专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07326805B2 Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof 失效
公开(公告)号：US07326805B2
公开(公告)日：2008-02-05
申请号：US10555875
申请日：2004-05-07
申请人： Charles Mioskowski , Cédric Catala , Alain Wagner
发明人： Charles Mioskowski , Cédric Catala , Alain Wagner
IPC分类号： C07C229/00
CPC分类号： C07C227/30 , C07B2200/07 , C07C227/16
摘要： The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids α or the derivatives thereof, having general formula (B), wherein: linkage C—O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, R1 and R2 represent: a hydrogen atom; or either R1 or R2 represents a hydrogen atom and the other substituent is a radical Ra, an acyl group —CORa, such as acetyl, or a functional group —COORa, —SO2Ra, —N (Ra, Rb), Ra and Rb, which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or R1 and R2 both represent a substituent as defined above. R3 represents a hydrogen atom or Ra and R4 has the significance of Ra. The invention is characterised in that it comprises: the isomerisation of a compound having formula (I), wherein R1, R2, Ra, R3 and R4 are as defined above, such as to produce a compound having formula (II); and the reduction of the carbonyl function thereof which, depending on the catalytic system employed and the formula (I) compound used, produces one of the isomers having general formula (III) or (IV) or a mixture thereof having formula (B). The invention can be used for the synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine.

2. 发明授权

US07871822B2 Method of use for characterizing the catalytic reactivity of catalyst(s) 失效
标题翻译：用于表征催化剂的催化反应性的方法
公开(公告)号：US07871822B2
公开(公告)日：2011-01-18
申请号：US10587177
申请日：2005-01-28
申请人： Alain Wagner , Cédric Catala
发明人： Alain Wagner , Cédric Catala
IPC分类号： G01N31/10
CPC分类号： C40B40/18 , B01J31/0235 , B01J31/0237 , B01J31/2239 , B01J31/2404 , B01J31/26 , B01J2219/00738 , B01J2231/005 , B01J2231/4266 , B01J2531/16 , B01J2531/26 , B01J2531/30 , B01J2531/40 , B01J2531/80 , B01J2531/824 , C40B30/08 , Y10T436/21 , Y10T436/212 , Y10T436/214 , Y10T436/216 , Y10T436/24
摘要： A method for selecting at least one catalyst from a catalyst library on the basis of the reactivity thereof in a chemical conversion process includes: (a) testing the catalytic activity of a first catalyst from said catalyst library with respect to a reaction medium containing, as the compounds to be converted, at least one reactivity probe having a labeling system and including at least one reaction unit capable of reacting in said chemical conversion; (b) analyzing the reaction medium after said catalytic test for the purpose of qualitatively and/or qualitatively characterizing the resulting compounds; (c) repeating steps (a) and (b) for at least one other catalyst in said library; and (d) comparing the analysis results for each catalyst in order to characterize at least one catalyst having the required reactivity in said chemical conversion.
摘要翻译：基于化学转化方法的反应性，从催化剂文库中选择至少一种催化剂的方法包括：（a）测定第一催化剂从所述催化剂文库相对于反应介质的催化活性，所述反应介质含有待转化的化合物，至少一种具有标记系统的反应性探针，并且包括能够在所述化学转化中反应的至少一个反应单元; （b）在所述催化试验之后分析反应介质，以定性和/或定性地表征所得化合物; （c）对所述文库中的至少一种其它催化剂重复步骤（a）和（b）; 和（d）比较每种催化剂的分析结果，以便表征在所述化学转化中具有所需反应性的至少一种催化剂。

3. 发明申请

US20090024575A1 METHODS FOR SIMILARITY SEARCHING OF CHEMICAL REACTIONS 有权
标题翻译：化学反应相似性检索方法
公开(公告)号：US20090024575A1
公开(公告)日：2009-01-22
申请号：US11779255
申请日：2007-07-17
申请人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
发明人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
IPC分类号： G06F7/00
CPC分类号： G06F19/702 , G06F19/707 , G06F19/708
摘要： A computer-based method for identifying at least one pair of similar chemical reactions between a plurality of reactions each related to preparation of at least one product from at least one reagent may include generating for each reaction a structural representation involving dynamic and conventional bonds and, based on the this structural representation, generating for each reaction a set of fragment descriptors of a predetermined length comprising the dynamical bonds and a corresponding descriptor vector. The method may further include calculating similarity indices between descriptor vectors of the plurality of reactions and comparing the similarity indices to identify at least one pair of similar reactions.
摘要翻译：用于鉴定多个反应中的至少一对相似化学反应的基于计算机的方法，每个反应各自与来自至少一种试剂的至少一种产物的制备有关可包括为每个反应产生涉及动态和常规键的结构表示，基于该结构表示，为每个反应生成包括动态键的预定长度的一组片段描述符和相应的描述符向量。该方法还可以包括计算多个反应的描述符向量之间的相似性指数，并比较相似性指数以识别至少一对相似的反应。

4. 发明授权

US06878745B2 Selective preventives/remedies for progressive lesions after organ damage 失效
标题翻译：器官损伤后进行性病变的选择性预防措施/补救措施
公开(公告)号：US06878745B2
公开(公告)日：2005-04-12
申请号：US10239783
申请日：2001-03-27
申请人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
发明人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
IPC分类号： A61K31/341 , A61K31/343 , A61K31/365 , A61P1/18 , A61P13/12 , A61P37/06 , A61P43/00 , C07D307/33 , C07D307/68 , A61K31/34 , A61K31/585
CPC分类号： C07D307/33 , A61K31/341 , A61K31/343 , A61K31/365 , C07D307/68 , G01N2500/10
摘要： Drugs for preventing and/or treating progressive lesions after organ damage without inhibiting the function of the organ or the regeneration function thereof, by selectively regulating the induction of cytotoxic effecter macrophages which are induced into damaged organ tissues in response to chemokines or cytokines expressed depending on the type of the damaged organ tissues.
摘要翻译：用于预防和/或治疗器官损伤后不进行器官功能或其再生功能的进行性病变的药物，其通过选择性调节细胞毒性作用剂巨噬细胞的诱导，所述细胞毒性巨噬细胞响应于依赖于表达的趋化因子或细胞因子而被诱导到损伤的器官组织受损器官组织的类型。

5. 发明授权

US06331434B1 Nitrogen-containing silicone useful for compacting nucleic acid sequences and use for transforming cells 失效
标题翻译：用于压实核酸序列和用于转化细胞的含氮硅氧烷
公开(公告)号：US06331434B1
公开(公告)日：2001-12-18
申请号：US09521822
申请日：2000-03-09
申请人： Rachel Decor , Charles Mioskowski , Marc Schmutz , Alain Wagner
发明人： Rachel Decor , Charles Mioskowski , Marc Schmutz , Alain Wagner
IPC分类号： C12N1588
CPC分类号： C08G83/001 , C08G77/388 , C12N15/8207 , C12N15/87 , C12N15/895
摘要： The present invention relates to a method of transforming cells in which an appropriate quantity of nucleic acid fragments is introduced into the cells. The nucleic acid fragments are introduced in the form of a nucleic acid composition comprising a nitrogen-containing silicone, useful for compacting the nucleic acid fragments; the compositions comprise aggregates of nucleic acid fragments and silicones according to the invention.
摘要翻译：本发明涉及转化细胞的方法，其中将适量的核酸片段引入细胞。以核酸组合物的形式引入核酸片段，所述核酸组合物包含可用于压实核酸片段的含氮硅氧烷; 组合物包含根据本发明的核酸片段和硅氧烷的聚集体。

6. 发明申请

US20070049773A1 Process for functionalising a phenolic compound carrying an electron-donating group 审中-公开
标题翻译：功能化携带电子给予基团的酚类化合物的方法
公开(公告)号：US20070049773A1
公开(公告)日：2007-03-01
申请号：US11592930
申请日：2006-11-03
申请人： Charles Mioskowski , Alain Wagner , Nicolas Bensel , Virginie Pevere , Jean-Roger Desmurs
发明人： Charles Mioskowski , Alain Wagner , Nicolas Bensel , Virginie Pevere , Jean-Roger Desmurs
IPC分类号： C07C39/24 , C07C39/34 , C07C45/90
CPC分类号： C07C45/46 , C07C45/565 , C07C231/12 , C07C231/14 , C07C303/28 , C07C303/30 , C07C233/18 , C07C309/66 , C07C49/84 , C07C47/575
摘要： The invention concerns a method for functionalizing a phenolic compound bearing an electron-donor group, in said group para position, inter alia a method for the amidoalkylation of a phenolic compound bearing an electron-donor group, and more particularly, a phenolic compound bearing an electron-donor group preferably, in the hydroxyl group ortho position. The method for functionalizing in para position with respect to an electron-donor group carried by a phenolic compound is characterised in that the phenolic compound bearing an electron-donor group is subjected to the following steps: a first step which consists of protecting the hydroxyl group in the form of a sulphonic ester function; a second step which consists in reacting the protected phenolic compound with an electrophilic reagent; optionally, a third step deprotecting the hydroxyl group.
摘要翻译：本发明涉及一种用于官能化带有电子给体基团的酚类化合物的方法，尤其是具有电子给体基团的酚类化合物的酰胺基烷基化方法，更具体地说，涉及带有电子给体基团优选在羟基邻位。相对于由酚类化合物携带的电子给体基团在对位官能化的方法的特征在于具有电子给体基团的酚类化合物经受以下步骤：第一步，其保护羟基呈磺酸酯官能团的形式; 第二步是使受保护的酚类化合物与亲电试剂反应; 任选地，第三步骤使羟基脱保护。

7. 发明申请

US20050058587A1 Heterogeneous catalyst consisting of an aggregate of metal-coated nanoparticles 审中-公开
标题翻译：由金属包覆的纳米颗粒的聚集体组成的非均相催化剂
公开(公告)号：US20050058587A1
公开(公告)日：2005-03-17
申请号：US10495872
申请日：2002-11-19
申请人： Alain Wagner
发明人： Alain Wagner
IPC分类号： B01J37/00 , B01J31/22 , B01J31/24 , B01J35/00 , B01J35/02 , C01B33/12
CPC分类号： B01J35/0013 , B01J35/023
摘要： The invention concerns mainly an aggregate of nanoparticles based on at least an inorganic material, functionalized at the surface with at least a metallic derivative, said functionalized nanoparticles being organized in said aggregate so as to form a three-dimensional porous structure comprising channels. The invention also concerns the use of said aggregate as heterogeneous catalyst.
摘要翻译：本发明主要涉及至少基于至少一种在至少一种金属衍生物的表面官能化的无机材料的纳米颗粒聚集体，所述官能化纳米颗粒被组织在所述聚集体中，从而形成包括通道的三维多孔结构。本发明还涉及所述骨料作为多相催化剂的用途。

8. 发明授权

US07991730B2 Methods for similarity searching of chemical reactions 有权
标题翻译：化学反应相似性检索方法
公开(公告)号：US07991730B2
公开(公告)日：2011-08-02
申请号：US11779255
申请日：2007-07-17
申请人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
发明人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
IPC分类号： G06F17/30 , G06F7/00 , G06F19/00
CPC分类号： G06F19/702 , G06F19/707 , G06F19/708
摘要： A computer-based method for identifying at least one pair of similar chemical reactions between a plurality of reactions each related to preparation of at least one product from at least one reagent may include generating for each reaction a structural representation involving dynamic and conventional bonds and, based on the this structural representation, generating for each reaction a set of fragment descriptors of a predetermined length comprising the dynamical bonds and a corresponding descriptor vector. The method may further include calculating similarity indices between descriptor vectors of the plurality of reactions and comparing the similarity indices to identify at least one pair of similar reactions.
摘要翻译：用于鉴定多个反应中的至少一对相似化学反应的基于计算机的方法，每个反应各自与来自至少一种试剂的至少一种产物的制备有关可包括为每个反应产生涉及动态和常规键的结构表示，基于该结构表示，为每个反应生成包括动态键的预定长度的一组片段描述符和相应的描述符向量。该方法还可以包括计算多个反应的描述符向量之间的相似性指数，并比较相似性指数以识别至少一对相似的反应。

9. 发明授权

US07420087B2 Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof 失效
标题翻译：制备4-羟基异亮氨酸非对映异构体及其对映体及其衍生物的方法
公开(公告)号：US07420087B2
公开(公告)日：2008-09-02
申请号：US10537293
申请日：2003-12-01
申请人： Charles Mioskowski , Alain Wagner , Sandra De Lamo Marin , Cedric Catala , Jean-Michel Becht
发明人： Charles Mioskowski , Alain Wagner , Sandra De Lamo Marin , Cedric Catala , Jean-Michel Becht
IPC分类号： C07C229/00 , C07D305/12
CPC分类号： C07D307/66 , C07C227/32 , C07C229/22
摘要： The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine.
摘要翻译：本发明涉及一种制备通式（I）的4-羟基异亮氨酸非对映异构体及其衍生物的方法，其特征在于其在直接得到式（I）衍生物的条件下还原式（II）的异恶唑衍生物，，或至少获得外消旋形式的结构（III）的内酯或对映异构体富集的混合物，然后在碱性条件下，在非质子或质子溶剂中，所需的内酯和任选的，分离所需的形式。本发明可用于特别制备（2S，3R，4S）-4-羟基异亮氨酸。

10. 发明申请

US20050143453A1 Selective preventing and therapeutic agents for progressive lesion after organic damage 审中-公开
标题翻译：有机损伤后进行性病变的选择性预防和治疗剂
公开(公告)号：US20050143453A1
公开(公告)日：2005-06-30
申请号：US11045394
申请日：2005-01-31
申请人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
发明人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
IPC分类号： A61K31/341 , A61K31/343 , A61K31/365 , A61P1/18 , A61P13/12 , A61P37/06 , A61P43/00 , C07D307/33 , C07D307/68 , C07D305/12 , C07D307/62
CPC分类号： C07D307/33 , A61K31/341 , A61K31/343 , A61K31/365 , C07D307/68 , G01N2500/10
摘要： An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.
摘要翻译：本发明的目的是提供一种用于预防和/或治疗有机损伤后的进行性损伤而不抑制其有机功能或再生功能的药剂，通过选择性地抑制诱导到受损器官中的细胞毒性效应物巨噬细胞的诱导响应于根据损伤的有机组织的类型表达的趋化因子和细胞因子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式