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    • 6. 发明授权
    • Methods for detecting fungal infection
    • 检测真菌感染的方法
    • US09383373B2
    • 2016-07-05
    • US12084702
    • 2006-11-15
    • Bernard S. GreenInna TzomikRina Arad-Yellin
    • Bernard S. GreenInna TzomikRina Arad-Yellin
    • G01N33/569C07K16/14C12P21/00C07D249/08C08F122/38G01N33/82
    • G01N33/82
    • Methods and kits which utilize a conjugate, preferably an adduct, of ergosterol for determining the presence or level of a broad spectrum of ergosterol-containing organisms (e.g., fungi) in various substrates are disclosed. These methods and kits can be used to accurately and efficiently diagnose a subject having a fungal infection, particularly invasive fungal infection, and to accurately and efficiently detect the presence of fungi and other ergosterol-containing organisms in other substrates. Antibodies and other compounds (e.g., molecularly imprinted polymers) that are capable of selectively binding to ergosterol or to an ergosterol-containing conjugate and methods of producing same are also disclosed.
    • 公开了利用麦角固醇的缀合物,优选加合物来确定各种底物中广谱含麦角固醇的生物(例如真菌)的存在或水平的方法和试剂盒。 这些方法和试剂盒可用于准确和有效地诊断具有真菌感染,特别是侵入性真菌感染的受试者,并且准确和有效地检测其它底物中真菌和其它含麦角固醇的生物体的存在。 还公开了能够选择性地结合麦角甾醇或含麦角固醇的缀合物的抗体和其它化合物(例如,分子印迹聚合物)及其生产方法。