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1. 发明申请

US20110104666A1 INSULIN RESISTANCE MARKER 审中-公开
标题翻译：胰岛素抵抗标记
公开(公告)号：US20110104666A1
公开(公告)日：2011-05-05
申请号：US12610977
申请日：2009-11-02
申请人： Toshiya Matsubara , Osamu NISHIMURA , Susumu Iwasa , Makoto Watanabe
发明人： Toshiya Matsubara , Osamu NISHIMURA , Susumu Iwasa , Makoto Watanabe
IPC分类号： C12Q1/68 , C07K7/08 , C07K14/00 , C12Q1/02 , C07K16/00 , C07H21/04
CPC分类号： C07K14/52 , C07K14/475 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N2500/04 , G01N2500/10 , G01N2800/042
摘要： It is provided an insulin resistance marker, a method of evaluating insulin resistance, a method of screening a substance that improves insulin resistance, and a pharmaceutical composition for improving insulin resistance. An insulin resistance marker including a polypeptide comprising at least any 15 continuous amino acids in the specific amino acid sequence (sequence of a proepithelin protein). An insulin resistance marker including a polynucleotide selected from the group consisting of a polynucleotide comprising at least any 45 continuous bases in the base sequence encoding the above specific amino acid sequence, and a polynucleotide that is complementary to the polynucleotide.
摘要翻译：本发明提供胰岛素抵抗标记，胰岛素抵抗评价方法，筛选改善胰岛素抵抗的物质的方法以及改善胰岛素抵抗的药物组合物。包括在特定氨基酸序列（前列腺素蛋白的序列）中包含至少15个连续氨基酸的多肽的胰岛素抵抗标记。包括选自包含编码上述特定氨基酸序列的碱基序列中至少任何45个连续碱基的多核苷酸的多核苷酸的多核苷酸和与该多核苷酸互补的多核苷酸的胰岛素抵抗标记。

2. 发明授权

US06482864B1 Sustained-release preparation of physiologically active polypeptide and production thereof 失效
标题翻译：生理活性多肽的缓释制剂及其制备
公开(公告)号：US06482864B1
公开(公告)日：2002-11-19
申请号：US09319023
申请日：1999-05-28
申请人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
发明人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
IPC分类号： A61K4732
CPC分类号： A61K9/1647 , A61K38/27 , Y10S514/964
摘要： A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the organic solvent, wherein the polypeptide is a powder obtained by lyophilizing an aqueous solution of the polypeptide which solution has a water-miscible organic solvent and/or a volatile salt; which improves the ease of handling of the physiologically active polypeptide powder in the process for producing the preparation; which makes it possible to industrially produce the sustained-release preparation in large scale; which provides a sustained-release preparation showing high and stable concentration of the active component in blood in long term, low initial release ratio of the physiologically active polypeptide, and high entrapment ratio of the polypeptide into the sustained-release preparation.
摘要翻译：一种缓释制剂的制备方法，其包括将生理活性多肽分散到生物可降解聚合物的有机溶剂溶液中并除去有机溶剂，其中所述多肽是通过将多肽溶液冻干得到的粉末水混溶性有机溶剂和/或挥发性盐; 这提高了在制备该制剂的过程中易于处理生理活性多肽粉末; 这使得可以大规模地工业生产缓释制剂; 其提供持续释放制剂，其显示出高生产活性多肽的长期，低的初始释放比例以及所述多肽进入缓释制剂的高滞留比，从而高效稳定血液中活性成分的浓度。

3. 发明授权

US5948773A Formulation comprising antibacterial substance and antiulcer substance 失效
标题翻译：制剂含抗菌物质和抗溃疡物质
公开(公告)号：US5948773A
公开(公告)日：1999-09-07
申请号：US863293
申请日：1997-05-27
申请人： Yohko Akiyama , Masafumi Nakao , Naoki Nagahara , Susumu Iwasa
发明人： Yohko Akiyama , Masafumi Nakao , Naoki Nagahara , Susumu Iwasa
IPC分类号： A61K9/16 , A61K9/32 , A61K9/50 , A61K9/58 , A61K31/43 , A61K31/44 , A61K45/06
CPC分类号： A61K45/06 , A61K31/43 , A61K31/44 , A61K9/1617 , A61K9/1635 , A61K9/5078 , A61K9/5084
摘要： The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal mucosa-adherent solid preparation. The formulation of the present invention shows long retention time in the gastrointestinal tract because of adhesion to the gastrointestinal tract mucosa, synergetically enhances the pharmaceutical effects of an antibacterial substance, specially antibiotic against Helicobacter pylori (HP) and an antiulcer substance, with very low doses of active ingredients, particularly the anti-HP antibiotic with low prevalence of side effects. The present agent is useful as an anti ulcer agent, showing potent anti-HP activity.
摘要翻译：本发明包括一种制剂，其包含抗菌物质和抗溃疡物质，其中至少任一种被配制成胃肠粘膜粘附固体制剂。本发明的制剂由于与胃肠道粘膜的粘附而在胃肠道中保留时间长，协同增强抗菌物质的药物作用，特别是针对幽门螺杆菌（HP）和抗溃疡物质的抗生素，具有非常低的剂量的活性成分，特别是副作用低的抗HP抗生素。本发明的药剂可用作抗溃疡剂，显示出有效的抗HP活性。

4. 发明授权

US5910492A Osteogenic promoting pharmaceutical composition 失效
标题翻译：成骨促进药物组成
公开(公告)号：US5910492A
公开(公告)日：1999-06-08
申请号：US719467
申请日：1996-09-25
申请人： Tetsuo Hoshino , Hiroya Muranishi , Shigehisa Taketomi , Susumu Iwasa
发明人： Tetsuo Hoshino , Hiroya Muranishi , Shigehisa Taketomi , Susumu Iwasa
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K47/26 , A61K47/36 , A61K31/67 , A61K31/66
CPC分类号： A61K31/683 , A61K9/0019 , A61K9/1647 , A61K47/26 , A61K47/36 , A61K9/2031
摘要： This invention provides a pharmaceutical composition comprising a non-peptide osteogenic promoting substance and a biodegradable polymer, which can be safely used as a prophylactic/therapeutic agent for various bone diseases (e.g., bone fractures).
摘要翻译：本发明提供了包含非肽成骨促进物质和生物可降解聚合物的药物组合物，其可以安全地用作各种骨疾病（例如骨折）的预防/治疗剂。

5. 发明授权

US06399103B1 Method of producing a sustained-release preparation 失效
标题翻译：缓释制剂的制备方法
公开(公告)号：US06399103B1
公开(公告)日：2002-06-04
申请号：US09712769
申请日：2000-11-14
申请人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
发明人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
IPC分类号： A61K700
CPC分类号： A61K38/27 , A61K9/143 , A61K9/146 , A61K9/1611 , A61K9/1647
摘要： A method of producing sustained-release microcapsules which comprises dispersing a physiologically active polypeptide into a solution of a biodegradable polymer and zinc oxide in an organic solvent, followed by removing the organic solvent; which provides a sustained-release preparation showing a high entrapment ratio of the physiologically active polypeptide and its constant high blood concentration levels over a long period of time.
摘要翻译：一种生产缓释微胶囊的方法，其包括将生理活性多肽分散在有机溶剂中的可生物降解的聚合物和氧化锌的溶液中，然后除去有机溶剂; 其提供在长时间内显示生理活性多肽的高滞留比和其恒定的高血药浓度水平的持续释放制剂。

6. 发明授权

US06197350B1 Method of producing a sustained-release preparation 失效
标题翻译：缓释制剂的制备方法
公开(公告)号：US06197350B1
公开(公告)日：2001-03-06
申请号：US09308971
申请日：1999-05-27
申请人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
发明人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
IPC分类号： A61F200
CPC分类号： A61K38/27 , A61K9/143 , A61K9/146 , A61K9/1611 , A61K9/1647
摘要： A method of producing sustained-release microcapsules which comprises dispersing a physiologically active polypeptide into a solution of a biodegradable polymer and zinc oxide in an organic solvent, followed by removing the organic solvent; which provides a sustained-release preparation showing a high entrapment ratio of the physiologically active polypeptide and its constant high blood concentration levels over a long period of time.
摘要翻译：一种生产缓释微胶囊的方法，其包括将生理活性多肽分散在有机溶剂中的可生物降解的聚合物和氧化锌的溶液中，然后除去有机溶剂; 其提供在长时间内显示生理活性多肽的高滞留比和其恒定的高血药浓度水平的持续释放制剂。

7. 发明授权

US06191107B1 Complex of human growth hormone and zinc 失效
标题翻译：人类生长激素和锌的复合物
公开(公告)号：US06191107B1
公开(公告)日：2001-02-20
申请号：US09151783
申请日：1998-09-11
申请人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
发明人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
IPC分类号： A61K3827
CPC分类号： A61K9/1647 , A61K38/27 , C07K14/61 , Y10S530/839
摘要： The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.
摘要翻译：本发明提供人体生长激素和含锌人体生长激素和锌的复合物，其摩尔比为约1:1.6至约1:2.4，以及包含人生长激素和锌的复合物的缓释制剂和可生物降解的聚合物，并且其具有高的人生长激素的截留比并表现出稳定的持续释放，抑制了初始爆发。

8. 发明授权

US5665570A Antibody-encoding recombinant DNA and its use 失效
标题翻译：抗体编码重组DNA及其用途
公开(公告)号：US5665570A
公开(公告)日：1997-09-09
申请号：US384545
申请日：1995-02-07
申请人： Hideo Yamagata , Shigezo Udaka , Yasushi Inoue , Hiroko Tada , Susumu Iwasa
发明人： Hideo Yamagata , Shigezo Udaka , Yasushi Inoue , Hiroko Tada , Susumu Iwasa
IPC分类号： C07K16/00 , C07K16/18 , C07K16/40 , C12N15/13 , C12N15/75 , C12P21/08 , C07H21/04 , C12N1/20
CPC分类号： C12N15/75 , C07K16/00 , C07K16/18 , C07K16/40 , C07K2319/00
摘要： A bacterium of the genus Bacillus is transformed by introducing a vector incorporating DNA encoding an antibody; the resulting transformant is cultivated in a medium to produce and accumulate the antibody in an active form in the culture liquid. According to this method, a recombinant antibody can be easily produced in an active form in large amounts, owing to success in secretory expression using a bacterium of the genus Bacillus.
摘要翻译：通过引入含有编码抗体的DNA的载体来转化芽孢杆菌属的细菌; 将所得转化体在培养基中培养，以活性形式产生并积累培养液中的抗体。根据该方法，由于使用芽孢杆菌属的细菌的分泌表达的成功，重组抗体可以大量容易地以活性形式产生。

9. 发明授权

US5506135A Hybrid monoclonal antibodies, their production and use 失效
标题翻译：混合单克隆抗体，其生产和使用
公开(公告)号：US5506135A
公开(公告)日：1996-04-09
申请号：US366366
申请日：1994-12-29
申请人： Susumu Iwasa , Tomofumi Kurokawa , Yukio Toyoda
发明人： Susumu Iwasa , Tomofumi Kurokawa , Yukio Toyoda
IPC分类号： A61K38/00 , A61K38/46 , A61K39/395 , A61K45/00 , A61K47/48 , C07K16/46 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , C12N5/18 , C07K16/36 , C07K16/40
CPC分类号： C07K16/468 , A61K47/4843 , A61K47/48676 , A61K38/00
摘要： The present invention provides a hybrid monoclonal antibody having specificities against fibrin and thrombolytic substance, a polydoma which produces said antibody and thrombolytic agent comprising said antibody and thrombolytic substance which is immunologically coupled thereto, and methods of using said antibody in combination with thrombolytic substance for lysis or removal of thrombi.
摘要翻译：本发明提供了具有纤维蛋白和溶栓物质特异性的杂交单克隆抗体，产生所述抗体的多核苷酸和包含所述抗体的血栓溶解剂和与其免疫相结合的溶栓物质，以及将所述抗体与溶栓物质组合使用的方法或去除血栓。

10. 发明授权

US5141736A Bispecific monoclonal antibody, its production and use 失效
标题翻译：双特异性单克隆抗体，其生产和使用
公开(公告)号：US5141736A
公开(公告)日：1992-08-25
申请号：US457343
申请日：1989-12-27
申请人： Susumu Iwasa , Kaori Harada , Yukio Toyoda
发明人： Susumu Iwasa , Kaori Harada , Yukio Toyoda
IPC分类号： A61K31/535 , A61K38/00 , A61K47/48 , C07K16/14 , C07K16/30 , C07K16/44 , C07K16/46 , C12P21/08
CPC分类号： A61K47/48384 , A61K31/535 , A61K47/48607 , A61K47/48676 , C07K16/14 , C07K16/3038 , C07K16/44 , C07K16/468 , A61K38/00 , Y10S435/972
摘要： The present invention discloses, a bispecific monoclonal antibody to an ansamitocin derivative and a target antigen, particularly tumor-associated antigen, which can carry an anasamitocin derivative in a stable and inactive form at other sites than the target and release the active-form ansamitocin derivative at the target site, so that an anticancer agent having excellent durability and selectivity with little adverse action can be prepared using the bispecific monoclonal antibody and ansamitocin derivatives.
摘要翻译：本发明公开了一种针对安沙霉素衍生物的双特异性单克隆抗体和靶抗原，特别是肿瘤相关抗原，其可以在比目标的其他位置携带稳定和无活性形式的阿沙米星衍生物，并释放活性形式的安曲霉素衍生物在目标部位，可以使用双特异性单克隆抗体和安曲霉素衍生物制备具有优异的耐久性和选择性，几乎没有不利作用的抗癌剂。

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