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    • 3. 发明授权
    • Tricyclic benzopyrane compound
    • 三环苯并吡喃化合物
    • US07964623B2
    • 2011-06-21
    • US12591353
    • 2009-11-17
    • Kazuhiko OhraiYukohiro ShigetaOsamu UesugiTakumi OkadaTomoyuki Matsuda
    • Kazuhiko OhraiYukohiro ShigetaOsamu UesugiTakumi OkadaTomoyuki Matsuda
    • A61K31/429C07D513/06
    • C07D513/04C07D491/04C07D515/04
    • This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.
    • 本发明涉及式(I)或(II)的苯并吡喃衍生物或其药学上可接受的盐,其中R1和R2彼此独立地为氢原子,C1-6烷基或C6-14芳基,R3为氢原子或C1- C 1-6烷基羰基氧基或与R 4一起形成键,R 4为氢原子,或与R 3一起形成键,m为0〜4的整数,n为0〜4的整数,V为单键,CR 7 R 8, NR9,O,S,SO或SO2,R5是氢原子或C1-6烷基,R6是氢原子,C1-6烷基,C3-8环烷基,C3-8环烯基,氨基,C1-6烷基氨基, C 1-6烷基氨基,C 6-14芳基氨基,C 2-9杂芳基氨基,C 6-14芳基,C 2-9杂芳基或C 2-9杂环基,A是与苯环稠合的5-,6-或7-元环作为构成原子 的环,氧原子,氮原子或硫原子可以单独或组合1〜3的数量包含在t中的不饱和键的数量 环是1,2或3,包括待稠合的苯环的不饱和键,构成环的碳原子可以是羰基或硫代羰基。 这些化合物可用作抗心律不齐剂。
    • 7. 发明申请
    • Tricyclic benzopyrane compound
    • 三环苯并吡喃化合物
    • US20100069374A1
    • 2010-03-18
    • US12591353
    • 2009-11-17
    • Kazuhiko OhraiYukohiro ShigetaOsamu UesugiTakumi OkadaTomoyuki Matsuda
    • Kazuhiko OhraiYukohiro ShigetaOsamu UesugiTakumi OkadaTomoyuki Matsuda
    • A61K31/542A61K31/5383A61K31/4985A61K31/519A61K31/436A61K31/429A61K31/424A61K31/4188A61K31/4162A61K31/407C07D513/04C07D498/04C07D491/052A61P9/06
    • C07D513/04C07D491/04C07D515/04
    • This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.
    • 本发明涉及式(I)或(II)的苯并吡喃衍生物或其药学上可接受的盐,其中R1和R2彼此独立地为氢原子,C1-6烷基或C6-14芳基,R3为氢原子或C1- C 1-6烷基羰基氧基或与R 4一起形成键,R 4为氢原子,或与R 3一起形成键,m为0〜4的整数,n为0〜4的整数,V为单键,CR 7 R 8, NR9,O,S,SO或SO2,R5是氢原子或C1-6烷基,R6是氢原子,C1-6烷基,C3-8环烷基,C3-8环烯基,氨基,C1-6烷基氨基, C 1-6烷基氨基,C 6-14芳基氨基,C 2-9杂芳基氨基,C 6-14芳基,C 2-9杂芳基或C 2-9杂环基,A是与苯环稠合的5-,6-或7-元环作为构成原子 的环,氧原子,氮原子或硫原子可以单独或组合1〜3的数量包含在t中的不饱和键的数量 环是1,2或3,包括待稠合的苯环的不饱和键,构成环的碳原子可以是羰基或硫代羰基。 这些化合物可用作抗心律不齐剂。
    • 8. 发明申请
    • SUBSTRATE PROCESSING APPARATUS
    • 基板加工设备
    • US20100050945A1
    • 2010-03-04
    • US12537017
    • 2009-08-06
    • Shinya MORITATakayuki NAKADATomoyuki MATSUDAKeisuke SAKASHITA
    • Shinya MORITATakayuki NAKADATomoyuki MATSUDAKeisuke SAKASHITA
    • C23C16/00
    • C23C16/4412
    • When a quartz part is placed on a floor, the inside of a furnace is not polluted by contaminants attached from the floor to a seal surface of the quartz part and entering the inside of the furnace. A substrate processing apparatus includes a reaction tube, a first joining surface, a second joining surface, and a third joining surface. The reaction tube includes a quartz inner tube and a quartz outer tube. The first joining surface is configured to air-tightly join the outer tube and a quartz manifold. The second joining surface is configured to air-tightly join the manifold and a quartz seal cover. The third joining surface is configured to air-tightly join the seal cover and a seal cap. An O-ring is installed at least one of the first, second, and third joining surfaces, and a protrusion is installed outside the O-ring installed at the jointing surface.
    • 当石英部件放置在地板上时,炉内部不会被从地板附着到石英部件的密封表面并进入炉内的污染物污染。 基板处理装置包括反应管,第一接合面,第二接合面和第三接合面。 反应管包括石英内管和石英外管。 第一接合表面构造成气密地连接外管和石英歧管。 第二接合表面构造成气密地连接歧管和石英密封盖。 第三连接表面构造成气密地连接密封盖和密封盖。 O形环安装在第一,第二和第三接合表面中的至少一个上,并且突起被安装在安装在接合表面处的O形环的外部。
    • 9. 发明申请
    • Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents
    • 三环苯并吡喃复合物作为抗心律不齐剂
    • US20080004262A1
    • 2008-01-03
    • US10590975
    • 2005-03-23
    • Kazuhiko OhraiYukohiro ShigetaOsamu UesugiTakumi OkadaTomoyuki Matsuda
    • Kazuhiko OhraiYukohiro ShigetaOsamu UesugiTakumi OkadaTomoyuki Matsuda
    • A61K31/436A61K31/403A61K31/495A61K31/517A61K31/538A61P9/06C07D209/56C07D221/02C07D235/02C07D241/36C07D265/38C07D515/12
    • C07D513/04C07D491/04C07D515/04
    • This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.
    • 本发明涉及式(I)或(II)的苯并吡喃衍生物或其药学上可接受的盐,其中R 1和R 2彼此独立地为氢原子,C C 1-6烷基或C 6-14芳基,R 3是氢原子或C 1-6 >烷基羰氧基,或与R 4连接形成键,R 4是氢原子,或与R 3 3一起形成键,m 为0〜4的整数,n为0〜4的整数,V为单键,CR 7,R 8,NR 9, >,O,S,SO或SO 2,R 5是氢原子或C 1-6烷基,R 6 C 1-6烷基,C 3-8环烷基,C 3-8环烯基,C 3-8环烷基,C 3-6环烷基, 氨基,C 1-6烷基氨基,二-C 1-6烷基氨基,C 6-14芳基氨基,C 2-9个杂芳基氨基,C 6-14-14芳基,C 2-9 - 杂芳基 A或C 2-9杂环基,A是与苯环稠合的5-,6-或7-元环,作为环的构成原子,氧原子,氮原子或硫原子可以 单独或以其组合存在1〜3的数量,环中的不饱和键数为1,2或3,包括要被稠合的苯环的不饱和键,构成环的碳原子可以是羰基 或硫代羰基。 这些化合物可用作抗心律不齐剂。