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1. 发明授权

US5702722A Liposomes with enhanced entrapment capacity, method and use 失效
标题翻译：具有增强的捕获能力，方法和用途的脂质体
公开(公告)号：US5702722A
公开(公告)日：1997-12-30
申请号：US527087
申请日：1995-09-12
申请人： Herve Tournier , Michel Schneider , Christian Guillot
发明人： Herve Tournier , Michel Schneider , Christian Guillot
IPC分类号： A61K9/127 , A61K49/04 , B01J13/02
CPC分类号： A61K9/1277 , Y10S514/945 , Y10T428/2984
摘要： The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
摘要翻译：本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3之间的三维膨胀结构。本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成扩展的三维多孔脂质结构，从而制备具有增强的捕获能力的脂质体囊泡的方法使脂质沉积物与水性载体相接触，并产生包裹载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或基质表面，用于沉积根据的方法。

2. 发明授权

US5980937A Liposomes with enhanced entrapment capacity and their use in imaging 失效
标题翻译：具有增强的捕获能力的脂质体及其在成像中的应用
公开(公告)号：US5980937A
公开(公告)日：1999-11-09
申请号：US909827
申请日：1997-08-12
申请人： Herve Tournier , Michel Schneider , Christian Guillot
发明人： Herve Tournier , Michel Schneider , Christian Guillot
IPC分类号： A61K9/127 , A61K49/04 , B01J13/02
CPC分类号： A61K9/1277 , Y10S514/945 , Y10T428/2984
摘要： The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
摘要翻译：本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3之间的三维膨胀结构。本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成扩展的三维多孔脂质结构，从而制备具有增强的捕获能力的脂质体囊泡的方法使脂质沉积物与水性载体相接触，并产生包裹载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或基质表面，用于沉积根据的方法。

3. 发明授权

US5895661A Liposome vesicle precursors 失效
标题翻译：脂质体囊泡前体
公开(公告)号：US5895661A
公开(公告)日：1999-04-20
申请号：US909097
申请日：1997-08-12
申请人： Herve Tournier , Michel Schneider , Christian Guillot
发明人： Herve Tournier , Michel Schneider , Christian Guillot
IPC分类号： A61K9/127 , A61K49/04 , B01J13/02
CPC分类号： A61K9/1277 , Y10S514/945 , Y10T428/2984
摘要： The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
摘要翻译：本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3之间的三维膨胀结构。本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成扩展的三维多孔脂质结构，从而制备具有增强的捕获能力的脂质体囊泡的方法使脂质沉积物与水性载体相接触，并产生包裹载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或基质表面，用于沉积根据的方法。

4. 发明授权

US5393530A Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated 失效
标题翻译：制备脂质体增强包封能力的方法
公开(公告)号：US5393530A
公开(公告)日：1995-02-28
申请号：US861889
申请日：1992-06-22
申请人： Michel Schneider , Herve Tournier , Roland Hyacinthe , Christian Guillot , Bernard Lamy
发明人： Michel Schneider , Herve Tournier , Roland Hyacinthe , Christian Guillot , Bernard Lamy
IPC分类号： A61K9/00 , A61K9/127 , A61K47/48 , A61K49/04 , B01J13/02 , A61K57/22
CPC分类号： A61K49/0466 , A61K9/1278
摘要： Liposome vesicles are prepared containing water or very dilute solutions encapsulated therein. These "empty" liposomes are suspended in a carrier liquid containing, dispersed therein, substances of interest to be loaded into the vesicles and incubated for a period of time at temperatures above the lipids transition temperature, whereby loading by transmembrane permeation occurs in high yields.
摘要翻译： PCT No.PCT / EP91 / 00377。 371日期：1992年6月22日 102（e）日期1992年6月22日PCT提交1992年12月9日PCT公布。公开号WO92 / 10166 日期：1992年6月25日。制备含有水或非常稀的溶液的脂质体囊泡。将这些“空”脂质体悬浮于含有分散在其中的感兴趣物质的载体液体中，将其装载到囊泡中，并在高于脂质转变温度的温度下温育一段时间，由此通过跨膜渗透的加载以高产率发生。

5. 发明申请

US20070196284A1 Liposomal assembly for therapeutic and/or diagnostic use 有权
标题翻译：用于治疗和/或诊断用途的脂质体组装
公开(公告)号：US20070196284A1
公开(公告)日：2007-08-23
申请号：US11596447
申请日：2005-05-31
申请人： Herve Tournier , Roland Hyacinthe , Michel Schneider
发明人： Herve Tournier , Roland Hyacinthe , Michel Schneider
IPC分类号： A61K49/10 , A61K9/127
CPC分类号： A61K9/1075 , A61K9/1271 , A61K48/0091 , A61K49/1812 , C12N15/88 , Y10S977/907 , Y10T428/2982
摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction. When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.
摘要翻译：用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本静电相互作用与所述脂质体的包膜的外表面相关联。当活性化合物掺入胶束中时，大量的所述活性化合物可以连接到单个脂质体。此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

6. 发明授权

US5445810A Injectable opacifying composition containing liposomes of high encapsulating capacity for X-ray examinations 失效
标题翻译：含有X射线检查的高封装能力的脂质体的注射不透明组合物
公开(公告)号：US5445810A
公开(公告)日：1995-08-29
申请号：US128206
申请日：1993-09-29
申请人： Michel Schneider , Herve Tournier , Bernard Lamy
发明人： Michel Schneider , Herve Tournier , Bernard Lamy
IPC分类号： A61K9/127 , A61K9/50 , A61K49/04
CPC分类号： A61K49/0466
摘要： Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated thereein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.
摘要翻译：可注射的含水组合物用于使某些器官不透明，以便通过X射线检查。该组合物基于含有包封的含有所述碘化不透明剂的水溶液的脂质体。由脂质体包封的碘的重量与其膜形成的脂质的重量之比不低于1.5mg / mg。

7. 发明授权

US07749485B2 Liposomal assembly for therapeutic and/or diagnostic use 有权
标题翻译：用于治疗和/或诊断用途的脂质体组装
公开(公告)号：US07749485B2
公开(公告)日：2010-07-06
申请号：US11596447
申请日：2005-05-31
申请人： Herve Tournier , Roland Hyacinthe , Michel Schneider
发明人： Herve Tournier , Roland Hyacinthe , Michel Schneider
IPC分类号： A61K51/00 , A61M36/14 , B32B5/16 , B01F3/00
CPC分类号： A61K9/1075 , A61K9/1271 , A61K48/0091 , A61K49/1812 , C12N15/88 , Y10S977/907 , Y10T428/2982
摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.
摘要翻译：用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的外壳的外表面结合。当将活性化合物并入胶束中时，大量的所述活性化合物可以连接到单个脂质体。此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

8. 发明授权

US6042809A Administrable compositions and methods for magnetic resonance imaging 有权
标题翻译：用于磁共振成像的可管理组合物和方法
公开(公告)号：US6042809A
公开(公告)日：2000-03-28
申请号：US132763
申请日：1998-08-12
申请人： Herve Tournier , Michel Schneider , Feng Yan , Jean Brochot
发明人： Herve Tournier , Michel Schneider , Feng Yan , Jean Brochot
IPC分类号： A61K9/48 , A61B5/055 , A61B8/00 , A61K49/00 , A61K49/18 , A61K49/22
CPC分类号： A61K49/1806 , A61K49/223
摘要： The invention relates to the application of hyperpolarized gases to magnetic resonance imaging (MRI) of living subjects. The invention also concerns administrable compositions, formulations, methods of making the compositions and formulations and contrast agents involving hyperpolarized gases, as well as their use in MRI.
摘要翻译：本发明涉及超极化气体对活体的磁共振成像（MRI）的应用。本发明还涉及可施用的组合物，制剂，制备组合物和制剂的方法以及涉及超极化气体的造影剂以及它们在MRI中的应用。

9. 发明授权

US5545395A Method of imaging using encapsulated magnetite particles 失效
标题翻译：使用封装的磁铁矿颗粒成像的方法
公开(公告)号：US5545395A
公开(公告)日：1996-08-13
申请号：US421330
申请日：1995-04-13
申请人： Herve Tournier , Roland Hyacinthe , Michel Schneider
发明人： Herve Tournier , Roland Hyacinthe , Michel Schneider
IPC分类号： A61K9/127 , A61B5/055 , A61K20060101 , A61K49/00 , A61K49/18
CPC分类号： A61K49/1806 , A61K49/1839 , Y10S977/838 , Y10S977/904 , Y10S977/905 , Y10S977/927 , Y10S977/96 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.
摘要翻译：适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

10. 发明授权

US5587199A Process of preparing particles for NMR imaging 失效
标题翻译：制备核磁共振成像颗粒的方法
公开(公告)号：US5587199A
公开(公告)日：1996-12-24
申请号：US421329
申请日：1995-04-13
申请人： Herve Tournier , Roland Hyacinthe , Michel Schneider
发明人： Herve Tournier , Roland Hyacinthe , Michel Schneider
IPC分类号： A61K9/127 , A61B5/055 , A61K20060101 , A61K49/00 , A61K49/18 , B05D7/00 , B05D3/12 , B06B1/00 , B32B9/00
CPC分类号： A61K49/1806 , A61K49/1839 , Y10S977/838 , Y10S977/904 , Y10S977/905 , Y10S977/927 , Y10S977/96 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.
摘要翻译：适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

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