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1. 发明授权

US09005174B2 Adhesive skin patch 有权
公开(公告)号：US09005174B2
公开(公告)日：2015-04-14
申请号：US13581079
申请日：2011-02-23
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
IPC分类号： A61F13/00 , A61K9/70
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.

2. 发明申请

US20120323191A1 ADHESIVE SKIN PATCH 有权
标题翻译：粘合皮肤贴
公开(公告)号：US20120323191A1
公开(公告)日：2012-12-20
申请号：US13581079
申请日：2011-02-23
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
IPC分类号： A61M35/00
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译：本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及从粘合剂层渗出药物的发生，从而防止药物含量的降低。构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突起部在其角落处的粘合剂贴剂。此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。

3. 发明授权

US08974816B2 Water resistant patch preparation 有权
标题翻译：防水贴片制剂
公开(公告)号：US08974816B2
公开(公告)日：2015-03-10
申请号：US12872447
申请日：2010-08-31
申请人： Kazuhiro Aoyagi , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Kazuhiro Aoyagi , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61K9/70 , A61F13/02 , A61F13/00
CPC分类号： A61F13/023 , A61F2013/00651 , A61F2013/0071 , A61K9/703 , A61K9/7038
摘要： The present invention provides a water resistant patch preparation having a central part and a peripheral part, which preparation is comprised of a support and an adhesive layer comprising a drug, which is formed on one surface of the support, wherein at least a part of a lateral end of the adhesive layer in the peripheral part is located inside a lateral end of the support, and the adhesive layer in the peripheral part has a thickness smaller than that of the adhesive layer in the central part.
摘要翻译：本发明提供一种具有中心部分和周边部分的防水贴剂，该制剂由载体和包含药物的粘合剂层组成，其形成在载体的一个表面上，其中至少一部分周边部分中的粘合剂层的侧端部位于支撑体的侧端内侧，周边部分中的粘合剂层的厚度小于中央部分的粘合剂层的厚度。

4. 发明申请

US20130006203A1 ADHESIVE PATCH CONTAINING BISOPROLOL 审中-公开
标题翻译：包含双酚的粘合剂
公开(公告)号：US20130006203A1
公开(公告)日：2013-01-03
申请号：US13581166
申请日：2011-02-23
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi , Jun Harima , Masakatsu Konno
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi , Jun Harima , Masakatsu Konno
IPC分类号： A61M35/00
CPC分类号： A61K31/138 , A61F13/02 , A61F13/0253 , A61F13/0259 , A61F2013/00646 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing of bisoprolol or a salt thereof from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译：本发明旨在提供一种粘合贴剂，其有效地抑制在储存期间粘合剂贴剂的粘合剂层的暴露区域渗出或粘附粘合剂层组分的发生以及比索洛尔或其粘合剂层，从而防止药物含量的降低。构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突起部在其角落处的粘合剂贴剂。此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。

5. 发明授权

US09326952B2 Adhesive skin patch 有权
标题翻译：粘贴皮肤贴
公开(公告)号：US09326952B2
公开(公告)日：2016-05-03
申请号：US13581079
申请日：2011-02-23
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Kazuhiro Aoyagi
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译：本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及从粘合剂层渗出药物的发生，从而防止药物含量的降低。构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突出部在其角落处的粘合剂贴剂。此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。

6. 发明申请

US20140158571A1 PACKAGING STRUCTURE FOR PATCHES 审中-公开
标题翻译：包装的包装结构
公开(公告)号：US20140158571A1
公开(公告)日：2014-06-12
申请号：US14232358
申请日：2012-07-13
申请人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
发明人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
IPC分类号： A61J1/00
CPC分类号： A61J1/00 , A61F13/00076 , A61F2013/00646 , A61F2013/00906
摘要： A packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131-134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).
摘要翻译：用于贴片的包装结构（100）包括具有彼此层压的周缘部分的第一和第二基底材料（120,130），并且其中包括贴片。第一和第二基材（120,130）具有第一至第四侧（121至124,131-134）。第一和第二基底材料（120,130）中的至少一个具有第一至第三开口部分（125至127,135至137）。第一至第三开口部（125〜127,135〜137）引导朝向密封部（120c，130c）的内周缘（120c1,120c2,120c4,130c1,130c2,130c4）开口。

7. 发明授权

US08141706B2 Patch package structure 有权
公开(公告)号：US08141706B2
公开(公告)日：2012-03-27
申请号：US12167085
申请日：2008-07-02
申请人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61B17/06
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.

8. 发明申请

US20100098747A1 PERCUTANEOUS ADMINISTRATION DEVICE OF BISOPROLOL 失效
标题翻译：双氯酚的经皮给药装置
公开(公告)号：US20100098747A1
公开(公告)日：2010-04-22
申请号：US12528194
申请日：2008-03-06
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译：本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。

9. 发明授权

US09808609B2 Patch and patch preparation 有权
公开(公告)号：US09808609B2
公开(公告)日：2017-11-07
申请号：US13983510
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61M35/00 , A61L31/12 , A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61M35/00 , A61K9/7053 , A61K31/405 , A61K31/663 , A61L31/129
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.

10. 发明授权

US08251213B2 Patch package structure 失效
标题翻译：贴片包装结构
公开(公告)号：US08251213B2
公开(公告)日：2012-08-28
申请号：US12167085
申请日：2008-07-02
申请人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61B17/06
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00165 , A61F2013/00365 , Y10T428/13
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
摘要翻译：贴片包装结构技术领域本发明涉及一种贴片包装结构，其包括：包括第一片材和第二片材的封装，所述第一片材和第二片材在其周边部分被密封在一起; 以及布置在所述包装中的贴片，所述贴片包含背衬，层压在所述背衬的至少一侧上的压敏粘合剂层以及保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫，所述剥离衬垫在其表面上具有在使用所述贴片时支撑所述剥离衬垫剥离的切割线，所述贴片设置在所述包装中，使得所述剥离衬垫面向所述第一片材的内表面，所述第一片材具有第一区域，其中所述第一片材的内表面面向所述剥离衬垫的切割线，所述第一片材在所述第一区域中具有所述第一片材的内表面与所述第一片材的内表面之间的最小第一距离，释放衬垫的表面，并且第一片材的内表面在第一区域中以最小第一距离与释放衬垫的表面间隔开。

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