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    • 1. 发明授权
    • Method and device for locating and mapping nerves
    • 用于定位和定位神经的方法和装置
    • US06535759B1
    • 2003-03-18
    • US09692418
    • 2000-10-20
    • Richard EpsteinDavid G. AbichakerRichard P. Rego
    • Richard EpsteinDavid G. AbichakerRichard P. Rego
    • A61B505
    • A61N1/36014
    • The present application discloses a method and device for locating and mapping the cavernosal nerve bundle by electro-stimulation to enable safe and effective implantation of radioactive seeds for prostate brachytherapy. By locating and mapping the cavernosal nerve bundle prior to seed implantation, the brachytherapist can make intra-operative decisions to avoid mechanical and radiational injury to the nerve which results in impotency or other prostate-Urethral complications. The device of the invention takes the form of an automated closed-looped electro-stimulating system having a handle for manipulating the device, a stimulating tip for applying an electro-stimulus to a tissue site, a control unit to activate and terminate application of the electro-stimulus and to interpret a tumescence response, a sensor for detecting and measuring a tumescence response, a patient ground return, and a display monitor to indicate the nature, stability and strength of the tumescence response to the brachytherapist. If the control unit concludes that the applied electro-stimulus failed to evoke a tumescence response in excess of a pre-determined baseline and that the tissue lacks cavernosal nerve bundle fibers, radioactive seeds can be implanted in the prostate through the stimulating tip which also serves as a brachytherapy seed implantation needle. Alternatively, the coordinates of the tissue site can be mapped on the perineal grid or on a pre-plan grid for later seed implantation.
    • 本申请公开了一种通过电刺激定位和映射海绵体神经束的方法和装置,以使安全有效地植入用于前列腺近距离放射治疗的放射性种子。 通过在种子植入之前定位和绘制海绵体神经束,近距离治疗师可以进行手术中的决定,以避免神经的机械和辐射损伤,导致阳ency或其他前列腺 - 尿道并发症。 本发明的装置采用自动化闭环电刺激系统的形式,其具有用于操纵装置的手柄,用于向组织部位施加电刺激的刺激尖端,控制单元以激活和终止应用 电刺激和解释肿胀反应,用于检测和测量肿胀反应的传感器,患者接地返回和显示监视器,以指示对brachytherapist的肿胀反应的性质,稳定性和强度。 如果控制单元得出结论,施加的电刺激不能引起超过预定基线的肿胀反应,并且组织缺乏海绵体神经束纤维,则放射性种子可以通过刺激尖端植入前列腺中,刺激尖端也服用 作为近距离放射治疗种子植入针。 或者,组织部位的坐标可以映射在会阴网格上或者在预先格栅上,以供后续的种子植入。