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1. 发明授权

US06602709B1 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
标题翻译：使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法
公开(公告)号：US06602709B1
公开(公告)日：2003-08-05
申请号：US09251896
申请日：1999-02-19
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12N508
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。

2. 发明授权

US07989203B2 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
标题翻译：使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法
公开(公告)号：US07989203B2
公开(公告)日：2011-08-02
申请号：US11450972
申请日：2006-06-09
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12N5/071
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。

3. 发明授权

US07129037B2 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
公开(公告)号：US07129037B2
公开(公告)日：2006-10-31
申请号：US10014877
申请日：2001-12-11
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12Q1/00 , G01N33/53 , C12N5/08 , C12N5/00
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.

4. 发明授权

US06750029B1 Methods and agents for the detection and modulation of cellular immunity to immune privileged antigens 失效
标题翻译：用于检测和调节免疫特异抗原的细胞免疫的方法和试剂
公开(公告)号：US06750029B1
公开(公告)日：2004-06-15
申请号：US09603635
申请日：2000-06-26
申请人： Robert B. Darnell , Matthew L. Albert , Nina Bhardwai
发明人： Robert B. Darnell , Matthew L. Albert , Nina Bhardwai
IPC分类号： G01N3353
CPC分类号： G01N33/5091 , C07K14/4748 , G01N33/564 , G01N33/56972 , G01N2333/715 , G01N2800/52
摘要： Recognition of the role of a cellular immune response to immune-privileged antigens in the etiology of paraneoplastic syndromes and tumor immunity has provided diagnostic and therapeutic methods for the detection of paraneoplastic antigen-specific cells, enhancing tumor immunity by increasing the population of cytotoxic T lymphocytes (CTLs), and suppressing cellular immunity to treat the paraneoplastic syndrome. Methods for the detection of memory and cytotoxic T lymphocytes are provided which utilize immune-privileged antigens or their peptides. Enhanced CTL production is provided by stimulating antigen presenting cells in vitro with immune-privileged antigen, with and without further exposure to T lymphocytes, prior to reintroduction of either the antigen-presenting cells and/or the T lymphocytes into the patient. Suppression of the cellular response to non-tumor cells expressing the immune-privileged antigen is provided by using agents which suppress; anti-cytokine therapy is also provided to limit cell surface expression of paraneoplastic antigens by non-tumor cells. Compositions comprising immune-privileged antigen peptides useful for diagnostic methods and therapeutic treatments are also described.
摘要翻译：认识到免疫特异性抗原在副肿瘤综合征和肿瘤免疫的病因中的免疫特异性抗原的作用已经为检测副肿瘤抗原特异性细胞提供了诊断和治疗方法，通过增加细胞毒性T淋巴细胞群体增强肿瘤免疫力（CTLs），并抑制细胞免疫以治疗副肿瘤综合征。提供了检测记忆和细胞毒性T淋巴细胞的方法，其利用免疫特异性抗原或其肽。在将抗原呈递细胞和/或T淋巴细胞重新引入患者体内之前，通过用免疫特异性抗原刺激抗原呈递细胞，同时或不进一步暴露于T淋巴细胞来提供增强的CTL产生。通过使用抑制的药剂来抑制对表达免疫特异抗原的非肿瘤细胞的细胞反应; 还提供抗细胞因子治疗以限制非肿瘤细胞的副肿瘤抗原的细胞表面表达。还描述了包含用于诊断方法和治疗性治疗的免疫特异性抗原肽的组合物。

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