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1. 发明授权

US08450441B2 Synthetic N-linked sialo-glycan-containing polymer and method for producing the same 失效
标题翻译：合成的N-连接唾液酸聚糖聚合物及其制备方法
公开(公告)号：US08450441B2
公开(公告)日：2013-05-28
申请号：US12666482
申请日：2008-06-24
申请人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
发明人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C08F251/00 , C07H15/06 , C12Q1/70
CPC分类号： C08G69/48 , A61K31/7012 , A61K47/645 , C08G69/04 , C08G69/10 , C08G69/40
摘要： A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.)
摘要翻译：一种含有N-连接的唾液酸聚糖的聚合物，其中使用一端具有氨基的化合物和另一端的羧基并由结构式（I）表示的唾液酸聚糖与γ-聚谷氨酸缩合，。式（I）（式中，Z表示羟基或式（II）表示的残基，n表示10以上的整数，条件是Z中的任一个以上可以由式（II）中，式（II）（式中，X表示羟基或乙酰氨基，Y1和Y2表示羟基或N-乙酰神经氨酸残基，L表示烃，m表示0 或1或2的整数，条件是Y1和Y2不相同。）

2. 发明申请

US20090018327A1 SUGAR CHAIN CONTAINING 4-POSITION HALOGENATED GALACTOSE AND APPLICATION THEREOF 失效
标题翻译：含有4-位羟基糖的糖链及其应用
公开(公告)号：US20090018327A1
公开(公告)日：2009-01-15
申请号：US11815329
申请日：2006-02-14
申请人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
发明人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
IPC分类号： C07H5/02 , C12P19/30
CPC分类号： C12P19/32 , C07H15/08
摘要： The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (wherein X represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor.The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II): (wherein each of R1 to R3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase.The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.
摘要翻译：本发明涉及例如末端具有由式（I）表示的4-位卤代半乳糖残基的寡糖：（其中，X表示卤素原子，R表示单糖，寡糖，或载体），含有寡糖的转移酶抑制剂，以及在糖基转移酶存在下抑制糖链延长反应的方法，该方法包括使用该抑制剂。本发明还提供了由式（II）表示的4-位卤代半乳糖糖核苷酸的制备方法：（式中，R 1〜R 3各自表示羟基，乙酰基，卤素原子或氢原子; X表示卤素原子; M表示氢离子或金属离子），其中该方法采用细菌来源的半乳糖激酶和细菌来源的己糖-1-磷酸尿苷酰转移酶。本发明还涉及设想用作药物和其它材料的4-位卤代半乳糖的糖链以及该化合物的应用。

3. 发明授权

US06890739B1 Use of uridine diphosphate glucose 4-epimerase 有权
标题翻译：使用尿苷二磷酸葡萄糖4-差向异构酶
公开(公告)号：US06890739B1
公开(公告)日：2005-05-10
申请号：US10130785
申请日：2000-11-22
申请人： Tomoki Hamamoto , Toshitada Noguchi
发明人： Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12N9/90 , C12P19/30 , C12P19/38
CPC分类号： C12P19/305 , C12N9/90
摘要： The present invention relates to a new use of uridine diphosphate glucose 4-epimerase (also called uridine diphosphate galactose 4-epimerase), and a method of converting uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to uridine diphosphate N-acetylgalactosamine (UDP-GalNAc) by using the said enzyme. The process for producing UDP-GalNAc by using the uridine diphosphate glucose 4-epimerase and the UDP-GalNAc supply system according to the present invention are practical and efficient, and greatly beneficial to the industries.
摘要翻译：本发明涉及尿苷二磷酸葡萄糖4-差向异构酶（也称为尿苷二磷酸半乳糖4-差向异构酶）的新用途，以及将尿苷二磷酸N-乙酰葡糖胺（UDP-GlcNAc）转化为尿苷二磷酸N-乙酰半乳糖胺（UDP- GalNAc）。通过使用本发明的尿苷二磷酸葡萄糖4-差向异构酶和UDP-GalNAc供给系统生产UDP-GalNAc的方法是实用和有效的，对工业有很大的益处。

4. 发明授权

US06287819B1 Process for producing uridine diphosphate-n-acetylglucosamine 失效
标题翻译：生产尿苷二磷酸正乙酰葡糖胺的方法
公开(公告)号：US06287819B1
公开(公告)日：2001-09-11
申请号：US09297306
申请日：1999-04-29
申请人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
发明人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12P1930
CPC分类号： C12N9/1205 , C12P19/305
摘要： A process for producing uridine diphosphate-N-acetylglucosamine (UDPAG) from uridylic acid (UMP) and N-acetylglucosamine by use of microorganism cells, characterized by adding N-acetylglucosamine kinase thereto. According to the present invention, UDPAG can be efficiently produced even when N-acetylglucosamine is used as a substrate.
摘要翻译：通过使用微生物细胞从尿苷酸（UMP）和N-乙酰葡糖胺生产尿苷二磷酸-N-乙酰氨基葡萄糖（UDPAG）的方法，其特征在于向其中加入N-乙酰葡糖胺激酶。根据本发明，即使使用N-乙酰氨基葡糖作为底物，也能够有效地制造UDPAG。

5. 发明授权

US6040158A Process for preparing sugar nucleotide 失效
标题翻译：制备糖核苷酸的方法
公开(公告)号：US6040158A
公开(公告)日：2000-03-21
申请号：US68198
申请日：1998-05-05
申请人： Kenji Takenouchi , Tomoki Hamamoto , Toshitada Noguchi
发明人： Kenji Takenouchi , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12P19/30 , C12P19/00 , C12P19/26 , C12P19/32 , C12P19/40
CPC分类号： C12P19/30 , C12P19/305
摘要： A process for preparing a sugar nucleotide from a nucleotide by using a yeast cell, characterized in that both a nucleoside diphosphate-sugar pyrophosphorylase and a sugar 1-phosphate are present in the reaction system. According to this process, various sugar nucleotides, which have been prepared only in low productivity by the conventional yeast cell process, can be efficiently prepared.
摘要翻译： PCT No.PCT / JP97 / 03021 Sec。 371日期：1998年5月5日 102（e）日期1998年5月5日PCT 1997年8月29日PCT公布。公开号WO98 / 11248 日期：1998年3月19日一种通过使用酵母细胞从核苷酸制备糖核苷酸的方法，其特征在于在反应体系中存在核苷二磷酸 - 糖焦磷酸化酶和糖1-磷酸二糖。根据该方法，可以有效地制备通过常规酵母细胞过程仅以低生产率制备的各种糖核苷酸。

6. 发明授权

US08728789B2 DNA fragment encoding a polyphosphate-driven nucleoside 5′-diphosphate kinase polypeptide 有权
标题翻译：编码多磷酸盐驱动的核苷5'-二磷酸激酶多肽的DNA片段
公开(公告)号：US08728789B2
公开(公告)日：2014-05-20
申请号：US11814700
申请日：2006-01-24
申请人： Kazuya Ishige , Toshitada Noguchi
发明人： Kazuya Ishige , Toshitada Noguchi
IPC分类号： C12N9/12 , C12N5/00 , C12N5/04 , C12N1/20 , C12N1/00 , C12N1/12 , C07H21/02 , C07H21/04
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/1241 , C12P19/32
摘要： The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (ATPS) and adenosine 5′-phosphosulfate kinase (APSK), wherein an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP.
摘要翻译：本发明提供了制备3'-磷酸腺苷5'-磷酸硫酸（PAPS）的方法，该方法包括使用腺苷5'-三磷酸硫酸化酶（ATPS）和腺苷5'-磷酸硫酸激酶（APSK）对ATP进行硫酸化和磷酸化，，其中包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和多磷酸盐：AMP磷酸转移酶（PAP）的腺苷5'-三磷酸（ATP）供应/再生系统，或使用包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和腺苷酸激酶（ADK）的腺苷5'-三磷酸（ATP）供应/再生系统代替ATP。

7. 发明授权

US08450088B2 Process for producing CMP-N-acetylneuraminic acid 失效
标题翻译：制备CMP-N-乙酰神经氨酸的方法
公开(公告)号：US08450088B2
公开(公告)日：2013-05-28
申请号：US10573385
申请日：2004-09-21
申请人： Tomoki Hamamoto , Kuniaki Nagaoka , Toshitada Noguchi
发明人： Tomoki Hamamoto , Kuniaki Nagaoka , Toshitada Noguchi
IPC分类号： C12P19/02 , C12P1/00 , C07H1/00 , C07H19/10
CPC分类号： C12P19/385 , C12P19/305
摘要： A method by which high-purity CMP-N-acetylneuraminic acid (HPLC purity, 95% or higher), which has been difficult to obtain with any technique other than chromatography, can be easily obtained in satisfactory yield by a simple operation without the need of chromatography. The process, which is for producing high-purity CMP-N-acetylneuraminic acid (CMP-NeuAc), is characterized by conducting a suitable combination of the following steps (1) to (4). Step 1: a step in which divalent cations are added to a solution containing CMP-NeuAc to thereby precipitate the phosphoric acid, pyrophosphoric acid, and nucleotide which coexist; Step 2: a step in which a phosphatase is added to a solution containing CMP-NeuAc to thereby convert the coexistent nucleotide into nucleoside; Step 3: a step in which an organic solvent is added to precipitate the CMP-NeuAc; and Step 4: a step in which the CMP-NeuAc precipitated is recovered.
摘要翻译：可以通过简单的操作容易地以令人满意的产率获得用色谱法以外的任何技术难以获得的高纯度CMP-N-乙酰神经氨酸（HPLC纯度，95％或更高）的方法，而不需要的色谱。用于生产高纯度CMP-N-乙酰神经氨酸（CMP-NeuAc）的方法的特征在于进行以下步骤（1）至（4）的合适组合。步骤1：将二价阳离子加入到含有CMP-NeuAc的溶液中以沉淀磷酸，焦磷酸和共存的核苷酸的步骤; 步骤2：将含有CMP-NeuAc的溶液中加入磷酸酶，从而将共存核苷酸转化为核苷的步骤; 步骤3：加入有机溶剂沉淀CMP-NeuAc的步骤; 步骤4：回收沉淀的CMP-NeuAc的步骤。

8. 发明申请

US20090269734A1 METHOD FOR DETERMINATION OF RECOGNITION SPECIFICITY OF VIRUS FOR RECEPTOR SUGAR CHAIN 审中-公开
标题翻译：用于确定受体糖链的病毒识别特异性的方法
公开(公告)号：US20090269734A1
公开(公告)日：2009-10-29
申请号：US12427636
申请日：2009-04-21
申请人： Yasuo SUZUKI , Akira Asai , Takashi Suzuki , Ilpal Jwa , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
发明人： Yasuo SUZUKI , Akira Asai , Takashi Suzuki , Ilpal Jwa , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
IPC分类号： C12Q1/70 , C07K9/00 , C12P19/18
CPC分类号： G01N33/548 , G01N33/56983
摘要： A method in which the recognition specificity of a virus for a receptor sugar chain can be easily determined with a simple instrument or apparatus is provided. In a method for determining the recognition specificity of a virus for a receptor sugar chain or for determining the change in a host infected in accordance with the mutation of virus comprising, a sample of the virus is brought into contact with a support having a polymer with sialo-oligosaccharide immobilized on the surface thereof; and the degree of binding therein is assayed to determine the recognition specificity of said virus for said receptor sugar chain and to determine the change in a host range. The method is suitable for the surveillance of virus.
摘要翻译：提供了利用简单的仪器或装置容易地确定病毒对受体糖链的识别特异性的方法。在用于确定受体糖链病毒的识别特异性或根据病毒突变感染的宿主的变化的方法中，使病毒样品与具有聚合物的载体接触，唾液酸寡糖固定在其表面上; 并测定其中的结合程度以确定所述病毒对所述受体糖链的识别特异性并确定宿主范围的变化。该方法适用于病毒监控。

9. 发明申请

US20090215114A1 METHOD OF ENZYMATICALLY SYNTHESIZING 3' -PHOSPHOADENOSINE-5' -PHOSPHOSULFATE 有权
标题翻译：精氨酸合成3'-磷酰基-5'-磷酸脂肪酸酯的方法
公开(公告)号：US20090215114A1
公开(公告)日：2009-08-27
申请号：US11814700
申请日：2006-01-24
申请人： Kazuya Ishige , Toshitada Noguchi
发明人： Kazuya Ishige , Toshitada Noguchi
IPC分类号： C12P21/02 , C07H21/04 , C12P19/32 , C12N9/12
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/1241 , C12P19/32
摘要： The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (ATPS) and adenosine 5′-phosphosulfate kinase (APSK), wherein an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP.
摘要翻译：本发明提供了一种制备3'-磷酸腺苷5'-磷酸硫酸（PAPS）的方法，该方法包括使用腺苷5'-三磷酸硫酸化酶（ATPS）和腺苷5'-磷酸硫酸激酶（APSK）对ATP进行硫酸化和磷酸化，，其中包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和多磷酸盐：AMP磷酸转移酶（PAP）的腺苷5'-三磷酸（ATP）供应/再生系统，或使用包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和腺苷酸激酶（ADK）的腺苷5'-三磷酸（ATP）供应/再生系统代替ATP。

10. 发明申请

US20090181362A1 METHOD FOR DETERMINATION OF RECOGNITION SPECIFICITY OF VIRUS FOR RECEPTOR SUGAR CHAIN 审中-公开
标题翻译：用于确定受体糖链的病毒识别特异性的方法
公开(公告)号：US20090181362A1
公开(公告)日：2009-07-16
申请号：US12065469
申请日：2006-08-29
申请人： Yasuo Suzuki , Akira Asai , Takashi Suzuki , Kazuya Hidari , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
发明人： Yasuo Suzuki , Akira Asai , Takashi Suzuki , Kazuya Hidari , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
IPC分类号： C12Q1/70 , C07H7/02
CPC分类号： G01N33/548 , G01N33/56983
摘要： A method is provided in which the recognition specificity of a virus for a receptor sugar chain can be easily determined with a simple instrument or apparatus. This method for determining the recognition specificity of a virus for a receptor sugar chain or for determining the change in a host infected in accordance with the mutation of virus includes the steps of bringing a sample of the virus into contact with a support having a polymer with sialo-oligosaccharide immobilized on the surface thereof; and assaying the degree of binding therein to determine the recognition specificity of the virus for the receptor sugar chain and to determine the change in a host range. The method is suitable for the surveillance of a virus.
摘要翻译：提供了一种方法，其中可以用简单的仪器或装置容易地确定病毒对受体糖链的识别特异性。用于确定病毒对受体糖链的识别特异性或用于根据病毒突变确定受感染宿主的变化的方法包括以下步骤：使病毒样品与具有聚合物的载体接触唾液酸寡糖固定在其表面上; 并测定其中的结合程度以确定病毒对受体糖链的识别特异性并确定宿主范围的变化。该方法适用于病毒监控。

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