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1. 发明申请

US20130017580A1 Synthesis of Prazole Compounds 有权
标题翻译：吡唑化合物的合成
公开(公告)号：US20130017580A1
公开(公告)日：2013-01-17
申请号：US13514750
申请日：2010-12-08
申请人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
发明人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
IPC分类号： C12N9/02 , C12N15/53 , C12P17/18 , C12P17/16
CPC分类号： C12N9/0073 , C12N9/0083 , C12P17/165 , C12P17/182 , C12Y114/13022 , C12Y114/99 , Y02P20/52
摘要： The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译：本公开涉及可用于制备吡唑化合物的非天然存在的单加氧酶多肽，编码多肽的多核苷酸，以及使用该多肽的方法。

2. 发明授权

US08895271B2 Synthesis of prazole compounds 有权
标题翻译：吡唑化合物的合成
公开(公告)号：US08895271B2
公开(公告)日：2014-11-25
申请号：US13514750
申请日：2010-12-08
申请人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
发明人： Yong Koy Bong , Michael D. Clay , Steven J. Collier , Benjamin Mijts , Michael Vogel , Xiyun Zhang , Jun Zhu , Jovana Nazor , Derek Smith , Shiwei Song
IPC分类号： C12Q1/44 , C12N9/00 , C12N9/02 , C12N1/20 , C12N15/00 , C07H21/04 , C12P17/18
CPC分类号： C12N9/0073 , C12N9/0083 , C12P17/165 , C12P17/182 , C12Y114/13022 , C12Y114/99 , Y02P20/52
摘要： The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译：本公开涉及可用于制备吡唑化合物的非天然存在的单加氧酶多肽，编码多肽的多核苷酸，以及使用该多肽的方法。

3. 发明申请

US20100063300A1 BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS 有权
标题翻译：用于制备主要纯度双熔体双酚化合物的生物化学方法
公开(公告)号：US20100063300A1
公开(公告)日：2010-03-11
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译：本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。

4. 发明授权

US08574876B2 Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds 有权
标题翻译：用于制备立体异构纯的稠合双环脯氨酸化合物的生物催化方法
公开(公告)号：US08574876B2
公开(公告)日：2013-11-05
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C12P7/62 , C12P13/22
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译：本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。

5. 发明授权

US08178333B2 Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds 有权
标题翻译：用于制备基本上立体异构纯的稠合双环脯氨酸化合物的生物催化方法
公开(公告)号：US08178333B2
公开(公告)日：2012-05-15
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C12N9/00 , C07H21/04
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein.
摘要翻译：本公开内容提供单胺氧化酶及其在生物催化方法中用于制备基本上对映异构体纯的以下结构式的杂双环化合物的方法，其中A，M，M'和R 5如本文所述。

6. 发明申请

US20120244581A1 Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds 有权
标题翻译：用于制备立体异构纯双环脯氨酸化合物的生物催化方法
公开(公告)号：US20120244581A1
公开(公告)日：2012-09-27
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C12P17/10
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译：本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。

7. 发明申请

US20120130087A1 Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors 有权
标题翻译：用于制备丙型肝炎蛋白酶抑制剂的独立纯纯双环脯氨酸化合物
公开(公告)号：US20120130087A1
公开(公告)日：2012-05-24
申请号：US13294930
申请日：2011-11-11
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52 , C07D487/14
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译：本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。

8. 发明授权

US4574919A Tree climbing implement 失效
标题翻译：爬树工具
公开(公告)号：US4574919A
公开(公告)日：1986-03-11
申请号：US682306
申请日：1984-12-17
申请人： Michael D. Clay
发明人： Michael D. Clay
IPC分类号： A63B27/02 , A63B27/00
CPC分类号： A63B27/02
摘要： A tree climbing implement adapted to be secured to the boot or shoe during a tree climbing operation and comprising a substantially L-shaped bracket engagable with the bottom of the boot, a spike-like element has one edge hingedly secured to one edge of the L-shaped bracket member and is movable between an extended position substantially perpendicular to the bracket member and a collapsed position substantially against or in abutting relation with respect to the bracket member for facilitating storing and/or transporting of the device. The spike-like member is of a unitary construction which greatly reduces the cost of manufacture of the implement.
摘要翻译：一种爬树工具，适于在攀爬操作期间固定到靴子或鞋上，并且包括与靴子的底部可接合的基本上L形的支架，穗状元件具有铰接地固定到L的一个边缘的一个边缘并且可以在基本上垂直于支架构件的延伸位置和基本上相对于支架构件抵靠或邻接的收缩位置之间移动，以便于装置的存储和/或运输。穗状构件是一体的构造，其大大降低了工具的制造成本。

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