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1. 发明授权

US06259945B1 Method and device for locating a nerve 失效
标题翻译：用于定位神经的方法和装置
公开(公告)号：US06259945B1
公开(公告)日：2001-07-10
申请号：US09303501
申请日：1999-04-30
申请人： Richard Epstein , David G. Abichaker
发明人： Richard Epstein , David G. Abichaker
IPC分类号： A61B505
CPC分类号： A61N1/36014
摘要： An improved method and device for locating a nerve based on a closed-loop automated system is described. The device applies an electro-stimulus to a target tissue area and measures and interprets a change in a response evoked by application of an electro-stimulus to determine the location and responsiveness of a nerve. The improvement of the invention comprises a method for determining if the signal of the response is stable prior to application of electro-stimulation to prevent misinterpretation of a response and to enhance the locating accuracy of the device.
摘要翻译：描述了一种用于基于闭环自动化系统定位神经的改进方法和装置。该装置对目标组织区域施加电刺激，并测量并解释通过应用电刺激诱发的响应的变化，以确定神经的位置和响应性。本发明的改进包括一种用于在施加电刺激之前确定响应信号是否稳定以防止对响应的误解的方法，并且提高装置的定位精度。

2. 发明授权

US06535759B1 Method and device for locating and mapping nerves 失效
标题翻译：用于定位和定位神经的方法和装置
公开(公告)号：US06535759B1
公开(公告)日：2003-03-18
申请号：US09692418
申请日：2000-10-20
申请人： Richard Epstein , David G. Abichaker , Richard P. Rego
发明人： Richard Epstein , David G. Abichaker , Richard P. Rego
IPC分类号： A61B505
CPC分类号： A61N1/36014
摘要： The present application discloses a method and device for locating and mapping the cavernosal nerve bundle by electro-stimulation to enable safe and effective implantation of radioactive seeds for prostate brachytherapy. By locating and mapping the cavernosal nerve bundle prior to seed implantation, the brachytherapist can make intra-operative decisions to avoid mechanical and radiational injury to the nerve which results in impotency or other prostate-Urethral complications. The device of the invention takes the form of an automated closed-looped electro-stimulating system having a handle for manipulating the device, a stimulating tip for applying an electro-stimulus to a tissue site, a control unit to activate and terminate application of the electro-stimulus and to interpret a tumescence response, a sensor for detecting and measuring a tumescence response, a patient ground return, and a display monitor to indicate the nature, stability and strength of the tumescence response to the brachytherapist. If the control unit concludes that the applied electro-stimulus failed to evoke a tumescence response in excess of a pre-determined baseline and that the tissue lacks cavernosal nerve bundle fibers, radioactive seeds can be implanted in the prostate through the stimulating tip which also serves as a brachytherapy seed implantation needle. Alternatively, the coordinates of the tissue site can be mapped on the perineal grid or on a pre-plan grid for later seed implantation.
摘要翻译：本申请公开了一种通过电刺激定位和映射海绵体神经束的方法和装置，以使安全有效地植入用于前列腺近距离放射治疗的放射性种子。通过在种子植入之前定位和绘制海绵体神经束，近距离治疗师可以进行手术中的决定，以避免神经的机械和辐射损伤，导致阳ency或其他前列腺 - 尿道并发症。本发明的装置采用自动化闭环电刺激系统的形式，其具有用于操纵装置的手柄，用于向组织部位施加电刺激的刺激尖端，控制单元以激活和终止应用电刺激和解释肿胀反应，用于检测和测量肿胀反应的传感器，患者接地返回和显示监视器，以指示对brachytherapist的肿胀反应的性质，稳定性和强度。如果控制单元得出结论，施加的电刺激不能引起超过预定基线的肿胀反应，并且组织缺乏海绵体神经束纤维，则放射性种子可以通过刺激尖端植入前列腺中，刺激尖端也服用作为近距离放射治疗种子植入针。或者，组织部位的坐标可以映射在会阴网格上或者在预先格栅上，以供后续的种子植入。

3. 发明授权

US5049510A Process for histological tissue specimen treatment that includes variable sensitivity level control 失效
标题翻译：包括变量敏感度水平控制的组织标本处理过程
公开(公告)号：US5049510A
公开(公告)日：1991-09-17
申请号：US461379
申请日：1990-01-05
申请人： Roger J. Repasi , David G. Abichaker , Jerry C. Premus
发明人： Roger J. Repasi , David G. Abichaker , Jerry C. Premus
IPC分类号： G01N1/30 , G01N1/31
CPC分类号： G01N1/31 , G01N2001/305 , Y10T436/2525
摘要： A histological tissue specimen treatment process includes the steps of placing a plurality of histological tissue specimens to be processed in chamber structure, closing the chamber structure, monitoring the level of a first tissue processing material flowed into the chamber structure with a sensor system that responds to a characteristic of the first tissue processing material, terminating the flow of the first tissue processing material when the histological tissue specimens are immersed in the first tissue processing material, flowing the first tissue processing material from the chamber structure after the histological tissue specimens have been immersed in the first tissue processing material for a predetermined time interval, monitoring the level of a second tissue processing material flowed into the chamber structure with the sensor system in a changed sensitivity condition, terminating the flow of the second tissue processing material when the plurality of histological tissue specimens are immersed in the second tissue processing material, and flowing the second tissue processing material from the chamber structure after the plurality of histological tissue specimens have been immersed in the second tissue processing material for a predetermined time interval.
摘要翻译：组织组织样本处理过程包括以下步骤：将待处理的多个组织学组织样本放置在腔室结构中，关闭腔室结构，监测流入腔室结构的第一组织处理材料的水平，该传感器系统响应于第一组织处理材料的特征，当组织学组织标本被浸入第一组织处理材料中时终止第一组织处理材料的流动，在组织学组织标本浸没之后使第一组织处理材料从腔室结构中流出在第一组织处理材料中以预定的时间间隔监测传感器系统处于改变的灵敏度条件下流入室结构的第二组织处理材料的水平，当多个组织学组织在第二组织处理材料浸渍第二组织处理材料之后，将多个组织样本浸入第二组织处理材料中，并将第二组织处理材料从腔室结构中流出，预定时间间隔。

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