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1. 发明授权

US08312763B2 Method and apparatus for trapping single particles in microfluidic channels 有权
标题翻译：在微流体通道中捕获单个颗粒的方法和装置
公开(公告)号：US08312763B2
公开(公告)日：2012-11-20
申请号：US12587898
申请日：2009-10-14
申请人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
发明人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
IPC分类号： G01N15/06
CPC分类号： G01N9/002 , G01N15/1056 , G01N15/12 , G01N2015/1043 , G01N2015/1087
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
摘要翻译：用于改善沉淀微通道谐振器（SMR）中的颗粒或细胞特性如质量的测量的方法和装置。装置特别包括用于在SMR中捕获颗粒以延长测量周期的设计。方法包括通过改变用于相同粒子或细胞上的重复测量的流体密度来提供差异测量的技术。

2. 发明申请

US20100297747A1 SYSTEM AND METHOD FOR MONITORING CELL GROWTH 审中-公开
标题翻译：用于监测细胞生长的系统和方法
公开(公告)号：US20100297747A1
公开(公告)日：2010-11-25
申请号：US12739509
申请日：2008-10-24
申请人： Scott R. Manalis , Andrea K. Bryan , Yao-Chung Weng , Thomas Burg , William H. Grover , Marc W. Kirschner , Paul Jorgensen , Michel Godin
发明人： Scott R. Manalis , Andrea K. Bryan , Yao-Chung Weng , Thomas Burg , William H. Grover , Marc W. Kirschner , Paul Jorgensen , Michel Godin
IPC分类号： C12M1/34
CPC分类号： G01N15/147 , G01N15/1056 , G01N15/12 , G01N15/1484 , G01N2015/1037
摘要： Microsystem for monitoring cell growth. A microfluidic structure is designed to allow cells to circulate therethrough and the microfluidic structure includes modules to monitor mass, mass density and fluorescence of the cell.
摘要翻译：用于监测细胞生长的微系统。微流体结构被设计成允许细胞循环通过，微流体结构包括监测细胞的质量，质量密度和荧光的模块。

3. 发明授权

US06770472B2 Direct DNA sequencing with a transcription protein and a nanometer scale electrometer 失效
标题翻译：用转录蛋白和纳米级静电计进行直接DNA测序
公开(公告)号：US06770472B2
公开(公告)日：2004-08-03
申请号：US09993338
申请日：2001-11-13
申请人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
发明人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
IPC分类号： C12M134
CPC分类号： C12Q1/6869 , C12Q2565/607 , C12Q2521/543 , C12Q2521/119
摘要： The present invention provides an apparatus and method for nucleotide or DNA sequencing by monitoring the molecular charge configuration as the DNA moves through a protein that is capable of transcribing the DNA. The apparatus and method provides a nanoscale electrometer that immobilizes the protein. The protein receives the DNA and transcribes the DNA. The nanoscale electrometer is a sensitive device that is capable of sensing and measuring the electronic charge that is released during the transcription process. The apparatus and method of the present invention further provides monitoring means that are attached to the nanoscale electrometer to monitor the electronic charge configuration as the DNA moves through the protein. Once the electronic charge configuration is established, a correlation is computed, using computing means, between the electronic charge configuration and a nucleotide signature of the DNA.
摘要翻译：本发明提供了一种用于核苷酸或DNA测序的装置和方法，该装置和方法通过在DNA通过能够转录DNA的蛋白质移动时监测分子电荷构型。该装置和方法提供固定蛋白质的纳米级静电计。蛋白质接受DNA并转录DNA。纳米级静电计是能够感测和测量在转录过程中释放的电子电荷的敏感器件。本发明的装置和方法还提供了监测装置，其连接到纳米级静电计，以在DNA通过蛋白质移动时监测电子电荷构型。一旦建立了电子充电配置，就使用计算装置在电子电荷配置和DNA的核苷酸特征之间计算相关性。

4. 发明授权

US08722419B2 Flow cytometry methods and immunodiagnostics with mass sensitive readout 有权
标题翻译：流式细胞术方法和免疫诊断与质量敏感读数
公开(公告)号：US08722419B2
公开(公告)日：2014-05-13
申请号：US12305733
申请日：2007-06-15
申请人： Scott R. Manalis , Thomas P. Burg , Michel Godin , Kenneth Babcock
发明人： Scott R. Manalis , Thomas P. Burg , Michel Godin , Kenneth Babcock
IPC分类号： G01N24/00 , G01N33/543 , G01N35/08 , G01N31/00
CPC分类号： G01N33/56966 , C12Q1/04 , G01N2015/1413 , G01N2015/1486 , G01N2333/70514 , Y10T436/101666 , Y10T436/117497 , Y10T436/24
摘要： Mass cytometry method. In one aspect, the method includes providing a sample having at least one cell type and mixing the sample with material such as nanoparticles functionalized with affinity molecules for the at least one cell type. The sample is transported through a suspended microchannel resonator to record a mass histogram and a cell count for the at least one cell type is determined from the histogram.
摘要翻译：质谱法在一个方面，该方法包括提供具有至少一种细胞类型的样品，并将样品与诸如用于至少一种细胞类型的亲和分子官能化的纳米粒子的材料混合。样品通过悬浮的微通道谐振器传输以记录质量直方图，并且从直方图确定至少一种细胞类型的细胞计数。

5. 发明授权

US06307202B1 Bimorph spirals for uncooled photothermal spectroscopy 失效
标题翻译：双相双螺旋线用于未冷却的光热光谱
公开(公告)号：US06307202B1
公开(公告)日：2001-10-23
申请号：US09332540
申请日：1999-06-14
申请人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
发明人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
IPC分类号： G01J510
CPC分类号： G01J5/40
摘要： A bimorph spiral which exhibits a shape-altering response to thermal radiation and is dimensioned to have a focussing effect on light, such as a visible light, by acting as a quasi-Fresnel element. The focussing effect varies as the shape of the bimorph spiral changes due to absorption of thermal radiation. An array of such bimorph spirals can be used for efficient, high-resolution and rapid uncooled photothermal spectroscopy.
摘要翻译：具有对热辐射形状改变的响应的双压电晶片螺旋，并且通过充当准菲涅尔元件的尺寸设计成具有对光（例如可见光）的聚焦效应。聚焦效应随着双压电晶片的形状由于热辐射的吸收而变化。这种双压电晶片阵列可用于高效，高分辨率和快速非冷却光热光谱。

6. 发明授权

US5908981A Interdigital deflection sensor for microcantilevers 失效
标题翻译：用于微型悬臂的交叉偏转传感器
公开(公告)号：US5908981A
公开(公告)日：1999-06-01
申请号：US708446
申请日：1996-09-05
申请人： Abdullah Atalar , Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
发明人： Abdullah Atalar , Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
IPC分类号： G01B9/02 , G01B9/04 , G01B11/30 , G01B21/30
CPC分类号： G01Q20/02 , B82Y35/00 , Y10S977/87 , Y10S977/873
摘要： A deflection sensor for a microcantilever includes two sets of interdigitated fingers, one (reference) set being attached to the substrate from which the microcantilever extends and the other (movable) set being attached to the tip of the microcantilever. Together the interdigitated fingers form an optical phase grating. The deflection of the microcantilever is measured by directing a light beam against the optical phase grating and detecting the intensity of the reflected light in the first (or other) component of the resulting diffraction pattern. As the microcantilever deflects, the reference and movable fingers move relative to one another creating large variations in the intensity of the zeroth and first order components of the diffraction pattern. To eliminate "1/f" noise the deflection of the microcantilever can be measured using an AC signal.
摘要翻译：用于微悬臂梁的偏转传感器包括两组交叉指状物，一个（参考）组附接到基体上，微型悬臂从该基底延伸，另一组（可移动）组附接到微悬臂梁的尖端。交叉指状物一起形成光学相位光栅。通过将光束引导到光学相位光栅并检测所得衍射图案的第一（或其它）分量中的反射光的强度来测量微悬臂梁的偏转。当微悬臂梁偏转时，参考和可动指状物相对于彼此移动，从而产生衍射图案的第零级和第一级分量的强度的大变化。为了消除“1 / f”噪声，可以使用AC信号测量微悬臂梁的偏转。

7. 发明授权

US6156216A Method for making nitride cantilevers devices 失效
标题翻译：制造氮化物悬臂装置的方法
公开(公告)号：US6156216A
公开(公告)日：2000-12-05
申请号：US152746
申请日：1998-09-14
申请人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
发明人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
IPC分类号： C25F3/00 , G01N27/24 , G01Q10/00 , G01Q30/14 , G01Q70/16 , G01R31/308 , B44C1/22
CPC分类号： G01N27/24 , B82Y35/00 , G01Q70/14 , G01Q70/16
摘要： A method for making a silicon stylus protruding through a nitride layer is used to fabricate nitride micro-apertures, silicon styluses supported by nitride cantilever arms and charge sensitive silicon styluses supported by nitride cantilever arms. The method uses an anisotropic dry etch to define the apertures of the nitride micro-apertures and the apexes of the silicon styluses. Nitride apertures made by this method are useful for supporting micro-electronics and micro-optical devices. Surface probing devices with silicon styluses supported by nitride cantilever arms have applications in AFM and STM and are particularly useful in applications that require an electrical connection between the silicon stylus and external circuitry through the cantilever arm.
摘要翻译：用于制造穿过氮化物层的硅触针的方法用于制造氮化物微孔，由氮化物悬臂支撑的硅触针和由氮化物悬臂支撑的电荷敏感硅探针。该方法使用各向异性干蚀刻来限定氮化硅微孔和硅探针的顶点的孔。通过该方法制造的氮化物孔径对于支持微电子和微型光学器件是有用的。具有由氮化物悬臂支撑的硅触针的表面探测装置在AFM和STM中具有应用，并且在需要通过悬臂的硅触针和外部电路之间的电连接的应用中特别有用。

8. 发明授权

US6002131A Scanning probe potentiometer 失效
标题翻译：扫描探头电位器
公开(公告)号：US6002131A
公开(公告)日：1999-12-14
申请号：US47887
申请日：1998-03-25
申请人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
发明人： Scott R. Manalis , Stephen C. Minne , Calvin F. Quate
IPC分类号： C25F3/00 , G01N27/24 , G01Q10/00 , G01Q30/14 , G01Q70/16 , G01R31/308 , G01R29/12
CPC分类号： G01Q60/60 , G01N27/24 , B82Y35/00 , Y10S977/854
摘要： A system for scanning and measuring a surface charge of a sample immersed in a conductive medium, such as an aqueous electrolytic solution or a gel, or positioned on a conducting plate. The system has a semiconductor with a probing surface clad in a charge-sensitive layer. The probing surface moves over the sample during scanning while a bias voltage V.sub.BIAS is applied to create a depletion layer in the semiconductor and to induce the system to alter a measurable electrical property. The electrical property is monitored with the aid of a measuring device and the measurement is correlated to the sample's surface charge. In a preferred embodiment the semiconductor is a part of a cantilever structure of the type having a probing tip and the probing surface is located on the apex of the probing tip thereby enabling examination of the topology and surface charge of the sample concurrently.
摘要翻译：一种用于扫描和测量浸渍在诸如电解质水溶液或凝胶的导电介质中的样品的表面电荷或定位在导电板上的系统。该系统具有包含在电荷敏感层中的探测表面的半导体。探测表面在扫描期间移动到样品上方，同时施加偏置电压VBIAS以在半导体中产生耗尽层并诱导系统改变可测量的电性能。借助于测量装置监测电气特性，测量与样品的表面电荷相关。在优选实施例中，半导体是具有探测尖端的类型的悬臂结构的一部分，并且探测表面位于探测尖端的顶点上，从而能够同时检查样品的拓扑和表面电荷。

9. 发明申请

US20120174657A1 Method for Measuring Bacterial Growth and Antibiotic Resistance using Suspended Microchannel Resonators 审中-公开
标题翻译：使用悬浮微通道谐振器测量细菌生长和抗生素抗性的方法
公开(公告)号：US20120174657A1
公开(公告)日：2012-07-12
申请号：US13348809
申请日：2012-01-12
申请人： Kenneth Babcock , Scott R. Manalis
发明人： Kenneth Babcock , Scott R. Manalis
IPC分类号： G01N29/00
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/0256 , G01N2291/0427
摘要： Methods for improving measurements of bacterial growth, such as mass, in Suspended Microchannel Resonators (SMR's). Methods include techniques to provide for bacterial growth over time in response to changing fluid environment to aid in determining parameters such as drug resistance and drug susceptibility. In particular the methods include trapping multiple bacteria in the SMR for a time period and varying the fluid to include sequences of nutrients and antibiotics, and measuring the rate of mass change of the bacteria in response to the changes in fluid composition.
摘要翻译：用于改善悬浮微通道谐振器（SMR）中细菌生长测量的方法，如质量。方法包括随着时间的推移提供细菌生长以响应于改变的流体环境以帮助确定诸如耐药性和药物敏感性的参数的技术。特别地，所述方法包括在SMR中捕获多种细菌一段时间并且改变流体以包括营养物和抗生素的序列，以及响应于流体组成的变化来测量细菌的质量变化速率。

10. 发明申请

US20100154535A1 Method and apparatus for trapping single particles in microfluidic channels 有权
标题翻译：在微流体通道中捕获单个颗粒的方法和装置
公开(公告)号：US20100154535A1
公开(公告)日：2010-06-24
申请号：US12587898
申请日：2009-10-14
申请人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
发明人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
IPC分类号： G01N9/00 , G01N29/22 , G01N1/04
CPC分类号： G01N9/002 , G01N15/1056 , G01N15/12 , G01N2015/1043 , G01N2015/1087
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
摘要翻译：用于改善沉淀微通道谐振器（SMR）中的颗粒或细胞特性如质量的测量的方法和装置。装置特别包括用于在SMR中捕获颗粒以延长测量周期的设计。方法包括通过改变用于相同粒子或细胞上的重复测量的流体密度来提供差异测量的技术。

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