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1. 发明申请

US20120135496A1 Protein Belonging to the TNF Superfamily Involved in Signal Transduction, Nucleic Acids Encoding Same and Methods of Use Thereof 有权
标题翻译：属于涉及信号转导的TNF超家族的蛋白质，编码相同的核酸及其使用方法
公开(公告)号：US20120135496A1
公开(公告)日：2012-05-31
申请号：US12840967
申请日：2010-07-21
申请人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
发明人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
IPC分类号： C07K16/18 , C12N9/96 , C07K16/46
CPC分类号： C07K16/2875 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/525 , C07K14/70575 , C07K2317/76 , C07K2319/30 , C12N15/1096
摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.
摘要翻译：公开了调节动物免疫应答的方法。这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。离体调节剂离体接触后，将成熟树突状细胞导入动物体内。因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。优选地，本发明的方法导致对动物中抗原的免疫应答增加。

2. 发明授权

US07622442B2 Protein belonging to the TNF superfamily involved in signal transduction and methods of use thereof 有权
标题翻译：参与信号转导的TNF超家族的蛋白质及其使用方法
公开(公告)号：US07622442B2
公开(公告)日：2009-11-24
申请号：US11241106
申请日：2005-09-30
申请人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
发明人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
IPC分类号： A61K38/17 , A61K38/19 , C07K14/00 , C07K14/52
CPC分类号： C07K16/2875 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/525 , C07K14/70575 , C07K2317/76 , C07K2319/30 , C12N15/1096
摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.
摘要翻译：公开了调节动物免疫应答的方法。这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突状细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。离体调节剂离体接触后，将成熟树突状细胞导入动物体内。因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。优选地，本发明的方法导致对动物中抗原的免疫应答增加。

3. 发明申请

US20090142271A1 DENDRITIC CELLS 审中-公开
公开(公告)号：US20090142271A1
公开(公告)日：2009-06-04
申请号：US12211019
申请日：2008-09-15
申请人： Karen Bulloch , Bruce McEwen , Ralph Steinman , Ulrike Waltraud Kaunzner , Jennifer C. Felger , Judit Gal Toth , Melinda M. Miller , Andres C. Gottfried-Blackmore
发明人： Karen Bulloch , Bruce McEwen , Ralph Steinman , Ulrike Waltraud Kaunzner , Jennifer C. Felger , Judit Gal Toth , Melinda M. Miller , Andres C. Gottfried-Blackmore
IPC分类号： A61K49/00 , C12N5/00 , C12N5/02 , C12Q1/68 , C12Q1/02
CPC分类号： C12N5/0639 , A01K2227/105 , A01K2267/0393 , C12N5/0622
摘要： The present invention provides systems for isolating, characterizing, and modulating brain dendritic cells. The invention may allow a better understanding of and opportunities to modulate neurodevelopmental processes (such as, for example, neurogenesis) and neurological diseases (such as, for example, Alzheimer's Disease).
摘要翻译：本发明提供用于分离，表征和调节脑树突状细胞的系统。本发明可以允许更好地理解和调节神经发育过程（例如神经发生）和神经系统疾病（例如阿尔茨海默病）的机会。

4. 发明申请

US20060257431A1 Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权
公开(公告)号：US20060257431A1
公开(公告)日：2006-11-16
申请号：US11450972
申请日：2006-06-09
申请人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.

5. 发明申请

US20060216316A1 In vivo expanded NKT cells and methods of use thereof 失效
标题翻译：体内扩增的NKT细胞及其使用方法
公开(公告)号：US20060216316A1
公开(公告)日：2006-09-28
申请号：US11378257
申请日：2006-03-20
申请人： Madhav Dhodapkar , Ralph Steinman
发明人： Madhav Dhodapkar , Ralph Steinman
IPC分类号： A61K39/00 , C12N5/08 , A61K31/739
CPC分类号： C12N5/0646 , A61K2039/5158 , A61K2039/57 , C12N5/0639 , C12N2500/36 , C12N2502/11
摘要： This invention relates to the in vivo expansion of NKT cells by their exposure to mature dendritic cells expressing α-galactosyl ceramide and to methods of use thereof in modulating immune responses, such as anti-cancer responses, and enhancing memory responses.
摘要翻译：本发明涉及通过暴露于表达α-半乳糖神经酰胺的成熟树突状细胞的NKT细胞的体内扩增及其在调节免疫应答（例如抗癌反应）和增强记忆应答中的用途的方法。

6. 发明申请

US20060159654A1 Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof 有权
标题翻译：涉及信号转导的TNF超家族的蛋白质，其编码的核酸及其使用方法
公开(公告)号：US20060159654A1
公开(公告)日：2006-07-20
申请号：US11241106
申请日：2005-09-30
申请人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
发明人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
IPC分类号： A61K38/19 , C07K14/525 , C12Q1/68 , C07H21/04 , C12P21/02 , C07K16/24
CPC分类号： C07K16/2875 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/525 , C07K14/70575 , C07K2317/76 , C07K2319/30 , C12N15/1096
摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.
摘要翻译：公开了调节动物免疫应答的方法。这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突状细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。离体调节剂离体接触后，将成熟树突状细胞导入动物体内。因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。优选地，本发明的方法导致对动物中抗原的免疫应答增加。

7. 发明申请

US20050282282A1 Methods of use of viral vectors to deliver antigen to dendritic cells 审中-公开
标题翻译：使用病毒载体将抗原递送至树突状细胞的方法
公开(公告)号：US20050282282A1
公开(公告)日：2005-12-22
申请号：US11187314
申请日：2005-07-21
申请人： Ralph Steinman , Nina Bhardwaj , Armin Bender
发明人： Ralph Steinman , Nina Bhardwaj , Armin Bender
IPC分类号： A61K39/00 , A61K39/145 , C12N5/08 , C12N7/04 , C12N15/86
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5154 , A61K2039/5252 , A61K2039/5254 , A61K2039/57 , C12N15/86 , C12N2760/16043 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are provided to dendritic cells using a viral vector such as influenza virus which may be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are infected with the vector are then capable of presenting the antigen and inducing cytotoxic T-lymphocyte activity or may also be used as vaccines.
摘要翻译：本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导T抗原特异性细胞毒性T淋巴细胞。本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。根据本发明，使用病毒载体如流感病毒将抗原提供给树突状细胞，所述病毒载体可被修饰以表达非天然抗原以呈递至树突状细胞。然后用载体感染的树突状细胞能够呈递抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用作疫苗。

8. 发明申请

US20070014795A1 Compositions and methods for enhanced dendritic cell maturation and function 审中-公开
标题翻译：增强树突细胞成熟和功能的组合物和方法
公开(公告)号：US20070014795A1
公开(公告)日：2007-01-18
申请号：US11317892
申请日：2005-12-27
申请人： Madhav Dhodapkar , Jeffrey Ravetch , Ralph Steinman , Kavita Dhodapkar
发明人： Madhav Dhodapkar , Jeffrey Ravetch , Ralph Steinman , Kavita Dhodapkar
IPC分类号： A61K39/395 , A61K35/14
CPC分类号： A61K45/06 , A61K31/4412 , A61K39/39541 , A61K2039/505 , C07K16/283 , C07K2317/76 , A61K2300/00
摘要： This invention relates to compositions comprising an agent, which inhibits signaling via the FcγRIIB receptor and an agent which stimulates or enhances signaling via an FcγRI receptor, an FcγRIIa receptor, an FcγRIII receptor, or a combination thereof. The invention also provides for the use of such compositions in stimulating or enhancing an immune response, and in treating, suppressing, or preventing cancer in a subject.
摘要翻译：本发明涉及包含通过FcγRIIB受体抑制信号传导的药剂和刺激或增强通过FcγR受体，FcγRIIa受体，FcγRIII受体或其组合的信号传导的药剂的组合物。本发明还提供了这样的组合物在刺激或增强免疫应答以及治疗，抑制或预防受试者癌症中的用途。

9. 发明授权

US08399628B2 Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same and methods of use thereof 有权
公开(公告)号：US08399628B2
公开(公告)日：2013-03-19
申请号：US12840967
申请日：2010-07-21
申请人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
发明人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
IPC分类号： C07K16/24
CPC分类号： C07K16/2875 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/525 , C07K14/70575 , C07K2317/76 , C07K2319/30 , C12N15/1096
摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

10. 发明申请

US20130064813A1 Protein Belonging to the TNF Superfamily Involved in Signal Transduction, Nucleic Acids Encoding Same and Methods of Use Thereof 有权
公开(公告)号：US20130064813A1
公开(公告)日：2013-03-14
申请号：US13586514
申请日：2012-08-15
申请人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
发明人： Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
IPC分类号： A61K39/395 , A61P37/02
CPC分类号： C07K16/2875 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/525 , C07K14/70575 , C07K2317/76 , C07K2319/30 , C12N15/1096
摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

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