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1. 发明授权

US06048893A Substituted phenyl compounds with a substituent having A 1,3-benzodioxole ring 有权
标题翻译：具有取代基的取代苯基化合物具有1,3-苯并间二氧杂环戊烯环
公开(公告)号：US06048893A
公开(公告)日：2000-04-11
申请号：US330288
申请日：1999-06-11
申请人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
发明人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
IPC分类号： C07C255/54 , C07D213/30 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12 , A61K31/335 , C07D317/60
CPC分类号： C07D213/30 , C07C255/54 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12
摘要： This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1是CN，CH2CN，CH = CHCN，CHO或CH = CHCO2H; R 2是芳基低级烷氧基，杂芳基低级烷氧基，芳基低级烷硫基或杂芳基低级烷硫基，其中芳基和杂芳基部分中的每一个任选被取代; R3是卤素; R 4是任选取代的芳基或任选取代的杂芳基; R5是羧基或酸等isostere; X是氧或硫; n为0或1; 或其N-氧化物，其前体药物溶剂化物或其药学上可接受的盐，该化合物具有内皮素拮抗剂活性。本发明还涉及制备式I化合物及其药物用途的方法。

2. 发明授权

US6124343A Substituted phenyl compounds with a substituent having a thienyl ring 失效
标题翻译：具有噻吩基环的取代基的取代苯基化合物
公开(公告)号：US6124343A
公开(公告)日：2000-09-26
申请号：US898547
申请日：1997-07-22
申请人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
发明人： Christopher Smith , Barry Porter , Roger Walsh , Tahir Majid , Clive McCarthy , Neil Harris , Peter Astles , Iain McLay , Andrew Morley , Andrew Bridge , Andrew Van Sickle , Frank Halley , Alan Roach , Martyn Foster
IPC分类号： C07C255/54 , C07D213/30 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12 , A61K31/381
CPC分类号： C07D213/30 , C07C255/54 , C07D213/61 , C07D237/08 , C07D263/56 , C07D275/02 , C07D277/24 , C07D307/12 , C07D317/54 , C07D333/16 , C07D405/12 , C07D411/12
摘要： This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1是CN，CH2CN，CH = CHCN，CHO或CH = CHCO2H; R 2是芳基低级烷氧基，杂芳基低级烷氧基，芳基低级烷硫基或杂芳基低级烷硫基，其中芳基和杂芳基部分中的每一个任选被取代; R3是卤素; R 4是任选取代的芳基或任选取代的杂芳基; R5是羧基或酸等isostere; X是氧或硫; n为0或1; 或其N-氧化物，其前体药物溶剂化物或其药学上可接受的盐，该化合物具有内皮素拮抗剂活性。本发明还涉及制备式I化合物及其药物用途的方法。

3. 发明申请

US20050267304A1 Azaindoles 失效
标题翻译：楝树
公开(公告)号：US20050267304A1
公开(公告)日：2005-12-01
申请号：US10995103
申请日：2004-11-23
申请人： Paul Cox , Tahir Majid , Justine Lai , Andrew Morley , Shelley Amendola , Stephanie Deprets , Christopher Edlin , Charles Gardner , Dorothea Kominos , Brian Pedgrift , Frank Halley , Timothy Gillespy , Michael Edwards , Francois Clerc , Conception Nemecek , Olivier Houille , Dominique Damour , Herve Bouchard , Daniel Bezard , Chantal Carrez
发明人： Paul Cox , Tahir Majid , Justine Lai , Andrew Morley , Shelley Amendola , Stephanie Deprets , Christopher Edlin , Charles Gardner , Dorothea Kominos , Brian Pedgrift , Frank Halley , Timothy Gillespy , Michael Edwards , Francois Clerc , Conception Nemecek , Olivier Houille , Dominique Damour , Herve Bouchard , Daniel Bezard , Chantal Carrez
IPC分类号： A61K20060101 , A61K31/437 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61P20060101 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D20060101 , C07D209/00 , C07D221/00 , C07D241/00 , C07D471/04 , C07D487/04 , C07D519/00 , C07D487/02 , A61K31/4745 , A61K31/498 , C07D471/02
CPC分类号： C07D519/00 , C07D471/04 , C07D487/04
摘要： The invention is directed to physiologically active compounds of general formula (I):— and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译：本发明涉及通式（I）的生理活性化合物： - 和含有这些化合物的组合物; 及其前药，以及这些化合物及其前药的药学上可接受的盐和溶剂合物，以及式（I）范围内的新化合物。这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

4. 发明授权

US07479501B2 Heteroaryl-cyclic acetals 有权
标题翻译：杂芳基环缩醛
公开(公告)号：US07479501B2
公开(公告)日：2009-01-20
申请号：US09871564
申请日：2001-05-31
申请人： Alan Collis , Frank Halley , Iain McLay
发明人： Alan Collis , Frank Halley , Iain McLay
IPC分类号： A61K31/4439 , C07D405/14
CPC分类号： C07D409/14 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) are described in which Het is a five or six membered heteroaromatic ring of the formula in which one of R1 and R2 is optionally substituted heteroaryl and the other is optionally substituted heteroaryl or optionally substituted aryl; X1 is a bond, X3 and X4 are each independently N or C and X2 and X5 are independently CH, N, NH, O or S; or X3 and X4 are C, one of X1, X2 and X5 is N and the others are N or CH; but excluding compounds in which X1 is a bond, one of X2 and X5 is N and the other is NH and X3 and X4 are both C; R3 represents a group -L1-R6; R4 represents hydrogen, alkyl or hydroxyalkyl; or R3 and R4, when attached to the same carbon atom, may form with the said carbon atom a cycloalkyl, cycloalkenyl or heterocycloalkyl ring or a group C═CH2; R5 represents hydrogen or alkyl; and m is zero or an integer 1 or 2; and N-oxides thereof, and their prodrugs; and pharmaceutically acceptable salts and solvates of compounds of formula (I) and N-oxides thereof, and their prodrugs. The compounds are TNF inhibitors and are useful as pharmaceuticals.
摘要翻译：描述式（I）的化合物，其中Het是下式的五或六元杂芳族环，其中R 1和R 2中的一个是任选取代的杂芳基，另一个是任选取代的杂芳基或任选取代的芳基; X1是键，X3和X4各自独立地是N或C，X2和X5独立地是CH，N，NH，O或S; 或X3和X4为C，X1，X2和X5之一为N，其余为N或CH; 但不包括X1为键的化合物，X2和X5之一为N，另一个为NH，X3和X4均为C; R3表示基团-L1-R6; R4表示氢，烷基或羟烷基; 或者R 3和R 4在连接到相同的碳原子时可与所述碳原子一起形成环烷基，环烯基或杂环烷基环或基团C-CH 2; R5代表氢或烷基; m为零或整数1或2; 和N-氧化物及其前药; 和式（I）化合物及其N-氧化物的药学上可接受的盐和溶剂合物及其前药。这些化合物是TNF抑制剂，可用作药物。

5. 发明申请

US20050090501A1 Heteroaryl-cyclic acetals 有权
标题翻译：杂芳基环缩醛
公开(公告)号：US20050090501A1
公开(公告)日：2005-04-28
申请号：US09871564
申请日：2001-05-31
申请人： Alan Collis , Frank Halley , Iain McLay
发明人： Alan Collis , Frank Halley , Iain McLay
IPC分类号： A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/06 , A61P19/02 , A61P27/02 , A61P35/00 , A61P43/00 , C07D405/14 , C07D409/14 , C07D413/14 , C07D45/04
CPC分类号： C07D409/14 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) are described in which Het is a five or six membered heteroaromatic ring of the formula in which one of R1 and R2 is optionally substituted heteroaryl and the other is optionally substituted heteroaryl or optionally substituted aryl; X1 is a bond, X3 and X4 are each independently N or C and X2 and X5 are independently CH, N, NH, O or S; or X3 and X4 are C, one of X1, X2 and X5 is N and the others are N or CH; but excluding compounds in which X1 is a bond, one of X2 and X5 is N and the other is NH and X3 and X4 are both C; R3 represents a group -L1-R6; R4 represents hydrogen, alkyl or hydroxyalkyl; or R3 and R4, when attached to the same carbon atom, may form with the said carbon atom a cycloalkyl, cycloalkenyl or heterocycloalkyl ring or a group C═CH2; R5 represents hydrogen or alkyl; and m is zero or an integer 1 or 2; and N-oxides thereof, and their prodrugs; and pharmaceutically acceptable salts and solvates of compounds of formula (I) and N-oxides thereof, and their prodrugs. The compounds are TNF inhibitors and are useful as pharmaceuticals.
摘要翻译：描述式（I）的化合物，其中Het是下式的五或六元杂芳族环，其中R 1和R 2中的一个是任选取代的杂芳基和另一个是任选取代的杂芳基或任选取代的芳基; X 1是一个键，X 3和X 4各自独立地是N或C和X 2和X 5个独立的是CH，N，NH，O或S; 或X 3和X 4是C，X 1，X 2和X 5之一为N，其余为N或CH; 但不包括其中X 1是一个键的化合物，X 2和X 5之一是N，另一个是NH和X ^{3＆lt; 4＆gt;和＆lt; 4＆gt;都是C; R 3表示基团-L 1→6→6; R 4表示氢，烷基或羟烷基; 或R 3和R 4，当连接到相同的碳原子时，可与所述碳原子一起形成环烷基，环烯基或杂环烷基环或C-CH 3基， SUB> 2 R 5表示氢或烷基; m为零或整数1或2; 和N-氧化物及其前药; 和式（I）化合物及其N-氧化物的药学上可接受的盐和溶剂合物及其前药。这些化合物是TNF抑制剂，可用作药物。}

6. 发明授权

US06989395B2 Imidazolyl-cyclic acetals 有权
标题翻译：咪唑基 - 环状缩醛
公开(公告)号：US06989395B2
公开(公告)日：2006-01-24
申请号：US10436609
申请日：2003-05-13
申请人： Paul L. Bamborough , Alan J. Collis , Frank Halley , Richard A. Lewis , David J. Lythgoe , Jeffrey M. McKenna , Iain M. McLay , Barry Porter , Andrew J. Ratcliffe , Paul A. Wallace
发明人： Paul L. Bamborough , Alan J. Collis , Frank Halley , Richard A. Lewis , David J. Lythgoe , Jeffrey M. McKenna , Iain M. McLay , Barry Porter , Andrew J. Ratcliffe , Paul A. Wallace
IPC分类号： C07D405/14 , A61K31/4427 , A61P11/06 , A61P19/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/10 , C07D493/10
摘要： Compounds of the following backbone structure: which are useful as Tumor necrosis factor (TNF) inhibitors in treating disease related to elevated TNF.
摘要翻译：以下骨架结构的化合物：其可用作治疗与升高的TNF相关的疾病的肿瘤坏死因子（TNF）抑制剂。

7. 发明授权

US06602877B1 Imidazolyl-cyclic acetals 有权
标题翻译：咪唑基 - 环状缩醛
公开(公告)号：US06602877B1
公开(公告)日：2003-08-05
申请号：US09456360
申请日：1999-12-08
申请人： Paul L. Bamborough , Alan J. Collis , Frank Halley , Richard A. Lewis , David J. Lythgoe , Jeffrey M. McKenna , Iain M. McLay , Barry Porter , Andrew J. Ratcliffe , Paul A. Wallace
发明人： Paul L. Bamborough , Alan J. Collis , Frank Halley , Richard A. Lewis , David J. Lythgoe , Jeffrey M. McKenna , Iain M. McLay , Barry Porter , Andrew J. Ratcliffe , Paul A. Wallace
IPC分类号： C07D23354
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/10 , C07D493/10
摘要： Compounds of formula (I) are described in which R1 is optionally substituted heteroaryl; R2 is optionally substituted aryl or optionally substituted heteroaryl; R3 is a group —L1—R7 or —L2—R8 [where L1 is an optionally substituted alkylene linkage; R7 is hydrogen, aryl, cyano, cycloalkyl, heteroaryl, heterocycloalkyl, nitro, —S(O)nR9, —NHSO2R9, —C(═Z)OR10, —C(═Z)R10, —OR10, —N(R11)—C(═Z)R9, —NY1Y2, —SO2NY1Y2, —C(═Z)—NY1Y2, —N(R11)—C(═Z)—NY1Y2, —N(OR10)—C(═Z)—NY1Y2, —N(OR10)—C(═Z)R10, —C(═NOR10)R10, —C(═Z)NR10OR12, —N(R11)—C(═NR13)—NY1Y2 or —N(R11)—C(═Z)OR11; L2 is a direct bond or a straight- or branched-carbon chain comprising from 2 to about 6 carbon atoms and contains a double or triple carbon-carbon bond; and R8 is hydrogen, aryl, cycloalkenyl, cycloalkyl, heteroaryl or heterocycloalkyl]; R4 is a group —L3—R14 [where L3 is a direct bond or an optionally substituted alkylene linkage and R14 is hydrogen, alkyl, azido, hydroxy, alkoxy, aryl, arylalkyloxy, aryloxy, carboxy (or an acid bioisostere), cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, heterocycloalkyl, heterocycloalkyloxy, nitro, —NY4Y5, —N(R10)—C(═Z)—R15; —N(R10)—C(═Z)—L4—R16, —NH—C(═Z)—NH—R15, —NH—C(═Z)—NH—L4—R16, —N(R10)—SO2—R15, —N(R10)—SO2—L4—R16, —S(O)nR9, —C(═Z)—NY4Y5 or —C(═Z)—OR9]; R5 is hydrogen, alkyl or hydroxyalkyl; or R4 and R5, when attached to the same carbon atom, may form with the said carbon atom a cycloalkyl, cycloalkenyl or heterocycloalkyl ring or a group C═CH2; R6 is hydrogen or alkyl; and m is zero or an integer 1 or 2; and N-oxides thereof, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of compounds of formula (I) and N-oxides thereof, and their prodrugs. The compounds are TNF inhibitors and are useful as pharmaceuticals.
摘要翻译：描述式（I）的化合物，其中R 1是任选取代的杂芳基; R2是任选取代的芳基或任选取代的杂芳基; R3是基团-L1-R7或-L2-R8 [其中L1是任选取代的亚烷基键; R 7是氢，芳基，氰基，环烷基，杂芳基，杂环烷基，硝基，-S（O）n R 9，-NHSO 2 R 9，-C（= Z）OR 10，-C（= Z）R 10，-OR 10，-N（R 11） -C（= Z）R9，-NY1Y2，-SO2NY1Y2，-C（= Z）-NY1Y2，-N（R11）-C（= Z）-NY1Y2，-N（OR10）-C（= Z）-NY1Y2 ，-N（OR 10）-C（= Z）R 10，-C（= NOR 10）R 10，-C（= Z）NR 10 OR 12，-N（R 11）-C（= NR 13）-NY 1 Y 2或-N（R 11） C（= Z）OR 11; L2是直接键或包含2至约6个碳原子并含有双或三碳 - 碳键的直链或支链碳链; 和R8是氢，芳基，环烯基，环烷基，杂芳基或杂环烷基]; R4是基团-L3-R14 [其中L3是直接键或任选取代的亚烷基键，R 14是氢，烷基，叠氮基，羟基，烷氧基，芳基，芳基烷氧基，芳氧基，羧基（或酸式生物电子等排体）杂芳基烷氧基，杂芳氧基，杂环烷基，杂环烷氧基，硝基，-NY 4 Y 5，-N（R 10）-C（= Z）-R 15; -N（R10）-C（= Z）-L4-R

8. 发明授权

US08461175B2 1-pyrazolo[4,3-c]isoquinoline derivatives, preparation thereof and therapeutic use thereof 有权
标题翻译： 1-吡唑并[4,3-c]异喹啉衍生物，其制备及其治疗用途
公开(公告)号：US08461175B2
公开(公告)日：2013-06-11
申请号：US13265981
申请日：2010-04-22
申请人： Georges Delettre , Stéphanie Deprets , Frank Halley , Laurent Schio , Fabienne Thompson
发明人： Georges Delettre , Stéphanie Deprets , Frank Halley , Laurent Schio , Fabienne Thompson
IPC分类号： C07D471/04 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to a compound of formula (I), where: R1 is a phenyl group optionally substituted by one or more halogen atoms; R2 is: a hydrogen atom or a halogen atom or a cyano group; a —C(═O)Y group where Y is a hydrogen atom, or a —NH2 or —OR3 group; a —C(═S)NH2 group; a —C(═NH)NH—OH group; a —CH2OH or —CH2F group; a —CH═N—OH group; a —CH═CH2 or —C═C—R3 group; a H or H R1 group being a hydrogen or (C1-C4)alkyl group; R3 is a hydrogen atom or (C1-C4)alkyl group; and R4 is a —NH2, (C1-C4)alkyl, (C1-C4)fluoroalkyl or (C3-C7)cycloalkyl group.
摘要翻译：本发明涉及式（I）化合物，其中：R 1是任选被一个或多个卤素原子取代的苯基; R2是：氢原子或卤素原子或氰基; Y为氢原子的-C（= O）Y基团，或-NH2或-OR3基团; -C（= S）NH 2基团; -C（= NH）NH-OH基团; -CH 2 OH或-CH 2 F基团; -CH = N-OH基团; -CH = CH 2或-C = C-R 3基团; H或H R 1基团为氢或（C 1 -C 4）烷基; R3是氢原子或（C1-C4）烷基; 并且R 4是-NH 2，（C 1 -C 4）烷基，（C 1 -C 4）氟烷基或（C 3 -C 7）环烷基。

9. 发明授权

US07435820B2 Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use 失效
标题翻译：包含它们的取代的四氢-1H-吡唑并[3,4-c]吡啶组合物，并使用
公开(公告)号：US07435820B2
公开(公告)日：2008-10-14
申请号：US11419794
申请日：2006-05-23
申请人： Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
发明人： Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译：取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。

10. 发明申请

US20070049594A1 Novel compounds and compositions as cathepsin inhibitors 审中-公开
标题翻译：新型化合物和组合物作为组织蛋白酶抑制剂
公开(公告)号：US20070049594A1
公开(公告)日：2007-03-01
申请号：US11295890
申请日：2005-12-07
申请人： Michael Graupe , John Patterson , David Aldous , Sukanthini Thurairatnam , Andreas Timm , John Link , Jiayao Li , Stephen Pickett , Frank Halley , Justine Lai
发明人： Michael Graupe , John Patterson , David Aldous , Sukanthini Thurairatnam , Andreas Timm , John Link , Jiayao Li , Stephen Pickett , Frank Halley , Justine Lai
IPC分类号： A61K31/501 , A61K31/50 , A61K31/4965 , A61K31/497 , C07D417/02 , C07D413/02
CPC分类号： C07D207/273 , A61K31/5375 , A61K31/5377 , C07C317/44 , C07C323/60 , C07D205/08 , C07D207/24 , C07D213/40 , C07D223/10 , C07D223/12 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/10 , C07D277/26 , C07D277/64 , C07D285/08 , C07D295/185 , C07D413/04 , C07D413/12 , Y02A50/411
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译：本发明涉及新的选择性组织蛋白酶S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。

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