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1. 发明授权

US4402197A Automatic washing machine or dishwasher 失效
标题翻译：自动洗衣机或洗碗机
公开(公告)号：US4402197A
公开(公告)日：1983-09-06
申请号：US293635
申请日：1981-08-06
申请人： Alain Groult , Augusto Porta , Herve Tournier
发明人： Alain Groult , Augusto Porta , Herve Tournier
IPC分类号： A47L15/00 , A47L15/44 , C02F1/467 , D06F35/00 , D06F43/00 , D06F39/02 , C25B1/26
CPC分类号： D06F35/003 , A47L15/4236 , A47L15/44 , C02F1/4674 , D06F35/004 , C02F2201/4612 , C02F2201/46125 , C02F2201/46145 , C02F2201/46155 , C02F2201/4618 , C02F2209/42 , C02F2303/04
摘要： This washing machine is provided with an electro chemical cell (4) having a brine tank (9) provided with a metering piston (16a, b 16b) actuated by an electro magnet (21) and connected by an electro valve (14) controlling a connection conduit (3) to a water supply conduit (1). The inlet opening of such connection conduit into the cell (4) is controlled by a float valve (11). The electro valve is a two-way valve (14, 14a) and controls simultaneously the outlet conduit (13) which opens into the washing tub of the washing machine. The power supply of the cell (4) is controlled by the program selector (8) of the machine.
摘要翻译： PCT No.PCT / CH80 / 00156 Sec。 371日期1981年8月6日 102（e）日期1981年8月6日PCT PCT日期为1980年12月17日PCT公布。公开号WO81 / 01863 日期：1981年7月9日。该洗衣机设置有电化学池（4），其具有设置有由电磁体（21）致动并由电磁体（21）驱动的计量活塞（16a，b 16b）的盐水箱（9）控制连接管道（3）到供水管道（1）的电动阀（14）。进入电池（4）的这种连接导管的入口由浮阀（11）控制。电动阀是双向阀（14,14a），同时控制通向洗衣机洗涤桶的出口导管（13）。电池（4）的电源由机器的程序选择器（8）控制。

2. 发明授权

US4194986A Powdered or flaked washing compositions adapted to automatic laundry machines 失效
标题翻译：适用于自动洗衣机的粉状或片状洗涤组合物
公开(公告)号：US4194986A
公开(公告)日：1980-03-25
申请号：US874227
申请日：1978-02-01
申请人： Herve Tournier , Alain Groult
发明人： Herve Tournier , Alain Groult
IPC分类号： C11D1/28 , C11D1/52 , C11D1/72 , C11D10/04 , C11D7/54 , C11D7/60
CPC分类号： C11D1/72 , C11D1/28 , C11D10/04 , C11D1/523 , C11D1/526
摘要： A detergent composition mainly for automatic laundering machines which comprises, on the basis of 100 parts by weight of total composition, at least 60 parts of soap and no more than 10 parts of a mixture of surfactants comprising 10 to 30% of at least one non-ionic polyoxyalkylated surfactant and 90 to 70% of an anionic surfactant selected essentially from .alpha.-sulfonated fatty acids derivatives, the remainder of the composition comprising at least one ingredient selected from alkaline detergent additives, bleaching agents, optical brighteners, fragrances, antiredeposition agents and enzymes.The non-ionic surfactants are preferably fatty acid amides derived from tallow, copra or palm-oil condensed with polyoxyethylene residues.The anionic surfactants are preferably .alpha.-sulfonated fatty esters or amides derived from tallow, copra or palm-oil. The proper combination of said non-ionic and anionic surfactants with soaps impart to the laundering compositions an excellent detergent ability and foam control even in very soft waters and non-polluting properties.
摘要翻译：一种主要用于自动洗衣机的洗涤剂组合物，其包含基于100重量份的总组合物，至少60份皂和不超过10份表面活性剂的混合物，其包含10至30％的至少一种非 - 阴离子聚氧烷基化表面活性剂和基本上选自α-磺化脂肪酸衍生物的90至70％阴离子表面活性剂，组合物的其余部分包含至少一种选自碱性洗涤剂添加剂，漂白剂，荧光增白剂，香料，抗再沉积剂和酶。非离子表面活性剂优选衍生自与聚氧乙烯残基缩合的牛油，椰子油或棕榈油的脂肪酸酰胺。阴离子表面活性剂优选为衍生自牛油，椰子油或棕榈油的α-磺化脂肪酸酯或酰胺。所述非离子和阴离子表面活性剂与皂的适当组合赋予洗涤组合物优异的洗涤能力和泡沫控制，即使在非常柔软的水和非污染性质中。

3. 发明授权

US5702722A Liposomes with enhanced entrapment capacity, method and use 失效
标题翻译：具有增强的捕获能力，方法和用途的脂质体
公开(公告)号：US5702722A
公开(公告)日：1997-12-30
申请号：US527087
申请日：1995-09-12
申请人： Herve Tournier , Michel Schneider , Christian Guillot
发明人： Herve Tournier , Michel Schneider , Christian Guillot
IPC分类号： A61K9/127 , A61K49/04 , B01J13/02
CPC分类号： A61K9/1277 , Y10S514/945 , Y10T428/2984
摘要： The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
摘要翻译：本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3之间的三维膨胀结构。本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成扩展的三维多孔脂质结构，从而制备具有增强的捕获能力的脂质体囊泡的方法使脂质沉积物与水性载体相接触，并产生包裹载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或基质表面，用于沉积根据的方法。

4. 发明授权

US5445810A Injectable opacifying composition containing liposomes of high encapsulating capacity for X-ray examinations 失效
标题翻译：含有X射线检查的高封装能力的脂质体的注射不透明组合物
公开(公告)号：US5445810A
公开(公告)日：1995-08-29
申请号：US128206
申请日：1993-09-29
申请人： Michel Schneider , Herve Tournier , Bernard Lamy
发明人： Michel Schneider , Herve Tournier , Bernard Lamy
IPC分类号： A61K9/127 , A61K9/50 , A61K49/04
CPC分类号： A61K49/0466
摘要： Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated thereein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.
摘要翻译：可注射的含水组合物用于使某些器官不透明，以便通过X射线检查。该组合物基于含有包封的含有所述碘化不透明剂的水溶液的脂质体。由脂质体包封的碘的重量与其膜形成的脂质的重量之比不低于1.5mg / mg。

5. 发明授权

US4587319A Salified acrylic allyloligosaccharide copolymer, a process for preparing the copolymer, and application as a super-absorbent 失效
标题翻译：盐化丙烯酸烯丙基低聚糖共聚物，制备共聚物的方法和作为超吸收剂的应用
公开(公告)号：US4587319A
公开(公告)日：1986-05-06
申请号：US682351
申请日：1984-11-19
申请人： Herve Tournier
发明人： Herve Tournier
IPC分类号： C08F220/00 , A61F13/53 , A61L15/60 , C08F16/12 , C08F20/00 , C08F216/12 , C08F216/14 , C08F220/10 , C08F220/42 , A61L15/00 , C08F220/04
CPC分类号： C08F216/12 , A61L15/60
摘要： The invention relates to liquid-absorbing products, in particular blood and urine. It concerns a salified acrylic allyloligosaccharide copolymer consisting in chemically combined form of at least one allyloligosaccharide with a mean degree of substitution of less than 4 per molecule and of at least one acrylic derivative with partly or totally salified carboxyl functions, said copolymer having a degree of retention, after 30 minutes in water salinated at 10 g/liter, exceeding 8 g of saline water per gram of copolymer.Preferably the allyloligosaccharide is allylsaccharose with DS 2 and the acrylic derivative is acrylic acid.The invention applies to using these polymers as additives to improve the absorption of absorbing materials used in personal hygiene.
摘要翻译： PCT No.PCT / FR84 / 00066 Sec。 371日期：1984年11月19日 102（e）1984年11月19日PCT PCT Filed 3月16日，1984 PCT Pub。公开号WO84 / 03706 日期：1984年9月27日。本发明涉及液体吸收产品，特别是血液和尿液。它涉及由化学组合形式的至少一种平均取代度低于每分子4的烯丙基寡糖和至少一种具有部分或全部盐化羧基官能团的丙烯酸衍生物组成的盐化丙烯酸类间苯二酚共聚物，所述共聚物具有在以10g /升盐析的水中30分钟后保留，每克共聚物超过8克盐水。优选地，所述烯丙基寡糖是具有＆amp;＆amp;＆amp;＆amp; 2＆gt;的丙烯酸蔗糖，丙烯酸衍生物是丙烯酸。本发明适用于使用这些聚合物作为添加剂以改善用于个人卫生的吸收材料的吸收。

6. 发明授权

US07749485B2 Liposomal assembly for therapeutic and/or diagnostic use 有权
标题翻译：用于治疗和/或诊断用途的脂质体组装
公开(公告)号：US07749485B2
公开(公告)日：2010-07-06
申请号：US11596447
申请日：2005-05-31
申请人： Herve Tournier , Roland Hyacinthe , Michel Schneider
发明人： Herve Tournier , Roland Hyacinthe , Michel Schneider
IPC分类号： A61K51/00 , A61M36/14 , B32B5/16 , B01F3/00
CPC分类号： A61K9/1075 , A61K9/1271 , A61K48/0091 , A61K49/1812 , C12N15/88 , Y10S977/907 , Y10T428/2982
摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.
摘要翻译：用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的外壳的外表面结合。当将活性化合物并入胶束中时，大量的所述活性化合物可以连接到单个脂质体。此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

7. 发明授权

US6042809A Administrable compositions and methods for magnetic resonance imaging 有权
标题翻译：用于磁共振成像的可管理组合物和方法
公开(公告)号：US6042809A
公开(公告)日：2000-03-28
申请号：US132763
申请日：1998-08-12
申请人： Herve Tournier , Michel Schneider , Feng Yan , Jean Brochot
发明人： Herve Tournier , Michel Schneider , Feng Yan , Jean Brochot
IPC分类号： A61K9/48 , A61B5/055 , A61B8/00 , A61K49/00 , A61K49/18 , A61K49/22
CPC分类号： A61K49/1806 , A61K49/223
摘要： The invention relates to the application of hyperpolarized gases to magnetic resonance imaging (MRI) of living subjects. The invention also concerns administrable compositions, formulations, methods of making the compositions and formulations and contrast agents involving hyperpolarized gases, as well as their use in MRI.
摘要翻译：本发明涉及超极化气体对活体的磁共振成像（MRI）的应用。本发明还涉及可施用的组合物，制剂，制备组合物和制剂的方法以及涉及超极化气体的造影剂以及它们在MRI中的应用。

8. 发明授权

US5545395A Method of imaging using encapsulated magnetite particles 失效
标题翻译：使用封装的磁铁矿颗粒成像的方法
公开(公告)号：US5545395A
公开(公告)日：1996-08-13
申请号：US421330
申请日：1995-04-13
申请人： Herve Tournier , Roland Hyacinthe , Michel Schneider
发明人： Herve Tournier , Roland Hyacinthe , Michel Schneider
IPC分类号： A61K9/127 , A61B5/055 , A61K20060101 , A61K49/00 , A61K49/18
CPC分类号： A61K49/1806 , A61K49/1839 , Y10S977/838 , Y10S977/904 , Y10S977/905 , Y10S977/927 , Y10S977/96 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.
摘要翻译：适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

9. 发明授权

US6060040A Cross-linked polymeric compositions for increasing the MRI contrast in visualising the digestive tract of patients 失效
标题翻译：用于增加患者消化道可视化MRI对比度的交联聚合物组合物
公开(公告)号：US6060040A
公开(公告)日：2000-05-09
申请号：US997453
申请日：1997-12-23
申请人： Herve Tournier , Philippe Bussat
发明人： Herve Tournier , Philippe Bussat
IPC分类号： A61K49/00 , A61K49/06 , C07C229/16 , C07C233/20 , C07C237/08 , C07C237/10 , C07C327/06 , C07C327/10 , C07D257/02 , C08F20/00 , C08F20/36 , C08F20/38 , C08F20/52 , C08F22/10 , A61B5/055
CPC分类号： C08F22/105 , A61K49/06 , C07C229/16 , C07C237/10 , C07D257/02 , C08F20/36 , Y10S514/836
摘要： The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R.sup.1 R.sup.2).dbd.CR.sup.3 --CO--Z--A (1) and/or C(R.sup.1 R.sup.2).dbd.CR.sup.3 --O--Z--A--Z--CO--CR.sup.3 .dbd.C(R.sup.1 R.sup.2) (2) in monomer, oligomer, homopolymer and copolymer forms, in which the R.sup.1, R.sup.2 and R.sup.3 represent H or saturated or unsaturated C.sub.1-10 aliphatic radicals optionally substituted by one or more OH groups; Z is a covalent bond or a linker spacer and A is a moiety capable of fixing a paramagnetic metal by chelation. Compounds of type (1) useful in the present invention are, for instance the polyalkylene-aminopolycaboxylic acids such as NTA, EDTA, DTPA, DOTA and like structures, possibly involving additional substituents; an example is the compound BOPTA which is a DTPA derivative carrying a benzyloxypropyl group.
摘要翻译：本发明提供作为消化道MR成像中的对比信号发生器，式C（R1R2）= CR3-CO-ZA（1）和/或C（R1R2）= CR3-OZAZ-的新型丙烯酸化合物的顺磁性金属螯合物， CO-CR 3 = C（R 1 R 2）（2）在单体，低聚物，均聚物和共聚物形式中，其中R 1，R 2和R 3表示H或任选被一个或多个OH基团取代的饱和或不饱和C 1-10脂族基团; Z是共价键或连接基团，A是通过螯合固定顺磁性金属的部分。可用于本发明的（1）型化合物是例如可能涉及另外的取代基的聚亚烷基 - 氨基多羧酸如NTA，EDTA，DTPA，DOTA等结构; 作为具有苄氧基丙基的DTPA衍生物的化合物BOPTA的实例。

10. 发明授权

US5393530A Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated 失效
标题翻译：制备脂质体增强包封能力的方法
公开(公告)号：US5393530A
公开(公告)日：1995-02-28
申请号：US861889
申请日：1992-06-22
申请人： Michel Schneider , Herve Tournier , Roland Hyacinthe , Christian Guillot , Bernard Lamy
发明人： Michel Schneider , Herve Tournier , Roland Hyacinthe , Christian Guillot , Bernard Lamy
IPC分类号： A61K9/00 , A61K9/127 , A61K47/48 , A61K49/04 , B01J13/02 , A61K57/22
CPC分类号： A61K49/0466 , A61K9/1278
摘要： Liposome vesicles are prepared containing water or very dilute solutions encapsulated therein. These "empty" liposomes are suspended in a carrier liquid containing, dispersed therein, substances of interest to be loaded into the vesicles and incubated for a period of time at temperatures above the lipids transition temperature, whereby loading by transmembrane permeation occurs in high yields.
摘要翻译： PCT No.PCT / EP91 / 00377。 371日期：1992年6月22日 102（e）日期1992年6月22日PCT提交1992年12月9日PCT公布。公开号WO92 / 10166 日期：1992年6月25日。制备含有水或非常稀的溶液的脂质体囊泡。将这些“空”脂质体悬浮于含有分散在其中的感兴趣物质的载体液体中，将其装载到囊泡中，并在高于脂质转变温度的温度下温育一段时间，由此通过跨膜渗透的加载以高产率发生。

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