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1. 发明授权

US08466290B2 STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient 有权
标题翻译：含有喹啉甲酰胺衍生物的STAT3抑制剂作为活性成分
公开(公告)号：US08466290B2
公开(公告)日：2013-06-18
申请号：US13003441
申请日：2009-07-10
申请人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Takane Yokotagawa , Osamu Takahashi , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
发明人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Takane Yokotagawa , Osamu Takahashi , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
IPC分类号： C07D215/38
CPC分类号： C07D401/12 , A61K31/4709 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like), or a pharmacologically acceptable salt thereof.
摘要翻译：本发明提供含有作为活性成分的式（I）所示的喹啉甲酰胺衍生物的STATS抑制剂（式中，W表示键或亚烷基链; X表示O，S或NR34; R1〜R8 和R 34各自表示H，卤素，烷基，苯基，呋喃基，噻吩基等）或其药理学上可接受的盐。

2. 发明申请

US20120302524A1 1,3,4-OXADIAZOLE-2-CARBOXAMIDE COMPOUND 有权
标题翻译： 1,3,4-氧杂氮杂-2-羧酰胺化合物
公开(公告)号：US20120302524A1
公开(公告)日：2012-11-29
申请号：US13519707
申请日：2010-12-28
申请人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Osamu Takahashi , Yoshiaki Masuda , Ayumu Muroya , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
发明人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Osamu Takahashi , Yoshiaki Masuda , Ayumu Muroya , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
IPC分类号： A61K31/4245 , C07D413/14 , A61K31/4439 , C07F7/10 , A61K31/695 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/4709 , A61K31/498 , C07D513/04 , A61K31/4545 , A61K31/541 , A61K31/437 , C07D487/04 , A61K31/55 , A61P35/00 , C07D413/04
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D498/04 , C07D513/04
摘要： Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).
摘要翻译：提供具有STAT3抑制活性并可用作抗癌剂的1,3,4-恶二唑-2-甲酰胺化合物。提供由式（I）表示的1,3,4-恶二唑-2-甲酰胺化合物或其药学上可接受的盐（在该式中，Ar表示呋喃基等; R 1表示氢原子等; -X-Y表示二苯基等二芳基）。

3. 发明授权

US07676350B2 Optimum design method and apparatus, and program for the same 失效
标题翻译：最佳设计方法和设备，以及相同的程序
公开(公告)号：US07676350B2
公开(公告)日：2010-03-09
申请号：US11778367
申请日：2007-07-16
申请人： Teruyoshi Washizawa , Akira Asai , Masayoshi Tachihara , Katsuhiko Sinjo , Nobuhiro Yoshikawa
发明人： Teruyoshi Washizawa , Akira Asai , Masayoshi Tachihara , Katsuhiko Sinjo , Nobuhiro Yoshikawa
IPC分类号： G06F17/50 , G06G7/48
CPC分类号： G06F17/11
摘要： In an optimum design method comprising a first solution determining step of solving an optimization problem of a first evaluation function for a state variable vector with a design variable vector being as a parameter, and a second solution determining step of solving an optimization problem of a second evaluation function for the design variable vector and the state variable vector thus obtained, the second solution determining step includes the steps of computing a gradient vector of the second evaluation function for the design variable vector, computing a first coefficient based on a value of a norm of the gradient vector, computing a search vector based on the first coefficient, computing a second coefficient, and updating the design variable vector based on the second coefficient. The second coefficient computing step includes the first solution determining step, the first solution determining step is executed as an iterative method based on the gradient vector, and the state variable vector is not initialized during iteration. The optimum design method is precisely adaptable for structural changes.
摘要翻译：一种最优设计方法，包括：第一解决方案确定步骤，用于以设计变量向量作为参数来求解用于状态变量向量的第一评估函数的优化问题;以及第二解决方案确定步骤，用于求解第二第二解决方案确定步骤包括以下步骤：计算用于设计变量向量的第二评估函数的梯度向量，基于规范的值计算第一系数;对于设计变量向量和状态变量向量的评估函数，的梯度向量，基于第一系数计算搜索向量，计算第二系数，并且基于第二系数更新设计变量向量。第二系数计算步骤包括第一解决方案确定步骤，基于梯度向量作为迭代方法执行第一解决方案确定步骤，并且在迭代期间不初始化状态变量向量。最佳设计方法适用于结构变化。

4. 发明申请

US20090269734A1 METHOD FOR DETERMINATION OF RECOGNITION SPECIFICITY OF VIRUS FOR RECEPTOR SUGAR CHAIN 审中-公开
标题翻译：用于确定受体糖链的病毒识别特异性的方法
公开(公告)号：US20090269734A1
公开(公告)日：2009-10-29
申请号：US12427636
申请日：2009-04-21
申请人： Yasuo SUZUKI , Akira Asai , Takashi Suzuki , Ilpal Jwa , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
发明人： Yasuo SUZUKI , Akira Asai , Takashi Suzuki , Ilpal Jwa , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
IPC分类号： C12Q1/70 , C07K9/00 , C12P19/18
CPC分类号： G01N33/548 , G01N33/56983
摘要： A method in which the recognition specificity of a virus for a receptor sugar chain can be easily determined with a simple instrument or apparatus is provided. In a method for determining the recognition specificity of a virus for a receptor sugar chain or for determining the change in a host infected in accordance with the mutation of virus comprising, a sample of the virus is brought into contact with a support having a polymer with sialo-oligosaccharide immobilized on the surface thereof; and the degree of binding therein is assayed to determine the recognition specificity of said virus for said receptor sugar chain and to determine the change in a host range. The method is suitable for the surveillance of virus.
摘要翻译：提供了利用简单的仪器或装置容易地确定病毒对受体糖链的识别特异性的方法。在用于确定受体糖链病毒的识别特异性或根据病毒突变感染的宿主的变化的方法中，使病毒样品与具有聚合物的载体接触，唾液酸寡糖固定在其表面上; 并测定其中的结合程度以确定所述病毒对所述受体糖链的识别特异性并确定宿主范围的变化。该方法适用于病毒监控。

5. 发明授权

US07587375B2 Optimization method and optimization apparatus 失效
标题翻译：优化方法和优化装置
公开(公告)号：US07587375B2
公开(公告)日：2009-09-08
申请号：US11075593
申请日：2005-03-09
申请人： Akira Asai , Shigeki Matsutani , Katsuhiko Shinjo , Masanori Kuroda , Daichi Tsutsumi
发明人： Akira Asai , Shigeki Matsutani , Katsuhiko Shinjo , Masanori Kuroda , Daichi Tsutsumi
IPC分类号： G06E1/00 , G06E3/00 , G06G7/00
CPC分类号： G06F17/11
摘要： The solution of a constrained optimization problem is easily solved by linearly approximating a point of interest to a first hypersurface given as a constraint and finding the extreme value of the objective function by moving a point r along a curved line having second-order osculation with the geodetic line of a hypersurface S(r)=c and passing through the point r.
摘要翻译：约束优化问题的解可以通过线性近似给定为约束的第一超曲面的兴趣点来容易地解决，并且通过沿着具有二阶交调的曲线沿着具有二阶交变的曲线移动点r来找到目标函数的极值超表面S（r）= c并通过点r的大地测量线。

6. 发明申请

US20090181362A1 METHOD FOR DETERMINATION OF RECOGNITION SPECIFICITY OF VIRUS FOR RECEPTOR SUGAR CHAIN 审中-公开
标题翻译：用于确定受体糖链的病毒识别特异性的方法
公开(公告)号：US20090181362A1
公开(公告)日：2009-07-16
申请号：US12065469
申请日：2006-08-29
申请人： Yasuo Suzuki , Akira Asai , Takashi Suzuki , Kazuya Hidari , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
发明人： Yasuo Suzuki , Akira Asai , Takashi Suzuki , Kazuya Hidari , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
IPC分类号： C12Q1/70 , C07H7/02
CPC分类号： G01N33/548 , G01N33/56983
摘要： A method is provided in which the recognition specificity of a virus for a receptor sugar chain can be easily determined with a simple instrument or apparatus. This method for determining the recognition specificity of a virus for a receptor sugar chain or for determining the change in a host infected in accordance with the mutation of virus includes the steps of bringing a sample of the virus into contact with a support having a polymer with sialo-oligosaccharide immobilized on the surface thereof; and assaying the degree of binding therein to determine the recognition specificity of the virus for the receptor sugar chain and to determine the change in a host range. The method is suitable for the surveillance of a virus.
摘要翻译：提供了一种方法，其中可以用简单的仪器或装置容易地确定病毒对受体糖链的识别特异性。用于确定病毒对受体糖链的识别特异性或用于根据病毒突变确定受感染宿主的变化的方法包括以下步骤：使病毒样品与具有聚合物的载体接触唾液酸寡糖固定在其表面上; 并测定其中的结合程度以确定病毒对受体糖链的识别特异性并确定宿主范围的变化。该方法适用于病毒监控。

7. 发明授权

US07349936B2 Interpolation method, apparatus for carrying out the method, and control program for implementing the method 失效
标题翻译：插值方法，执行方法的装置以及用于实现该方法的控制程序
公开(公告)号：US07349936B2
公开(公告)日：2008-03-25
申请号：US10632136
申请日：2003-07-31
申请人： Akira Asai , Shigeki Matsutani
发明人： Akira Asai , Shigeki Matsutani
IPC分类号： G06F7/38
CPC分类号： G06F17/175
摘要： There is provided an interpolation method for the Volume-of-Fluid (VOF) applied to a two-phase incompressible fluid, in particular, which makes it possible to cause time evolution of a shape-describing function based on the Volume-of-Fluid (VOF) method while preserving a sharpness of a shape described by the function. The method defines a function F on a one-dimensional structured grid formed on a one-dimensional real region, the function being defined through definition of a value thereof at a center of each cell within the one-dimensional structured grid, as an interpolation function H. With respect to a cell of interest on the one-dimensional structured grid, a slope is set to zero if a forward difference and a backward difference of the function f have different signs, and to a value twice as large as a smaller one of absolute values of the forward difference and the backward difference if the forward difference and the backward difference have the same sign. The function F on a partial region of the one-dimensional real region determined by the cell of interest is defined by a linear function having a value of F0 at a center of the cell of interest and the slope.
摘要翻译：提供了一种应用于两相不可压缩流体的流体流体（VOF）的插值方法，特别地，这可以使基于流体体积的形状描述函数的时间演化（VOF）方法，同时保持由该功能描述的形状的清晰度。该方法定义了在一维实体区域上形成的一维结构网格上的函数F，该函数通过在一维结构化网格内的每个单元的中心定义其值作为内插函数来定义对于一维结构化网格上的感兴趣的单元格，如果函数f的前向差和后向差具有不同的符号，则将斜率设置为零，并且将其设置为与小的两倍大的值如果正向差和后向差具有相同的符号，则前向差和后向差的绝对值。由感兴趣单元确定的一维实际区域的部分区域上的函数F由在关注单元格的中心处具有值F0的线性函数和斜率来定义。

8. 发明授权

US07235830B2 Semiconductor device and process for manufacturing the same 失效
标题翻译：半导体装置及其制造方法
公开(公告)号：US07235830B2
公开(公告)日：2007-06-26
申请号：US11260197
申请日：2005-10-28
申请人： Haruyuki Sorada , Takeshi Takagi , Akira Asai , Akira Inoue
发明人： Haruyuki Sorada , Takeshi Takagi , Akira Asai , Akira Inoue
IPC分类号： H01L29/76
CPC分类号： H01L29/78696 , H01L21/76264 , H01L21/76281 , H01L29/1054 , H01L29/66742 , H01L29/78687 , Y10S438/933 , Y10S438/938
摘要： The present invention provides a semiconductor device comprising: a semiconductor layer (3); a gate electrode (11) formed on the semiconductor layer (3) via a gate insulation film (10); and a first insulation film (13) formed at one or more of sidewalls of the semiconductor layer (3), the gate insulation film (10) and the gate electrode (11); wherein the first insulation film (13) overlies a part of the gate insulation film (10) surface. According to the semiconductor device, leakage current at the isolation edge can be suppressed and thus reliability can be improved.
摘要翻译：本发明提供一种半导体器件，包括：半导体层（3）; 经由栅极绝缘膜（10）形成在所述半导体层（3）上的栅电极（11）; 以及形成在所述半导体层（3），所述栅极绝缘膜（10）和所述栅电极（11）的侧壁的一个或多个的第一绝缘膜（13）。其中所述第一绝缘膜（13）覆盖所述栅极绝缘膜（10）表面的一部分。根据半导体装置，可以抑制隔离边缘处的漏电流，从而可以提高可靠性。

9. 发明授权

US07203606B2 Information processing apparatus for numerically analyzing incompressible fluid and method therefor 失效
标题翻译：用于数值分析不可压缩流体的信息处理装置及其方法
公开(公告)号：US07203606B2
公开(公告)日：2007-04-10
申请号：US11275142
申请日：2005-12-15
申请人： Kota Nakano , Akira Asai
发明人： Kota Nakano , Akira Asai
IPC分类号： G01F17/00
CPC分类号： G06F17/5018 , G06F2217/16
摘要： During an incompressible fluid movement, three consecutive times during the movement of the fluid are called first, second, and third times in time order, calculation is performed with two different types of lattices for the first and third times and for the second time. Momentum and mass density at the first time are temporally developed to the third time in accordance with a conservation law by using an upwind velocity field. A pressure at the second time is determined so that a velocity field derived from momenta at the third time satisfies an incompressibility condition, and the field at the third time is corrected by adding a change in momentum caused by a pressure term using the determined pressure. This prevents pressure vibration and avoids the complexity of advective term calculation.
摘要翻译：在不可压缩的流体运动期间，在流体运动期间连续三次被称为第一次，第二次和第三次的时间顺序，对于第一次和第三次以及第二次以两种不同类型的格架进行计算。第一次的动量和质量密度通过使用逆风速度场根据守恒定律在时间上发展到第三次。确定第二次的压力使得从第三次的动量导出的速度场满足不可压缩条件，并且通过使用所确定的压力加上由压力项引起的动量变化来校正第三次的场。这可以防止压力振动，避免平流项计算的复杂性。

10. 发明授权

US07197486B2 Optimization method with constraints and apparatus therefor 失效
标题翻译：具有限制和优化方法的优化方法
公开(公告)号：US07197486B2
公开(公告)日：2007-03-27
申请号：US10192158
申请日：2002-07-11
申请人： Akira Asai , Shigeki Matsutani
发明人： Akira Asai , Shigeki Matsutani
IPC分类号： G06F7/10
CPC分类号： G06Q10/04 , Y10S706/919
摘要： In a method for determining a minimum value of an optimization function under constraints given by equations, a set of points which satisfy the constraints is regarded as a Riemannian manifold within a finite-dimensional real-vector space, the Riemannian manifold is approached from an initial position within the real-vector space. An exponential map regarding a geodesic line equation with respect to a tangent vector on the Riemannian manifold ends at a finite order, an approximate geodesic line is generated as a one-dimensional orbit. An approximate parallel-translation is performed on the tangent vector on the Riemannian manifold and on the orbit generated in the orbit generating step by finite-order approximation of the exponential map regarding the parallel translation of the tangent vector. By repeating the above-described procedure from the position at which a minimum value is given until the minimum value on the orbit converges, the solution of the optimization problem with constraints is determined using a simple calculation procedure.
摘要翻译：在用等式确定的约束条件下确定优化函数的最小值的方法中，满足约束的一组点被认为是有限维实空间中的黎曼流形，黎曼流形从初始在实数向量空间内的位置。关于黎曼流形上的切线向量的测地线方程的指数图以有限的顺序结束，生成近似测线，作为一维轨道。对黎曼流形上的切线向量和在轨道生成步骤中产生的轨道上的切线矢量进行近似平行平移，通过有限次逼近关于切线矢量的并行平移的指数图。通过从给出最小值的位置重复上述过程直到轨道上的最小值收敛，使用简单的计算过程来确定具有约束的优化问题的解。

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