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1. 发明授权

US08298572B2 Adhesive pharmaceutical preparation containing bisoprolol 有权
标题翻译：含比索洛尔的粘合剂制剂
公开(公告)号：US08298572B2
公开(公告)日：2012-10-30
申请号：US12097260
申请日：2006-12-13
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61K47/10 , A61K47/32 , A61K31/045 , A61K31/138
CPC分类号： A61K9/7053 , A61K31/138 , A61K47/10 , A61K47/32
摘要： In the adhesive pharmaceutical preparation of the invention containing bisoprolol, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a free base of bisoprolol and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the free base of bisoprolol can be specifically increased. As a result, not only it becomes possible to increase blending amount of the free base of bisoprolol but also bleed of the free base of bisoprolol from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.
摘要翻译：在含有比索洛尔的本发明的粘合剂药物制剂中，在背衬的一侧层压压敏粘合剂层。压敏粘合剂层含有具有12至28个碳原子的支链一元醇，比索洛尔的游离碱和聚异丁烯压敏粘合剂。因此，可以特异性地增加聚异丁烯压敏粘合剂与比索洛尔的游离碱的相容性。结果，可以抑制比索洛尔的游离碱的混合量的增加，而且可以抑制比索洛尔的游离碱从压敏粘合剂层的渗出，而且还可以抑制压敏粘合特性从实用的角度来看可以获得足够的。

2. 发明申请

US20090169604A1 Adhesive Pharmaceutical Preparation Containing Bisoprolol 有权
标题翻译：含有比索洛尔的胶粘剂药物制剂
公开(公告)号：US20090169604A1
公开(公告)日：2009-07-02
申请号：US12097260
申请日：2006-12-13
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61K31/135 , A61P9/00
CPC分类号： A61K9/7053 , A61K31/138 , A61K47/10 , A61K47/32
摘要： In the adhesive pharmaceutical preparation of the invention containing bisoprolol, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a free base of bisoprolol and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the free base of bisoprolol can be specifically increased. As a result, not only it becomes possible to increase blending amount of the free base of bisoprolol but also bleed of the free base of bisoprolol from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.
摘要翻译：在含有比索洛尔的本发明的粘合剂药物制剂中，在背衬的一侧层压压敏粘合剂层。压敏粘合剂层含有具有12至28个碳原子的支链一元醇，比索洛尔的游离碱和聚异丁烯压敏粘合剂。因此，可以特异性地增加聚异丁烯压敏粘合剂与比索洛尔的游离碱的相容性。结果，可以抑制比索洛尔的游离碱的混合量的增加，而且可以抑制比索洛尔的游离碱从压敏粘合剂层的渗出，而且还可以抑制压敏粘合特性从实用的角度来看可以获得足够的。

3. 发明授权

US08808731B2 Adhesive pharmaceutical preparation containing bisoprolol 有权
标题翻译：含比索洛尔的粘合剂制剂
公开(公告)号：US08808731B2
公开(公告)日：2014-08-19
申请号：US12066095
申请日：2006-09-07
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61P9/12 , A61K31/135
CPC分类号： A61K31/138 , A61K9/7053
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisoprolol can be administered continuously into the living body through the skin surface.
摘要翻译：具有对皮肤表面刺激性低的粘合性药物制剂，在制剂中保持比索洛尔优异的稳定性，并且允许将药理学有效量的比索洛尔连续给予生物体。粘合剂制剂10包括支撑体1，层压在载体1的一个表面上的粘合剂层2.粘合剂层2的特征在于含有比索洛尔，聚异丁烯，增粘剂和与聚异丁烯和增粘剂相容的有机液体成分。因此，可以提供粘合性药物制剂，其具有良好的粘附性，对皮肤的刺激性较差，并且几乎不会留下剥离或从皮肤表面除去而几乎不产生疼痛，几乎没有糊剂。此外，比索洛尔在制剂中非常稳定地保持，并且可以通过皮肤表面连续向生物体中施用药理学有效量的比索洛尔。

4. 发明申请

US20090291126A1 ADHESIVE PHARMACEUTICAL PREPARATION CONTAINING BISOPROLOL 有权
标题翻译：含有双酚的胶体药物制剂
公开(公告)号：US20090291126A1
公开(公告)日：2009-11-26
申请号：US12066095
申请日：2006-09-07
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61P9/12 , A61K31/135
CPC分类号： A61K31/138 , A61K9/7053
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisoprolol can be administered continuously into the living body through the skin surface.
摘要翻译：具有对皮肤表面刺激性低的粘合性药物制剂，在制剂中保持比索洛尔优异的稳定性，并且允许将药理学有效量的比索洛尔连续给予生物体。粘合剂制剂10包括支撑体1，层压在载体1的一个表面上的粘合剂层2.粘合剂层2的特征在于含有比索洛尔，聚异丁烯，增粘剂和与聚异丁烯和增粘剂相容的有机液体成分。因此，可以提供粘合性药物制剂，其具有良好的粘附性，对皮肤的刺激性较差，并且几乎不会留下剥离或从皮肤表面除去而几乎不产生疼痛，几乎没有糊剂。此外，比索洛尔在制剂中非常稳定地保持，并且可以通过皮肤表面连续向生物体中施用药理学有效量的比索洛尔。

5. 发明申请

US20100098747A1 PERCUTANEOUS ADMINISTRATION DEVICE OF BISOPROLOL 失效
标题翻译：双氯酚的经皮给药装置
公开(公告)号：US20100098747A1
公开(公告)日：2010-04-22
申请号：US12528194
申请日：2008-03-06
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译：本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。

6. 发明授权

US08703178B2 Percutaneous administration device of bisoprolol 失效
标题翻译：比索洛尔经皮给药装置
公开(公告)号：US08703178B2
公开(公告)日：2014-04-22
申请号：US12528194
申请日：2008-03-06
申请人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
发明人： Yoshihiro Iwao , Kensuke Matsuoka , Katsuhiro Okada , Kunihiro Minami , Shuichiro Yuasa
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译：本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。

7. 发明申请

US20100092544A1 Adhesive composition for patch and use thereof 审中-公开
标题翻译：用于贴剂的粘合剂组合物及其用途
公开(公告)号：US20100092544A1
公开(公告)日：2010-04-15
申请号：US12285735
申请日：2008-10-14
申请人： Katsuhiro Okada , Yoshihiro Iwao , Katsuyuki Ookubo
发明人： Katsuhiro Okada , Yoshihiro Iwao , Katsuyuki Ookubo
IPC分类号： A61K9/70 , C09J193/04 , C09J145/02 , C09J125/04
CPC分类号： C09J135/06 , A61K9/7023 , C08L7/00 , C08L9/06 , C08L23/22 , C08L35/06 , C08L2205/02 , C08L2666/02 , C09J145/02 , C09J193/04
摘要： The present invention provides an adhesive composition for patch, containing a rubber elastomer and a tackifier having a weight average molecular weight of 1200-2500, a patch having a support and an adhesive layer containing the composition, which is provided on at least one surface of the support, and a patch preparation having an adhesive layer containing a percutaneously absorbable drug (excluding bisoprolol).
摘要翻译：本发明提供了一种贴剂用粘合剂组合物，其包含橡胶弹性体和重均分子量为1200-2500的增粘剂，具有支持体的贴剂和含有该组合物的粘合剂层，其设置在至少一个表面上载体和具有含有经皮吸收性药物（不包括比索洛尔）的粘合剂层的贴剂）。

8. 发明申请

US20090169603A1 Adhesive Pharmaceutical Preparation 审中-公开
标题翻译：胶粘剂制剂
公开(公告)号：US20090169603A1
公开(公告)日：2009-07-02
申请号：US12097220
申请日：2006-12-13
申请人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada
发明人： Yoshihiro Iwao , Katsuyuki Ookubo , Katsuhiro Okada
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K47/10 , A61K47/32
摘要： In the adhesive pharmaceutical preparation of the invention, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a drug which is liquid at room temperature or around room temperature (in which, free base of bisoprolol is excluded) and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the drug can be specifically increased. As a result, not only it becomes possible to increase blending amount of the drug but also bleed of the drug from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.
摘要翻译：在本发明的粘合剂药物制剂中，在背衬的一侧层压粘合剂层。压敏粘合剂层含有具有12至28个碳原子的支链一元醇，在室温或室温附近为液体的药物（其中排除比索洛尔的游离碱）和聚异丁烯压敏粘合剂。因此，可以特别提高聚异丁烯压敏粘合剂与药物的相容性。结果，不仅能够增加药物的配合量，而且可以抑制药物从压敏粘合剂层的渗出，并且还可以抑制从实用的角度出发的压敏粘合特性视图可以获得。

9. 发明授权

US09808609B2 Patch and patch preparation 有权
公开(公告)号：US09808609B2
公开(公告)日：2017-11-07
申请号：US13983510
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61M35/00 , A61L31/12 , A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61M35/00 , A61K9/7053 , A61K31/405 , A61K31/663 , A61L31/129
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.

10. 发明授权

US08251213B2 Patch package structure 失效
标题翻译：贴片包装结构
公开(公告)号：US08251213B2
公开(公告)日：2012-08-28
申请号：US12167085
申请日：2008-07-02
申请人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Katsuhiro Okada , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61B17/06
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00165 , A61F2013/00365 , Y10T428/13
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
摘要翻译：贴片包装结构技术领域本发明涉及一种贴片包装结构，其包括：包括第一片材和第二片材的封装，所述第一片材和第二片材在其周边部分被密封在一起; 以及布置在所述包装中的贴片，所述贴片包含背衬，层压在所述背衬的至少一侧上的压敏粘合剂层以及保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫，所述剥离衬垫在其表面上具有在使用所述贴片时支撑所述剥离衬垫剥离的切割线，所述贴片设置在所述包装中，使得所述剥离衬垫面向所述第一片材的内表面，所述第一片材具有第一区域，其中所述第一片材的内表面面向所述剥离衬垫的切割线，所述第一片材在所述第一区域中具有所述第一片材的内表面与所述第一片材的内表面之间的最小第一距离，释放衬垫的表面，并且第一片材的内表面在第一区域中以最小第一距离与释放衬垫的表面间隔开。

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