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1. 发明授权

US09193957B2 Engineered imine reductases and methods for the reductive animation of ketone and amine compounds 有权
标题翻译：酮和胺化合物的还原动力的工程亚胺还原酶和方法
公开(公告)号：US09193957B2
公开(公告)日：2015-11-24
申请号：US13890944
申请日：2013-05-09
申请人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/00 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/18
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译：本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法产品化合物。

2. 发明授权

US09057085B2 Lov-D acyltransferase mediated acylation 有权
标题翻译： Lov-D酰基转移酶介导的酰化
公开(公告)号：US09057085B2
公开(公告)日：2015-06-16
申请号：US13499364
申请日：2010-09-24
申请人： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
发明人： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
IPC分类号： C12P21/06 , C12N9/10 , C12P17/06 , C07K14/00 , C12P7/62
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译：提出了使用LovD酰基转移酶，具有酰基的硫酯和（i）硫醇清除剂和/或（ii）沉淀剂对化学底物改进酰化的方法。还提出了使用（i）活性炭作为硫醇清除剂和/或（ii）氢氧化铵作为沉淀剂来生产辛伐他汀的改进方法。

3. 发明授权

US08932836B2 Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine 有权
标题翻译：用于合成（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的生物催化剂和方法
公开(公告)号：US08932836B2
公开(公告)日：2015-01-13
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
IPC分类号： C12N9/10 , C12P13/00
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译：本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

4. 发明授权

US08334266B2 Process for and intermediates in the preparation of canfosfamide and its salts 有权
标题翻译：用于制备卡非司酮及其盐的方法和中间体
公开(公告)号：US08334266B2
公开(公告)日：2012-12-18
申请号：US13429065
申请日：2012-03-23
申请人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernandez Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
发明人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernandez Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
IPC分类号： A61K38/07 , C07K38/06
CPC分类号： C07K5/0205 , A61K38/00 , C07F9/2408 , C07F9/2458 , C07K5/0215 , C07K5/0606 , C07K5/06191
摘要： A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
摘要翻译：一种在制备头孢噻吩及其盐的过程和中间体。一些中间体具有抗癌活性。

5. 发明申请

US20120238772A1 PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS 有权
标题翻译：在制备氰氟虫及其盐的过程和中间体
公开(公告)号：US20120238772A1
公开(公告)日：2012-09-20
申请号：US13429065
申请日：2012-03-23
申请人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernández Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
发明人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernández Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
IPC分类号： C07F9/24 , C07C323/59
CPC分类号： C07K5/0205 , A61K38/00 , C07F9/2408 , C07F9/2458 , C07K5/0215 , C07K5/0606 , C07K5/06191
摘要： A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
摘要翻译：一种在制备头孢噻吩及其盐的过程和中间体。一些中间体具有抗癌活性。

6. 发明申请

US20120190086A1 KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS 有权
标题翻译：糖酸盐介质介导的选择性路线至ALPHA氯化醇
公开(公告)号：US20120190086A1
公开(公告)日：2012-07-26
申请号：US13378618
申请日：2010-06-22
申请人： Yong Koy Bong , Michael Vogel , Steven J. Collier , Vesna Mitchell , Jagadeesh Mavinahalli
发明人： Yong Koy Bong , Michael Vogel , Steven J. Collier , Vesna Mitchell , Jagadeesh Mavinahalli
IPC分类号： C12N9/04 , C12N15/63 , C12N1/21 , C12P17/02 , C12N1/19 , C12N5/10 , C12N15/53 , C12P13/02
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
摘要翻译：本公开涉及工程化酮还原酶多肽及其用于从α-氯代酮制备α-氯代醇的用途。还提供了编码工程化酮还原酶多肽和能够表达工程化酮还原酶多肽的宿主细胞的多核苷酸。

7. 发明授权

US06826499B2 Method and apparatus for calibrating and initializing an electronically commutated motor 有权
标题翻译：用于校准和初始化电子换向电机的方法和装置
公开(公告)号：US06826499B2
公开(公告)日：2004-11-30
申请号：US10232356
申请日：2002-08-30
申请人： Mark P. Colosky , Steven J. Collier-Hallman , Roy McCann , Phillip Weilhammer , James Charles Tallant, II
发明人： Mark P. Colosky , Steven J. Collier-Hallman , Roy McCann , Phillip Weilhammer , James Charles Tallant, II
IPC分类号： H02P118
CPC分类号： H02P6/20 , H02P6/182 , H02P2209/07
摘要： Disclosed herein is a method and system for initializing a rotating device such as an electronically commutated electric machine. The system comprises: an electric machine; a position sensor subsystem operatively connected to the electric machine configured to measure a position and transmit a position signal to a controller. The controller executes a method initializing position for the electric machine, the method comprising: establishing a sensor subsystem datum indicative of a measurement reference point for a sensor subsystem; obtaining a calibration value corresponding to a distance to a selected magnetic reference position for the electric machine, relative to the sensor subsystem datum; and measuring a position and calculating a position delta relative to an initial reference. The method also includes: estimating an offset from the sensor subsystem datum to an initial reference; determining an absolute position estimate of the electric machine relative to the magnetic reference position. The absolute position estimate is responsive to the calibration value, the position delta, and the offset from the sensor subsystem datum to the initial reference.
摘要翻译：这里公开了一种用于初始化诸如电子换向电机的旋转装置的方法和系统。该系统包括：电机; 操作地连接到电机的位置传感器子系统被配置成测量位置并将位置信号传送到控制器。所述控制器执行所述电机的方法初始化位置，所述方法包括：建立指示传感器子系统的测量基准点的传感器子系统数据; 相对于传感器子系统数据获得对应于电机的选定磁参考位置的距离的校准值; 并且测量位置并计算相对于初始参考的位置增量。该方法还包括：估计从传感器子系统数据到初始参考的偏移; 确定电机相对于磁参考位置的绝对位置估计。绝对位置估计响应于校准值，位置增量和从传感器子系统基准到初始参考的偏移量。

8. 发明申请

US20130164794A1 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE 有权
标题翻译：（1R，2R）-2-（3,4-二甲氧基苯基）环己基胺的合成的生物化学和方法
公开(公告)号：US20130164794A1
公开(公告)日：2013-06-27
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
IPC分类号： C12N9/10
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译：本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

9. 发明申请

US20130017580A1 Synthesis of Prazole Compounds 有权
标题翻译：吡唑化合物的合成
公开(公告)号：US20130017580A1
公开(公告)日：2013-01-17
申请号：US13514750
申请日：2010-12-08
申请人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
发明人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
IPC分类号： C12N9/02 , C12N15/53 , C12P17/18 , C12P17/16
CPC分类号： C12N9/0073 , C12N9/0083 , C12P17/165 , C12P17/182 , C12Y114/13022 , C12Y114/99 , Y02P20/52
摘要： The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译：本公开涉及可用于制备吡唑化合物的非天然存在的单加氧酶多肽，编码多肽的多核苷酸，以及使用该多肽的方法。

10. 发明申请

US20120149073A1 Ketoreductase Polypeptides for the Preparation of Phenylephrine 有权
标题翻译：酮还原酶用于制备去氧肾上腺素的多肽
公开(公告)号：US20120149073A1
公开(公告)日：2012-06-14
申请号：US13390677
申请日：2010-08-19
申请人： Oscar Alvizo , Steven J. Collier , Joerg Hennemann , Seong Ho Oh , Wenjuan Zha
发明人： Oscar Alvizo , Steven J. Collier , Joerg Hennemann , Seong Ho Oh , Wenjuan Zha
IPC分类号： C12N9/02 , C12N15/63 , C12P13/00 , C12N1/19 , C12N5/10 , C12N15/53 , C12N1/21
CPC分类号： C12N9/0006 , A61K31/137 , C12P13/001 , C12Y101/01184
摘要： The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.
摘要翻译：本公开涉及工程化酮还原酶多肽和使用多肽来生产去氧肾上腺素的方法。

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