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1. 发明授权

US06259945B1 Method and device for locating a nerve 失效
标题翻译：用于定位神经的方法和装置
公开(公告)号：US06259945B1
公开(公告)日：2001-07-10
申请号：US09303501
申请日：1999-04-30
申请人： Richard Epstein , David G. Abichaker
发明人： Richard Epstein , David G. Abichaker
IPC分类号： A61B505
CPC分类号： A61N1/36014
摘要： An improved method and device for locating a nerve based on a closed-loop automated system is described. The device applies an electro-stimulus to a target tissue area and measures and interprets a change in a response evoked by application of an electro-stimulus to determine the location and responsiveness of a nerve. The improvement of the invention comprises a method for determining if the signal of the response is stable prior to application of electro-stimulation to prevent misinterpretation of a response and to enhance the locating accuracy of the device.
摘要翻译：描述了一种用于基于闭环自动化系统定位神经的改进方法和装置。该装置对目标组织区域施加电刺激，并测量并解释通过应用电刺激诱发的响应的变化，以确定神经的位置和响应性。本发明的改进包括一种用于在施加电刺激之前确定响应信号是否稳定以防止对响应的误解的方法，并且提高装置的定位精度。

2. 发明授权

US5834291A Inviable phages, their production and DNA thereof 失效
公开(公告)号：US5834291A
公开(公告)日：1998-11-10
申请号：US468027
申请日：1995-06-06
申请人： Thomas Lee Mattson , Richard Epstein
发明人： Thomas Lee Mattson , Richard Epstein
IPC分类号： C12N15/70 , C12N15/00 , C12N15/11 , C12Q1/68
CPC分类号： C12N15/70
摘要： Inviable T4 phage-like particles capable of directing the expression of large non-T4 DNA fragments from T4 expression control sequences are produced. Thus, E. coli harboring pBR322 derivatives containing cloned T4 gene 23 DNA sequences were infected with T4 phage carrying a deletion of the denB gene. Homology-dependent recombination results in the production of inviable phage-like particles containing DNA molecules composed of multiple, tandemly repeated copies of entire plasmid molecules covalently linked to single copies of normal phage genes. The yield of these inviable particles, intially low, was increased by means of a reiterated infection process that involves the use of a cloned T4 origin of replication. When T4 gene 32 expression control sequences linked in proper orientation to a DNA sequence coding for the non-T4 protein .beta.-galactosidase were also cloned in one such pBR322 derivative (pVH773), inviable phage particles capable of directing the synthesis of enzymatically active .beta.-galactosidase were produced. The present process is applicable to other T-even bacterio-phages.

3. 发明授权

US09574801B1 Solid state optical refrigeration using stark manifold resonances in crystals 有权
标题翻译：固体光学制冷在晶体中使用严格的歧管共振
公开(公告)号：US09574801B1
公开(公告)日：2017-02-21
申请号：US12977465
申请日：2010-12-23
申请人： Denis V. Seletskiy , Richard Epstein , Markus P. Hehlen , Mansoor Sheik-Bahae
发明人： Denis V. Seletskiy , Richard Epstein , Markus P. Hehlen , Mansoor Sheik-Bahae
IPC分类号： F25B21/00 , F25B23/00
CPC分类号： F25B21/00 , F25B23/00 , H01S3/0408 , H01S3/061 , H01S3/094038 , H01S3/1618 , H01S3/1653 , H01S3/173 , Y02B30/66
摘要： A method and device for cooling electronics is disclosed. The device includes a doped crystal configured to resonate at a Stark manifold resonance capable of cooling the crystal to a temperature of from about 110K to about 170K. The crystal host resonates in response to input from an excitation laser tuned to exploit the Stark manifold resonance corresponding to the cooling of the crystal.
摘要翻译：公开了一种用于冷却电子设备的方法和装置。该器件包括被配置为在能够将晶体冷却至约110K至约170K的温度的斯塔克歧管共振下共振的掺杂晶体。晶体主机响应来自激发激光器的输入而谐振，激发激光器被调谐以利用对应于晶体冷却的斯塔克歧管共振。

4. 发明申请

US20110066145A1 RF cosmetic rejuvenation device and procedure 有权
标题翻译：射频化妆品年轻化装置及程序
公开(公告)号：US20110066145A1
公开(公告)日：2011-03-17
申请号：US12586006
申请日：2009-09-17
申请人： Richard Epstein , Jonathan Achenbach
发明人： Richard Epstein , Jonathan Achenbach
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B2018/00452
摘要： An electrode especially useful for RF skin tightening procedures is characterized by an active front that is conical in part with the conical surface having a cone angle that is shallower than the corresponding angle in known electrodes. Preferably, the electrode of the invention has a conical section whose surface forms an angle greater than 60 degrees with the longitudinal axis of the electrode, and the outside diameter of the conical section is greater than 50% of the overall outside diameter of the electrode.
摘要翻译：特别适用于RF皮肤紧固程序的电极的特征在于活动前部，其锥形部分具有比已知电极中的相应角度浅的锥角。优选地，本发明的电极具有锥形部分，其表面与电极的纵向轴线形成大于60度的角度，并且锥形部分的外径大于电极总体外径的50％。

5. 发明申请

US20150075181A1 Optical Refrigerator 审中-公开
标题翻译：光学冰箱
公开(公告)号：US20150075181A1
公开(公告)日：2015-03-19
申请号：US14476351
申请日：2014-09-03
申请人： Richard Epstein , Jay Viktor Alden
发明人： Richard Epstein , Jay Viktor Alden
IPC分类号： F25B23/00
CPC分类号： F25B23/003 , H01S3/0408
摘要： An optical refrigerator comprises a laser source, a cooling crystal, a cavity for enhancing the absorption of the laser light in the cooling crystal, a thermal link which connects a cold finger to the cooling crystal and prevents the fluorescence from heating the cold finger, an absorbing chamber to remove the fluorescence and eliminate the waste heat, an a mechanical support that keeps the cooling crystal properly aligned with the laser beam and minimizes heat leakage.
摘要翻译：光学冰箱包括激光源，冷却晶体，用于增强冷却晶体中的激光吸收的空腔，将冷指连接到冷却晶体并防止荧光加热冷手指的热连接，吸收室以除去荧光并消除废热，这是机械支撑件，其保持冷却晶体与激光束正确对准并最小化热泄漏。

6. 发明申请

US20130195616A1 WAVE-DRIVEN BLOWER AND ELECTRIC MOTOR/GENERATOR 审中-公开
标题翻译：波驱动风扇和电动机/发电机
公开(公告)号：US20130195616A1
公开(公告)日：2013-08-01
申请号：US13876218
申请日：2011-10-12
申请人： Richard Epstein
发明人： Richard Epstein
IPC分类号： F01D25/12
CPC分类号： F01D25/12 , F04B19/006 , F04B19/20 , F04F7/00
摘要： The present invention provides a wave-driven blower and a wave-driven generator. Embodiments can accelerate fluid flows with waves requiring with no or minimal moving parts. The waves driving the flow can be surface-thermal waves on the walls of the device. The velocity of the surface-thermal wave entrains the fluid near the surface and imparts a velocity to the fluid. Other types of waves can generate fluid flow. These other waves can be produced by variations in chemical composition, ionic concentration, chemical potential, total pressure, partial pressure and surface texture. Operating as a generator, the device extracts energy from a flowing fluid to amplify wave motions. The wave motions in turn generate electrical power or some other form of useable power
摘要翻译：本发明提供了一种波浪式鼓风机和波浪式发电机。实施例可以在没有或最小的移动部件的情况下加速需要波浪的流体流动。驱动流动的波浪可以是设备壁上的表面热波。表面热波的速度使表面附近的流体携带，并向流体施加速度。其他类型的波浪可以产生流体流动。这些其他波可以通过化学成分，离子浓度，化学势，总压力，分压和表面纹理的变化产生。作为发电机操作，该装置从流动的流体中提取能量以放大波动。波动反过来产生电力或某种其他形式的可用功率

7. 发明授权

US08359104B2 RF cosmetic rejuvenation device and procedure 有权
标题翻译：射频化妆品年轻化装置及程序
公开(公告)号：US08359104B2
公开(公告)日：2013-01-22
申请号：US12586006
申请日：2009-09-17
申请人： Richard Epstein , Jonathan Achenbach
发明人： Richard Epstein , Jonathan Achenbach
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/14 , A61B2018/00452
摘要： An electrode especially useful for RF skin tightening procedures is characterized by an active front that is conical in part with the conical surface having a cone angle that is shallower than the corresponding angle in known electrodes. Preferably, the electrode of the invention has a conical section whose surface forms an angle greater than 60 degrees with the longitudinal axis of the electrode, and the outside diameter of the conical section is greater than 50% of the overall outside diameter of the electrode.
摘要翻译：特别适用于RF皮肤紧固程序的电极的特征在于活动前部，其锥形部分具有比已知电极中的相应角度浅的锥角。优选地，本发明的电极具有锥形部分，其表面与电极的纵向轴线形成大于60度的角度，并且锥形部分的外径大于电极总体外径的50％。

8. 发明授权

US06535759B1 Method and device for locating and mapping nerves 失效
标题翻译：用于定位和定位神经的方法和装置
公开(公告)号：US06535759B1
公开(公告)日：2003-03-18
申请号：US09692418
申请日：2000-10-20
申请人： Richard Epstein , David G. Abichaker , Richard P. Rego
发明人： Richard Epstein , David G. Abichaker , Richard P. Rego
IPC分类号： A61B505
CPC分类号： A61N1/36014
摘要： The present application discloses a method and device for locating and mapping the cavernosal nerve bundle by electro-stimulation to enable safe and effective implantation of radioactive seeds for prostate brachytherapy. By locating and mapping the cavernosal nerve bundle prior to seed implantation, the brachytherapist can make intra-operative decisions to avoid mechanical and radiational injury to the nerve which results in impotency or other prostate-Urethral complications. The device of the invention takes the form of an automated closed-looped electro-stimulating system having a handle for manipulating the device, a stimulating tip for applying an electro-stimulus to a tissue site, a control unit to activate and terminate application of the electro-stimulus and to interpret a tumescence response, a sensor for detecting and measuring a tumescence response, a patient ground return, and a display monitor to indicate the nature, stability and strength of the tumescence response to the brachytherapist. If the control unit concludes that the applied electro-stimulus failed to evoke a tumescence response in excess of a pre-determined baseline and that the tissue lacks cavernosal nerve bundle fibers, radioactive seeds can be implanted in the prostate through the stimulating tip which also serves as a brachytherapy seed implantation needle. Alternatively, the coordinates of the tissue site can be mapped on the perineal grid or on a pre-plan grid for later seed implantation.
摘要翻译：本申请公开了一种通过电刺激定位和映射海绵体神经束的方法和装置，以使安全有效地植入用于前列腺近距离放射治疗的放射性种子。通过在种子植入之前定位和绘制海绵体神经束，近距离治疗师可以进行手术中的决定，以避免神经的机械和辐射损伤，导致阳ency或其他前列腺 - 尿道并发症。本发明的装置采用自动化闭环电刺激系统的形式，其具有用于操纵装置的手柄，用于向组织部位施加电刺激的刺激尖端，控制单元以激活和终止应用电刺激和解释肿胀反应，用于检测和测量肿胀反应的传感器，患者接地返回和显示监视器，以指示对brachytherapist的肿胀反应的性质，稳定性和强度。如果控制单元得出结论，施加的电刺激不能引起超过预定基线的肿胀反应，并且组织缺乏海绵体神经束纤维，则放射性种子可以通过刺激尖端植入前列腺中，刺激尖端也服用作为近距离放射治疗种子植入针。或者，组织部位的坐标可以映射在会阴网格上或者在预先格栅上，以供后续的种子植入。

9. 发明授权

US5559018A Inviable phages, their production and DNA thereof 失效
标题翻译：不可侵犯的噬菌体，其生产和DNA
公开(公告)号：US5559018A
公开(公告)日：1996-09-24
申请号：US946033
申请日：1992-09-15
申请人： Thomas L. Mattson , Richard Epstein
发明人： Thomas L. Mattson , Richard Epstein
IPC分类号： C12N15/70 , C12N15/00 , C12N15/63
CPC分类号： C12N15/70
摘要： Inviable T4 phage-like particles capable of directing the expression of large non-T4 DNA fragments from T4 expression control sequences are produced. Thus, E. coli harboring pBR322 derivatives containing cloned T4 gene 23 DNA sequences were infected with T4 phage carrying a deletion of the denB gene. Homology-dependent recombination results in the production of inviable phage-like particles containing DNA molecules composed of multiple, tandemly repeated copies of entire plasmid molecules covalently linked to single copies of normal phage genes. The yield of these inviable particles, intially low, was increased by means of a reiterated infection process that involves the use of a cloned T4 origin of replication. When T4 gene 32 expression control sequences linked in proper orientation to a DNA sequence coding for the non-T4 protein .beta.-galactosidase were also cloned in one such pBR322 derivative (pVH773), inviable phage particles capable of directing the synthesis of enzymatically active .beta.-galactosidase were produced. The present process is applicable to other T-even bacterio-phages.
摘要翻译：产生能够引导来自T4表达调控序列的大的非T4 DNA片段表达的不可维生的T4噬菌体样颗粒。因此，含有克隆的T4基因23个DNA序列的pBR322衍生物的大肠杆菌用携带denB基因缺失的T4噬菌体感染。同源性依赖性重组导致产生含有DNA分子的易发生的噬菌体样颗粒，其由与正常噬菌体基因的单拷贝共价连接的整个质粒分子的多个串联重复拷贝组成。通过涉及使用克隆的T4复制起点的重复的感染过程，这些不可侵犯的颗粒的产量是非常低的。当将T4基因32表达控制序列与编码非T4蛋白质β-半乳糖苷酶的DNA序列连接的表达调控序列也克隆在一个这样的pBR322衍生物（pVH773）中时，能够引导酶活性β- 产生半乳糖苷酶。本方法适用于其他T-even细菌噬菌体。

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