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1. 发明授权

US08834359B2 Method of controlling endoscope and endoscope 有权
标题翻译：内窥镜和内窥镜控制方法
公开(公告)号：US08834359B2
公开(公告)日：2014-09-16
申请号：US12890136
申请日：2010-09-24
申请人： Satoshi Ozawa , Azuchi Endo , Akihiko Erikawa , Takayuki Iida
发明人： Satoshi Ozawa , Azuchi Endo , Akihiko Erikawa , Takayuki Iida
IPC分类号： A61B1/06 , A61B1/04 , G01N21/00 , G06K9/40 , G06K9/00
CPC分类号： A61B1/0638 , A61B1/063 , A61B1/0653 , A61B1/0669
摘要： An endoscope 100 includes a first light source 45 that emits white illumination light, a second light source 47 that emits narrow-band light and an imaging section that has an imaging device 21 having plural detection pixels and images a region to be observed. The imaging section is caused to output a captured image signal including both a return light component of the white illumination light from the region to be observed by and a return light component of the narrow-band light the white illumination light. From the captured image signal, the return light component of the narrow-band light is selectively extracted, and a brightness level of the extracted return light component of the narrow-band light is changed by changing a light amount of light emitted from the second light source 47.
摘要翻译：内窥镜100包括发射白色照明光的第一光源45，发射窄带光的第二光源47和具有多个检测像素的成像装置21和要观察的区域的图像的摄像部。使得成像部分输出包括来自待观察区域的白色照明光的返回光分量和窄带光的白光照明光的返回光分量的捕获图像信号。从拍摄图像信号中，选择性地提取窄带光的返回光分量，并且通过改变从第二光发射的光的光量来改变所提取的窄带光的返回光分量的亮度水平来源47。

2. 发明申请

US20140099695A1 CELL-ADHERING LIGHT-CONTROLLABLE SUBSTRATE 审中-公开
标题翻译：细胞附着的光控基材
公开(公告)号：US20140099695A1
公开(公告)日：2014-04-10
申请号：US14111150
申请日：2012-04-11
申请人： Toshiaki Furuta , Akinobu Suzuki , Hisashi Sugiyama , Satoshi Ozawa , Hiroko Tada
发明人： Toshiaki Furuta , Akinobu Suzuki , Hisashi Sugiyama , Satoshi Ozawa , Hiroko Tada
IPC分类号： C12N11/08 , C12M1/00
CPC分类号： C12N11/08 , C12M25/06 , C12M33/00 , C12M41/36 , C12M47/02 , C12N1/02 , C12N5/0068 , C12N11/06 , C12N2529/10 , C12N2539/10
摘要： An object of the present invention is to enable simpler operation in real time and culture while removing unnecessary cells from cultured cells for purification in analyzing, fractionating, and culturing the cells alive and to analyze and fractionate desired cells from the cultured cells to increase the purity, recovery rate, and viability of the cells. The present invention employs a cell-adhesive photocontrollable base material, wherein light irradiation causes the bond dissociation of a photolabile group comprising a coumarinylmethyl skeleton to produce the separation of a cell-adhesive material to leave a non-cell-adhesive material. As a result, cell images can be detected and analyzed to obtain the positional information of desired cells. Based on the positional information thus obtained, the cells can be analyzed and fractionated alive.
摘要翻译：本发明的目的是使得能够实时和培养更简单的操作，同时从培养细胞中除去不需要的细胞以进行分析，分级和培养细胞，并从培养的细胞中分析和分离所需细胞以增加纯度，回收率和细胞存活率。本发明采用细胞粘合剂可光控制的基材，其中光照射导致包含香豆素甲基骨架的光不稳定基团的键解离以产生细胞粘合剂材料的分离以留下非细胞粘合剂材料。结果，可以检测和分析细胞图像以获得所需细胞的位置信息。基于这样获得的位置信息，可以对细胞进行分析和分离。

3. 发明申请

US20140011960A1 CELL-ADHESIVE PHOTOCONTROLLABLE BASE MATERIAL 审中-公开
标题翻译：细胞粘合光电材料基材
公开(公告)号：US20140011960A1
公开(公告)日：2014-01-09
申请号：US14002192
申请日：2012-02-06
申请人： Tomohiro Konno , Kazuhiko Ishihara , Batzaya Byambaa , Hisashi Sugiyama , Satoshi Ozawa
发明人： Tomohiro Konno , Kazuhiko Ishihara , Batzaya Byambaa , Hisashi Sugiyama , Satoshi Ozawa
IPC分类号： C12N5/071
CPC分类号： C12N5/0602 , C12M25/02 , C12M33/00 , C12M47/04
摘要： In analyzing, fractionating, and culturing cells alive, operations can be more simply made in real time and culture can be performed while removing unnecessary cells from cultured cells for purification. Desired cells are also analyzed and fractionated from the cultured cells to increase the purity, recovery rate, and viability of the cells. A cell-adhesive photocontrollable base material is used in which light irradiation causes the bond dissociation of a photolabile group comprising an O-nitrobenzyl skeleton to irreversibly change the surface of the irradiated portion thereof from that of the cell-adhesive material to that of a non-cell-adhesive material. Cell images are detected and analyzed to obtain the positional information of desired cells. Based on this information, areas among cells and a cell-adhesive photocontrollable material are cut by second light irradiation. On the other hand, the surface of the base material is changed from a cell-adhesive one to a non-cell-adhesive one by first light irradiation to produce the detachment between cells and the base material. This enables cells to be analyzed and fractionated alive.
摘要翻译：在细胞分析，分离和培养细胞中，可以更简单地进行操作，并且可以在从培养细胞中除去不需要的细胞以进行纯化的同时进行培养。还对所需的细胞进行分析并从培养的细胞中分离，以提高细胞的纯度，回收率和活力。使用细胞粘合剂可光控制的基材，其中光照射导致包含O-硝基苄基骨架的光不稳定基团的键解离不可逆地将其照射部分的表面从细胞粘合剂材料的表面改变为非 - - 细胞粘合剂材料。检测并分析细胞图像以获得所需细胞的位置信息。基于该信息，通过第二次光照射来切断细胞和细胞粘合剂可光控制材料中的区域。另一方面，通过第一光照射将基材的表面从电池粘合剂的表面改变为非电池粘合的表面，以产生电池与基材之间的分离。这使得细胞能够被分析和活化分离。

4. 发明申请

US20130176563A1 Biopolymer Optical Analysis Device and Method 有权
标题翻译：生物聚合物光学分析装置及方法
公开(公告)号：US20130176563A1
公开(公告)日：2013-07-11
申请号：US13812801
申请日：2011-07-21
申请人： Satoshi Ozawa , Takashi Anazawa , Rena Akahori , Satoshi Takahashi , Takeshi Ohura , Masashi Kiguchi
发明人： Satoshi Ozawa , Takashi Anazawa , Rena Akahori , Satoshi Takahashi , Takeshi Ohura , Masashi Kiguchi
IPC分类号： G01J3/02
CPC分类号： G01J3/0267 , B82Y5/00 , B82Y15/00 , C12Q1/6869 , G01N21/658 , G01N33/48721 , C12Q2565/631 , C12Q2565/632
摘要： The present invention provides a device and method for analyzing the characteristics of a biopolymer with excellent mechanical stability, high spatial resolution and sensitivity using a simple device construction. Specifically, the Raman scattered light of a biopolymer is measured and the properties of monomer units forming the biopolymer are analyzed by using a biopolymer property analysis chip (100a) characterized by comprising: a solid substrate (110); at least one nanopore (120) disposed in the solid substrate (110); and one or more electrically conductive thin films (130a, 130b) disposed on the solid substrate (110). The biopolymer property analysis chip (100a) is characterized in that the electrically conductive thin films (130a, 130b) are disposed partially on the solid substrate (110) where the nanopore (120) is formed and a biopolymer which has penetrated into the nanopore (120) is caused to generate Raman scattered light by means of irradiation with external light.
摘要翻译：本发明提供一种使用简单的装置结构分析具有优异机械稳定性，高空间分辨率和灵敏度的生物聚合物的特性的装置和方法。具体地，测量生物聚合物的拉曼散射光，并通过使用生物聚合物性质分析芯片（100a）分析形成生物聚合物的单体单元的性质，其特征在于包括：固体基材（110）; 设置在所述固体基板（110）中的至少一个纳米孔（120）; 以及设置在固体基板（110）上的一个或多个导电薄膜（130a，130b）。生物聚合物性质分析芯片（100a）的特征在于，导电薄膜（130a，130b）部分地设置在形成有纳米孔（120）的固体基板（110）上，并且已经渗透到纳米孔中的生物聚合物 120）通过外部光照射产生拉曼散射光。

5. 发明授权

US08197751B2 Apparatus for chemiluminescent assay and detection 有权
公开(公告)号：US08197751B2
公开(公告)日：2012-06-12
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N15/06 , G01N33/00 , G01N33/48 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

6. 发明申请

US20120010465A1 ENDOSCOPE APPARATUS 审中-公开
标题翻译：内窥镜装置
公开(公告)号：US20120010465A1
公开(公告)日：2012-01-12
申请号：US13177274
申请日：2011-07-06
申请人： Akihiko ERIKAWA , Satoshi OZAWA , Takayuki IIDA
发明人： Akihiko ERIKAWA , Satoshi OZAWA , Takayuki IIDA
IPC分类号： A61B1/04 , A61B1/06
CPC分类号： A61B1/043 , A61B1/05 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0653 , A61B1/0669 , A61B1/07
摘要： A first irradiation portion that radiates white light onto a subject, a second irradiation portion that radiates narrow bandwidth light having a narrower wavelength bandwidth than the white light, and an observation window used to observe the subject are respectively disposed on a leading end surface of an endoscope insertion portion. Each of the first and second irradiation portions includes a pair of irradiation windows for emitting light therefrom. A straight line passing through a center point of the observation window and bisecting the leading end surface is defined as a boundary line. The pair of irradiation windows of the first irradiation portion are disposed on both sides of the boundary line. The pair of irradiation windows of the second irradiation portion are disposed on the both sides of the boundary line. Spectra of lights radiated from the irradiation windows of the second irradiation portion can be changed individually.
摘要翻译：将白光照射到被摄体上的第一照射部分，辐射比白光更窄的波长带宽的窄带宽光的第二照射部分和用于观察被摄体的观察窗分别设置在内窥镜插入部。第一和第二照射部分中的每一个包括用于从其发射光的一对照射窗口。将通过观察窗的中心点并将前端面平分的直线定义为边界线。第一照射部的一对照射窗设置在边界线的两侧。第二照射部分的一对照射窗设置在边界线的两侧。可以分别改变从第二照射部的照射窗照射的光的光谱。

7. 发明申请

US20110237894A1 ENDOSCOPE APPARATUS 有权
标题翻译：内窥镜装置
公开(公告)号：US20110237894A1
公开(公告)日：2011-09-29
申请号：US13017349
申请日：2011-01-31
申请人： Satoshi OZAWA , Takayuki IIDA , Yasuhiro MINETOMA , Akihiko ERIKAWA
发明人： Satoshi OZAWA , Takayuki IIDA , Yasuhiro MINETOMA , Akihiko ERIKAWA
IPC分类号： A61B1/06
CPC分类号： A61B1/00188 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0653 , A61B1/0684 , A61B1/07
摘要： To provide an endoscope apparatus in which the observation image can be varied continuously as the observation magnification is varied by a zoom magnification varying manipulation so that an observation image suitable for an endoscope diagnosis is obtained at each observation magnification, and to thereby prevent the operator from feeling uncomfortable and increase the accuracy of a diagnosis. An endoscope apparatus is equipped with illuminating unit having plural light sources which generate light beams having different spectra, for illuminating an observation subject; imaging unit for imaging the observation subject; observation magnification varying unit for varying observation magnification of the imaging of the imaging unit; and light quantity ratio varying unit for continuously varying an emission light quantity ratio between the plural light sources according to the observation magnification that is set by the observation magnification varying unit.
摘要翻译：为了提供一种内窥镜装置，其中，随着观察倍率通过变焦倍率变化操作而变化，观察图像可以连续变化，从而在每个观察放大倍数下获得适合于内窥镜诊断的观察图像，从而防止操作者感觉不舒服，提高了诊断的准确性。一种内窥镜装置具备：具有多个光源的照明单元，该光源产生具有不同光谱的光束，用于照明观察对象物; 用于对观察对象成像的成像单元; 用于改变所述成像单元的成像的观察倍率的观察倍率变化单元; 以及光量比变化单元，用于根据由观察倍率变化单元设定的观察倍率连续地改变多个光源之间的发射光量比。

8. 发明申请

US20110091355A1 APPARATUS FOR CHEMILUMINESCENT ASSAY AND DETECTION 有权
标题翻译：用于荧光测定和检测的装置
公开(公告)号：US20110091355A1
公开(公告)日：2011-04-21
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

9. 发明申请

US20110069163A1 ENDOSCOPE APPARATUS AND ILLUMINATION CONTROL METHOD OF ENDOSCOPE APPARATUS 有权
标题翻译：内窥镜装置的内窥镜装置和照明控制方法
公开(公告)号：US20110069163A1
公开(公告)日：2011-03-24
申请号：US12888819
申请日：2010-09-23
申请人： Satoshi OZAWA , Takayuki IIda
发明人： Satoshi OZAWA , Takayuki IIda
IPC分类号： H04N7/18
CPC分类号： A61B1/0653 , A61B1/063 , A61B1/0638 , H05B33/0869
摘要： Provided are a plurality of semiconductor light emitting elements having different central light emission wavelengths, a multiplexer means for multiplexing lights, and a central wavelength converting means for controlling a light emission amount ratio of the plurality of semiconductor light emitting elements by the use of a wavelength conversion table in which a central wavelength of multiplexed laser light is obtained on the basis of information of a light emission amount and the central light emission wavelengths. Accordingly, the central wavelength of the multiplexed light is controlled to be a predetermined wavelength.
摘要翻译：提供具有不同的中心发光波长的多个半导体发光元件，多路复用灯的多路复用器装置和用于通过使用波长来控制多个半导体发光元件的发光量比的中心波长转换装置转换表，其中基于发光量和中心发光波长的信息获得多路复用激光的中心波长。因此，复用光的中心波长被控制为预定波长。

10. 发明授权

US07879290B2 Apparatus for chemiluminescent assay and detection 有权
标题翻译：用于化学发光测定和检测的装置
公开(公告)号：US07879290B2
公开(公告)日：2011-02-01
申请号：US12034880
申请日：2008-02-21
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N15/06 , G01N33/00 , G01N33/48 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

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