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1. 发明申请

US20060257431A1 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
公开(公告)号：US20060257431A1
公开(公告)日：2006-11-16
申请号：US11450972
申请日：2006-06-09
申请人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.

2. 发明申请

US20050282282A1 Methods of use of viral vectors to deliver antigen to dendritic cells 审中-公开
标题翻译：使用病毒载体将抗原递送至树突状细胞的方法
公开(公告)号：US20050282282A1
公开(公告)日：2005-12-22
申请号：US11187314
申请日：2005-07-21
申请人： Ralph Steinman , Nina Bhardwaj , Armin Bender
发明人： Ralph Steinman , Nina Bhardwaj , Armin Bender
IPC分类号： A61K39/00 , A61K39/145 , C12N5/08 , C12N7/04 , C12N15/86
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5154 , A61K2039/5252 , A61K2039/5254 , A61K2039/57 , C12N15/86 , C12N2760/16043 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are provided to dendritic cells using a viral vector such as influenza virus which may be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are infected with the vector are then capable of presenting the antigen and inducing cytotoxic T-lymphocyte activity or may also be used as vaccines.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导T抗原特异性细胞毒性T淋巴细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，使用病毒载体如流感病毒将抗原提供给树突状细胞，所述病毒载体可被修饰以表达非天然抗原以呈递至树突状细胞。然后用载体感染的树突状细胞能够呈递抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用作疫苗。

3. 发明授权

US06602709B1 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
标题翻译：使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法
公开(公告)号：US06602709B1
公开(公告)日：2003-08-05
申请号：US09251896
申请日：1999-02-19
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12N508
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。

4. 发明授权

US06455299B1 Methods of use of viral vectors to deliver antigen to dendritic cells 有权
标题翻译：使用病毒载体将抗原递送至树突状细胞的方法
公开(公告)号：US06455299B1
公开(公告)日：2002-09-24
申请号：US09310560
申请日：1999-05-12
申请人： Ralph M. Steinman , Nina Bhardwaj
发明人： Ralph M. Steinman , Nina Bhardwaj
IPC分类号： C12N700
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5154 , A61K2039/5252 , A61K2039/5254 , A61K2039/57 , C12N15/86 , C12N2760/16043 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are provided to dendritic cells using a viral vector such as influenza virus which may be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are infected with the vector are then capable of presenting the antigen and inducing cytotoxic T lymphocyte activity or may also be used as vaccines.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导T抗原特异性细胞毒性T淋巴细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，使用病毒载体如流感病毒将抗原提供给树突状细胞，所述病毒载体可被修饰以表达非天然抗原以呈递至树突状细胞。然后用载体感染的树突状细胞能够呈递抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用作疫苗。

5. 发明申请

US20140030216A1 METHODS, AGENTS AND PEPTIDES FOR INDUCING AN IMMUNE RESPONSE TO MATRIX METALLOPROTEINASE-2 EXPRESSING TUMORS 有权
标题翻译：用于诱导对基质金属蛋白酶-2表达肿瘤的免疫应答的方法，代理和肽
公开(公告)号：US20140030216A1
公开(公告)日：2014-01-30
申请号：US13914112
申请日：2013-06-10
申请人： Emmanuelle Godefroy , Francine Jotereau , Nina Bhardwaj
发明人： Emmanuelle Godefroy , Francine Jotereau , Nina Bhardwaj
IPC分类号： C12N9/64 , A61K38/20 , G01N33/569 , A61K39/00
CPC分类号： G01N33/56977 , A61K38/005 , A61K38/208 , A61K39/0011 , A61K2039/572 , C07K2319/01 , C07K2319/33 , C07K2319/55 , C12N9/6491 , G01N33/5743 , G01N2800/52
摘要： The present invention relates to enhancing, modulating or stimulating the immune response to MMP-2 expressing tumors, including melanoma, and to the modulation and application of immune modulators and MMP-2 peptides for melanoma or other MMP-2 expressing tumor vaccines. The invention provides methods and means to activate an effective response to MMP-2 expressing tumors and modulate the ability of MMP-2 to skew CD4+ T cell responses toward that of TH2 cells, which are less effective mediators of tumor cell clearance than TH1 cells. Methods and assays are provided for screening for compounds, agents, or peptides capable of enhancing or activating immune responses, particularly to melanoma.
摘要翻译：本发明涉及增强，调节或刺激对表达MMP-2的肿瘤（包括黑素瘤）的免疫应答，以及用于黑素瘤或其他MMP-2表达肿瘤疫苗的免疫调节剂和MMP-2肽的调节和应用。本发明提供了激活对表达MMP-2的肿瘤的有效反应的方法和手段，并且调节MMP-2相对于TH2细胞倾斜CD4 + T细胞应答的能力，TH2细胞与TH1细胞相比是较不有效的肿瘤细胞清除介质。提供了用于筛选能够增强或激活免疫应答，特别是黑素瘤的化合物，试剂或肽的方法和试验。

6. 发明授权

US07989203B2 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
标题翻译：使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法
公开(公告)号：US07989203B2
公开(公告)日：2011-08-02
申请号：US11450972
申请日：2006-06-09
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12N5/071
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。

7. 发明授权

US07129037B2 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
公开(公告)号：US07129037B2
公开(公告)日：2006-10-31
申请号：US10014877
申请日：2001-12-11
申请人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew L. Albert , Nina Bhardwaj , Ralph M. Steinman , Kayo Inaba , Robert Darnell
IPC分类号： C12Q1/00 , G01N33/53 , C12N5/08 , C12N5/00
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.

8. 发明授权

US06300090B1 Methods of use of viral vectors to deliver antigen to dendritic cells 失效
标题翻译：使用病毒载体将抗原递送至树突状细胞的方法
公开(公告)号：US06300090B1
公开(公告)日：2001-10-09
申请号：US08693586
申请日：1996-08-01
申请人： Ralph M. Steinman , Nina Bhardwaj
发明人： Ralph M. Steinman , Nina Bhardwaj
IPC分类号： G01N3353
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5154 , A61K2039/5252 , A61K2039/5254 , A61K2039/57 , C12N15/86 , C12N2760/16043 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are provided to dendritic cells using a viral vector such as influenza virus which may be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are infected with the vector are then capable of presenting the antigen and inducing cytotoxic T lymphocyte activity or may also be used as vaccines.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导T抗原特异性细胞毒性T淋巴细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，使用病毒载体如流感病毒将抗原提供给树突状细胞，所述病毒载体可被修饰以表达非天然抗原以呈递至树突状细胞。然后用载体感染的树突状细胞能够呈递抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用作疫苗。

9. 发明申请

US20110275089A1 Methods for predicting survival in metastatic melanoma patients 有权
标题翻译：预测转移性黑色素瘤患者生存的方法
公开(公告)号：US20110275089A1
公开(公告)日：2011-11-10
申请号：US12932068
申请日：2011-02-17
申请人： Dusan Bogunovic , Nina Bhardwaj , David O'Neill
发明人： Dusan Bogunovic , Nina Bhardwaj , David O'Neill
IPC分类号： C12Q1/68 , C12Q1/06
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5743 , G01N2800/52
摘要： Cellular and genetic signatures and methods of using same for subcategorizing stage III melanoma tumors are described herein. The signatures and methods are particularly useful with regard to establishing more distinct criteria on which basis to differentiate stage IIIB and IIIC melanoma patients. Assessment of the cellular and genetic signatures of a melanoma sample using methods described herein yields information on which basis differential survival duration and sensitivity to various cancer therapies can be predicted for a Stage IIIB or Stage IIIC melanoma patients. As described herein, gene expression profiling, determination of mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) and CD3+ cells in metastatic lesions may be utilized to predict or assess drug response, drug sensitivity, and clinical outcome in metastatic melanoma patients.
摘要翻译：本文描述了细胞和遗传标记以及将其用于次级分类III期黑素瘤肿瘤的方法。签署和方法对于建立更明确的标准来区分IIIB期和IIIC期黑素瘤患者是特别有用的。使用本文所述的方法评估黑素瘤样品的细胞和遗传标记产生关于IIIB期或IIIC期黑素瘤患者可以预测基础差异存活期和对各种癌症疗法的敏感性的信息。如本文所述，转移性病变中的基因表达谱，有丝分裂指数（MI）的测定和肿瘤浸润性白细胞（TIL）和CD3 +细胞的定量可用于预测或评估转移性黑素瘤中的药物反应，药物敏感性和临床结果耐心。

10. 发明申请

US20110195045A1 Methods, agents and peptides for inducing an immune response to matrix metalloproteinase-2 expressing tumors 有权
标题翻译：用于诱导基质金属蛋白酶-2表达肿瘤的免疫应答的方法，试剂和肽
公开(公告)号：US20110195045A1
公开(公告)日：2011-08-11
申请号：US12930592
申请日：2011-01-11
申请人： Emmanuelle Godefroy , Francine Jotereau , Nina Bhardwaj
发明人： Emmanuelle Godefroy , Francine Jotereau , Nina Bhardwaj
IPC分类号： A61K39/00 , A61K38/20 , C12Q1/02 , G01N33/53 , C07K7/08 , A61K35/12 , A61P35/00 , A61P37/04
CPC分类号： G01N33/56977 , A61K38/005 , A61K38/208 , A61K39/0011 , A61K2039/572 , C07K2319/01 , C07K2319/33 , C07K2319/55 , C12N9/6491 , G01N33/5743 , G01N2800/52
摘要： The present invention relates to enhancing, modulating or stimulating the immune response to MMP-2 expressing tumors, including melanoma, and to the modulation and application of immune modulators and MMP-2 peptides for melanoma or other MMP-2 expressing tumor vaccines. The invention provides methods and means to activate an effective response to MMP-2 expressing tumors and modulate the ability of MMP-2 to skew CD4+ T cell responses toward that of TH2 cells, which are less effective mediators of tumor cell clearance than TH1 cells. Methods and assays are provided for screening for compounds, agents, or peptides capable of enhancing or activating immune responses, particularly to melanoma.
摘要翻译：本发明涉及增强，调节或刺激对表达MMP-2的肿瘤（包括黑素瘤）的免疫应答，以及用于黑素瘤或其他MMP-2表达肿瘤疫苗的免疫调节剂和MMP-2肽的调节和应用。本发明提供了激活对表达MMP-2的肿瘤的有效反应的方法和手段，并且调节MMP-2相对于TH2细胞倾斜CD4 + T细胞应答的能力，TH2细胞与TH1细胞相比是较不有效的肿瘤细胞清除介质。提供了用于筛选能够增强或激活免疫应答，特别是黑素瘤的化合物，试剂或肽的方法和试验。

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