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1. 发明申请

US20130236470A1 THERAPEUTIC AGENT FOR MALIGNANT TUMORS EXPRESSING MHC CLASS II 有权
标题翻译：用于表达MHC II类的恶性肿瘤的治疗剂
公开(公告)号：US20130236470A1
公开(公告)日：2013-09-12
申请号：US13877844
申请日：2011-10-04
申请人： Shuji Matsuoka , Yasuyuki Ishii
发明人： Shuji Matsuoka , Yasuyuki Ishii
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/34 , G01N2333/70539
摘要： Provided is a novel therapeutic agent specific for a malignant tumor expressing MHC class II. The present invention provides an antibody recognizing a protein constituting MHC class II expressed on a malignant tumor, the antibody comprising at least one selected from heavy chain CDR1 (amino acid sequence represented by positions 49 to 54 of SEQ ID NO: 54), heavy chain CDR2 (amino acid sequence represented by positions 69 to 84 of SEQ ID NO: 54), heavy chain CDR3 (amino acid sequence represented by positions 117 to 128 of SEQ ID NO: 54), light chain CDR1 (amino acid sequence represented by positions 46 to 55 of SEQ ID NO: 56), light chain CDR2 (amino acid sequence represented by positions 71 to 77 of SEQ ID NO: 56), and light chain CDR3 (amino acid sequence represented by positions 100 to 108 of SEQ ID NO: 56).
摘要翻译：提供一种特异于表达II类MHC的恶性肿瘤的新型治疗剂。本发明提供一种抗体，其识别构成在恶性肿瘤上表达的II类MHC的蛋白质，所述抗体包含选自重链CDR1（SEQ ID NO：54的49至54位的氨基酸序列）中的至少一种，重链 CDR2（SEQ ID NO：54的位置69〜84所示的氨基酸序列），重链CDR3（SEQ ID NO：54的117〜128位的氨基酸序列），轻链CDR1（氨基酸序列 SEQ ID NO：56的46〜55），轻链CDR2（由SEQ ID NO：56的71〜77位表示的氨基酸序列）和轻链CDR3（SEQ ID NO：：56）。

2. 发明授权

US09303083B2 Therapeutic agent for malignant tumors expressing MHC class II 有权
标题翻译：表达MHC II类恶性肿瘤的治疗剂
公开(公告)号：US09303083B2
公开(公告)日：2016-04-05
申请号：US13877844
申请日：2011-10-04
申请人： Shuji Matsuoka , Yasuyuki Ishii
发明人： Shuji Matsuoka , Yasuyuki Ishii
IPC分类号： C07K16/28 , C07K16/18 , C07K16/30
CPC分类号： C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/34 , G01N2333/70539
摘要： Provided is a novel therapeutic agent specific for a malignant tumor expressing MHC class II. The present invention provides an antibody recognizing a protein constituting MHC class II expressed on a malignant tumor, the antibody comprising at least one selected from heavy chain CDR1 (amino acid sequence represented by positions 49 to 54 of SEQ ID NO: 54), heavy chain CDR2 (amino acid sequence represented by positions 69 to 84 of SEQ ID NO: 54), heavy chain CDR3 (amino acid sequence represented by positions 117 to 128 of SEQ ID NO: 54), light chain CDR1 (amino acid sequence represented by positions 46 to 55 of SEQ ID NO: 56), light chain CDR2 (amino acid sequence represented by positions 71 to 77 of SEQ ID NO: 56), and light chain CDR3 (amino acid sequence represented by positions 100 to 108 of SEQ ID NO: 56).
摘要翻译：提供一种特异于表达II类MHC的恶性肿瘤的新型治疗剂。本发明提供一种抗体，其识别构成在恶性肿瘤上表达的II类MHC的蛋白质，所述抗体包含选自重链CDR1（SEQ ID NO：54的49至54位的氨基酸序列）中的至少一种，重链 CDR2（SEQ ID NO：54的第69〜84位的氨基酸序列），重链CDR3（SEQ ID NO：54的117〜128位的氨基酸序列），轻链CDR1（由位置 SEQ ID NO：56的46〜55），轻链CDR2（由SEQ ID NO：56的71〜77位表示的氨基酸序列）和轻链CDR3（SEQ ID NO：：56）。

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