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1. 发明授权

US09024631B2 Transport and detection of superparamagnetic particles by nanowire 有权
标题翻译：通过纳米线传输和检测超顺磁性粒子
公开(公告)号：US09024631B2
公开(公告)日：2015-05-05
申请号：US13297059
申请日：2011-11-15
申请人： Geoffrey Stephen Beach , Elizabeth Ashera Rapoport
发明人： Geoffrey Stephen Beach , Elizabeth Ashera Rapoport
IPC分类号： G01R33/02 , G01R33/12
CPC分类号： G01R33/1276 , G01R33/02 , Y10S977/901 , Y10S977/902 , Y10S977/932 , Y10S977/953 , Y10S977/96
摘要： An apparatus, method and computer-readable medium configured to transport a constituent of fluid sample that binds to a functionalized magnetic particle. The apparatus includes a substrate connected to an input port, a magnetic nanowire, and either a temporally changing magnetic field generator or a spin-polarized current source. The magnetic nanowire is disposed in a surface of the substrate. The width and thickness of the magnetic nanowire are configured so that a domain wall propagating along the nanowire in response to the temporally changing magnetic field continuously couples to a superparamagnetic particle introduced into the input port.
摘要翻译：一种设备，方法和计算机可读介质，其被配置为传送结合于官能化磁性颗粒的流体样品的成分。该装置包括连接到输入端口，磁性纳米线以及时间上变化的磁场发生器或自旋极化电流源的基板。磁性纳米线设置在基板的表面中。磁纳米线的宽度和厚度被构造成使得响应于时间上变化的磁场沿着纳米线传播的畴壁连续耦合到引入到输入端口的超顺磁性颗粒。

2. 发明授权

US07615995B2 Thin film device for detection of physical quantities 失效
标题翻译：用于检测物理量的薄膜装置
公开(公告)号：US07615995B2
公开(公告)日：2009-11-10
申请号：US11512217
申请日：2006-08-30
申请人： Daniele Pullini , Gianfranco Innocenti , Piermario Repetto , Antonio Ruotolo
发明人： Daniele Pullini , Gianfranco Innocenti , Piermario Repetto , Antonio Ruotolo
IPC分类号： G01R33/02
CPC分类号： G01R33/09 , Y10S977/96
摘要： A thin-film device for detecting the variation of intensity of physical quantities, in particular a magnetic field, in a continuous way, comprises an electrical circuit including one or more sensitive elements, which are designed to vary their own electrical resistance as a function of the intensity of a physical quantity to be detected. One or more of the sensitive elements comprise at least one nanoconstriction, and the nanoconstriction comprises at least two pads made of magnetic material, associated to which are respective magnetizations oriented in directions substantially opposite to one another and connected through a nanochannel. The nanochannel is able to set up a domain wall that determines the electrical resistance of the nanoconstriction as a function of the position, with respect to the nanochannel, of the domain wall formed in the sensor device. At least one cross section of the nanochannel is configured so as to present a variable extension along one or more axes as a function of different values of the physical quantity to be detected.
摘要翻译：用于以连续方式检测物理量，特别是磁场的强度的变化的薄膜装置包括电路，该电路包括一个或多个敏感元件，其被设计成根据要检测的物理量的强度。敏感元件中的一个或多个包括至少一个纳米收缩，并且纳米收缩包括由磁性材料制成的至少两个焊盘，所述至少两个焊盘是相互磁化的，它们彼此相反并且通过纳米通道连接。纳米通道能够建立一个畴壁，其根据在传感器装置中形成的畴壁相对于纳米通道的位置确定纳米收缩的电阻。纳米通道的至少一个横截面被配置为根据要检测的物理量的不同值的一个或多个轴呈现可变的延伸。

3. 发明申请

US20040150396A1 Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes 有权
标题翻译：用于测量与分析物结合的磁敏感颗粒的积累的方法和装置
公开(公告)号：US20040150396A1
公开(公告)日：2004-08-05
申请号：US10625720
申请日：2003-07-22
发明人： Michael Bancroft Simmonds , Kurt Gordon Jensen , Jost Hermann Diederichs , Randall Christopher Black
IPC分类号： G01N027/72 , G01R033/12
CPC分类号： B82Y15/00 , B82Y25/00 , G01N27/745 , G01N35/0098 , G01R33/12 , Y10S977/773 , Y10S977/838 , Y10S977/96
摘要： An apparatus is provided for quantitatively measuring combinations of magnetic particles combined with analytes whose amount or other characteristic quality is to be determined. The magnetic particles are complexed with the analytes to be determined and are excited in a magnetic field. The magnetizations of the magnetic particles are thereby caused to oscillate at the excitation frequency in the manner of a dipole to create their own fields. These fields are inductively coupled to at least one sensor such as sensing coils fabricated in a gradiometer configuration. The output signals from the sensing coils are appropriately amplified and processed to provide useful output indications.
摘要翻译：提供了一种设备，用于定量测量与要测定其量或其他特征质量的分析物组合的磁性颗粒的组合。磁性颗粒与要测定的分析物复合，并在磁场中被激发。因此磁性粒子的磁化以激励频率以偶极子的方式振荡以产生它们自己的场。这些场感应耦合到至少一个传感器，例如以梯度计配置制造的感测线圈。来自感测线圈的输出信号被适当地放大和处理以提供有用的输出指示。

4. 发明申请

US20020179939A1 Four-terminal system for reading the state of a phase qubit 有权
标题翻译：用于读取相位量子位状态的四端系统
公开(公告)号：US20020179939A1
公开(公告)日：2002-12-05
申请号：US10194704
申请日：2002-07-12
发明人： Zdravko Ivanov , Alexander Tzalentchuk , Jeremy P. Hilton , Alexander Maassen van den Brink
IPC分类号： H01L031/072
CPC分类号： G06N99/002 , B82Y10/00 , H01L39/225 , Y10S977/70 , Y10S977/812 , Y10S977/838 , Y10S977/933 , Y10S977/96
摘要： Quantum computing systems and methods that use opposite magnetic moment states read the state of a qubit by applying current through the qubit and measuring a Hall effect voltage across the width of the current. For reading, the qubit is grounded to freeze the magnetic moment state, and the applied current is limited to pulses incapable of flipping the magnetic moment. Measurement of the Hall effect voltage can be achieved with an electrode system that is capacitively coupled to the qubit. An insulator or tunnel barrier isolates the electrode system from the qubit during quantum computing. The electrode system can include a pair of electrodes for each qubit. A readout control system uses a voltmeter or other measurement device that connects to the electrode system, a current source, and grounding circuits. For a multi-qubit system, selection logic can select which qubit or qubits are read.
摘要翻译：使用相反磁矩状态的量子计算系统和方法通过在电流上施加电流并测量电流宽度上的霍尔效应电压来读取量子位的状态。为了读取，量子位接地，以冻结磁矩状态，施加的电流限于不能翻转磁矩的脉冲。可以通过电容耦合到量子位的电极系统来实现霍尔效应电压的测量。绝缘体或隧道势垒在量子计算过程中将电极系统与量子位隔离。电极系统可以包括用于每个量子位的一对电极。读出控制系统使用连接到电极系统，电流源和接地电路的电压表或其它测量装置。对于多量子位系统，选择逻辑可以选择读取哪个量子位或量子位。

5. 发明授权

US5998224A Magnetically assisted binding assays utilizing a magnetically responsive reagent 失效
标题翻译：使用磁响应试剂的磁辅助结合测定
公开(公告)号：US5998224A
公开(公告)日：1999-12-07
申请号：US857440
申请日：1997-05-16
申请人： Thomas E. Rohr , Tuan A. Elstrom , Lawrence V. Howard , Eric B. Shain
发明人： Thomas E. Rohr , Tuan A. Elstrom , Lawrence V. Howard , Eric B. Shain
IPC分类号： G01N33/553 , G01N33/543
CPC分类号： G01N33/54333 , G01N33/54366 , Y10S436/806 , Y10S977/773 , Y10S977/838 , Y10S977/89 , Y10S977/92 , Y10S977/96
摘要： Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.
摘要翻译：使用磁响应试剂对磁场影响的响应的测定方法，以定性或定量测量特异性结合对成员之间的结合。根据本发明，分析物的存在介导了磁性响应试剂是否结合流动的固相试剂。结合的程度将调节磁响应试剂或可移动固相试剂或两者的响应对磁场的影响。因此，通过测量对磁响应试剂或可移动固相试剂的磁场的响应，可以准确地确定测试样品中包含的分析物的存在或量。本发明利用各种装置来实施所述的测定方法。

6. 发明授权

US5545395A Method of imaging using encapsulated magnetite particles 失效
标题翻译：使用封装的磁铁矿颗粒成像的方法
公开(公告)号：US5545395A
公开(公告)日：1996-08-13
申请号：US421330
申请日：1995-04-13
申请人： Herve Tournier , Roland Hyacinthe , Michel Schneider
发明人： Herve Tournier , Roland Hyacinthe , Michel Schneider
IPC分类号： A61K9/127 , A61B5/055 , A61K20060101 , A61K49/00 , A61K49/18
CPC分类号： A61K49/1806 , A61K49/1839 , Y10S977/838 , Y10S977/904 , Y10S977/905 , Y10S977/927 , Y10S977/96 , Y10T428/2991 , Y10T428/2998 , Y10T436/24
摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.
摘要翻译：适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

7. 发明申请

US20130266328A1 QUANTUM ENTANGLEMENT COMMUNICATIONS SYSTEM 审中-公开
公开(公告)号：US20130266328A1
公开(公告)日：2013-10-10
申请号：US13835937
申请日：2013-03-15
申请人： Marc S. Paller
发明人： Marc S. Paller
IPC分类号： H04B10/25
CPC分类号： H04B10/25 , B82Y10/00 , H04B10/90 , Y10S977/742 , Y10S977/774 , Y10S977/842 , Y10S977/882 , Y10S977/96
摘要： Apparatus for transmitting and receiving information using one or more quantum-entangled particles. The apparatus may include a first substrate including a first row of quantum dots and a second substrate including a second row of quantum dots. The apparatus may also include a beam splitter configured to inject a first particle into a first quantum dot and to inject a second particle into a second quantum dot. A physical property of the first particle may be in a quantum-entangled state with a physical property of the second particle. The apparatus may further include a first wave source configured to move the first particle along the first row of quantum dot, and a second wave source configured to move the second particle along the second row of quantum dots.

8. 发明申请

US20080296255A1 Magnetic Porous Particles and Method of Making 有权
标题翻译：磁性多孔颗粒及其制备方法
公开(公告)号：US20080296255A1
公开(公告)日：2008-12-04
申请号：US11632914
申请日：2005-07-18
申请人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
发明人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
IPC分类号： H01L21/311 , B32B5/18
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention provides porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure that produces a predetermined optical response and magnetic material adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译：本发明提供产生预定光学响应且可以磁性操作的多孔颗粒。本发明的优选颗粒具有产生预定光学响应的多孔结构和附着于颗粒的磁性材料。另一个优选的颗粒是两亲性的。由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。本磁性颗粒的磁性使粒子本身受到操纵，例如振动，移动和重新取向。多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。

9. 发明授权

US06673631B1 Simultaneous isolation and quantitation of DNA 有权
标题翻译：同时分离和定量DNA
公开(公告)号：US06673631B1
公开(公告)日：2004-01-06
申请号：US09377986
申请日：1999-08-20
申请人： Allan M. Tereba , Rex M. Bitner , Susan C. Koller , Craig E. Smith , Daniel D. Kephart , Steven J. Ekenberg
发明人： Allan M. Tereba , Rex M. Bitner , Susan C. Koller , Craig E. Smith , Daniel D. Kephart , Steven J. Ekenberg
IPC分类号： C12Q168
CPC分类号： C12N15/1013 , C12Q1/6806 , Y10S977/838 , Y10S977/904 , Y10S977/916 , Y10S977/92 , Y10S977/924 , Y10S977/96
摘要： The present invention provides methods for isolating a defined quantity of DNA target material from other substances in a medium. The method may be carried out using a known quantity of a silica-containing solid support, such as silica magnetic particles, having a definable capacity for reversibly binding DNA target material, and DNA target material in excess of the binding capacity of the particles. The methods of the present invention involve forming a complex of the silica magnetic particles and the DNA target material in a mixture of the medium and particles, and separating the complex from the mixture using external magnetic force. The DNA target material may then be eluted from the complex. The quantity of DNA target material eluted may be determined based on a calibration model. The methods of the present invention permit isolation of DNA target material which is within a known quantity range. The methods of the invention eliminate the step of quantitating purified biological samples prior to further processing, such as amplification, Short Tandem Repeat (STR) analysis, and DNA sequencing. Samples of the DNA target materials may be obtained from liquid or solid media, such as liquid blood or paper.
摘要翻译：本发明提供了将定义量的DNA靶物质与介质中的其它物质分离的方法。该方法可以使用已知量的具有可定义的可逆结合DNA靶材料的能力的二氧化硅固体载体，例如二氧化硅磁性颗粒和超过颗粒结合能力的DNA靶材料进行。本发明的方法包括在介质和颗粒的混合物中形成二氧化硅磁性颗粒和DNA靶材料的复合物，并且使用外部磁力将复合物与混合物分离。然后DNA靶物质可以从络合物中洗脱出来。可以基于校准模型确定洗脱的DNA靶物质的量。本发明的方法允许分离已知量范围内的DNA靶材料。本发明的方法消除了在进一步加工之前定量纯化的生物样品的步骤，例如扩增，短串联重复（STR）分析和DNA测序。可以从液体或固体培养基（例如液体血液或纸）获得DNA靶材料的样品。

10. 发明授权

US06580102B2 Four-terminal system for reading the state of a phase qubit 有权
公开(公告)号：US06580102B2
公开(公告)日：2003-06-17
申请号：US09875776
申请日：2001-06-05
申请人： Zdravko Ivanov , Alexander Tzalentchuk , Jeremy P. Hilton , Alexander Maassen van den Brink
发明人： Zdravko Ivanov , Alexander Tzalentchuk , Jeremy P. Hilton , Alexander Maassen van den Brink
IPC分类号： H01L31072
CPC分类号： G06N99/002 , B82Y10/00 , H01L39/225 , Y10S977/70 , Y10S977/812 , Y10S977/838 , Y10S977/933 , Y10S977/96
摘要： Quantum computing systems and methods that use opposite magnetic moment states read the state of a qubit by applying current through the qubit and measuring a Hall effect voltage across the width of the current. For reading, the qubit is grounded to freeze the magnetic moment state, and the applied current is limited to pulses incapable of flipping the magnetic moment. Measurement of the Hall effect voltage can be achieved with an electrode system that is capacitively coupled to the qubit. An insulator or tunnel barrier isolates the electrode system from the qubit during quantum computing. The electrode system can include a pair of electrodes for each qubit. A readout control system uses a voltmeter or other measurement device that connects to the electrode system, a current source, and grounding circuits. For a multi-qubit system, selection logic can select which qubit or qubits are read.

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