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1. 发明授权

US09433533B2 Patch package structure 有权
标题翻译：贴片包装结构
公开(公告)号：US09433533B2
公开(公告)日：2016-09-06
申请号：US11972910
申请日：2008-01-11
申请人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61M35/00 , A61F13/02 , A61F13/551 , A61F15/00 , A61F13/00 , A61B17/06
CPC分类号： A61F13/0203 , A61F13/551 , A61F15/001
摘要： The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of the patch; and, at the boundary between the sealed part where the first and second sheet materials are sealed together and an unsealed part, the outer surface of the second sheet material rises at an obtuse angle.
摘要翻译：本发明提供了一种贴片包装结构，其包括：包括平面的第一片材和已经模制的第二片材的封装，第一和第二片材在其周边部分被密封在一起，并且贴片布置在其中贴片包含背衬的包装中，层压在背衬的至少一侧上的压敏粘合剂层和保护压敏粘合剂层的压敏粘合剂表面的剥离衬垫; 第二片材已经被模制成在其至少大致中心区域具有突出部分，突出部分具有比剥离衬垫的平面外形大的平面外形，并且具有至少一个凹部; d不小于T，其中d是第一片材的内表面和凹陷部分的第二片材的内表面之间的最小间隙距离，T是贴片的厚度; 并且在第一和第二片材密封在一起的密封部分与未密封部分之间的边界处，第二片材的外表面以钝角上升。

2. 发明授权

US09351942B2 Patch and patch preparation 有权
标题翻译：补丁和补丁准备
公开(公告)号：US09351942B2
公开(公告)日：2016-05-31
申请号：US13983481
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译：本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁硅酸铝在贴片制剂中，上述粘合剂层还含有药物。

3. 发明授权

US09326952B2 Adhesive skin patch 有权
标题翻译：粘贴皮肤贴
公开(公告)号：US09326952B2
公开(公告)日：2016-05-03
申请号：US13581079
申请日：2011-02-23
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译：本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及从粘合剂层渗出药物的发生，从而防止药物含量的降低。构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突出部在其角落处的粘合剂贴剂。此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。

4. 发明申请

US20130315978A1 PATCH AND PATCH PREPARATION 有权
标题翻译：配对和配对准备
公开(公告)号：US20130315978A1
公开(公告)日：2013-11-28
申请号：US13983481
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61K9/70 , A61K31/663 , A61K31/405
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译：本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁硅酸铝在贴片制剂中，上述粘合剂层还含有药物。

5. 发明申请

US20130310777A1 PATCH AND PATCH PREPARATION 有权
标题翻译：配对和配对准备
公开(公告)号：US20130310777A1
公开(公告)日：2013-11-21
申请号：US13983510
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61M35/00 , A61L31/12
CPC分类号： A61M35/00 , A61K9/7053 , A61K31/405 , A61K31/663 , A61L31/129
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译：本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为500,000-1,600,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁硅酸铝在贴片制剂中，上述粘合剂层还含有药物。

6. 发明授权

US08127926B2 Patch package structure 有权
标题翻译：贴片包装结构
公开(公告)号：US08127926B2
公开(公告)日：2012-03-06
申请号：US12644160
申请日：2009-12-22
申请人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61L15/16
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00897
摘要： A patch package structure which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, a peripheral area of the first sheet material having been sealed to a peripheral area of the second sheet material to constitute the package, and a patch disposed in the package; in which the patch includes a backing, a pressure-sensitive adhesive layer formed on at least one side of the backing, and a release liner which protects the pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having a weakening line for assisting a removal of the release liner; and in which the second sheet material has specific first protrudent part, second protrudent part, third protrudent part and elevated part in a central area thereof except the peripheral area thereof.
摘要翻译：一种贴片包装结构，包括：包括平面的第一片材和已经模制的第二片材的封装，第一片材的周边区域被密封到第二片材的周边区域，以构成第包装和贴在包装中的贴片; 其中所述贴剂包括背衬，形成在所述背衬的至少一侧上的压敏粘合剂层和保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫，所述剥离衬垫具有弱化用于帮助去除脱模衬垫的管线; 并且其中所述第二片材在其外围区域的中心区域中具有特定的第一突出部分，第二突出部分，第三突出部分和升高部分。

7. 发明申请

US20100158991A1 PATCH PACKAGE STRUCTURE 有权
标题翻译： PATCH包装结构
公开(公告)号：US20100158991A1
公开(公告)日：2010-06-24
申请号：US12644160
申请日：2009-12-22
申请人： Katsuhiro OKADA , Yoshihiro IWAO , Kensuke MATSUOKA
发明人： Katsuhiro OKADA , Yoshihiro IWAO , Kensuke MATSUOKA
IPC分类号： A61K9/00 , B32B37/02 , A61P43/00 , B65D85/16 , A61M35/00
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00897
摘要： A patch package structure which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, a peripheral area of the first sheet material having been sealed to a peripheral area of the second sheet material to constitute the package, and a patch disposed in the package; in which the patch includes a backing, a pressure-sensitive adhesive layer formed on at least one side of the backing, and a release liner which protects the pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having a weakening line for assisting a removal of the release liner; and in which the second sheet material has specific first protrudent part, second protrudent part, third protrudent part and elevated part in a central area thereof except the peripheral area thereof.
摘要翻译：一种贴片包装结构，包括：包括平面的第一片材和已经模制的第二片材的封装，第一片材的周边区域被密封到第二片材的周边区域，以构成第包装和贴在包装中的贴片; 其中所述贴剂包括背衬，形成在所述背衬的至少一侧上的压敏粘合剂层和保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫，所述剥离衬垫具有弱化用于帮助去除脱模衬垫的管线; 并且其中所述第二片材在其外围区域的中心区域中具有特定的第一突出部分，第二突出部分，第三突出部分和升高部分。

8. 发明申请

US20090169604A1 Adhesive Pharmaceutical Preparation Containing Bisoprolol 有权
标题翻译：含有比索洛尔的胶粘剂药物制剂
公开(公告)号：US20090169604A1
公开(公告)日：2009-07-02
申请号：US12097260
申请日：2006-12-13
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61K31/135 , A61P9/00
CPC分类号： A61K9/7053 , A61K31/138 , A61K47/10 , A61K47/32
摘要： In the adhesive pharmaceutical preparation of the invention containing bisoprolol, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a free base of bisoprolol and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the free base of bisoprolol can be specifically increased. As a result, not only it becomes possible to increase blending amount of the free base of bisoprolol but also bleed of the free base of bisoprolol from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.
摘要翻译：在含有比索洛尔的本发明的粘合剂药物制剂中，在背衬的一侧层压压敏粘合剂层。压敏粘合剂层含有具有12至28个碳原子的支链一元醇，比索洛尔的游离碱和聚异丁烯压敏粘合剂。因此，可以特异性地增加聚异丁烯压敏粘合剂与比索洛尔的游离碱的相容性。结果，可以抑制比索洛尔的游离碱的混合量的增加，而且可以抑制比索洛尔的游离碱从压敏粘合剂层的渗出，而且还可以抑制压敏粘合特性从实用的角度来看可以获得足够的。

9. 发明申请

US20090169603A1 Adhesive Pharmaceutical Preparation 审中-公开
标题翻译：胶粘剂制剂
公开(公告)号：US20090169603A1
公开(公告)日：2009-07-02
申请号：US12097220
申请日：2006-12-13
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K47/10 , A61K47/32
摘要： In the adhesive pharmaceutical preparation of the invention, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a drug which is liquid at room temperature or around room temperature (in which, free base of bisoprolol is excluded) and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the drug can be specifically increased. As a result, not only it becomes possible to increase blending amount of the drug but also bleed of the drug from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.
摘要翻译：在本发明的粘合剂药物制剂中，在背衬的一侧层压粘合剂层。压敏粘合剂层含有具有12至28个碳原子的支链一元醇，在室温或室温附近为液体的药物（其中排除比索洛尔的游离碱）和聚异丁烯压敏粘合剂。因此，可以特别提高聚异丁烯压敏粘合剂与药物的相容性。结果，不仅能够增加药物的配合量，而且可以抑制药物从压敏粘合剂层的渗出，并且还可以抑制从实用的角度出发的压敏粘合特性视图可以获得。

10. 发明申请

US20090011159A1 PATCH PACKAGE STRUCTURE 失效
标题翻译： PATCH包装结构
公开(公告)号：US20090011159A1
公开(公告)日：2009-01-08
申请号：US12167085
申请日：2008-07-02
申请人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： B32B1/02
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00165 , A61F2013/00365 , Y10T428/13
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
摘要翻译：贴片包装结构技术领域本发明涉及一种贴片包装结构，其包括：包括第一片材和第二片材的封装，所述第一片材和第二片材在其周边部分被密封在一起; 以及布置在所述包装中的贴片，所述贴片包含背衬，层压在所述背衬的至少一侧上的压敏粘合剂层以及保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫，所述剥离衬垫在其表面上具有在使用所述贴片时支撑所述剥离衬垫剥离的切割线，所述贴片设置在所述包装中，使得所述剥离衬垫面向所述第一片材的内表面，所述第一片材具有第一区域，其中所述第一片材的内表面面向所述剥离衬垫的切割线，所述第一片材在所述第一区域中具有所述第一片材的内表面与所述第一片材的内表面之间的最小第一距离，释放衬垫的表面，并且第一片材的内表面在第一区域中以最小第一距离与释放衬垫的表面间隔开。

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