPC分类号： B42D15/022 , B60R11/0217 , G06F1/1605 , G06F1/1616 , G06F1/1688 , G06F9/02 , G07F9/02 , H04R1/021 , H04R1/025 , H04R1/028 , H04R1/24 , H04R1/26 , H04R1/2811 , H04R3/04 , H04R5/02 , H04R5/027 , H04R7/045 , H04R7/06 , H04R7/08 , H04R9/025 , H04R9/045 , H04R9/066 , H04R17/00 , H04R2201/021 , H04R2307/029 , H04R2440/07 , H04R2499/13 , H04R2499/15
摘要： A vehicle having a passenger compartment (102) characterised by a loudspeaker (81) in the passenger compartment comprising a distributed mode acoustic radiator (2) and a transducer (9) mounted wholly and exclusively on the radiator to vibrate the radiator to cause it to resonate.
摘要翻译：一种具有乘客舱（102）的车辆，其特征在于乘客舱中的扬声器（81），包括分布式声辐射器（2）和传感器（9），传感器全部和全部安装在散热器上以使散热器振动谐振。

8. 发明授权

US09159207B2 Haptic device 有权
标题翻译：触觉装置
公开(公告)号：US09159207B2
公开(公告)日：2015-10-13
申请号：US13811901
申请日：2011-07-25
申请人： Neil Harris
发明人： Neil Harris
IPC分类号： H04B3/36 , G01F7/00 , G01F23/00 , G08B6/00 , G06F3/01 , G06F3/043 , G06F3/041
CPC分类号： G08B6/00 , G06F3/016 , G06F3/041 , G06F3/0436
摘要： A method of generating a haptic sensation comprising: determining an initial estimate of a filter to be applied to a respective signal input to each transducer; defining a model of the system; calculating the vibration of the member as an output of the model of the system; calculating a reference error value for the output of the model; determining changed parameter values of the parameters of the model; recalculating the error value for the output of the model; comparing the recalculated error value with the reference error value; setting the recalculated error value as the reference error value, setting the changed parameter values as the model parameters, and repeating the above steps, or outputting the model parameters; generating a new filter using the output model parameters; and applying the new filters to respective input signals applied to each transducer to generate vibration within the member to provide the haptic sensation.
摘要翻译：一种产生触觉感觉的方法，包括：确定要应用于输入到每个换能器的相应信号的滤波器的初始估计; 定义系统的模型; 计算构件的振动作为系统模型的输出; 计算模型输出的参考误差值; 确定模型参数的变化参数值; 重新计算模型输出的误差值; 将重新计算的误差值与参考误差值进行比较; 将重新计算的误差值设置为参考误差值，将改变的参数值设置为模型参数，并重复上述步骤或输出模型参数; 使用输出模型参数生成新的过滤器; 以及将新的滤波器应用到施加到每个换能器的相应输入信号，以在该构件内产生振动以提供触觉感。

9. 外观设计

USD698601S1 Beverage bottle 有权
公开(公告)号：USD698601S1
公开(公告)日：2014-02-04
申请号：US29433006
申请日：2012-09-24
申请人： Neil Harris
设计人： Neil Harris

10. 发明申请

US20130278400A1 HAPTIC DEVICE 有权
标题翻译：快乐设备
公开(公告)号：US20130278400A1
公开(公告)日：2013-10-24
申请号：US13811901
申请日：2011-07-25
申请人： Neil Harris
发明人： Neil Harris
IPC分类号： G08B6/00
CPC分类号： G08B6/00 , G06F3/016 , G06F3/041 , G06F3/0436
摘要： A method of generating a haptic sensation comprising: determining an initial estimate of a filter to be applied to a respective signal input to each transducer; defining a model of the system; calculating the vibration of the member as an output of the model of the system; calculating a reference error value for the output of the model; determining changed parameter values of the parameters of the model; recalculating the error value for the output of the model; comparing the recalculated error value with the reference error value; setting the recalculated error value as the reference error value, setting the changed parameter values as the model parameters, and repeating the above steps, or outputting the model parameters; generating a new filter using the output model parameters; and applying the new filters to respective input signals applied to each transducer to generate vibration within the member to provide the haptic sensation.
摘要翻译：一种产生触觉感觉的方法，包括：确定要应用于输入到每个换能器的相应信号的滤波器的初始估计; 定义系统的模型; 计算构件的振动作为系统模型的输出; 计算模型输出的参考误差值; 确定模型参数的变化参数值; 重新计算模型输出的误差值; 将重新计算的误差值与参考误差值进行比较; 将重新计算的误差值设置为参考误差值，将改变的参数值设置为模型参数，并重复上述步骤或输出模型参数; 使用输出模型参数生成新的过滤器; 以及将新的滤波器应用到施加到每个换能器的相应输入信号，以在该构件内产生振动以提供触觉感。

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