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1. 发明授权

US5645849A Hemostatic patch 失效
标题翻译：止血补片
公开(公告)号：US5645849A
公开(公告)日：1997-07-08
申请号：US487659
申请日：1995-06-07
申请人： Thaddeus P. Pruss , James A. Will
发明人： Thaddeus P. Pruss , James A. Will
IPC分类号： A61F13/00 , A61F13/02 , A61L15/44 , A61L15/58 , A61L15/64 , A61L24/00 , A61L26/00 , A61K9/70
CPC分类号： A61L26/009 , A61F13/0203 , A61L15/44 , A61L15/64 , A61L24/0015 , A61L24/0042 , A61F2013/00221 , A61F2013/00472 , A61L2300/418 , A61L2300/434 , A61L2400/04
摘要： A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl.sub.2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The EACA raises the pH of the acidic fluid associated with the wound and thereby accelerates the activation of the thrombin.
摘要翻译：在其表面具有止血剂作为止血剂的无纤维素底物可有效促进由凝血酶引起的血液凝固速度的促凝血量的凝血酶与ε氨基己酸（EACA）的量的混合物，作为止血补片是安全，便宜，并快速控制伤口出血。通过将凝血酶，EACA和CaCl 2施用于可生物降解的泡沫塑料的刚性片材，例如可吸收的明胶海绵，并压缩干燥片材以产生符合器官轮廓的柔性片材，而不需要预润湿。 EACA提高与伤口相关的酸性流体的pH值，从而加速凝血酶的活化。

2. 发明授权

US5643596A Hemostatic patch 失效
标题翻译：止血补片
公开(公告)号：US5643596A
公开(公告)日：1997-07-01
申请号：US474127
申请日：1995-06-07
申请人： Thaddeus P. Pruss , James A. Will
发明人： Thaddeus P. Pruss , James A. Will
IPC分类号： A61F13/00 , A61F13/02 , A61L15/44 , A61L15/58 , A61L15/64 , A61L24/00 , A61L26/00 , A61K9/70
CPC分类号： A61L26/009 , A61F13/0203 , A61L15/44 , A61L15/64 , A61L24/0015 , A61L24/0042 , A61F2013/00221 , A61F2013/00472 , A61L2300/418 , A61L2300/434 , A61L2400/04
摘要： A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl.sub.2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The problem associated with thrombin-fibrinogen glues of adhesion of the wounded surface of the organ to adjacent tissue is avoided by applying the hemostatic agent to only the wound-contacting face of the sheet.
摘要翻译：在其表面具有止血剂作为止血剂的无纤维素底物可有效促进由凝血酶引起的血液凝固速度的促凝血量的凝血酶与ε氨基己酸（EACA）的量的混合物，作为止血补片是安全，便宜，并快速控制伤口出血。通过将凝血酶，EACA和CaCl 2施用于可生物降解的泡沫塑料的刚性片材，例如可吸收的明胶海绵，并压缩干燥片材以产生符合器官轮廓的柔性片材，而不需要预润湿。通过将止血剂仅施加到片材的伤口接触面上来避免与器官的受伤表面对相邻组织的粘附的凝血酶 - 纤维蛋白原胶粘剂相关的问题。

3. 发明授权

US4918061A Method of preventing diseases caused by gram-negative endotoxin in mammals 失效
标题翻译：预防哺乳动物革兰氏阴性内毒素引起的疾病的方法
公开(公告)号：US4918061A
公开(公告)日：1990-04-17
申请号：US206994
申请日：1988-06-08
申请人： Christian R. H. Raetz , Richard A. Proctor , James A. Will
发明人： Christian R. H. Raetz , Richard A. Proctor , James A. Will
IPC分类号： A61K31/70 , C07H11/04 , C07H13/06 , C12P19/26
CPC分类号： C07H11/04 , A61K31/70 , C07H13/06 , C12P19/26
摘要： A method of treating animals to protect them from the toxic effects of gram-negative endotoxin comprises administering to said animals a safe and effective amount of a compound having lipid X activity.
摘要翻译：治疗动物以保护其免受革兰氏阴性内毒素的毒性作用的方法包括向所述动物施用安全有效量的具有脂质X活性的化合物。

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