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1. 发明授权

US5766861A Method for screening catalytic non-enzyme polypeptides and proteins 失效
标题翻译：筛选催化非酶多肽和蛋白质的方法
公开(公告)号：US5766861A
公开(公告)日：1998-06-16
申请号：US481277
申请日：1995-08-22
申请人： Zelig Eshhar , Bernard S. Green , Dan S. Tawfik
发明人： Zelig Eshhar , Bernard S. Green , Dan S. Tawfik
IPC分类号： G01N33/68 , G01N33/573
CPC分类号： G01N33/68 , G01N33/6854 , G01N2333/901
摘要： A method for screening or detection of a non-enzyme catalytic polypeptide or protein for the conversion of a substrate S to a product P is provided, in which a preparation containing the potential catalyst is contacted with the substrate S immobilized to a support and the immobilized product P obtained is detected, preferably by immunoassay. The method is preferably used for the screening of hybridoma supernatants for catalytic monoclonal antibodies that catalyze acyl transfer reactions, e.g., hydrolysis or aminolysis, condensation reactions and resolution of enantiomers.
摘要翻译： PCT No.PCT / US94 / 00424 Sec。 371日期：1995年8月22日 102（e）日期1995年8月22日PCT 1994年1月12日PCT PCT。 WO94 / 16332 PCT出版物日期1994年7月21日提供了用于筛选或检测用于将底物S转化为产物P的非酶催化多肽或蛋白质的方法，其中将含有潜在催化剂的制剂与固定至检测支持物和获得的固定化产物P，优选通过免疫测定法检测。该方法优选用于筛选用于催化酰基转移反应（例如水解或氨解，缩合反应和拆分对映体）的催化单克隆抗体的杂交瘤上清液。

2. 发明申请

US20090111129A1 Methods and Kits for Detecting Fungal Infection 有权
标题翻译：检测真菌感染的方法和试剂盒
公开(公告)号：US20090111129A1
公开(公告)日：2009-04-30
申请号：US12084702
申请日：2006-11-15
申请人： Bernard S. Green , Inna Tzomik , Rina Arad-Yellin
发明人： Bernard S. Green , Inna Tzomik , Rina Arad-Yellin
IPC分类号： G01N33/569 , C07K16/14 , C12P21/00 , C07D249/08 , C08F122/38
CPC分类号： G01N33/82
摘要： Methods and kits which utilize a conjugate, preferably an adduct, of ergosterol for determining the presence or level of a broad spectrum of ergosterol-containing organisms (e.g., fungi) in various substrates are disclosed. These methods and kits can be used to accurately and efficiently diagnose a subject having a fungal infection, particularly invasive fungal infection, and to accurately and efficiently detect the presence of fungi and other ergosterol-containing organisms in other substrates. Antibodies and other compounds (e.g., molecularly imprinted polymers) that are capable of selectively binding to ergosterol or to an ergosterol-containing conjugate and methods of producing same are also disclosed.
摘要翻译：公开了利用麦角固醇的缀合物，优选加合物来确定各种底物中广谱含麦角固醇的生物（例如真菌）的存在或水平的方法和试剂盒。这些方法和试剂盒可用于准确和有效地诊断具有真菌感染，特别是侵入性真菌感染的受试者，并且准确和有效地检测其它底物中真菌和其它含麦角固醇的生物体的存在。还公开了能够选择性地结合麦角甾醇或含麦角固醇的缀合物的抗体和其它化合物（例如，分子印迹聚合物）及其生产方法。

3. 发明申请

US20140010867A1 TREATMENT OF PROLIFERATIVE DISORDERS WITH A CHEMILUMINESCENT AGENT 有权
标题翻译：用亮剂代谢治疗增生性疾病
公开(公告)号：US20140010867A1
公开(公告)日：2014-01-09
申请号：US14006733
申请日：2012-03-22
申请人： Bernard S. Green , Galia Luboshits , Michael A. Firer
发明人： Bernard S. Green , Galia Luboshits , Michael A. Firer
IPC分类号： A61K31/5025 , A61K45/06 , C07D471/04
CPC分类号： A61K31/5025 , A61K9/1271 , A61K31/222 , A61K31/337 , A61K31/473 , A61K31/4985 , A61K31/502 , A61K31/661 , A61K38/1767 , A61K38/44 , A61K45/06 , A61K47/558 , C07D471/04 , C12Y113/12007 , A61K2300/00
摘要： Methods employing chemiluminescent agents as therapeutically active agents in the treatment of proliferative disorders are disclosed. The chemiluminiscent agents are used in the disclosed method without a therapeutically effective amount of a photosensitizer. Novel chemiluminescent agents having the general formula: are also disclosed, wherein X, Y, Z, R3 and R5-R9 are as defined herein.
摘要翻译：公开了使用化学发光剂作为治疗活性剂治疗增殖性疾病的方法。化学发光剂用于所公开的方法，而无需治疗有效量的光敏剂。还公开了具有以下通式的新型化学发光剂：其中X，Y，Z，R 3和R 5 -R 9如本文所定义。

4. 发明授权

US3979816A Boiler tube extractor and method 失效
标题翻译：锅炉管提取器及方法
公开(公告)号：US3979816A
公开(公告)日：1976-09-14
申请号：US541975
申请日：1975-01-17
申请人： Bernard S. Green
发明人： Bernard S. Green
IPC分类号： B23P19/02
CPC分类号： B23P19/022 , Y10T29/49352 , Y10T29/53796
摘要： A boiler tube extractor comprising an elongated member which can be coupled to and extend forwardly of the tube sheet of a boiler. An actuable pulling means can be coupled between the end of the elongated member remote from the tube sheet and the tube which is to be extracted. When the means is actuated, the boiler tube is extracted.
摘要翻译：一种锅炉管提取器，包括可与锅炉的管板连接并向前延伸的细长构件。可致动的拉动装置可以连接在远离管板的细长构件的端部和待提取的管之间。当装置启动时，锅炉管被抽出。

5. 发明授权

US09464079B2 Treatment of proliferative disorders with a chemiluminescent agent 有权
标题翻译：用化学发光剂治疗增殖性疾病
公开(公告)号：US09464079B2
公开(公告)日：2016-10-11
申请号：US14006733
申请日：2012-03-22
申请人： Bernard S. Green , Galia Luboshits , Michael A. Firer
发明人： Bernard S. Green , Galia Luboshits , Michael A. Firer
IPC分类号： C07D471/04 , A61K31/222 , A61K31/337 , A61K31/473 , A61K31/4985 , A61K31/502 , A61K31/5025 , A61K31/661 , A61K45/06 , A61K38/44 , A61K38/17 , A61K47/48
CPC分类号： A61K31/5025 , A61K9/1271 , A61K31/222 , A61K31/337 , A61K31/473 , A61K31/4985 , A61K31/502 , A61K31/661 , A61K38/1767 , A61K38/44 , A61K45/06 , A61K47/558 , C07D471/04 , C12Y113/12007 , A61K2300/00
摘要： Methods employing chemiluminescent agents as therapeutically active agents in the treatment of proliferative disorders are disclosed. The chemiluminiscent agents are used in the disclosed method without a therapeutically effective amount of a photosensitizer. Novel chemiluminescent agents having the general formula: are also disclosed, wherein X, Y, Z, R3 and R5-R9 are as defined herein.
摘要翻译：公开了使用化学发光剂作为治疗活性剂治疗增殖性疾病的方法。化学发光剂用于所公开的方法，而无需治疗有效量的光敏剂。还公开了具有以下通式的新型化学发光剂：其中X，Y，Z，R 3和R 5 -R 9如本文所定义。

6. 发明授权

US09383373B2 Methods for detecting fungal infection 有权
标题翻译：检测真菌感染的方法
公开(公告)号：US09383373B2
公开(公告)日：2016-07-05
申请号：US12084702
申请日：2006-11-15
申请人： Bernard S. Green , Inna Tzomik , Rina Arad-Yellin
发明人： Bernard S. Green , Inna Tzomik , Rina Arad-Yellin
IPC分类号： G01N33/569 , C07K16/14 , C12P21/00 , C07D249/08 , C08F122/38 , G01N33/82
CPC分类号： G01N33/82
摘要： Methods and kits which utilize a conjugate, preferably an adduct, of ergosterol for determining the presence or level of a broad spectrum of ergosterol-containing organisms (e.g., fungi) in various substrates are disclosed. These methods and kits can be used to accurately and efficiently diagnose a subject having a fungal infection, particularly invasive fungal infection, and to accurately and efficiently detect the presence of fungi and other ergosterol-containing organisms in other substrates. Antibodies and other compounds (e.g., molecularly imprinted polymers) that are capable of selectively binding to ergosterol or to an ergosterol-containing conjugate and methods of producing same are also disclosed.
摘要翻译：公开了利用麦角固醇的缀合物，优选加合物来确定各种底物中广谱含麦角固醇的生物（例如真菌）的存在或水平的方法和试剂盒。这些方法和试剂盒可用于准确和有效地诊断具有真菌感染，特别是侵入性真菌感染的受试者，并且准确和有效地检测其它底物中真菌和其它含麦角固醇的生物体的存在。还公开了能够选择性地结合麦角甾醇或含麦角固醇的缀合物的抗体和其它化合物（例如，分子印迹聚合物）及其生产方法。

7. 发明授权

US06638498B2 Molecularly imprinted polymers for the treatment and diagnosis of medical conditions 失效
公开(公告)号：US06638498B2
公开(公告)日：2003-10-28
申请号：US09893643
申请日：2001-06-29
申请人： Bernard S. Green , Morris Priwler
发明人： Bernard S. Green , Morris Priwler
IPC分类号： A61K3174
CPC分类号： B01J20/268 , A61K31/785 , A61K31/787 , C08F226/06 , C08F246/00
摘要： Improved molecularly imprinted polymers (MIPs) with both higher and more specific binding capacity for particular bile acids and/or salts, including the synthesis of such MIPs, the compounds themselves, and specific applications thereof. As an example of a particularly preferred specific application of these compounds, the present invention encompasses the use of the MIPs as sequestrants in the gastrointestinal tract, particularly in order to bind and therefore remove toxins from the gastrointestinal tract. In addition, the present invention is also useful for treatment of various diseases which are related to, and/or characterized by, an effect of bile acids and salts, such as atherosclerosis, liver disease and various diseases of the gastrointestinal tract. The MIP compounds of the present invention are also useful for combination therapy with other medications and for diagnosis and monitoring of diseases.

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