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1. 发明申请

US20060257431A1 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
公开(公告)号：US20060257431A1
公开(公告)日：2006-11-16
申请号：US11450972
申请日：2006-06-09
申请人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.

2. 发明授权

US06602709B1 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
标题翻译：使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法
公开(公告)号：US06602709B1
公开(公告)日：2003-08-05
申请号：US09251896
申请日：1999-02-19
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12N508
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。

3. 发明授权

US5716938A Mattress freshener and room deodorizer composition 失效
标题翻译：床垫清新剂和室内除臭剂组成
公开(公告)号：US5716938A
公开(公告)日：1998-02-10
申请号：US686154
申请日：1996-07-24
申请人： Robert Darnell Provitt
发明人： Robert Darnell Provitt
IPC分类号： A61L9/01 , A61L9/04 , A61K7/46
CPC分类号： A61L9/01 , A61L9/046
摘要： A powder composition for refreshing a mattress and deodorizing the air in a room where the mattress is located is disclosed. The composition has a fragrance constituent comprising about 8% to 12% by weight, a powder constituent comprising about 8% to 12% by weight, a desiccant constituent comprising about 2% to 8% by weight, and a filler constituent comprising about 68% to 82% by weight. The composition accomplishes both the refreshing of the mattress and the deodorizing of the air in one application, thereby saving labor cost associated therewith in institutional settings such as hospitals, prisons or the like. The fragrance constituent comes in a plurality of scents. The ratio of powder to the fragrance is about between 1:1 to 1.5:1 by weight. The fragrance constituent can be either a solid or liquid material.
摘要翻译：公开了一种用于刷新床垫并在床垫所在的房间中对空气进行除臭的粉末组合物。该组合物具有包含约8％至12％重量的香料成分，包含约8％至12％重量的粉末成分，约2％至8％重量的干燥剂成分和包含约68％至82重量％。组合物在一个应用中完成了床垫的清洁和空气的除臭，从而在诸如医院，监狱等的制度设置中节省了与其相关联的劳动力成本。香料成分含有多种香味。粉末与香料的重量比约为1：1至1.5：1。香料组分可以是固体或液体材料。

4. 发明授权

US07989203B2 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
标题翻译：使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法
公开(公告)号：US07989203B2
公开(公告)日：2011-08-02
申请号：US11450972
申请日：2006-06-09
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12N5/071
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。

5. 发明授权

US07129037B2 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
公开(公告)号：US07129037B2
公开(公告)日：2006-10-31
申请号：US10014877
申请日：2001-12-11
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12Q1/00 , G01N33/53 , C12N5/08 , C12N5/00
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.

6. 发明申请

US20110076676A1 Method of Purifying RNA Binding Protein-RNA Complexes 审中-公开
标题翻译：纯化RNA结合蛋白-RNA复合物的方法
公开(公告)号：US20110076676A1
公开(公告)日：2011-03-31
申请号：US12509856
申请日：2009-07-27
申请人： Robert Darnell , Kirk Jensen , Jernej Ule
发明人： Robert Darnell , Kirk Jensen , Jernej Ule
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12N15/1003 , C12N15/1006 , C12Q1/6806
摘要： The present invention provides methods for purifying RNA molecules interacting with an RNA binding protein (RBP), and the use of such methods to analyze a gene expression profile of a cell. The invention also provides sequences of RNA molecules that mediate binding to an RBP, proteins encoded by the sequences, a method of identifying the sequences, and the use of the sequences in a screen to identify bioactive molecules. The invention also provides RNA motifs found among the sequences and compounds that bind the RNA motifs. In addition, the invention provides methods of treating diseases associated with a function of an RNA binding protein.
摘要翻译：本发明提供了用于纯化与RNA结合蛋白（RBP）相互作用的RNA分子的方法，以及使用这些方法来分析细胞的基因表达谱。本发明还提供介导与RBP结合的RNA分子的序列，由序列编码的蛋白质，鉴定序列的方法以及筛选中序列用于鉴定生物活性分子的序列。本发明还提供在结合RNA基序的序列和化合物中发现的RNA基序。此外，本发明提供了治疗与RNA结合蛋白的功能相关的疾病的方法。

7. 发明申请

US20050130151A1 Method and identification of downstream mrna ligands to fmrp and their role in fragile x syndrome and associated disorders 失效
标题翻译：下游mrna配体对fmrp的方法和鉴定及其在脆性x综合征及相关疾病中的作用
公开(公告)号：US20050130151A1
公开(公告)日：2005-06-16
申请号：US10495728
申请日：2002-11-15
申请人： Stephen Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert Darnell , Jennifer Darnell , Jack Keene , Scott Tenenbaum
发明人： Stephen Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert Darnell , Jennifer Darnell , Jack Keene , Scott Tenenbaum
IPC分类号： A01K67/027 , C07H21/04 , C07K14/705 , C07K16/28 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal antibody to FMRP and a consensus sequence for the RNA binding region has been identified. Arrays for identifying compounds, proteins, nucleotides, and the like that modulate the RNA targets or associated genes are provided. Additionally, methods for modulating RNA targets are provided.
摘要翻译：提供了用于鉴定和/或调节涉及脆性X综合征和其它相关病症的RNA转录物和/或基因的组合物和方法。特别地，已经通过FMRP的新型单克隆抗体鉴定了脆性X智力迟钝蛋白（FMRP）的RNA靶标，并且已经鉴定了RNA结合区域的共有序列。提供了用于鉴定调节RNA靶标或相关基因的化合物，蛋白质，核苷酸等的阵列。另外，提供了调节RNA靶标的方法。

8. 发明申请

US20050227251A1 Method of purifying RNA binding protein-RNA complexes 审中-公开
标题翻译： RNA结合蛋白RNA复合物的纯化方法
公开(公告)号：US20050227251A1
公开(公告)日：2005-10-13
申请号：US10971736
申请日：2004-10-25
申请人： Robert Darnell , Kirk Jensen , Jernej Ule
发明人： Robert Darnell , Kirk Jensen , Jernej Ule
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6809 , C12N15/1003 , C12N15/1006 , C12Q1/6806
摘要： The present invention provides methods for purifying RNA molecules interacting with an RNA binding protein (RBP), and the use of such methods to analyze a gene expression profile of a cell. The invention also provides sequences of RNA molecules that mediate binding to an RBP, proteins encoded by the sequences, a method of identifying the sequences, and the use of the sequences in a screen to identify bioactive molecules. The invention also provides RNA motifs found among the sequences and compounds that bind the RNA motifs. In addition, the invention provides methods of treating diseases associated with a function of an RNA binding protein.
摘要翻译：本发明提供了用于纯化与RNA结合蛋白（RBP）相互作用的RNA分子的方法，以及使用这些方法来分析细胞的基因表达谱。本发明还提供介导与RBP结合的RNA分子的序列，由序列编码的蛋白质，鉴定序列的方法以及筛选中序列用于鉴定生物活性分子的序列。本发明还提供在结合RNA基序的序列和化合物中发现的RNA基序。此外，本发明提供了治疗与RNA结合蛋白的功能相关的疾病的方法。

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