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1. 发明授权

US08309040B2 Microfluidic control apparatus and method of assembling the same 有权
标题翻译：微流控制装置及其组装方法
公开(公告)号：US08309040B2
公开(公告)日：2012-11-13
申请号：US12542627
申请日：2009-08-17
申请人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
发明人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
IPC分类号： B01J8/00 , B01L3/00
CPC分类号： B01J19/0093 , B01J2219/00373 , B01J2219/00376 , B01J2219/00891 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0457 , B01L2400/0487 , B01L2400/06 , Y10T29/494 , Y10T29/49826
摘要： Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.
摘要翻译：提供了一种微流控制装置，其包括至少一个控制装置和微流控制芯片。当将微流控制芯片装载到控制装置时，将提供给控制装置的针插入到微流控制芯片的反应溶液储存室中，其中反应溶液储存室用密封胶带密封。因此，在微流控制芯片和控制装置之间容易形成流体连接而没有泄漏。

2. 发明申请

US20120164747A1 METHOD OF EXTRACTING PLASMA BY AGGLUTINATION OF BLOOD CELLS AND PLASMA SEPARATION DEVICE THEREFOR 审中-公开
标题翻译：通过血细胞分化提取血浆的方法及其等离子体分离装置
公开(公告)号：US20120164747A1
公开(公告)日：2012-06-28
申请号：US13315494
申请日：2011-12-09
申请人： YO HAN CHOI , KWANG HYO CHUNG , GUN YONG SUNG
发明人： YO HAN CHOI , KWANG HYO CHUNG , GUN YONG SUNG
IPC分类号： G01N1/34 , B01D35/00
CPC分类号： G01N33/5094 , G01N33/80 , Y10T436/25125
摘要： The present invention relates to a plasma extraction method in which a complex of a blood cell-specific antibody and a protein having the ability to bind to the Fc region of the antibody is used to induce the agglutination of blood cells in blood, thereby increasing plasma separation efficiency, and to a plasma separation device therefor. According to the method, plasma can be separated from whole blood in high efficiency, and rapid plasma separation is possible, so that rapid diagnosis can be performed even with a small amount of blood.
摘要翻译：本发明涉及一种血浆提取方法，其中使用血细胞特异性抗体和具有结合抗体Fc区的能力的蛋白质的复合物诱导血液中血细胞的凝集，从而增加血浆中的血浆分离效率，以及其等离子体分离装置。根据该方法，可以高效地将血浆与全血分离，能够进行快速的血浆分离，因此即使用少量的血液也能进行快速诊断。

3. 发明申请

US20100157300A1 LIQUID SAMPLE ANALYSIS CHIP READING SYSTEM, AND ANALYSIS METHOD AND UBIQUITOUS READING SYSTEM USING THE SAME 审中-公开
标题翻译：液体样品分析芯片读取系统，分析方法和使用本发明的读取系统
公开(公告)号：US20100157300A1
公开(公告)日：2010-06-24
申请号：US12503755
申请日：2009-07-15
申请人： Dae-Sik Lee , Yo-Han Choi , Hyun-Woo Song , Moon-Youn Jung , Seon-Hee Park , Gun-Yong Sung
发明人： Dae-Sik Lee , Yo-Han Choi , Hyun-Woo Song , Moon-Youn Jung , Seon-Hee Park , Gun-Yong Sung
IPC分类号： G01J3/46
CPC分类号： G01N21/253 , G01N21/8483 , G01N2201/0256 , G01N2201/0826
摘要： Provided is a liquid sample analysis chip reading system. The reading system includes an analysis chip, a light emitting part, a plurality of light wave-guides, and a light receiving part. The analysis chip includes a plurality of detecting parts. The light emitting part includes three light sources emitting light having wavelengths (or colors) different from each other. The plurality of light wave-guides irradiate the light emitted from the light emitting part onto the plurality of corresponding detecting parts, respectively. The light receiving part includes a plurality of light receiving devices for receiving the light having a specific color reflected from each of the plurality of corresponding detecting parts of the analysis chip. The three light sources are discontinuously controlled to emit light onto the plurality of light wave-guides.
摘要翻译：提供了一种液体样品分析芯片读取系统。读取系统包括分析芯片，发光部分，多个光波导和光接收部分。分析芯片包括多个检测部分。发光部分包括发射具有彼此不同的波长（或颜色）的光的三个光源。多个光波导将从发光部发射的光分别照射到多个相应的检测部上。光接收部分包括多个光接收装置，用于接收从分析芯片的多个相应的检测部分中的每一个反射的具有特定颜色的光。不连续地控制三个光源以将光发射到多个光波导上。

4. 发明申请

US20100029902A1 COATED NANOPARTICLES AND METHOD FOR COATING NANOPARTICLES 审中-公开
标题翻译：包覆纳米颗粒和涂覆纳米颗粒的方法
公开(公告)号：US20100029902A1
公开(公告)日：2010-02-04
申请号：US12324821
申请日：2008-11-26
申请人： Yo-Han CHOI , Sanghee Kim
发明人： Yo-Han CHOI , Sanghee Kim
IPC分类号： C07K2/00
CPC分类号： G01N33/532 , B01J2219/005 , B01J2219/00725 , B82Y30/00 , G01N33/587
摘要： Provided are coated nanoparticles and a method for coating nanoparticles. The coated nanoparticles are coated with proteins to prevent aggregation of the coated nanoparticles. The method for coating nanoparticles may include mixing an excessive amount of proteins with the nanoparticles. Alternatively, the method for coating nanoparticles may include coating with first proteins, treating with ultrasonic waves, and coating with second proteins.
摘要翻译：提供涂覆纳米颗粒和涂覆纳米颗粒的方法。包被的纳米颗粒用蛋白质包被以防止被覆纳米颗粒的聚集。包被纳米颗粒的方法可包括将过量的蛋白质与纳米颗粒混合。或者，用于涂覆纳米颗粒的方法可以包括用第一蛋白质包衣，用超声波处理和用第二蛋白质包被。

5. 发明申请

US20070292778A1 Methods of measuring critical dimensions and related devices 有权
标题翻译：测量关键尺寸和相关设备的方法
公开(公告)号：US20070292778A1
公开(公告)日：2007-12-20
申请号：US11811979
申请日：2007-06-13
申请人： Kyoung-Yoon Bang , Hae-Young Jeong , Yong-Hoon Kim , Yo-Han Choi , Hyung-Joo Lee
发明人： Kyoung-Yoon Bang , Hae-Young Jeong , Yong-Hoon Kim , Yo-Han Choi , Hyung-Joo Lee
IPC分类号： G03C5/00 , G06K9/00 , G01B11/00
CPC分类号： G01B11/24 , G03F7/70625 , G06T7/001 , G06T2207/30148
摘要： A method of measuring a critical dimension may include forming an object pattern on a substrate and forming a plurality of reference patterns on the substrate, wherein each of the plurality of reference patterns has a different critical dimension. An optical property of each of the plurality of reference patterns may be measured to provide a respective measured optical property for each of the reference patterns, and an optical property of the object pattern may be measured to provide a measured optical property of the object pattern. The measured optical property of the object pattern may be compared with the measured optical properties of the reference patterns, and a critical dimension of the object pattern may be determined as being the same as the critical dimension of the reference pattern having the measured optical property that is closest to the measured optical property of the object pattern. Related devices are also discussed.
摘要翻译：测量临界尺寸的方法可以包括在衬底上形成对象图案并在衬底上形成多个参考图案，其中多个参考图案中的每一个具有不同的临界尺寸。可以测量多个参考图案中的每一个的光学特性以为每个参考图案提供相应的测量光学特性，并且可以测量对象图案的光学特性以提供对象图案的测量光学特性。可以将对象图案的测量光学性质与参考图案的测量光学性质进行比较，并且可以将对象图案的临界尺寸确定为与具有测量的光学性质的参考图案的临界尺寸相同，最接近被测物体图案的光学特性。还讨论了相关设备。

6. 发明授权

US08585013B2 Magnetic microvalve using metal ball and method of manufacturing the same 有权
标题翻译：使用金属球的磁性微型阀及其制造方法
公开(公告)号：US08585013B2
公开(公告)日：2013-11-19
申请号：US12872289
申请日：2010-08-31
申请人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Young Jun Kim , Moon Youn Jung , Seon Hee Park
发明人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Young Jun Kim , Moon Youn Jung , Seon Hee Park
IPC分类号： F16K31/08
CPC分类号： F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0034 , F16K99/0046 , F16K2099/0078
摘要： There is provided a magnetic microvalve using a metal ball and a method of manufacturing the same. A magnetic microvalve using a metal ball according to an aspect of the invention may include: an upper substrate having a microchannel serving as a passage through which a fluid moves, a fluid inlet through which the fluid flows into the microchannel, and a fluid outlet through which the fluid, having passed through the microchannel, flows out of the microchannel; a lower substrate having a trench locally provided therein; a PDMS/metal ball combination having a metal ball and PDMS surrounding the metal ball so that the metal ball is located in a central portion thereof, the PDMS/metal ball combination being inserted into the trench provided in the lower substrate; and a magnet located above the microchannel, provided in the upper substrate, and generating magnetic force.
摘要翻译：提供了使用金属球的磁性微型阀及其制造方法。使用根据本发明的一个方面的金属球的磁性微型阀可以包括：具有作为流体移动通道的微通道的上基板，流体流入微通道的流体入口，以及流体出口通过已经通过微通道的流体流出微通道; 具有局部设置在其中的沟槽的下基板; 具有围绕金属球的金属球和PDMS的PDMS /金属球组合，使得金属球位于其中心部分，PDMS /金属球组合插入设置在下基板中的沟槽中; 以及设置在上基板上的微通道上方的磁体，并产生磁力。

7. 发明申请

US20130149216A1 DEVICE FOR STORING REAGENT AND METHOD OF DISCHARGING REAGENT THEREOF 有权
标题翻译：用于储存试剂的装置和放出试剂的方法
公开(公告)号：US20130149216A1
公开(公告)日：2013-06-13
申请号：US13528777
申请日：2012-06-20
申请人： Kwang Hyo CHUNG , Yo Han Choi , Jong Heon Yang , Chan Woo Park , Chil Seong Ah , Wan Joong Kim , Gun Yong Sung
发明人： Kwang Hyo CHUNG , Yo Han Choi , Jong Heon Yang , Chan Woo Park , Chil Seong Ah , Wan Joong Kim , Gun Yong Sung
IPC分类号： B01L3/00
CPC分类号： B01L3/0268 , B01L3/502715 , B01L3/52 , B01L2200/16 , B01L2300/0816 , B01L2400/0481 , F04B43/043
摘要： Provided are a device for storing a reagent capable of being adhered to a biochip and supplying the stored reagent to the biochip, and a method of discharging a reagent thereof. The device for storing a reagent includes an elastic film pressurizing part configured to pressurize an elastic film by magnetic force, and a reagent discharging part configured to store the reagent and discharge the reagent through an outlet by using the deformation in the elastic film due to the pressurization. According to the present invention, a magnetic force controlling device can be small-sized and the reagent can be automatically, high-precisely, and reproducibly supplied through the magnetic force control.
摘要翻译：提供了一种用于存储能够粘附到生物芯片并将储存的试剂供应到生物芯片的试剂的装置及其试剂的排出方法。用于存储试剂的装置包括：弹性膜加压部，其被配置为通过磁力对弹性膜加压;以及试剂排出部，其构造成存储试剂，并且通过使用弹性膜中的变形通过出口排出试剂，加压。根据本发明，磁力控制装置可以小型化，并且可以通过磁力控制自动，高精度地且可重复地提供试剂。

8. 发明授权

US08057672B2 Disposable multi-layered filtration device for the separation of blood plasma 有权
标题翻译：一次性多层过滤装置，用于分离血浆
公开(公告)号：US08057672B2
公开(公告)日：2011-11-15
申请号：US12133295
申请日：2008-06-04
申请人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
发明人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
IPC分类号： B01D69/06 , B01D63/08 , B01D29/00
CPC分类号： G01N33/491 , B01L3/502753 , B01L2300/043 , B01L2300/0645 , B01L2300/0681 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B33Y80/00
摘要： Provided is a disposable multi-layered filtration device for the separation of blood plasma which can be applied to a biochip and appropriate for disposal uses. The filtration device for the separation of blood plasma includes: an upper substrate including a blood inlet; an intermediate substrate including a filtering unit for extracting blood plasma from blood flowing through the blood inlet; and a lower substrate including an air outlet, wherein the upper substrate, the intermediate substrate, and the lower substrate are stacked and adhered.
摘要翻译：提供了一种用于分离血浆的一次性多层过滤装置，其可以应用于生物芯片并适合于处置用途。用于分离血浆的过滤装置包括：包括血液入口的上基板; 中间基板，包括用于从流过血液入口的血液中提取血浆的过滤单元; 以及包括空气出口的下基板，其中所述上基板，所述中间基板和所述下基板被堆叠和粘附。

9. 发明申请

US20100267127A1 POLYMERASE CHAIN REACTION APPARATUS 审中-公开
标题翻译：聚合物链反应装置
公开(公告)号：US20100267127A1
公开(公告)日：2010-10-21
申请号：US12484797
申请日：2009-06-15
申请人： Kwang Hyo CHUNG , Yo Han CHOI , JuHyun JEON , Moon Youn JUNG
发明人： Kwang Hyo CHUNG , Yo Han CHOI , JuHyun JEON , Moon Youn JUNG
IPC分类号： C12M1/02
CPC分类号： B01L7/525 , B01L3/5027 , B01L2200/028 , B01L2200/147 , B01L2300/0816 , B01L2300/088 , B01L2300/1805 , B01L2300/1827 , B01L2400/0445
摘要： Provided is a polymerase chain reaction (PCR) apparatus. A PCR is performed using the module assembly-type PCR apparatus. The module assembly-type PCR apparatus includes a first module, a second module, and a third module. A sample is provided to the first module. The second module provides different temperature ranges to the first module to generate thermal convection. The third module controls an operation of the second module. The first module is separably coupled to the second module. The second module is electrically separably coupled to the third module.
摘要翻译：提供了聚合酶链反应（PCR）装置。使用模块组装型PCR装置进行PCR。模块组装型PCR装置包括第一模块，第二模块和第三模块。样品提供给第一个模块。第二模块为第一模块提供不同的温度范围以产生热对流。第三模块控制第二模块的操作。第一模块可分离地耦合到第二模块。第二模块可电分离地耦合到第三模块。

10. 发明申请

US20090120865A1 DISPOSABLE MULTI-LAYERED FILTRATION DEVICE FOR THE SEPARATION OF BLOOD PLASMA 有权
标题翻译：用于分离血浆等离子体的多层过滤装置
公开(公告)号：US20090120865A1
公开(公告)日：2009-05-14
申请号：US12133295
申请日：2008-06-04
申请人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
发明人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
IPC分类号： B01D25/12 , B01D27/08 , B01D35/30
CPC分类号： G01N33/491 , B01L3/502753 , B01L2300/043 , B01L2300/0645 , B01L2300/0681 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B33Y80/00
摘要： Provided is a disposable multi-layered filtration device for the separation of blood plasma which can be applied to a biochip and appropriate for disposal uses. The filtration device for the separation of blood plasma includes: an upper substrate including a blood inlet; an intermediate substrate including a filtering unit for extracting blood plasma from blood flowing through the blood inlet; and a lower substrate including an air outlet, wherein the upper substrate, the intermediate substrate, and the lower substrate are stacked and adhered.
摘要翻译：提供了一种用于分离血浆的一次性多层过滤装置，其可以应用于生物芯片并适合于处置用途。用于分离血浆的过滤装置包括：包括血液入口的上基板; 中间基板，包括用于从流过血液入口的血液中提取血浆的过滤单元; 以及包括空气出口的下基板，其中所述上基板，所述中间基板和所述下基板被堆叠和粘附。

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