专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06331434B1 Nitrogen-containing silicone useful for compacting nucleic acid sequences and use for transforming cells 失效
标题翻译：用于压实核酸序列和用于转化细胞的含氮硅氧烷
公开(公告)号：US06331434B1
公开(公告)日：2001-12-18
申请号：US09521822
申请日：2000-03-09
申请人： Rachel Decor , Charles Mioskowski , Marc Schmutz , Alain Wagner
发明人： Rachel Decor , Charles Mioskowski , Marc Schmutz , Alain Wagner
IPC分类号： C12N1588
CPC分类号： C08G83/001 , C08G77/388 , C12N15/8207 , C12N15/87 , C12N15/895
摘要： The present invention relates to a method of transforming cells in which an appropriate quantity of nucleic acid fragments is introduced into the cells. The nucleic acid fragments are introduced in the form of a nucleic acid composition comprising a nitrogen-containing silicone, useful for compacting the nucleic acid fragments; the compositions comprise aggregates of nucleic acid fragments and silicones according to the invention.
摘要翻译：本发明涉及转化细胞的方法，其中将适量的核酸片段引入细胞。以核酸组合物的形式引入核酸片段，所述核酸组合物包含可用于压实核酸片段的含氮硅氧烷; 组合物包含根据本发明的核酸片段和硅氧烷的聚集体。

2. 发明授权

US6068980A Nitrogen-containing silicone useful for compacting nucleic acid sequences and use for transforming cells 失效
标题翻译：用于压实核酸序列和用于转化细胞的含氮硅氧烷
公开(公告)号：US6068980A
公开(公告)日：2000-05-30
申请号：US286406
申请日：1999-04-05
申请人： Rachel Decor , Charles Mioskowski , Marc Schmutz , Alain Wagner
发明人： Rachel Decor , Charles Mioskowski , Marc Schmutz , Alain Wagner
IPC分类号： C08G77/388 , C08G83/00 , C12N15/82 , C12N15/87 , C12N15/89 , C12Q1/68
CPC分类号： C08G83/001 , C08G77/388 , C12N15/8207 , C12N15/87 , C12N15/895
摘要： The present invention relates to a method of transforming cells in which an appropriate quantity of nucleic acid fragments is introduced into the cells. The nucleic acid fragments are introduced in the form of a nucleic acid composition comprising a nitrogen-containing silicone, useful for compacting the nucleic acid fragments; the compositions comprise aggregates of nucleic acid fragments and silicones according to the invention.
摘要翻译：本发明涉及转化细胞的方法，其中将适量的核酸片段引入细胞。以核酸组合物的形式引入核酸片段，所述核酸组合物包含可用于压实核酸片段的含氮硅氧烷; 组合物包含根据本发明的核酸片段和硅氧烷的聚集体。

3. 发明授权

US06878745B2 Selective preventives/remedies for progressive lesions after organ damage 失效
标题翻译：器官损伤后进行性病变的选择性预防措施/补救措施
公开(公告)号：US06878745B2
公开(公告)日：2005-04-12
申请号：US10239783
申请日：2001-03-27
申请人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
发明人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
IPC分类号： A61K31/341 , A61K31/343 , A61K31/365 , A61P1/18 , A61P13/12 , A61P37/06 , A61P43/00 , C07D307/33 , C07D307/68 , A61K31/34 , A61K31/585
CPC分类号： C07D307/33 , A61K31/341 , A61K31/343 , A61K31/365 , C07D307/68 , G01N2500/10
摘要： Drugs for preventing and/or treating progressive lesions after organ damage without inhibiting the function of the organ or the regeneration function thereof, by selectively regulating the induction of cytotoxic effecter macrophages which are induced into damaged organ tissues in response to chemokines or cytokines expressed depending on the type of the damaged organ tissues.
摘要翻译：用于预防和/或治疗器官损伤后不进行器官功能或其再生功能的进行性病变的药物，其通过选择性调节细胞毒性作用剂巨噬细胞的诱导，所述细胞毒性巨噬细胞响应于依赖于表达的趋化因子或细胞因子而被诱导到损伤的器官组织受损器官组织的类型。

4. 发明申请

US20070049773A1 Process for functionalising a phenolic compound carrying an electron-donating group 审中-公开
标题翻译：功能化携带电子给予基团的酚类化合物的方法
公开(公告)号：US20070049773A1
公开(公告)日：2007-03-01
申请号：US11592930
申请日：2006-11-03
申请人： Charles Mioskowski , Alain Wagner , Nicolas Bensel , Virginie Pevere , Jean-Roger Desmurs
发明人： Charles Mioskowski , Alain Wagner , Nicolas Bensel , Virginie Pevere , Jean-Roger Desmurs
IPC分类号： C07C39/24 , C07C39/34 , C07C45/90
CPC分类号： C07C45/46 , C07C45/565 , C07C231/12 , C07C231/14 , C07C303/28 , C07C303/30 , C07C233/18 , C07C309/66 , C07C49/84 , C07C47/575
摘要： The invention concerns a method for functionalizing a phenolic compound bearing an electron-donor group, in said group para position, inter alia a method for the amidoalkylation of a phenolic compound bearing an electron-donor group, and more particularly, a phenolic compound bearing an electron-donor group preferably, in the hydroxyl group ortho position. The method for functionalizing in para position with respect to an electron-donor group carried by a phenolic compound is characterised in that the phenolic compound bearing an electron-donor group is subjected to the following steps: a first step which consists of protecting the hydroxyl group in the form of a sulphonic ester function; a second step which consists in reacting the protected phenolic compound with an electrophilic reagent; optionally, a third step deprotecting the hydroxyl group.
摘要翻译：本发明涉及一种用于官能化带有电子给体基团的酚类化合物的方法，尤其是具有电子给体基团的酚类化合物的酰胺基烷基化方法，更具体地说，涉及带有电子给体基团优选在羟基邻位。相对于由酚类化合物携带的电子给体基团在对位官能化的方法的特征在于具有电子给体基团的酚类化合物经受以下步骤：第一步，其保护羟基呈磺酸酯官能团的形式; 第二步是使受保护的酚类化合物与亲电试剂反应; 任选地，第三步骤使羟基脱保护。

5. 发明授权

US07420087B2 Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof 失效
标题翻译：制备4-羟基异亮氨酸非对映异构体及其对映体及其衍生物的方法
公开(公告)号：US07420087B2
公开(公告)日：2008-09-02
申请号：US10537293
申请日：2003-12-01
申请人： Charles Mioskowski , Alain Wagner , Sandra De Lamo Marin , Cedric Catala , Jean-Michel Becht
发明人： Charles Mioskowski , Alain Wagner , Sandra De Lamo Marin , Cedric Catala , Jean-Michel Becht
IPC分类号： C07C229/00 , C07D305/12
CPC分类号： C07D307/66 , C07C227/32 , C07C229/22
摘要： The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine.
摘要翻译：本发明涉及一种制备通式（I）的4-羟基异亮氨酸非对映异构体及其衍生物的方法，其特征在于其在直接得到式（I）衍生物的条件下还原式（II）的异恶唑衍生物，，或至少获得外消旋形式的结构（III）的内酯或对映异构体富集的混合物，然后在碱性条件下，在非质子或质子溶剂中，所需的内酯和任选的，分离所需的形式。本发明可用于特别制备（2S，3R，4S）-4-羟基异亮氨酸。

6. 发明授权

US07326805B2 Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof 失效
公开(公告)号：US07326805B2
公开(公告)日：2008-02-05
申请号：US10555875
申请日：2004-05-07
申请人： Charles Mioskowski , Cédric Catala , Alain Wagner
发明人： Charles Mioskowski , Cédric Catala , Alain Wagner
IPC分类号： C07C229/00
CPC分类号： C07C227/30 , C07B2200/07 , C07C227/16
摘要： The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids α or the derivatives thereof, having general formula (B), wherein: linkage C—O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, R1 and R2 represent: a hydrogen atom; or either R1 or R2 represents a hydrogen atom and the other substituent is a radical Ra, an acyl group —CORa, such as acetyl, or a functional group —COORa, —SO2Ra, —N (Ra, Rb), Ra and Rb, which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or R1 and R2 both represent a substituent as defined above. R3 represents a hydrogen atom or Ra and R4 has the significance of Ra. The invention is characterised in that it comprises: the isomerisation of a compound having formula (I), wherein R1, R2, Ra, R3 and R4 are as defined above, such as to produce a compound having formula (II); and the reduction of the carbonyl function thereof which, depending on the catalytic system employed and the formula (I) compound used, produces one of the isomers having general formula (III) or (IV) or a mixture thereof having formula (B). The invention can be used for the synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine.

7. 发明申请

US20050143453A1 Selective preventing and therapeutic agents for progressive lesion after organic damage 审中-公开
标题翻译：有机损伤后进行性病变的选择性预防和治疗剂
公开(公告)号：US20050143453A1
公开(公告)日：2005-06-30
申请号：US11045394
申请日：2005-01-31
申请人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
发明人： Michio Ishibashi , Alain Wagner , Charles Mioskowski , Catherine Sylvain
IPC分类号： A61K31/341 , A61K31/343 , A61K31/365 , A61P1/18 , A61P13/12 , A61P37/06 , A61P43/00 , C07D307/33 , C07D307/68 , C07D305/12 , C07D307/62
CPC分类号： C07D307/33 , A61K31/341 , A61K31/343 , A61K31/365 , C07D307/68 , G01N2500/10
摘要： An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.
摘要翻译：本发明的目的是提供一种用于预防和/或治疗有机损伤后的进行性损伤而不抑制其有机功能或再生功能的药剂，通过选择性地抑制诱导到受损器官中的细胞毒性效应物巨噬细胞的诱导响应于根据损伤的有机组织的类型表达的趋化因子和细胞因子。

8. 发明授权

US07361668B2 Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors 失效
标题翻译：奎宁环衍生物的制备方法及其作为m2和/或m3毒蕈碱受体抑制剂的用途
公开(公告)号：US07361668B2
公开(公告)日：2008-04-22
申请号：US10490436
申请日：2002-09-23
申请人： Michel Guyaux , Chimmanamada U. Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Matteo Zanda
发明人： Michel Guyaux , Chimmanamada U. Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Matteo Zanda
IPC分类号： A61K31/45 , A61K43/96 , A61K43/40 , C07D453/02
CPC分类号： C07D453/02
摘要： The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.
摘要翻译：本发明涉及式I或II的奎宁环衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。本发明化合物对于m 3和/或m 2毒蕈碱受体显示出高亲和力，特别适用于治疗尿失禁。

9. 发明申请

US20070043240A1 Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof 失效
公开(公告)号：US20070043240A1
公开(公告)日：2007-02-22
申请号：US10555875
申请日：2004-05-07
申请人： Charles Mioskowski , Cedric Catala , Alain Wagner
发明人： Charles Mioskowski , Cedric Catala , Alain Wagner
IPC分类号： C07C227/12
CPC分类号： C07C227/30 , C07B2200/07 , C07C227/16
摘要： The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids α or the derivatives thereof, having general formula (B), wherein: linkage C—O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, R1 and R2 represent: a hydrogen atom; or either R1 or R2 represents a hydrogen atom and the other substituent is a radical Ra, an acyl group —CORa, such as acetyl, or a functional group —COORa, —SO2Ra, —N (Ra, Rb), Ra and Rb, which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or R1 and R2 both represent a substituent as defined above. R3 represents a hydrogen atom or Ra and R4 has the significance of Ra. The invention is characterised in that it comprises: the isomerisation of a compound having formula (I), wherein R1, R2, Ra, R3 and R4 are as defined above, such as to produce a compound having formula (II); and the reduction of the carbonyl function thereof which, depending on the catalytic system employed and the formula (I) compound used, produces one of the isomers having general formula (III) or (IV) or a mixture thereof having formula (B). The invention can be used for the synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine.

10. 发明授权

US06384273B1 Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group 失效
标题翻译：至少具有电子给体基团的碳环芳族衍生物的正交金属化方法
公开(公告)号：US06384273B1
公开(公告)日：2002-05-07
申请号：US09700467
申请日：2001-01-24
申请人： Virginie Pevere , Jean Roger Desmurs , Charles Mioskowski , Alain Wagner , Arnaud Gissot
发明人： Virginie Pevere , Jean Roger Desmurs , Charles Mioskowski , Alain Wagner , Arnaud Gissot
IPC分类号： C07C6500
CPC分类号： C07F1/04 , C07B61/00 , C07C41/30 , C07C45/00 , C07C51/15 , C07C315/04 , C07C47/575 , C07C65/21 , C07C317/22 , C07C43/2055
摘要： The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one alkaline metal in the presence of a compound of formula (I): RX, wherein: R represents a hydrocarbon radical having 1 to 20 carbon atoms which can be a saturated or unsaturated, linear or branched, acyclic aliphatic radical; a saturated or unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical bearing a cyclic substituent; and X represents a bromine or chlorine atom.
摘要翻译：本发明涉及一种至少具有电子给体基团的碳环芳族衍生物的正交金属化方法，其特征在于它包括在式（1）化合物存在下使所述碳环芳族衍生物与有效量的至少一种碱金属反应 I）：RX，其中：R表示具有1至20个碳原子的烃基，其可以是饱和或不饱和的，直链或支链的无环脂族基团; 饱和或不饱和的单环或多环脂环族基团; 具有环状取代基的饱和或不饱和的直链或支链脂族基团; X表示溴或氯原子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式