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1. 发明授权

US06287819B1 Process for producing uridine diphosphate-n-acetylglucosamine 失效
标题翻译：生产尿苷二磷酸正乙酰葡糖胺的方法
公开(公告)号：US06287819B1
公开(公告)日：2001-09-11
申请号：US09297306
申请日：1999-04-29
申请人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
发明人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12P1930
CPC分类号： C12N9/1205 , C12P19/305
摘要： A process for producing uridine diphosphate-N-acetylglucosamine (UDPAG) from uridylic acid (UMP) and N-acetylglucosamine by use of microorganism cells, characterized by adding N-acetylglucosamine kinase thereto. According to the present invention, UDPAG can be efficiently produced even when N-acetylglucosamine is used as a substrate.
摘要翻译：通过使用微生物细胞从尿苷酸（UMP）和N-乙酰葡糖胺生产尿苷二磷酸-N-乙酰氨基葡萄糖（UDPAG）的方法，其特征在于向其中加入N-乙酰葡糖胺激酶。根据本发明，即使使用N-乙酰氨基葡糖作为底物，也能够有效地制造UDPAG。

2. 发明授权

US08728789B2 DNA fragment encoding a polyphosphate-driven nucleoside 5′-diphosphate kinase polypeptide 有权
标题翻译：编码多磷酸盐驱动的核苷5'-二磷酸激酶多肽的DNA片段
公开(公告)号：US08728789B2
公开(公告)日：2014-05-20
申请号：US11814700
申请日：2006-01-24
申请人： Kazuya Ishige , Toshitada Noguchi
发明人： Kazuya Ishige , Toshitada Noguchi
IPC分类号： C12N9/12 , C12N5/00 , C12N5/04 , C12N1/20 , C12N1/00 , C12N1/12 , C07H21/02 , C07H21/04
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/1241 , C12P19/32
摘要： The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (ATPS) and adenosine 5′-phosphosulfate kinase (APSK), wherein an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP.
摘要翻译：本发明提供了制备3'-磷酸腺苷5'-磷酸硫酸（PAPS）的方法，该方法包括使用腺苷5'-三磷酸硫酸化酶（ATPS）和腺苷5'-磷酸硫酸激酶（APSK）对ATP进行硫酸化和磷酸化，，其中包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和多磷酸盐：AMP磷酸转移酶（PAP）的腺苷5'-三磷酸（ATP）供应/再生系统，或使用包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和腺苷酸激酶（ADK）的腺苷5'-三磷酸（ATP）供应/再生系统代替ATP。

3. 发明申请

US20090215114A1 METHOD OF ENZYMATICALLY SYNTHESIZING 3' -PHOSPHOADENOSINE-5' -PHOSPHOSULFATE 有权
标题翻译：精氨酸合成3'-磷酰基-5'-磷酸脂肪酸酯的方法
公开(公告)号：US20090215114A1
公开(公告)日：2009-08-27
申请号：US11814700
申请日：2006-01-24
申请人： Kazuya Ishige , Toshitada Noguchi
发明人： Kazuya Ishige , Toshitada Noguchi
IPC分类号： C12P21/02 , C07H21/04 , C12P19/32 , C12N9/12
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/1241 , C12P19/32
摘要： The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (ATPS) and adenosine 5′-phosphosulfate kinase (APSK), wherein an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP.
摘要翻译：本发明提供了一种制备3'-磷酸腺苷5'-磷酸硫酸（PAPS）的方法，该方法包括使用腺苷5'-三磷酸硫酸化酶（ATPS）和腺苷5'-磷酸硫酸激酶（APSK）对ATP进行硫酸化和磷酸化，，其中包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和多磷酸盐：AMP磷酸转移酶（PAP）的腺苷5'-三磷酸（ATP）供应/再生系统，或使用包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和腺苷酸激酶（ADK）的腺苷5'-三磷酸（ATP）供应/再生系统代替ATP。

4. 发明授权

US07863438B2 Stable salt of 3′-phosphoadenosine 5′-phosphosulfate 有权
标题翻译： 3'-磷酸腺苷5'-磷酸硫酸盐的稳定盐
公开(公告)号：US07863438B2
公开(公告)日：2011-01-04
申请号：US12093743
申请日：2006-11-16
申请人： Kazuya Ishige , Takashi Kawakami , Toshitada Noguchi
发明人： Kazuya Ishige , Takashi Kawakami , Toshitada Noguchi
IPC分类号： C07H19/22
CPC分类号： C07H19/20
摘要： The present invention provides a stable salt of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) and a production method therefor.The present invention is directed to a stable salt of PAPS (amine salt), which is formed between PAPS and an amine compound, and to a method for producing a stable salt of PAPS, which includes adding an amine compound to an aqueous PAPS solution in an amount by mole equal to or greater than that of PAPS, and lyophilizing the resultant solution.The present invention has first realized production of a solid-form PAPS salt having considerably improved stability through a very simple technique. Since the thus-produced amine salt of PAPS is very stable, the salt can be stored or employed without taking much care about decomposition thereof at ambient temperature.
摘要翻译：本发明提供稳定的3'-磷酸腺苷5'-磷酸硫酸盐（PAPS）及其制备方法。本发明涉及在PAPS和胺化合物之间形成的PAPS（胺盐）的稳定盐，以及PAPS稳定盐的制备方法，其包括向PAPS水溶液中加入胺化合物摩尔量等于或大于PAPS的量，并冻干所得溶液。本发明首先通过非常简单的技术实现了具有显着提高的稳定性的固体PAPS盐的生产。由于如此制得的PAPS胺盐非常稳定，所以可以在不在室温下分解的情况下储存或使用该盐。

5. 发明申请

US20090118491A1 STABLE SALT OF 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE 有权
标题翻译：稳定的3'-磷酸腺苷5'-磷酸肌酸盐
公开(公告)号：US20090118491A1
公开(公告)日：2009-05-07
申请号：US12093743
申请日：2006-11-16
申请人： Kazuya Ishige , Takashi Kawakami , Toshitada Noguchi
发明人： Kazuya Ishige , Takashi Kawakami , Toshitada Noguchi
IPC分类号： C07H19/20
CPC分类号： C07H19/20
摘要： The present invention provides a stable salt of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) and a production method therefor.The present invention is directed to a stable salt of PAPS (amine salt), which is formed between PAPS and an amine compound, and to a method for producing a stable salt of PAPS, which includes adding an amine compound to an aqueous PAPS solution in an amount by mole equal to or greater than that of PAPS, and lyophilizing the resultant solution.The present invention has first realized production of a solid-form PAPS salt having considerably improved stability through a very simple technique. Since the thus-produced amine salt of PAPS is very stable, the salt can be stored or employed without taking much care about decomposition thereof at ambient temperature.
摘要翻译：本发明提供稳定的3'-磷酸腺苷5'-磷酸硫酸盐（PAPS）及其制备方法。本发明涉及在PAPS和胺化合物之间形成的PAPS（胺盐）的稳定盐，以及PAPS稳定盐的制备方法，其包括向PAPS水溶液中加入胺化合物摩尔量等于或大于PAPS的量，并冻干所得溶液。本发明首先通过非常简单的技术实现了具有显着提高的稳定性的固体PAPS盐的生产。由于如此制得的PAPS胺盐非常稳定，所以盐可以在环境温度下储存或使用而不用担心其分解。

6. 发明授权

US5968783A Process for the preparation of sugar nucleotides 失效
标题翻译：制备糖核苷酸的方法
公开(公告)号：US5968783A
公开(公告)日：1999-10-19
申请号：US43175
申请日：1998-03-16
申请人： Kazuya Ishige , Kenji Takenouchi
发明人： Kazuya Ishige , Kenji Takenouchi
IPC分类号： C12P19/30 , C12N1/18 , C12P19/00 , C12P19/28
CPC分类号： C12P19/30
摘要： The present invention relates to a process for preparing sugar nucleotides from nucleotides and sugar derivatives by the use of yeast, characterized in that the reactions are conducted at 20.degree. C. or below. According to this process, even when the preparation is conducted on an enlarged scale, a reduction in the yield of a sugar nucleotide can be inhibited by a very simple means; lowering the reaction temperature 20.degree. C. or below. Thus, the process is an extremely practical one applicable to the mass-production of sugar nucleotides.
摘要翻译： PCT No.PCT / JP97 / 02387第 371日期：1998年3月16日 102（e）1998年3月16日PCT 1997年7月10日PCT公布。第WO98 / 02566号公报日期1998年1月22日本发明涉及通过使用酵母从核苷酸和糖衍生物制备糖核苷酸的方法，其特征在于反应在20℃以下进行。根据该方法，即使在制剂进行扩大的情况下，也可以通过非常简单的手段抑制糖核苷酸的收率降低; 降低反应温度20℃以下。因此，该方法是适用于大量生产糖核苷酸的非常实用的方法。

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