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1. 发明授权

US08509383B2 System and method for motion adaptive optimization for radiation therapy delivery 有权
标题翻译：用于放射治疗输送的运动自适应优化的系统和方法
公开(公告)号：US08509383B2
公开(公告)日：2013-08-13
申请号：US12259038
申请日：2008-10-27
申请人： Weiguo Lu , Mingli Chen , Quan Chen , Kenneth J. Ruchala , Gustavo H. Olivera
发明人： Weiguo Lu , Mingli Chen , Quan Chen , Kenneth J. Ruchala , Gustavo H. Olivera
IPC分类号： A61N5/10 , A61B6/03 , A61B6/04 , H05G1/44 , H05G1/42
CPC分类号： A61N5/1049 , A61N5/1037 , A61N5/1067
摘要： A system and method of optimizing delivery of a radiation therapy treatment. The system optimizes treatment delivery in real-time to take into account a variety of factors, such as patient anatomical and physiological changes (e.g., respiration and other movement, etc.), and machine configuration changes (e.g., beam output factors, couch error, leaf error, etc.).
摘要翻译：一种优化辐射治疗治疗的系统和方法。该系统实时优化治疗传递，以考虑各种因素，如患者解剖和生理变化（例如呼吸和其他运动等）和机器配置变化（例如，束输出因子，沙发误差，叶错误等）。

2. 发明授权

US07839972B2 System and method of evaluating dose delivered by a radiation therapy system 有权
标题翻译：评估放射治疗系统传递的剂量的系统和方法
公开(公告)号：US07839972B2
公开(公告)日：2010-11-23
申请号：US11459097
申请日：2006-07-21
申请人： Kenneth J. Ruchala , Gustavo H. Olivera , Eric Schnarr , Weiguo Lu , Thomas R. Mackie
发明人： Kenneth J. Ruchala , Gustavo H. Olivera , Eric Schnarr , Weiguo Lu , Thomas R. Mackie
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61N5/1037 , A61N5/1038 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N5/1071 , A61N2005/1072
摘要： A system and method of evaluating dose delivered by a radiation therapy system using a marker that indicates motion. The marker is associated with the patient. In one method of operation, the method includes delivering radiation to the patient, monitoring motion of the marker during the delivering radiation, and evaluating a dose delivered to the patient based at least in part on the motion of the marker. In another method of operation, the method includes delivering radiation to the patient, obtaining information relating to the delivery of radiation, estimating dose to the marker based at least in part on the information, acquiring dose received by the marker, and comparing the received dose with the estimated dose.
摘要翻译：一种评估使用指示运动的标记的放射治疗系统递送的剂量的系统和方法。标记与患者相关联。在一种操作方法中，该方法包括向患者传送辐射，监测在递送辐射期间标记物的运动，以及至少部分地基于标记物的运动评估递送给患者的剂量。在另一种操作方法中，所述方法包括向患者传送辐射，获得与辐射传递相关的信息，至少部分地基于所述信息估计所述标记的剂量，获取由所述标记接收的剂量，以及将所述接收剂量与估计剂量。

3. 发明申请

US20100228116A1 SYSTEM AND METHOD OF OPTIMIZING A HETEROGENEOUS RADIATION DOSE TO BE DELIVERED TO A PATIENT 审中-公开
标题翻译：优化异位辐射剂量给患者的系统和方法
公开(公告)号：US20100228116A1
公开(公告)日：2010-09-09
申请号：US12717086
申请日：2010-03-03
申请人： Weiguo Lu , Kenneth J. Ruchala
发明人： Weiguo Lu , Kenneth J. Ruchala
IPC分类号： A61N5/00 , A61B5/055 , G06G7/60 , G06G7/62
CPC分类号： A61N5/103 , A61B6/032 , A61N5/1038 , A61N5/1042 , G06F19/321 , G06F19/3481
摘要： A radiation therapy treatment system and method of optimizing a heterogeneous dose to be delivered to a patient. The system includes a computer processor and a software program stored in a computer readable medium accessible by the computer processor. The software program is operable to receive a prescribed heterogeneous radiation dose to be delivered to the patient, determine a homogeneous reference dose, calculate a complementary radiation dose by determining a difference between the homogeneous reference dose and the heterogeneous radiation dose, generate a treatment plan for the patient, the treatment plan including an optimized radiation dose to be delivered to the patient, combine the complementary radiation dose and the optimized radiation dose, evaluate the combined radiation dose with respect to the homogeneous reference dose, and display the combined radiation dose.
摘要翻译：一种放射疗法治疗系统和优化要递送给患者的异质剂量的方法。该系统包括计算机处理器和存储在可由计算机处理器访问的计算机可读介质中的软件程序。所述软件程序可操作以接收要递送给患者的规定的异质辐射剂量，确定均匀参考剂量，通过确定所述同质参考剂量和所述异质辐射剂量之间的差异来计算互补辐射剂量，产生治疗计划患者，包括要递送给患者的优化辐射剂量的治疗计划结合了补充辐射剂量和优化的辐射剂量，评估相对于均匀参考剂量的组合辐射剂量，并显示组合的辐射剂量。

4. 发明授权

US07639854B2 Method and system for processing data relating to a radiation therapy treatment plan 有权
标题翻译：用于处理与放射治疗治疗计划有关的数据的方法和系统
公开(公告)号：US07639854B2
公开(公告)日：2009-12-29
申请号：US11459108
申请日：2006-07-21
申请人： Eric Schnarr , Kenneth J. Ruchala , Gustavo H. Olivera , Weiguo Lu , Jeffrey M. Kapatoes , Jason Haimerl , John H. Hughes , Thomas R. Mackie
发明人： Eric Schnarr , Kenneth J. Ruchala , Gustavo H. Olivera , Weiguo Lu , Jeffrey M. Kapatoes , Jason Haimerl , John H. Hughes , Thomas R. Mackie
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1042 , A61N5/1048 , A61N5/1049 , A61N5/1065 , A61N5/1067 , A61N5/1069 , A61N5/107
摘要： A system and method of automatically processing data relating to a radiation therapy treatment plan. The method includes the acts of acquiring image data of a patient, generating a treatment plan for the patient based at least in part on the image data, the treatment plan including a calculated radiation dose to be delivered to the patient, acquiring an on-line image of the patient in substantially a treatment position, delivering at least a portion of the calculated radiation dose to the patient, and automatically recalculating the radiation dose received by the patient.
摘要翻译：一种自动处理与放射治疗治疗计划有关的数据的系统和方法。该方法包括获取患者的图像数据的动作，至少部分地基于图像数据生成针对患者的治疗计划，治疗计划包括计算出的要递送给患者的辐射剂量，获取在线将患者的图像基本上处于治疗位置，将计算出的辐射剂量的至少一部分递送给患者，并自动重新计算由患者接收的辐射剂量。

5. 发明申请

US20070189591A1 METHOD OF PLACING CONSTRAINTS ON A DEFORMATION MAP AND SYSTEM FOR IMPLEMENTING SAME 有权
标题翻译：在变形地图上放置约束的方法和实现其的系统
公开(公告)号：US20070189591A1
公开(公告)日：2007-08-16
申请号：US11459061
申请日：2006-07-21
申请人： Weiguo Lu , Gustavo Olivera , Kenneth Ruchala , Eric Schnarr
发明人： Weiguo Lu , Gustavo Olivera , Kenneth Ruchala , Eric Schnarr
IPC分类号： G06K9/00
CPC分类号： A61N5/103 , A61N5/1031 , A61N5/1037 , A61N5/1038 , A61N5/1042 , A61N5/1048 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1041
摘要： A system and method of placing constraints on a deformation map. The method includes the acts of generating a deformation map between two images, identifying a defined structure in one of the images, applying the deformation map to relate the defined structure from the one image onto the other image to create a deformation-based defined structure, modifying the deformation-based defined structure, and updating the deformation map in response to the step of modifying the deformation-based defined structure.
摘要翻译：在变形图上放置约束的系统和方法。该方法包括在两个图像之间生成变形图的动作，识别其中一个图像中的定义的结构，应用变形图以将所定义的结构从一个图像关联到另一个图像上以创建基于变形的定义结构，修改基于变形的定义的结构，并且响应于修改基于变形的定义结构的步骤来更新变形图。

6. 发明申请

US20070041497A1 METHOD AND SYSTEM FOR PROCESSING DATA RELATING TO A RADIATION THERAPY TREATMENT PLAN 有权
标题翻译：用于处理与辐射治疗方案有关的数据的方法和系统
公开(公告)号：US20070041497A1
公开(公告)日：2007-02-22
申请号：US11459108
申请日：2006-07-21
申请人： Eric Schnarr , Kenneth Ruchala , Gustavo Olivera , Weiguo Lu , Jeffrey Kapatoes , Jason Haimerl , John Hughes , Thomas Mackie
发明人： Eric Schnarr , Kenneth Ruchala , Gustavo Olivera , Weiguo Lu , Jeffrey Kapatoes , Jason Haimerl , John Hughes , Thomas Mackie
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1042 , A61N5/1048 , A61N5/1049 , A61N5/1065 , A61N5/1067 , A61N5/1069 , A61N5/107
摘要： A system and method of automatically processing data relating to a radiation therapy treatment plan. The method includes the acts of acquiring image data of a patient, generating a treatment plan for the patient based at least in part on the image data, the treatment plan including a calculated radiation dose to be delivered to the patient, acquiring an on-line image of the patient in substantially a treatment position, delivering at least a portion of the calculated radiation dose to the patient, and automatically recalculating the radiation dose received by the patient.
摘要翻译：一种自动处理与放射治疗治疗计划有关的数据的系统和方法。该方法包括获取患者的图像数据的动作，至少部分地基于图像数据生成针对患者的治疗计划，治疗计划包括计算出的要递送给患者的辐射剂量，获取在线将患者的图像基本上处于治疗位置，将计算出的辐射剂量的至少一部分递送给患者，并自动重新计算由患者接收的辐射剂量。

7. 发明授权

US08406844B2 Method for modification of radiotherapy treatment delivery 有权
标题翻译：放射治疗传递的修改方法
公开(公告)号：US08406844B2
公开(公告)日：2013-03-26
申请号：US10506866
申请日：2003-03-06
申请人： Kenneth J. Ruchala , Gustavo H. Olivera , Jeffrey M. Kapatoes , Paul J. Reckwerdt , Weiguo Lu , John H. Hughes
发明人： Kenneth J. Ruchala , Gustavo H. Olivera , Jeffrey M. Kapatoes , Paul J. Reckwerdt , Weiguo Lu , John H. Hughes
IPC分类号： A61B5/05
CPC分类号： A61N5/103 , A61N5/1038 , A61N5/1065 , A61N5/1067 , A61N5/1069 , A61N2005/1061 , G06F19/00
摘要： A method of contoured-anatomy dose repositioning (CADR) as a means to automatically reposition a patient to better recover the planned dose distribution without reoptimizinq the treatment plan. CADR utilizes planning CT images, the planned dose distribution, and on-line images for repositioning dose distribution on a given day. Contours are also placed upon the images using manual, automatic, template-based, or other techniques. CADR then optimizes the rigid-body repositioning of the patient so that the daily dose distribution closely matches the planned dose distribution.
摘要翻译：一种轮廓解剖学剂量重新定位（CADR）的方法，作为自动重新定位患者的手段，以更好地恢复计划的剂量分布，而无需重新计算治疗计划。 CADR利用计划的CT图像，计划的剂量分布和在线图像在给定的一天重新定位剂量分布。使用手动，自动，基于模板或其他技术的轮廓也被放置在图像上。然后，CADR优化患者的刚体重新定位，使得日剂量分布与计划的剂量分布密切相关。

8. 发明授权

US08229068B2 System and method of detecting a breathing phase of a patient receiving radiation therapy 有权
标题翻译：检测接受放射治疗的患者的呼吸阶段的系统和方法
公开(公告)号：US08229068B2
公开(公告)日：2012-07-24
申请号：US11459078
申请日：2006-07-21
申请人： Weiguo Lu , Kenneth J. Ruchala , Mingli Chen , Quan Chen , Gustavo H. Olivera
发明人： Weiguo Lu , Kenneth J. Ruchala , Mingli Chen , Quan Chen , Gustavo H. Olivera
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/1042 , A61N5/1067 , A61N2005/1061
摘要： A system and method of detecting a breathing phase of a patient receiving radiation therapy is disclosed. The method, in one implementation, includes the acts of obtaining a plurality of patient images representing phases of a breathing cycle, delivering radiation to the patient, collecting transmission data of the patient during the delivering radiation, and comparing the transmission data to the plurality of patient images.
摘要翻译：公开了一种检测接受放射治疗的患者的呼吸阶段的系统和方法。该方法在一个实施方式中包括获取表示呼吸周期的相位的多个患者图像的动作，向患者传送辐射，在传送辐射期间收集患者的传输数据，以及将传输数据与多个病人图像。

9. 发明申请

US20110019889A1 System and method of applying anatomically-constrained deformation 审中-公开
标题翻译：应用解剖约束变形的系统和方法
公开(公告)号：US20110019889A1
公开(公告)日：2011-01-27
申请号：US12802947
申请日：2010-06-17
申请人： David Thomas Gering , Weiguo Lu , Kenneth J. Ruchala
发明人： David Thomas Gering , Weiguo Lu , Kenneth J. Ruchala
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61N5/103 , A61N5/1038 , A61N5/1042 , G06T7/12 , G06T7/174 , G06T2207/10081 , G06T2207/10144 , G06T2207/20128 , G06T2207/30008 , G06T2207/30016
摘要： System and method of generating a warp field to generate a deformed image. The system and method use segmentation in a new method of image deformation with the intent of improving the anatomical significance of the results. Instead of allowing each image voxel to move in any direction, only a few anatomical motions are permissible. The planning image and the daily image are both segmented automatically. These segmentations are then analyzed to define the values of the few anatomical parameters that govern the allowable motions. Given these model parameters, a deformation or warp field is generated directly without iteration. The warp field is applied to the planning image or the daily image to deform the image. The deformed image can be displayed to a user.
摘要翻译：产生翘曲场以产生变形图像的系统和方法。系统和方法在图像变形的新方法中使用分割，旨在提高结果的解剖意义。而不是允许每个图像体素在任何方向移动，只允许一些解剖运动。规划图像和日常图像都自动分段。然后分析这些分段以定义管理允许运动的少数解剖学参数的值。给定这些模型参数，直接生成变形或翘曲场，而不进行迭代。翘曲区域应用于规划图像或每日图像以使图像变形。变形的图像可以显示给用户。

10. 发明授权

US07609809B2 System and method of generating contour structures using a dose volume histogram 有权
标题翻译：使用剂量体积直方图生成轮廓结构的系统和方法
公开(公告)号：US07609809B2
公开(公告)日：2009-10-27
申请号：US11459143
申请日：2006-07-21
申请人： Jeffrey M. Kapatoes , Gustavo H. Olivera , Eric Schnarr , Weiguo Lu , Kenneth J. Ruchala , Paul J. Reckwerdt , John H. Hughes , Thomas R. Mackie
发明人： Jeffrey M. Kapatoes , Gustavo H. Olivera , Eric Schnarr , Weiguo Lu , Kenneth J. Ruchala , Paul J. Reckwerdt , John H. Hughes , Thomas R. Mackie
IPC分类号： A61N5/10 , H05G1/28
CPC分类号： A61N5/103 , A61N5/1042 , A61N5/1048 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1074
摘要： A system and method of defining a new region of interest for an existing region of interest using a dose volume histogram. The method includes the acts of generating a dose volume histogram of radiation dose for a pre-existing region of interest, selecting a subset of the dose volume histogram, and defining a new region of interest that corresponds to the selected subset of the dose volume histogram.
摘要翻译：使用剂量体积直方图来定义现有感兴趣区域的新感兴趣区域的系统和方法。该方法包括产生用于预先存在的感兴趣区域的辐射剂量的剂量体积直方图的动作，选择剂量体积直方图的子集，以及定义对应于剂量体积直方图的选定子集的新的感兴趣区域。

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