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1. 发明授权

US08808731B2 Adhesive pharmaceutical preparation containing bisoprolol 有权
标题翻译：含比索洛尔的粘合剂制剂
公开(公告)号：US08808731B2
公开(公告)日：2014-08-19
申请号：US12066095
申请日：2006-09-07
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61P9/12 , A61K31/135
CPC分类号： A61K31/138 , A61K9/7053
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisoprolol can be administered continuously into the living body through the skin surface.
摘要翻译：具有对皮肤表面刺激性低的粘合性药物制剂，在制剂中保持比索洛尔优异的稳定性，并且允许将药理学有效量的比索洛尔连续给予生物体。粘合剂制剂10包括支撑体1，层压在载体1的一个表面上的粘合剂层2.粘合剂层2的特征在于含有比索洛尔，聚异丁烯，增粘剂和与聚异丁烯和增粘剂相容的有机液体成分。因此，可以提供粘合性药物制剂，其具有良好的粘附性，对皮肤的刺激性较差，并且几乎不会留下剥离或从皮肤表面除去而几乎不产生疼痛，几乎没有糊剂。此外，比索洛尔在制剂中非常稳定地保持，并且可以通过皮肤表面连续向生物体中施用药理学有效量的比索洛尔。

2. 发明申请

US20140158571A1 PACKAGING STRUCTURE FOR PATCHES 审中-公开
标题翻译：包装的包装结构
公开(公告)号：US20140158571A1
公开(公告)日：2014-06-12
申请号：US14232358
申请日：2012-07-13
申请人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
发明人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
IPC分类号： A61J1/00
CPC分类号： A61J1/00 , A61F13/00076 , A61F2013/00646 , A61F2013/00906
摘要： A packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131-134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).
摘要翻译：用于贴片的包装结构（100）包括具有彼此层压的周缘部分的第一和第二基底材料（120,130），并且其中包括贴片。第一和第二基材（120,130）具有第一至第四侧（121至124,131-134）。第一和第二基底材料（120,130）中的至少一个具有第一至第三开口部分（125至127,135至137）。第一至第三开口部（125〜127,135〜137）引导朝向密封部（120c，130c）的内周缘（120c1,120c2,120c4,130c1,130c2,130c4）开口。

3. 发明授权

US08703178B2 Percutaneous administration device of bisoprolol 失效
标题翻译：比索洛尔经皮给药装置
公开(公告)号：US08703178B2
公开(公告)日：2014-04-22
申请号：US12528194
申请日：2008-03-06
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译：本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。

4. 发明申请

US20120189796A1 PATCH 审中-公开
标题翻译：补丁
公开(公告)号：US20120189796A1
公开(公告)日：2012-07-26
申请号：US13357718
申请日：2012-01-25
申请人： Kazuhiro AOYAGI , Yoshihiro IWAO , Kensuke MATSUOKA , Tomoya TANAKA
发明人： Kazuhiro AOYAGI , Yoshihiro IWAO , Kensuke MATSUOKA , Tomoya TANAKA
IPC分类号： B32B33/00
CPC分类号： A61K9/703 , A61F2013/00646 , A61K9/7053 , A61M35/00 , Y10T428/1476
摘要： The present invention relates to a sheet-shaped patch including a pressure-sensitive adhesive layer on one surface of a backing to provide a pressure-sensitive adhesive surface showing adhesiveness at ordinary temperature and further including a release liner covering the pressure-sensitive adhesive surface. More specifically, the present invention relates to a sheet-shaped patch where the release liner is formed in a state of being splittable by a parting line. The patch ensures that the pressure-sensitive adhesive surface can be kept from being largely exposed due to slight stress before use and at the same time, the release liner can be easily split when using the patch.
摘要翻译：本发明涉及一种片状贴片，其包括在背衬的一个表面上的压敏粘合剂层，以提供在常温下显示粘合性的压敏粘合剂表面，并且还包括覆盖该压敏粘合剂表面的剥离衬垫。更具体地，本发明涉及一种片状贴片，其中剥离衬垫形成为可由分型线分割的状态。该贴剂确保了压敏粘合剂表面在使用之前由于轻微的应力而能够被大大暴露，并且同时使用贴片时可以容易地分离剥离衬垫。

5. 发明申请

US20110243998A1 PATCH PREPARATION AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译： PATCH制备及其生产方法
公开(公告)号：US20110243998A1
公开(公告)日：2011-10-06
申请号：US13074911
申请日：2011-03-29
申请人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61K9/00 , A61K31/445 , A61K31/4174 , A61K31/34 , A61K31/192 , A61K31/195 , A61K31/4152 , A61K31/46
CPC分类号： A61K9/7061 , A61K9/7053
摘要： The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the adhesive layer, while a crystal of the drug is formed during preservation after the physical stimulation. The patch preparation which does not require an increase in the area and thickness of an adhesive layer, achieves a sufficiently high skin permeation amount of the drug, shows good adhesiveness to skin, and permits a long-term adhesion to skin. The invention also provides a method of producing the patch preparation.
摘要翻译：本发明提供了一种补片制剂，其包含（a）支持物和（b）在载体表面上含有药物的粘合剂层，其中在施加物理刺激之后立即在粘合剂层中形成药物的晶体而在物理刺激后的保存期间形成药物的晶体。不需要增加粘合剂层的面积和厚度的贴片制剂能够获得足够高的皮肤渗透量的药物，对皮肤具有良好的粘附性，并且可以长期粘附到皮肤上。本发明还提供一种制备贴剂的方法。

6. 发明申请

US20100122927A1 BLISTER PACKAGE 有权
标题翻译：吸塑包装
公开(公告)号：US20100122927A1
公开(公告)日：2010-05-20
申请号：US12618931
申请日：2009-11-16
申请人： Kensuke MATSUOKA , Yoshihiro Iwao , Katsuhiro Okada
发明人： Kensuke MATSUOKA , Yoshihiro Iwao , Katsuhiro Okada
IPC分类号： B65D83/00
CPC分类号： B65D75/366 , B65D2215/00
摘要： Provision of a blister package that cannot be opened easily by infants, but can be opened easily, certainly and safely by a user when in use. A blister package 100 containing a blister 1 and a cover sheet 2, wherein the blister has a groove 3 formed in an outer edge section 1A thereof where the cover sheet is adhered and the groove 3 is free of adhesion of the sheet. The cover sheet is adhered to the outermost circumference 1a of the outer edge section 1A, the groove 3 is formed on the inward side of the outermost circumference 1a, and the cover sheet is not adhered to the area on the inward side of the groove 3.
摘要翻译：提供婴儿不能轻松打开的泡罩包装，但使用时可以方便，安全地打开。包含泡罩1和覆盖片2的泡罩包装100，其中泡罩具有形成在其外缘部分1A中的覆盖片粘附的槽3，并且槽3没有片材的粘附。覆盖片附着在外缘部1A的最外周1a上，槽3形成在最外周1a的内侧，覆盖片不粘附在槽3的内侧的区域。

7. 发明申请

US20100092544A1 Adhesive composition for patch and use thereof 审中-公开
标题翻译：用于贴剂的粘合剂组合物及其用途
公开(公告)号：US20100092544A1
公开(公告)日：2010-04-15
申请号：US12285735
申请日：2008-10-14
申请人： Katsuhiro Okada , Yoshihiro Iwao , Katsuyuki Ookubo
发明人： Katsuhiro Okada , Yoshihiro Iwao , Katsuyuki Ookubo
IPC分类号： A61K9/70 , C09J193/04 , C09J145/02 , C09J125/04
CPC分类号： C09J135/06 , A61K9/7023 , C08L7/00 , C08L9/06 , C08L23/22 , C08L35/06 , C08L2205/02 , C08L2666/02 , C09J145/02 , C09J193/04
摘要： The present invention provides an adhesive composition for patch, containing a rubber elastomer and a tackifier having a weight average molecular weight of 1200-2500, a patch having a support and an adhesive layer containing the composition, which is provided on at least one surface of the support, and a patch preparation having an adhesive layer containing a percutaneously absorbable drug (excluding bisoprolol).
摘要翻译：本发明提供了一种贴剂用粘合剂组合物，其包含橡胶弹性体和重均分子量为1200-2500的增粘剂，具有支持体的贴剂和含有该组合物的粘合剂层，其设置在至少一个表面上载体和具有含有经皮吸收性药物（不包括比索洛尔）的粘合剂层的贴剂）。

8. 发明申请

US20090291126A1 ADHESIVE PHARMACEUTICAL PREPARATION CONTAINING BISOPROLOL 有权
标题翻译：含有双酚的胶体药物制剂
公开(公告)号：US20090291126A1
公开(公告)日：2009-11-26
申请号：US12066095
申请日：2006-09-07
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61P9/12 , A61K31/135
CPC分类号： A61K31/138 , A61K9/7053
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisoprolol can be administered continuously into the living body through the skin surface.
摘要翻译：具有对皮肤表面刺激性低的粘合性药物制剂，在制剂中保持比索洛尔优异的稳定性，并且允许将药理学有效量的比索洛尔连续给予生物体。粘合剂制剂10包括支撑体1，层压在载体1的一个表面上的粘合剂层2.粘合剂层2的特征在于含有比索洛尔，聚异丁烯，增粘剂和与聚异丁烯和增粘剂相容的有机液体成分。因此，可以提供粘合性药物制剂，其具有良好的粘附性，对皮肤的刺激性较差，并且几乎不会留下剥离或从皮肤表面除去而几乎不产生疼痛，几乎没有糊剂。此外，比索洛尔在制剂中非常稳定地保持，并且可以通过皮肤表面连续向生物体中施用药理学有效量的比索洛尔。

9. 发明申请

US20090166229A1 Patch package structure 有权
标题翻译：贴片包装结构
公开(公告)号：US20090166229A1
公开(公告)日：2009-07-02
申请号：US12314564
申请日：2008-12-12
申请人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
发明人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
IPC分类号： A61B19/02 , B65D81/26
CPC分类号： A61L15/24 , C08L33/20
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译：本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。该目的可以通过采用以下结构来实现。具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在补丁1。

10. 发明申请

US20080118725A1 ADHESIVE PREPARATION 审中-公开
标题翻译：胶粘制品
公开(公告)号：US20080118725A1
公开(公告)日：2008-05-22
申请号：US11943624
申请日：2007-11-21
申请人： Yoshihiro IWAO , Katsuyuki OKUBO , Katsuhiro OKADA , Kensuke MATSUOKA
发明人： Yoshihiro IWAO , Katsuyuki OKUBO , Katsuhiro OKADA , Kensuke MATSUOKA
IPC分类号： B32B7/12
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7069 , A61L15/26 , A61L15/58 , B32B7/12 , B32B27/12 , C09J7/29 , C09J2400/263 , C09J2467/006 , Y10T156/10 , Y10T428/24959 , C08L67/00
摘要： The invention provides an adhesive preparation including a backing, and a pressure-sensitive adhesive layer which contains a drug and is disposed on at least one side of the backing; in which the backing includes a polyester film having a thickness of 0.5 to 6.0 μm, and a polyester nonwoven fabric directly bound to the film. The pressure-sensitive adhesive layer preferably is directly or indirectly laminated on the nonwoven-fabric side of the backing. The adhesive preparation of the invention is flexible enough to comply to the skin and has reduced skin irritation and high stability.
摘要翻译：本发明提供了一种粘合剂制剂，其包括背衬和压敏粘合剂层，其包含药物并设置在背衬的至少一侧上; 其中背衬包括厚度为0.5至6.0μm的聚酯膜和直接结合到膜的聚酯非织造织物。压敏粘合剂层优选直接或间接层压在背衬的非织造织物侧上。本发明的粘合剂制剂具有足够的柔韧性以适应皮肤并具有降低的皮肤刺激性和高稳定性。

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