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1. 发明申请

US20150024019A1 ANTIMICROBIAL-COATED MEDICAL ARTICLES 有权
标题翻译：抗微生物涂层医学文章
公开(公告)号：US20150024019A1
公开(公告)日：2015-01-22
申请号：US13699345
申请日：2011-05-25
申请人： Mahfuza B. Ali , Naiyong Jing , Valeri Lirine , Pradnya V. Nagarkar , Caroline M. Ylitalo , Nancy S. Lennhoff , Matthew T. Scholz , Ranjani V. Parthasarathy
发明人： Mahfuza B. Ali , Naiyong Jing , Valeri Lirine , Pradnya V. Nagarkar , Caroline M. Ylitalo , Nancy S. Lennhoff , Matthew T. Scholz , Ranjani V. Parthasarathy
IPC分类号： A61L29/08 , B05D3/02 , B05D3/06 , A61L29/16
CPC分类号： C09D5/1637 , A61L29/085 , A61L29/16 , A61L2300/216 , A61L2300/404 , A61L2420/02 , B05D3/02 , B05D3/06 , C03C17/30 , C03C17/42 , C08F220/06 , C08F220/18 , C08F220/34 , C08F230/08 , C08G77/26 , C09D5/1675 , C09D5/1693 , C09D183/10 , G06F3/041 , G06F3/047 , Y10T428/31663
摘要： The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
摘要翻译：本公开提供具有抗微生物活性的聚合物和其上涂覆有聚合物的制品。聚合物包括包含第一阳离子组分的第一侧基，包含非极性组分的第二侧基和包含有机硅烷组分的第三侧基。本公开还包括用抗微生物聚合物涂覆医疗器械制品和体液接收基底的方法。所述方法还包括使用粘附促进组分。

2. 发明申请

US20100233717A1 METHODS FOR DETECTING TOXIGENIC MICROBES 审中-公开
标题翻译：检测毒素微生物的方法
公开(公告)号：US20100233717A1
公开(公告)日：2010-09-16
申请号：US12741147
申请日：2008-11-05
申请人： Jesse D. Miller , Ranjani V. Parthasarathy
发明人： Jesse D. Miller , Ranjani V. Parthasarathy
IPC分类号： C12Q1/68 , C07H1/06 , C07H21/04
CPC分类号： C12Q1/689
摘要： The present invention provides methods and oligonucleotides for detecting toxigenic microbes, such as toxigenic Clostridium spp., in a sample.
摘要翻译：本发明提供了用于检测样品中产毒性微生物如产毒梭菌的方法和寡核苷酸。

3. 发明申请

US20100151469A1 SAMPLE-PROCESSING REAGENT COMPOSITIONS, METHODS, AND DEVICES 审中-公开
标题翻译：样品处理试剂组合物，方法和装置
公开(公告)号：US20100151469A1
公开(公告)日：2010-06-17
申请号：US12597394
申请日：2008-04-25
申请人： Wensheng Xia , Ranjani V. Parthasarathy
发明人： Wensheng Xia , Ranjani V. Parthasarathy
IPC分类号： C12Q1/68 , C12N9/00 , C12N9/48 , C12N9/36 , C12N9/50 , C12N9/42 , C12N1/06 , C40B40/10 , C12M1/00
CPC分类号： C12N15/1006
摘要： Stable compositions comprising a nucleic acid binding support material comprising a substrate with functional groups attached to the substrate; a lysing enzyme; a water dispersible matrix material; and a saccharide, methods of using the compositions, and products and devices which include the compositions are disclosed.
摘要翻译：包含核酸结合支持材料的稳定组合物，所述核酸结合载体材料包含具有连接至所述底物的官能团的底物; 裂解酶; 水分散基质材料; 和糖，公开了使用组合物的方法，以及包括该组合物的产品和装置。

4. 发明授权

US07347976B2 Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix 失效
标题翻译：在疏水基质中使用亲水性固体载体从生物混合物中除去有机分子的方法和装置
公开(公告)号：US07347976B2
公开(公告)日：2008-03-25
申请号：US10027226
申请日：2001-12-20
申请人： Ranjani V. Parthasarathy , Raj Rajagopal , Vicky L. Morris , William Bedingham , Barry W. Robole
发明人： Ranjani V. Parthasarathy , Raj Rajagopal , Vicky L. Morris , William Bedingham , Barry W. Robole
IPC分类号： B01L11/00
CPC分类号： C12N15/1006 , Y10T428/25 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses a solid-phase extraction material that includes a hydrophilic solid support at least partially embedded within a hydrophobic matrix.
摘要翻译：用于从使用固相萃取材料的生物样品混合物中去除小负电荷分子的方法和装置，所述固相萃取材料包括至少部分嵌入疏水基质内的亲水性固体支持物。

5. 发明授权

US08460689B2 Oral care method and kit 有权
标题翻译：口腔护理方法和试剂盒
公开(公告)号：US08460689B2
公开(公告)日：2013-06-11
申请号：US12775197
申请日：2010-05-06
申请人： Katie F. Wlaschin , Alan R. Dombrowski , Matthew T. Scholz , Ranjani V. Parthasarathy
发明人： Katie F. Wlaschin , Alan R. Dombrowski , Matthew T. Scholz , Ranjani V. Parthasarathy
IPC分类号： A61K8/43 , A61K6/00 , A61K31/155
CPC分类号： A61K31/155 , A61M16/04
摘要： A method of moisturizing while decolonizing mammalian tissue, the method comprising applying a multi-valent cationic antiseptic composition to the tissue, and applying a moisturizer composition to at least a portion of the same tissue; wherein the mammalian tissue is oral tissue of a subject; wherein the multi-valent cationic antiseptic is other than a metal ion; and wherein the applied compositions essentially exclude any component which causes a precipitate when combined with a multi-valent cationic antiseptic contained in the multi-valent cationic antiseptic composition when tested according to Test Method F, and/or wherein the moisturizer composition is such that a log reduction in the number of viable bacterial cells of at least 2 is provided when 106 cfu of Pseudomonas aeruginosa are combined with a mixture 1.1 g of the moisturizer composition and 1.5 g of the multi-valent cationic antiseptic composition containing 0.12 weight percent of the multi-valent cationic antiseptic according to Test Method B; an oral care kit comprising a composition comprising the multi-valent cationic antiseptic and the moisturizer composition; and a method of moisturizing oral tissue of a patient requiring intubation using the moisturizer composition and an endotracheal tube coated or impregnated with a cationic antiseptic are provided.
摘要翻译：一种在哺乳动物组织非殖化时保湿的方法，该方法包括将多价阳离子防腐组合物施用于组织，以及将保湿组合物施用于相同组织的至少一部分; 其中哺乳动物组织是受试者的口腔组织; 其中所述多价阳离子防腐剂不是金属离子; 并且其中当根据测试方法F测试时，所施加的组合物基本上排除任何与多价阳离子防腐组合物中所含的多价阳离子防腐剂组合时引起沉淀的组分，和/或其中所述保湿组合物使得当将106 cfu的绿脓假单胞菌与1.1g的保湿组合物和1.5g多价阳离子防腐剂组合物混合在一起时，提供至少2个活细菌细胞数目的对数减少，该组合物含有0.12重量％的多根据测试方法B的阳离子抗菌剂; 口腔护理套件，其包含包含所述多价阳离子防腐剂和所述保湿组合物的组合物; 提供了使用保湿组合物和使用阳离子防腐剂涂布或浸渍的气管内导管的需要插管的患者的口腔组织的保湿方法。

6. 发明授权

US07939249B2 Methods for nucleic acid isolation and kits using a microfluidic device and concentration step 有权
标题翻译：核酸分离方法和使用微流控装置和浓缩步骤的试剂盒
公开(公告)号：US07939249B2
公开(公告)日：2011-05-10
申请号：US10852085
申请日：2004-05-24
申请人： Ranjani V. Parthasarathy , Katya Ericson , William Bedingham
发明人： Ranjani V. Parthasarathy , Katya Ericson , William Bedingham
IPC分类号： C12Q1/68
CPC分类号： C12N15/10 , Y10T436/25
摘要： The present invention provides methods and kits for isolating nucleic acid from a sample, preferably from a biological sample, using a microfluidic device and a concentration step.
摘要翻译：本发明提供了使用微流体装置和浓缩步骤从样品，优选来自生物样品中分离核酸的方法和试剂盒。

7. 发明申请

US20100167304A1 VARIABLE VALVE APPARATUS AND METHODS 有权
标题翻译：可变阀装置及方法
公开(公告)号：US20100167304A1
公开(公告)日：2010-07-01
申请号：US12719704
申请日：2010-03-08
申请人： William Bedingham , Barry W. Robole , Ranjani V. Parthasarathy , Katya Ericson
发明人： William Bedingham , Barry W. Robole , Ranjani V. Parthasarathy , Katya Ericson
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502738 , B01L2300/0806 , B01L2400/0409 , B01L2400/0677
摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.
摘要翻译：公开了具有可变阀结构的样品处理装置及其使用方法。阀结构允许去除位于处理室内的样品材料的选定部分。通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。

8. 发明申请

US20100136554A1 SUPPORTED REAGENTS, METHODS, AND DEVICES 有权
标题翻译：支持的试剂，方法和装置
公开(公告)号：US20100136554A1
公开(公告)日：2010-06-03
申请号：US12597410
申请日：2008-04-25
申请人： Ranjani V. Parthasarathy , Michael E. Danielson , John C. Faletti , William Bedingham
发明人： Ranjani V. Parthasarathy , Michael E. Danielson , John C. Faletti , William Bedingham
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/5027 , B01L2200/12 , B01L2200/16 , B01L2300/0803 , B01L2300/0864 , B01L2300/0887 , G01N33/54366 , G01N33/54393
摘要： Methods of providing at least one reagent for use in a device for processing sample material, delivering at least one reagent to a device for processing sample material, and adding at least one reagent to at least one of the steps in a process for detecting or assaying a nucleic acid; a support film coated with a dry reagent layer; and a device for processing sample material having a support film coated with a dry reagent layer contained within at least one chamber of the device are disclosed.
摘要翻译：提供用于处理样品材料的装置中的至少一种试剂的方法，将至少一种试剂输送到用于处理样品材料的装置，以及在检测或测定方法中的至少一个步骤中加入至少一种试剂核酸; 涂覆有干试剂层的支撑膜; 并且公开了一种用于处理样品材料的装置，其具有涂覆有包含在该装置的至少一个室中的干试剂层的支撑膜。

9. 发明申请

US20100062421A1 COMPOSITIONS, METHODS, AND DEVICES FOR ISOLATING BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于分离生物材料的组合物，方法和装置
公开(公告)号：US20100062421A1
公开(公告)日：2010-03-11
申请号：US12597326
申请日：2008-04-25
申请人： Wensheng Xia , Paul N. Holt , Ranjani V. Parthasarathy , Manjiri T. Kshirsagar
发明人： Wensheng Xia , Paul N. Holt , Ranjani V. Parthasarathy , Manjiri T. Kshirsagar
IPC分类号： C12Q1/70 , C07H21/02 , C12Q1/68 , C12M1/33 , C12N7/02 , C12N1/06 , C12N1/20
CPC分类号： C12N15/1006 , G01N33/569
摘要： Compositions, methods, devices, and kits, which include an immobilized-metal support material comprising a substrate having a plurality of —C(O)O− or —P(O)(—OH)2-x(—O−)x groups bound to the substrate and a plurality of metal ions, My+, bound to the —C(O)O− or —P(O)(—OH)2-x(—O−)x groups; wherein M is selected from the group consisting of zirconium, gallium, iron, aluminum, scandium, titanium, vanadium, yttrium, and a lanthanide; y is an integer from 3 to 6; and x is 1 or 2, and to which microorganisms and polynucleotides bind, and which can be used for separating and optionally assaying microorganisms and/or a polynucleotide from a sample material are disclosed.
摘要翻译：组合物，方法，装置和试剂盒，其包括固定金属载体材料，其包含具有多个-C（O）O-或-P（O）（-OH）2-x（-O-）x 结合到基底和与-C（O）O-或-P（O）（ - OH）2-x（-O-）x基团结合的多个金属离子My +的基团; 其中M选自锆，镓，铁，铝，钪，钛，钒，钇和镧系元素; y为3〜6的整数; 并且x为1或2，并且公开了微生物和多核苷酸结合，并且其可用于从样品材料分离和任选地测定微生物和/或多核苷酸。

10. 发明授权

US06750261B1 High internal phase emulsion foams containing polyelectrolytes 失效
公开(公告)号：US06750261B1
公开(公告)日：2004-06-15
申请号：US10409378
申请日：2003-04-08
申请人： Susannah C. Clear , Ranjani V. Parthasarathy , Ravi K. Sura , Philip P. Soo
发明人： Susannah C. Clear , Ranjani V. Parthasarathy , Ravi K. Sura , Philip P. Soo
IPC分类号： C08J928
CPC分类号： C08J7/047 , C08J2321/00 , C08J2433/00
摘要： This invention relates to foams made by polymerizing high internal phase emulsions (HIPE) containing polyelectrolytes. The emulsions comprise a continuous oil phase and a co- or discontinuous aqueous phase. The resulting foams are useful as a separations medium.

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