专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08148112B2 Sugar chain containing 4-position halogenated galactose and application thereof 失效
标题翻译：含有4-位卤代半乳糖的糖链及其应用
公开(公告)号：US08148112B2
公开(公告)日：2012-04-03
申请号：US11815329
申请日：2006-02-14
申请人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
发明人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
IPC分类号： C12P19/50 , C12P19/52 , C12P19/26 , C07H15/00 , C07H5/04 , C07H5/06 , C08B37/00
CPC分类号： C12P19/32 , C07H15/08
摘要： The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (wherein X represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor. The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II): (wherein each of R1 to R3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase. The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.
摘要翻译：本发明涉及例如末端具有由式（I）表示的4位卤代半乳糖残基的寡糖：（其中X表示卤素原子，R表示单糖，寡糖或载体），含有寡糖的转移酶抑制剂，以及在糖基转移酶存在下抑制糖链延长反应的方法，该方法包括使用该抑制剂。本发明还提供了由式（II）表示的4-位卤代半乳糖糖核苷酸的制备方法：（式中，R 1〜R 3各自表示羟基，乙酰基，卤素原子或氢原子; X表示卤素原子; M表示氢离子或金属离子），其中该方法采用细菌来源的半乳糖激酶和细菌来源的己糖-1-磷酸尿苷酰转移酶。本发明还涉及设想用作药物和其它材料的4-位卤代半乳糖的糖链以及该化合物的应用。

2. 发明申请

US20090018327A1 SUGAR CHAIN CONTAINING 4-POSITION HALOGENATED GALACTOSE AND APPLICATION THEREOF 失效
标题翻译：含有4-位羟基糖的糖链及其应用
公开(公告)号：US20090018327A1
公开(公告)日：2009-01-15
申请号：US11815329
申请日：2006-02-14
申请人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
发明人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
IPC分类号： C07H5/02 , C12P19/30
CPC分类号： C12P19/32 , C07H15/08
摘要： The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (wherein X represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor.The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II): (wherein each of R1 to R3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase.The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.
摘要翻译：本发明涉及例如末端具有由式（I）表示的4-位卤代半乳糖残基的寡糖：（其中，X表示卤素原子，R表示单糖，寡糖，或载体），含有寡糖的转移酶抑制剂，以及在糖基转移酶存在下抑制糖链延长反应的方法，该方法包括使用该抑制剂。本发明还提供了由式（II）表示的4-位卤代半乳糖糖核苷酸的制备方法：（式中，R 1〜R 3各自表示羟基，乙酰基，卤素原子或氢原子; X表示卤素原子; M表示氢离子或金属离子），其中该方法采用细菌来源的半乳糖激酶和细菌来源的己糖-1-磷酸尿苷酰转移酶。本发明还涉及设想用作药物和其它材料的4-位卤代半乳糖的糖链以及该化合物的应用。

3. 发明申请

US20050170470A1 Process for producing 2'-deoxyguanosine 审中-公开
标题翻译：生产2'-脱氧鸟苷的方法
公开(公告)号：US20050170470A1
公开(公告)日：2005-08-04
申请号：US10500226
申请日：2002-12-20
申请人： Toshitada Noguchi , Tomoki Hamamoto , Kiyoshi Okuyama , Susumu Shibuya
发明人： Toshitada Noguchi , Tomoki Hamamoto , Kiyoshi Okuyama , Susumu Shibuya
IPC分类号： C12P19/40 , C07H5/06 , C12P19/30
CPC分类号： C12P19/40
摘要： The invention provides a process for producing 2′-deoxyguanosine, characterized in that the process includes reacting one compound selected from the group consisting of guanosine, guanosine 5′-monophosphate, and 2-amino-6-substituted purine with 2′-deoxynucleoside in the presence of nucleoside deoxyribosyl transferase and a hydrolase. According to the process of the present invention, 2′-deoxyguanosine can be synthesized efficiently from inexpensive and easily available starting materials. Since no guanosine, which disturbs purification, is virtually present in a reaction mixture, isolation and purification of 2′-deoxyguanosine can be performed in a very simple manner. Thus, the process for producing 2′-deoxyguanosine is practical.
摘要翻译：本发明提供了一种生产2'-脱氧鸟苷的方法，其特征在于该方法包括使选自鸟苷，鸟苷5'-单磷酸和2-氨基-6-取代嘌呤的一种化合物与2'-脱氧核苷一起反应存在核苷脱氧核糖基转移酶和水解酶。根据本发明的方法，可以从廉价且容易获得的起始材料中有效地合成2'-脱氧鸟苷。由于干扰净化的鸟苷实际上不存在于反应混合物中，所以可以以非常简单的方式进行2'-脱氧鸟苷的分离和纯化。因此，生产2'-脱氧鸟苷的方法是实用的。

4. 发明授权

US06287819B1 Process for producing uridine diphosphate-n-acetylglucosamine 失效
标题翻译：生产尿苷二磷酸正乙酰葡糖胺的方法
公开(公告)号：US06287819B1
公开(公告)日：2001-09-11
申请号：US09297306
申请日：1999-04-29
申请人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
发明人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12P1930
CPC分类号： C12N9/1205 , C12P19/305
摘要： A process for producing uridine diphosphate-N-acetylglucosamine (UDPAG) from uridylic acid (UMP) and N-acetylglucosamine by use of microorganism cells, characterized by adding N-acetylglucosamine kinase thereto. According to the present invention, UDPAG can be efficiently produced even when N-acetylglucosamine is used as a substrate.
摘要翻译：通过使用微生物细胞从尿苷酸（UMP）和N-乙酰葡糖胺生产尿苷二磷酸-N-乙酰氨基葡萄糖（UDPAG）的方法，其特征在于向其中加入N-乙酰葡糖胺激酶。根据本发明，即使使用N-乙酰氨基葡糖作为底物，也能够有效地制造UDPAG。

5. 发明授权

US08450441B2 Synthetic N-linked sialo-glycan-containing polymer and method for producing the same 失效
标题翻译：合成的N-连接唾液酸聚糖聚合物及其制备方法
公开(公告)号：US08450441B2
公开(公告)日：2013-05-28
申请号：US12666482
申请日：2008-06-24
申请人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
发明人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C08F251/00 , C07H15/06 , C12Q1/70
CPC分类号： C08G69/48 , A61K31/7012 , A61K47/645 , C08G69/04 , C08G69/10 , C08G69/40
摘要： A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.)
摘要翻译：一种含有N-连接的唾液酸聚糖的聚合物，其中使用一端具有氨基的化合物和另一端的羧基并由结构式（I）表示的唾液酸聚糖与γ-聚谷氨酸缩合，。式（I）（式中，Z表示羟基或式（II）表示的残基，n表示10以上的整数，条件是Z中的任一个以上可以由式（II）中，式（II）（式中，X表示羟基或乙酰氨基，Y1和Y2表示羟基或N-乙酰神经氨酸残基，L表示烃，m表示0 或1或2的整数，条件是Y1和Y2不相同。）

6. 发明授权

US06890739B1 Use of uridine diphosphate glucose 4-epimerase 有权
标题翻译：使用尿苷二磷酸葡萄糖4-差向异构酶
公开(公告)号：US06890739B1
公开(公告)日：2005-05-10
申请号：US10130785
申请日：2000-11-22
申请人： Tomoki Hamamoto , Toshitada Noguchi
发明人： Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12N9/90 , C12P19/30 , C12P19/38
CPC分类号： C12P19/305 , C12N9/90
摘要： The present invention relates to a new use of uridine diphosphate glucose 4-epimerase (also called uridine diphosphate galactose 4-epimerase), and a method of converting uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to uridine diphosphate N-acetylgalactosamine (UDP-GalNAc) by using the said enzyme. The process for producing UDP-GalNAc by using the uridine diphosphate glucose 4-epimerase and the UDP-GalNAc supply system according to the present invention are practical and efficient, and greatly beneficial to the industries.
摘要翻译：本发明涉及尿苷二磷酸葡萄糖4-差向异构酶（也称为尿苷二磷酸半乳糖4-差向异构酶）的新用途，以及将尿苷二磷酸N-乙酰葡糖胺（UDP-GlcNAc）转化为尿苷二磷酸N-乙酰半乳糖胺（UDP- GalNAc）。通过使用本发明的尿苷二磷酸葡萄糖4-差向异构酶和UDP-GalNAc供给系统生产UDP-GalNAc的方法是实用和有效的，对工业有很大的益处。

7. 发明授权

US6040158A Process for preparing sugar nucleotide 失效
标题翻译：制备糖核苷酸的方法
公开(公告)号：US6040158A
公开(公告)日：2000-03-21
申请号：US68198
申请日：1998-05-05
申请人： Kenji Takenouchi , Tomoki Hamamoto , Toshitada Noguchi
发明人： Kenji Takenouchi , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12P19/30 , C12P19/00 , C12P19/26 , C12P19/32 , C12P19/40
CPC分类号： C12P19/30 , C12P19/305
摘要： A process for preparing a sugar nucleotide from a nucleotide by using a yeast cell, characterized in that both a nucleoside diphosphate-sugar pyrophosphorylase and a sugar 1-phosphate are present in the reaction system. According to this process, various sugar nucleotides, which have been prepared only in low productivity by the conventional yeast cell process, can be efficiently prepared.
摘要翻译： PCT No.PCT / JP97 / 03021 Sec。 371日期：1998年5月5日 102（e）日期1998年5月5日PCT 1997年8月29日PCT公布。公开号WO98 / 11248 日期：1998年3月19日一种通过使用酵母细胞从核苷酸制备糖核苷酸的方法，其特征在于在反应体系中存在核苷二磷酸 - 糖焦磷酸化酶和糖1-磷酸二糖。根据该方法，可以有效地制备通过常规酵母细胞过程仅以低生产率制备的各种糖核苷酸。

8. 发明授权

US07955825B2 Process for producing CMP-N-acetylneuraminic acid 失效
标题翻译：制备CMP-N-乙酰神经氨酸的方法
公开(公告)号：US07955825B2
公开(公告)日：2011-06-07
申请号：US10521576
申请日：2003-01-15
申请人： Toshitada Noguchi , Tomoki Hamamoto
发明人： Toshitada Noguchi , Tomoki Hamamoto
IPC分类号： C12P7/40
CPC分类号： C12N9/1241 , C12N9/88 , C12N9/90 , C12P19/305
摘要： The present invention is directed to a process for producing CMP-N-acetylneuraminic acid (CMP-NeuAc), comprising adding to the cultured E. coli cells which has been transformed with both the DNA encoding N-acetylglucosamine-6-phosphate 2-epimerase (GlcNAc-6P 2-epimerase) and the DNA encoding N-acetylneuraminic acid synthase (NeuAc synthase) and exhibit activities of N-acetylglucosamine-6-phosphate 2-epimerase and N-acetylneuraminic acid synthase, a phosphate buffer containing baker's yeast cells, CMP, N-acetylglucosamine (GlcNAc), magnesium, xylene, glucose, and CMP-N-acetylneuraminic acid synthase (CMP-NeuAc synthase) to provide a reaction mixture, and allowing the reaction to proceed and produce CMP-N-acetylneuraminic acid (CMP-NeuAc), and wherein the process does not require adding ATP.
摘要翻译：本发明涉及一种生产CMP-N-乙酰神经氨酸（CMP-NeuAc）的方法，其包括将已经用编码N-乙酰葡糖胺-6-磷酸2-差向异构酶的DNA转化的培养的大肠杆菌细胞（GlcNAc-6P 2-差向异构酶）和编码N-乙酰神经氨酸合酶（NeuAc合酶）的DNA，并显示N-乙酰葡糖胺-6-磷酸2-差向异构酶和N-乙酰神经氨酸合酶（含有面包酵母细胞的磷酸盐缓冲液）的活性， CMP，N-乙酰氨基葡萄糖（GlcNAc），镁，二甲苯，葡萄糖和CMP-N-乙酰神经氨酸合成酶（CMP-NeuAc合成酶）以提供反应混合物，并使反应进行并产生CMP- N-乙酰神经氨酸 CMP-NeuAc），并且其中该方法不需要加入ATP。

9. 发明申请

US20100168366A1 NOVEL SYNTHETIC N-LINKED SIALO-GLYCAN-CONTAINING POLYMER AND METHOD FOR PRODUCING THE SAME 失效
标题翻译：新型合成N-连接的含有糖的聚糖聚合物及其制造方法
公开(公告)号：US20100168366A1
公开(公告)日：2010-07-01
申请号：US12666482
申请日：2008-06-24
申请人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
发明人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C08F251/00
CPC分类号： C08G69/48 , A61K31/7012 , A61K47/645 , C08G69/04 , C08G69/10 , C08G69/40
摘要： A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.)
摘要翻译：一种含有N-连接的唾液酸聚糖的聚合物，其中唾液酸聚糖用一端具有氨基和另一端的羧基并由结构式（I）表示的化合物缩合成γ-聚谷氨酸，。式（I）（式中，Z表示羟基或式（II）表示的残基，n表示10以上的整数，条件是Z中的任一个以上可以由式（II）中，式（II）（式中，X表示羟基或乙酰氨基，Y1和Y2表示羟基或N-乙酰神经氨酸残基，L表示烃，m表示0 或1或2的整数，条件是Y1和Y2不相同。）

10. 发明申请

US20080070285A1 Process for Producing Cmp-N-Acetylneuraminic Acid 失效
标题翻译：生产Cmp-N-乙酰神经氨酸的方法
公开(公告)号：US20080070285A1
公开(公告)日：2008-03-20
申请号：US10573385
申请日：2004-09-21
申请人： Tomoki Hamamoto , Kuniaki Nagaoka , Toshitada Noguchi
发明人： Tomoki Hamamoto , Kuniaki Nagaoka , Toshitada Noguchi
IPC分类号： C12P19/02
CPC分类号： C12P19/385 , C12P19/305
摘要： A method by which high-purity CMP-N-acetylneuraminic acid (HPLC purity, 95% or higher), which has been difficult to obtain with any technique other than chromatography, can be easily obtained in satisfactory yield by a simple operation without the need of chromatography. The process, which is for producing high-purity CMP-N-acetylneuraminic acid (CMP-NeuAc), is characterized by conducting a suitable combination of the following steps (1) to (4). Step 1: a step in which divalent cations are added to a solution containing CMP-NeuAc to thereby precipitate the phosphoric acid, pyrophosphoric acid, and nucleotide which coexist; Step 2: a step in which a phosphatase is added to a solution containing CMP-NeuAc to thereby convert the coexistent nucleotide into nucleoside; Step 3: a step in which an organic solvent is added to precipitate the CMP-NeuAc; and Step 4: a step in which the CMP-NeuAc precipitated is recovered.
摘要翻译：可以通过简单的操作容易地以令人满意的产率获得用色谱法以外的任何技术难以获得的高纯度CMP-N-乙酰神经氨酸（HPLC纯度，95％或更高）的方法，而不需要的色谱。用于生产高纯度CMP-N-乙酰神经氨酸（CMP-NeuAc）的方法的特征在于进行以下步骤（1）至（4）的适当组合。步骤1：将二价阳离子加入到含有CMP-NeuAc的溶液中以沉淀磷酸，焦磷酸和共存的核苷酸的步骤; 步骤2：将含有CMP-NeuAc的溶液中加入磷酸酶，从而将共存核苷酸转化为核苷的步骤; 步骤3：加入有机溶剂沉淀CMP-NeuAc的步骤; 步骤4：回收沉淀的CMP-NeuAc的步骤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式