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1. 发明申请

US20090306781A1 High Wear-Resistant Bearing Material and Artificial Joint Replacement Using the Same 有权
标题翻译：高耐磨轴承材料和使用其的人造关节置换
公开(公告)号：US20090306781A1
公开(公告)日：2009-12-10
申请号：US12223669
申请日：2007-02-05
申请人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
发明人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
IPC分类号： A61F2/30 , B32B27/08 , C08J3/28
CPC分类号： A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4059 , A61F2/4081 , A61F2/4202 , A61F2/4241 , A61F2/4425 , A61F2/468 , A61F2002/3065 , A61F2002/30654 , A61F2002/30884 , A61F2002/30904 , A61F2002/30934 , A61F2002/3493 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/3682 , A61F2002/4018 , A61F2002/4051 , A61F2002/4062 , A61L27/34 , A61L27/50 , Y10T428/31913
摘要： The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.
摘要翻译：本发明提供耐久性优异并能够长时间保持耐磨性的轴承材料。本发明的轴承材料是用于在潮湿环境下使用的高耐磨轴承材料10，包括：由具有亚甲基的聚合物材料制成的基体12; 以及覆盖基板12的支承面16的聚合物层30，聚合物层30包含具有磷酸胆碱基并且从支承表面16接枝的聚合物链，其中滑动表面16的磷酸指数通过除以在滑动面上测定的红外光谱中的亚甲基的峰强度的磷酸基的峰强度不小于0.28。

2. 发明申请

US20080112838A1 Non-Oriented Electrical Steel Superior In Core Loss 有权
标题翻译：无磁导电钢优于铁芯损耗
公开(公告)号：US20080112838A1
公开(公告)日：2008-05-15
申请号：US11666844
申请日：2005-09-28
申请人： Masafumi Miyazaki , Wataru Ohashi , Yousuke Kurosaki , Takeshi Kubota , Hiroshi Harada , Tomohiro Konno , Yutaka Matsumoto , Koichi Kirishiki
发明人： Masafumi Miyazaki , Wataru Ohashi , Yousuke Kurosaki , Takeshi Kubota , Hiroshi Harada , Tomohiro Konno , Yutaka Matsumoto , Koichi Kirishiki
IPC分类号： C22C38/18 , C22C38/00 , C22C38/02
CPC分类号： H01F1/14791 , C22C38/02 , C22C38/04 , C22C38/06 , H01F1/16
摘要： Non-oriented electrical steel sheet superior in core loss characterized by containing, by mass %, C: 0.01% or less, Si: 0.1% to 7.0%, Al: 0.1% to 3.0%, Mn: 0.1% to 2.0%, N: 0.005% or less, Ti: 0.02% or less, REM: 0.05% or less, S: 0.005% or less, O: 0.005% or less, and a balance of iron and unavoidable impurities and having a mass % of S shown by [S], a mass % of O shown by [O], a mass % of REM shown by [REM], a mass % of Ti shown by [Ti], and a mass % of N shown by [N] satisfying [Formula 1] and [Formula 2]: [REM]2×[O]2×[S]≧1×10−15[Formula 1] ([REM]2×[O]2×[S])÷([Ti]×[N])≧1×10−10[Formula 2]
摘要翻译：铁损优异的无方向性电工钢板，其特征在于以质量％计含有C：0.01％以下，Si：0.1〜7.0％，Al：0.1〜3.0％，Mn：0.1〜2.0％，N ：0.005％以下，Ti：0.02％以下，REM：0.05％以下，S：0.005％以下，O：0.005％以下，余量为铁和不可避免的杂质，S为质量％通过[S]表示[O]表示的O的质量％，[REM]所示的REM的质量％，[Ti]所示的Ti的质量％，[N]所示的N的质量％满足 [式1]和[式2]：<？in-line-formula description =“In-line Formulas”end =“lead”？> [REM] ^{2 x [O] 2×[S]> = 1×10 -15 [式1] <？在线公式描述=“在线公式”end =“tail”？> <？in -line-formula description =“In-line Formulas”end =“lead”？>（[REM] ^{2 x [O] ^{2 x [S]）/（ [Ti] x [N]）> = 1×10 -10 [式2] <？in-line-formula description =“In-line Formulas”end =“tail”？>}}}

3. 发明授权

US09052242B2 Device and method for measuring surface temperature of cast piece 有权
标题翻译：铸件表面温度测量装置及方法
公开(公告)号：US09052242B2
公开(公告)日：2015-06-09
申请号：US13264056
申请日：2010-01-08
申请人： Hiroshi Harada , Masanori Yamana , Atsushi Saida , Masaki Nagashima , Tomohiro Konno
发明人： Hiroshi Harada , Masanori Yamana , Atsushi Saida , Masaki Nagashima , Tomohiro Konno
IPC分类号： G01K7/00 , G01K7/02 , G01K11/00 , G01K7/38 , B22D2/00
CPC分类号： G01K7/38 , B22D2/006 , G01K2217/00
摘要： A cast piece surface temperature measuring device includes: a magnetic field exciting device which applies an AC magnetic field substantially perpendicular to a surface of a cast piece; a magnetic field detecting device which detects the AC magnetic field to detect a magnetic flux varied in response to a surface temperature of the cast piece; and a surface temperature deriving device which derives the surface temperature of the cast piece based on an induced electromotive force obtained by detecting the AC magnetic field by the magnetic field detecting device and a predetermined relation data. The magnetic field exciting device includes a solenoidal excitation coil, the magnetic field detecting device includes a solenoidal detection coil interposed between the surface of the cast piece and the excitation coil, and the relation data indicates a correspondence relationship between the surface temperature of the cast piece and the induced electromotive force in a temperature range including a predetermined Curie point.
摘要翻译：铸件表面温度测量装置包括：施加基本垂直于铸件表面的交流磁场的磁场激励装置; 磁场检测装置，其检测AC磁场以检测响应于铸件的表面温度而变化的磁通量; 以及表面温度导出装置，其基于通过由磁场检测装置检测交流磁场和预定关系数据而获得的感应电动势导出铸件的表面温度。磁场激励装置包括螺线管励磁线圈，磁场检测装置包括插入在铸件表面和励磁线圈之间的螺线管检测线圈，关系数据表示铸件表面温度之间的对应关系以及在包括预定居里点的温度范围内的感应电动势。

4. 发明申请

US20120038353A1 DEVICE AND METHOD FOR MEASURING SURFACE TEMPERATURE OF CAST PIECE 有权
标题翻译：用于测量铸件表面温度的装置和方法
公开(公告)号：US20120038353A1
公开(公告)日：2012-02-16
申请号：US13264056
申请日：2010-01-08
申请人： Hiroshi Harada , Masanori Yamana , Atsushi Saida , Masaki Nagashima , Tomohiro Konno
发明人： Hiroshi Harada , Masanori Yamana , Atsushi Saida , Masaki Nagashima , Tomohiro Konno
IPC分类号： G01R33/12
CPC分类号： G01K7/38 , B22D2/006 , G01K2217/00
摘要： A cast piece surface temperature measuring device includes: a magnetic field exciting device which applies an AC magnetic field substantially perpendicular to a surface of a cast piece; a magnetic field detecting device which detects the AC magnetic field to detect a magnetic flux varied in response to a surface temperature of the cast piece; and a surface temperature deriving device which derives the surface temperature of the cast piece based on an induced electromotive force obtained by detecting the AC magnetic field by the magnetic field detecting device and a predetermined relation data. The magnetic field exciting device includes a solenoidal excitation coil, the magnetic field detecting device includes a solenoidal detection coil interposed between the surface of the cast piece and the excitation coil, and the relation data indicates a correspondence relationship between the surface temperature of the cast piece and the induced electromotive force in a temperature range including a predetermined Curie point.
摘要翻译：铸件表面温度测量装置包括：施加基本垂直于铸件表面的交流磁场的磁场激励装置; 磁场检测装置，其检测AC磁场以检测响应于铸件的表面温度而变化的磁通量; 以及表面温度导出装置，其基于通过由磁场检测装置检测交流磁场和预定关系数据而获得的感应电动势导出铸件的表面温度。磁场激励装置包括螺线管励磁线圈，磁场检测装置包括插入在铸件表面和励磁线圈之间的螺线管检测线圈，关系数据表示铸件表面温度之间的对应关系以及在包括预定居里点的温度范围内的感应电动势。

5. 发明申请

US20110059176A1 MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE 审中-公开
标题翻译：防止组织粘合的材料和预防联合合同的材料
公开(公告)号：US20110059176A1
公开(公告)日：2011-03-10
申请号：US12744251
申请日：2008-11-14
申请人： Toru Moro , Kozo Nakamura , Hiroshi Kawaguchi , Noriyuki Ishiyama , Kazuhiko Ishihara , Tomohiro Konno , Tadashi Ohyama , Mizuna Yoshikawa
发明人： Toru Moro , Kozo Nakamura , Hiroshi Kawaguchi , Noriyuki Ishiyama , Kazuhiko Ishihara , Tomohiro Konno , Tadashi Ohyama , Mizuna Yoshikawa
IPC分类号： A61K9/14 , A61P41/00 , A61K31/785
CPC分类号： A61K31/715 , A61K31/765 , A61K31/80
摘要： The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.The tissue adhesion prevention material and/or the joint contracture prevention material of the present invention comprise, as the main component, a composition comprising a compound having a polyvalent hydroxyl group and a polymer containing phosphorylcholine groups and phenylboronic acid groups.
摘要翻译：本发明提供了一种在外科手术时可以在患病区域制备的组织粘附防止材料，通过在适于温和条件的温和条件下，在包含水作为主要成分的介质中制备具有柔性结构和高溶质渗透性的三维聚合物结构身体组织成分（即，在常温和常压下）而不进行化学反应或采用诸如加热或光或辐射照射的物理过程。这使得可以提供能够有效地防止受影响的区域中的组织对周围组织的术后粘附和关节的可动部的挛缩的组织粘合防止材料和接合挛缩防止材料。本发明的组织粘附防止材料和/或接合挛缩防止材料以包含具有多价羟基的化合物和含有磷酸胆碱基团的聚合物和苯基硼酸基的组成为主要成分。

6. 发明申请

US20100262237A1 Biomaterial, Joint Prosthesis Using the Biomaterial and Method of Producing the Same 有权
标题翻译：生物材料，使用生物材料的联合假体及其生产方法
公开(公告)号：US20100262237A1
公开(公告)日：2010-10-14
申请号：US12225758
申请日：2007-03-26
申请人： Masayuki Kyomoto , Kazuhiko Ishihara , Yasuhiko Iwasaki , Toru Moro , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Tomohiro Konno , Noboru Yamawaki
发明人： Masayuki Kyomoto , Kazuhiko Ishihara , Yasuhiko Iwasaki , Toru Moro , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Tomohiro Konno , Noboru Yamawaki
IPC分类号： A61F2/02 , B32B3/10 , B05D3/06
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2002/30685 , A61F2002/30934 , A61F2002/3611 , A61F2310/00011 , A61F2310/00179 , A61L27/42 , B05D1/18 , B05D3/067 , B23K35/3618 , C22F1/11 , C22F1/183 , Y10T428/24917 , Y10T428/24926 , Y10T428/31536
摘要： The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
摘要翻译：本发明的目的是提供一种关节假体，轴承材料及其制造方法，其抑制滑动部分的磨损，并且即使在重复的日常操作中也抑制磨料粉末的生产。为了实现该目的，提供了一种生物材料，包括：由金属，合金或陶瓷制成的基底; 以及层叠在基材上的生物相容性材料层，其中通过表面处理在基材上形成羟基，而生物相容性材料层包含含有磷酸胆碱基团的聚合物，基材和生物相容性材料层通过粘合剂层结合，与基材的羟基和生物相容性材料层结合。

7. 发明授权

US09175035B2 Oligopeptide sequence specifically bonding to phenylboronic acid group 有权
标题翻译：特异性结合苯基硼酸基团的寡肽序列
公开(公告)号：US09175035B2
公开(公告)日：2015-11-03
申请号：US13982755
申请日：2012-01-30
申请人： Tomohiro Konno , Kazuhiko Ishihara , Hirokazu Nishida
发明人： Tomohiro Konno , Kazuhiko Ishihara , Hirokazu Nishida
IPC分类号： G01N33/53 , A61K39/21 , C07K1/22 , C07K17/06 , C07K17/08 , C07K17/14 , C12N9/02 , G01N33/543
CPC分类号： C07K1/22 , C07K17/06 , C07K17/08 , C07K17/14 , C12N9/0069 , G01N33/54353
摘要： An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.
摘要翻译：本发明的目的在于提供作为固定化蛋白质分子的方法，能够控制待固定分子取向的蛋白质固定化方法和方法，而不需要复杂的工艺和化学物质即可稳定地分离用于固定的组不影响蛋白质的活性和功能。具体地说，本发明涉及一种用于固定分子的方法，包括通过将包含含羟基的氨基酸的标记肽序列附着在分子上而形成标记分子的步骤; 并使具有苯基硼酸基团的分子与标记分子接触，由具有苯基硼酸基团的分子捕获标记分子。

8. 发明授权

US09044323B2 High wear-resistant bearing material and artificial joint replacement using the same 有权
标题翻译：高耐磨轴承材料和人造关节置换使用相同
公开(公告)号：US09044323B2
公开(公告)日：2015-06-02
申请号：US12223669
申请日：2007-02-05
申请人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
发明人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
IPC分类号： A61F2/30 , A61F2/46 , A61L27/34 , A61L27/50 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44
CPC分类号： A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4059 , A61F2/4081 , A61F2/4202 , A61F2/4241 , A61F2/4425 , A61F2/468 , A61F2002/3065 , A61F2002/30654 , A61F2002/30884 , A61F2002/30904 , A61F2002/30934 , A61F2002/3493 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/3682 , A61F2002/4018 , A61F2002/4051 , A61F2002/4062 , A61L27/34 , A61L27/50 , Y10T428/31913
摘要： The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.
摘要翻译：本发明提供耐久性优异并能够长时间保持耐磨性的轴承材料。本发明的轴承材料是用于在潮湿环境下使用的高耐磨轴承材料10，包括：由具有亚甲基的聚合物材料制成的基体12; 以及覆盖基板12的支承面16的聚合物层30，聚合物层30包含具有磷酸胆碱基并且从支承表面16接枝的聚合物链，其中滑动表面16的磷酸指数通过除以在滑动面上测定的红外光谱中的亚甲基的峰强度的磷酸基的峰强度不小于0.28。

9. 发明申请

US20140011960A1 CELL-ADHESIVE PHOTOCONTROLLABLE BASE MATERIAL 审中-公开
标题翻译：细胞粘合光电材料基材
公开(公告)号：US20140011960A1
公开(公告)日：2014-01-09
申请号：US14002192
申请日：2012-02-06
申请人： Tomohiro Konno , Kazuhiko Ishihara , Batzaya Byambaa , Hisashi Sugiyama , Satoshi Ozawa
发明人： Tomohiro Konno , Kazuhiko Ishihara , Batzaya Byambaa , Hisashi Sugiyama , Satoshi Ozawa
IPC分类号： C12N5/071
CPC分类号： C12N5/0602 , C12M25/02 , C12M33/00 , C12M47/04
摘要： In analyzing, fractionating, and culturing cells alive, operations can be more simply made in real time and culture can be performed while removing unnecessary cells from cultured cells for purification. Desired cells are also analyzed and fractionated from the cultured cells to increase the purity, recovery rate, and viability of the cells. A cell-adhesive photocontrollable base material is used in which light irradiation causes the bond dissociation of a photolabile group comprising an O-nitrobenzyl skeleton to irreversibly change the surface of the irradiated portion thereof from that of the cell-adhesive material to that of a non-cell-adhesive material. Cell images are detected and analyzed to obtain the positional information of desired cells. Based on this information, areas among cells and a cell-adhesive photocontrollable material are cut by second light irradiation. On the other hand, the surface of the base material is changed from a cell-adhesive one to a non-cell-adhesive one by first light irradiation to produce the detachment between cells and the base material. This enables cells to be analyzed and fractionated alive.
摘要翻译：在细胞分析，分离和培养细胞中，可以更简单地进行操作，并且可以在从培养细胞中除去不需要的细胞以进行纯化的同时进行培养。还对所需的细胞进行分析并从培养的细胞中分离，以提高细胞的纯度，回收率和活力。使用细胞粘合剂可光控制的基材，其中光照射导致包含O-硝基苄基骨架的光不稳定基团的键解离不可逆地将其照射部分的表面从细胞粘合剂材料的表面改变为非 - - 细胞粘合剂材料。检测并分析细胞图像以获得所需细胞的位置信息。基于该信息，通过第二次光照射来切断细胞和细胞粘合剂可光控制材料中的区域。另一方面，通过第一光照射将基材的表面从电池粘合剂的表面改变为非电池粘合的表面，以产生电池与基材之间的分离。这使得细胞能够被分析和活化分离。

10. 发明授权

US08047265B2 Electromagnetic stirrer coil 有权
标题翻译：电磁搅拌器盘管
公开(公告)号：US08047265B2
公开(公告)日：2011-11-01
申请号：US13068284
申请日：2011-05-05
申请人： Hiroshi Harada , Akinori Wakagi , Tomohiro Konno , Keisuke Fujisaki , Ryu Hirayama , Sumio Matsumori , Yasuji Tomizawa
发明人： Hiroshi Harada , Akinori Wakagi , Tomohiro Konno , Keisuke Fujisaki , Ryu Hirayama , Sumio Matsumori , Yasuji Tomizawa
IPC分类号： B22D27/02
CPC分类号： B22D11/115
摘要： The present invention provides a previously unattainable compact and high thrust electromagnetic stirrer coil, that is, an electromagnetic stirrer coil for stirring molten steel in a mold by electromagnetic force, in which electromagnetic stirrer coil a space factor of the yoke sectional area (−) with respect to an inside area in a vertical cross-section of said electromagnetic stirrer coil is 0.5 to 0.9 and a yoke width B is 100 mm to 300 mm. Preferably, a magnetomotive force F of said electromagnetic stirrer coil divided by the yoke width B, that is, a value of F/B, is 800 kAT/m or more.
摘要翻译：本发明提供了一种以前不可能实现的紧凑型和高推力电磁搅拌器线圈，即用于通过电磁力在模具中搅拌钢水的电磁搅拌器盘管，其中电磁搅拌器盘管是轭截面积（ - ）的空间系数与相对于所述电磁搅拌器盘管的垂直截面的内侧区域为0.5〜0.9，轭宽B为100mm〜300mm。优选地，所述电磁搅拌器线圈的磁通量F除以轭宽度B，即F / B的值为800kAT / m以上。

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