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1. 发明授权

US08932836B2 Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine 有权
标题翻译：用于合成（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的生物催化剂和方法
公开(公告)号：US08932836B2
公开(公告)日：2015-01-13
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
IPC分类号： C12N9/10 , C12P13/00
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译：本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

2. 发明申请

US20130164794A1 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE 有权
标题翻译：（1R，2R）-2-（3,4-二甲氧基苯基）环己基胺的合成的生物化学和方法
公开(公告)号：US20130164794A1
公开(公告)日：2013-06-27
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
IPC分类号： C12N9/10
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译：本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

3. 发明授权

US09006460B2 Process for preparing aminocyclohexyl ether compounds 有权
标题翻译：制备氨基环己基醚化合物的方法
公开(公告)号：US09006460B2
公开(公告)日：2015-04-14
申请号：US13817274
申请日：2011-08-08
申请人： John Limanto , Gregory L. Beutner , Jingjun Yin , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Cheol K. Chung , Gregory Hughes , Zhijian Liu , Brendan Grau , Jacob Janey
发明人： John Limanto , Gregory L. Beutner , Jingjun Yin , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Cheol K. Chung , Gregory Hughes , Zhijian Liu , Brendan Grau , Jacob Janey
IPC分类号： C07D207/12 , C12P17/10
CPC分类号： C07D207/12 , C07C217/52 , C07D207/416 , C12P17/10
摘要： The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.
摘要翻译：本发明涉及制备式I的氨基环己基醚化合物或其药学上可接受的盐和酯的方法。特别地，本发明涉及制备（1R，2R）-2 - [（3R） - 羟基吡咯烷基] -1-（3,4-二甲氧基苯乙氧基） - 环己烷以及各种中间体的方法。

4. 发明申请

US20130149751A1 PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS 有权
公开(公告)号：US20130149751A1
公开(公告)日：2013-06-13
申请号：US13817274
申请日：2011-08-08
申请人： John Limanto , Gregory L. Beutner , Jingjun Yin , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Cheol K. Chung , Gregory Hughes , Zhijian Liu , Brendan Grau , Jacob Janey
发明人： John Limanto , Gregory L. Beutner , Jingjun Yin , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Cheol K. Chung , Gregory Hughes , Zhijian Liu , Brendan Grau , Jacob Janey
IPC分类号： C12P17/10
CPC分类号： C07D207/12 , C07C217/52 , C07D207/416 , C12P17/10
摘要： The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.

5. 发明授权

US09193957B2 Engineered imine reductases and methods for the reductive animation of ketone and amine compounds 有权
标题翻译：酮和胺化合物的还原动力的工程亚胺还原酶和方法
公开(公告)号：US09193957B2
公开(公告)日：2015-11-24
申请号：US13890944
申请日：2013-05-09
申请人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/00 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/18
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译：本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法产品化合物。

6. 发明申请

US20120190085A1 Transaminase Reactions 有权
标题翻译：转氨酶反应
公开(公告)号：US20120190085A1
公开(公告)日：2012-07-26
申请号：US13378963
申请日：2010-06-21
申请人： Gregory Hughes , Paul N. Devine , Fred J. Fleitz , Brendan T. Grau , John Limanto , Christopher Savile , Emily Mundorff
发明人： Gregory Hughes , Paul N. Devine , Fred J. Fleitz , Brendan T. Grau , John Limanto , Christopher Savile , Emily Mundorff
IPC分类号： C12P13/00 , C12P17/10 , C12P17/12
CPC分类号： C12P17/10 , C12N9/1096 , C12P13/001 , C12P13/04 , C12P17/12 , C12P17/182 , C12Y206/01 , Y02P20/52
摘要： The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
摘要翻译：本公开涉及在由前手性酮合成手性胺时使用转氨酶多肽的方法。

7. 发明授权

US08921079B2 Transaminase reactions 有权
标题翻译：转氨酶反应
公开(公告)号：US08921079B2
公开(公告)日：2014-12-30
申请号：US13378963
申请日：2010-06-21
申请人： Gregory Hughes , Paul N. Devine , Fred J. Fleitz , Brendan T. Grau , John Limanto , Christopher Savile , Emily Mundorff
发明人： Gregory Hughes , Paul N. Devine , Fred J. Fleitz , Brendan T. Grau , John Limanto , Christopher Savile , Emily Mundorff
IPC分类号： C12P13/00 , C12P17/10 , C12P17/12 , C12N9/10 , C12P17/18
CPC分类号： C12P17/10 , C12N9/1096 , C12P13/001 , C12P13/04 , C12P17/12 , C12P17/182 , C12Y206/01 , Y02P20/52
摘要： The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
摘要翻译：本公开涉及在由前手性酮合成手性胺时使用转氨酶多肽的方法。

8. 发明申请

US20140106413A1 IMMOBILIZED TRANSAMINASES AND PROCESS FOR MAKING AND USING IMMOBILIZED TRANSAMINASE 有权
标题翻译：固定化的多胺和制备和使用固定化的转移酶的方法
公开(公告)号：US20140106413A1
公开(公告)日：2014-04-17
申请号：US14117410
申请日：2012-06-18
申请人： Matthew D. Truppo , Jacob M. Janey , Gregory Hughes
发明人： Matthew D. Truppo , Jacob M. Janey , Gregory Hughes
IPC分类号： C12N9/10 , C12P17/18
CPC分类号： C12N9/1096 , C12N11/08 , C12P13/001 , C12P17/182 , Y02P20/52
摘要： The invention is directed to immobilized transaminases and methods of making and using them.
摘要翻译：本发明涉及固定化的转氨酶及其制备和使用方法。

9. 发明授权

US09587229B2 Immobilized transaminases and process for making and using immobilized transaminase 有权
标题翻译：固定化转氨酶和制备和使用固定化转氨酶的方法
公开(公告)号：US09587229B2
公开(公告)日：2017-03-07
申请号：US14117410
申请日：2012-06-18
申请人： Matthew D. Truppo , Jacob M. Janey , Gregory Hughes
发明人： Matthew D. Truppo , Jacob M. Janey , Gregory Hughes
IPC分类号： C12N9/10 , C12P13/00 , C12P17/18 , C12N11/08
CPC分类号： C12N9/1096 , C12N11/08 , C12P13/001 , C12P17/182 , Y02P20/52
摘要： The invention is directed to immobilized transaminases and methods of making and using them.
摘要翻译：本发明涉及固定化的转氨酶及其制备和使用方法。

10. 发明申请

US20100241073A1 Heat exchanger connector assembly 有权
标题翻译：热交换器连接器组件
公开(公告)号：US20100241073A1
公开(公告)日：2010-09-23
申请号：US12382454
申请日：2009-03-17
申请人： Eric Andersen , David Baker , Gregory Hughes , Liam O'Shea , Gary Searle
发明人： Eric Andersen , David Baker , Gregory Hughes , Liam O'Shea , Gary Searle
IPC分类号： A61F7/12 , F28F9/02
CPC分类号： F28F9/0246 , A61M5/44 , A61M39/10 , A61M39/105 , A61M2039/1072 , Y10S604/905
摘要： A connector assembly for a heat exchanger has a fitting and a mount to which the fitting couples. The fitting has an elongate body having a proximal portion and a distal portion. At the proximal portion there is a crossbar, and at the distal portion there are an inlet and an outlet that protrude away from the body. Two wings extend from the body in a direction opposite to that of the inlet and outlet. There is formed on each of the wings a locking protrusion. The mount has a top portion where there is a groove dimensioned to accept the crossbar of the fitting. A longitudinal channel is formed orthogonal to the groove in the mount. Two sidewalls extend from the mount each for accepting a corresponding one of the wings, when the fitting is coupled to the mount. Apertures are provided at the sidewalls to engage the protrusion at the wings so that, once the fitting is coupled to the mount, it is secured thereto, until a force is exerted to compress the wings towards each other to disengage the protrusions from the apertures. To couple the fitting to the mount, a user first positions the crossbar of the fitting onto the groove of the mount, with the body of the fitting at an angle relative to the mount. With the crossbar resting on the groove, a pivot point is established between the fitting and the mount, so that the body of the fitting can be pivotally positioned within the channel of the mount. At that time the inlet and outlet of the fitting are mated to an output port and an input port, respectively, of the mount; and the protrusions at the wings of the fitting are engaged to the apertures at the sidewalls of the mount. An infusate line and a heat exchanger are connected to the proximal end and distal end, respectively, of the fitting.
摘要翻译：用于热交换器的连接器组件具有配件和配件相配合的安装件。配件具有细长体，其具有近端部分和远端部分。在近端部分处有横杆，并且在远侧部分处具有远离身体突出的入口和出口。两个翼沿着与入口和出口相反的方向从身体延伸。在每个翼上形成有锁定突起。安装座具有顶部，其中有一个凹槽的尺寸以接受配件的横杆。纵向通道形成为与安装件中的凹槽正交。当配件联接到安装座时，两个侧壁从每个安装件延伸以接收相应的一个翼。孔设置在侧壁处以与翼部处的突起接合，使得一旦接头联接到安装件上，其被固定到其上，直到施加力以将翼片朝向彼此压缩以使突起与孔分离。为了将配件联接到安装座，用户首先将配件的横杆定位在安装件的凹槽上，使配件的主体相对于安装座成一角度。在横杆搁置在槽上，在配件和安装座之间建立枢轴点，使得配件的主体可以枢转地定位在安装件的通道内。此时，配件的入口和出口分别与安装座的输出端口和输入端口配合; 并且配件的翼部处的突起接合到安装件的侧壁处的孔。输液管线和热交换器分别连接到配件的近端和远端。

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