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1. 发明申请

US20100233717A1 METHODS FOR DETECTING TOXIGENIC MICROBES 审中-公开
标题翻译：检测毒素微生物的方法
公开(公告)号：US20100233717A1
公开(公告)日：2010-09-16
申请号：US12741147
申请日：2008-11-05
申请人： Jesse D. Miller , Ranjani V. Parthasarathy
发明人： Jesse D. Miller , Ranjani V. Parthasarathy
IPC分类号： C12Q1/68 , C07H1/06 , C07H21/04
CPC分类号： C12Q1/689
摘要： The present invention provides methods and oligonucleotides for detecting toxigenic microbes, such as toxigenic Clostridium spp., in a sample.
摘要翻译：本发明提供了用于检测样品中产毒性微生物如产毒梭菌的方法和寡核苷酸。

2. 发明申请

US20110189665A1 METHODS FOR DETECTING DRUG-RESISTANT MICROBES 审中-公开
标题翻译：检测耐药微生物的方法
公开(公告)号：US20110189665A1
公开(公告)日：2011-08-04
申请号：US12673246
申请日：2008-08-12
申请人： Jesse D. Miller , Hsi-Chou C. Liu , Ranjani V. Parthasarathy
发明人： Jesse D. Miller , Hsi-Chou C. Liu , Ranjani V. Parthasarathy
IPC分类号： C12Q1/68 , C07H1/06 , C07H21/04
CPC分类号： C12Q1/689
摘要： The present invention provides methods and oligonucleotides for detecting drug-resistant microbes, such as vancomycin resistant Enterococcus spp., in a sample.
摘要翻译：本发明提供了在样品中检测耐药性微生物的方法和寡核苷酸，例如耐万古霉素肠球菌属。

3. 发明授权

US08846335B2 Device for rapidly detecting microorganisms 有权
标题翻译：用于快速检测微生物的装置
公开(公告)号：US08846335B2
公开(公告)日：2014-09-30
申请号：US13703149
申请日：2011-06-27
申请人： Stephanie J. Moeller , Jimmie R. Baran, Jr. , Jesse D. Miller , Neil Percy
发明人： Stephanie J. Moeller , Jimmie R. Baran, Jr. , Jesse D. Miller , Neil Percy
IPC分类号： C12Q1/08 , C12N11/04 , C12Q1/06 , C12M1/00 , B82Y5/00
CPC分类号： B01L9/52 , B82Y5/00 , C12M23/20 , C12M23/22 , C12M25/06 , C12M41/36 , C12Q1/06 , Y10T428/259
摘要： The disclosure includes: a coating composition, comprising a powdered cold-water-soluble gelling agent and surface-modified nanoparticles disposed in the powdered cold-water-soluble gelling agent; a coated film that includes a transparent film coated with the coating composition; and a device for growing microorganisms, including the coated film releasably attached to at least a portion of a body member that includes a self-supporting and water-proof substrate.
摘要翻译：本发明包括：涂料组合物，其包含粉末状冷水溶性胶凝剂和设置在粉末状冷水溶性胶凝剂中的表面改性纳米颗粒; 包括涂覆有所述涂料组合物的透明膜的涂膜; 以及用于生长微生物的装置，包括可释放地附着到包括自支撑和防水衬底的主体构件的至少一部分上的涂膜。

4. 发明申请

US20100203537A1 DUAL OLIGONUCLEOTIDE METHOD OF NUCLEIC ACID DETECTION 失效
标题翻译：核酸检测的双寡核苷酸方法
公开(公告)号：US20100203537A1
公开(公告)日：2010-08-12
申请号：US12680049
申请日：2008-09-26
申请人： Jesse D. Miller
发明人： Jesse D. Miller
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/686 , C12Q1/6818 , C12Q1/6853 , C12Q2563/107 , C12Q2531/113 , C12Q2527/107 , C12Q2525/161
摘要： Methods for amplifying and detecting nucleic acids are described, as well as sets of 5′ labeled oligonucleotides.
摘要翻译：描述了用于扩增和检测核酸的方法，以及5'标记寡核苷酸的组。

5. 发明授权

US08753834B2 Microbial detection article 有权
标题翻译：微生物检测文章
公开(公告)号：US08753834B2
公开(公告)日：2014-06-17
申请号：US13519284
申请日：2010-12-30
申请人： Jesse D. Miller , Stephanie J. Moeller , Kurt J. Halverson
发明人： Jesse D. Miller , Stephanie J. Moeller , Kurt J. Halverson
IPC分类号： C12Q1/04
CPC分类号： G01N33/56911 , C12M23/20 , C12M25/02 , C12M41/36 , C12Q1/04 , C12Q1/06 , G01N33/569
摘要： The disclosure provides an article for the detection of a microorganism in a liquid sample. The article comprises a microporous membrane and a barrier layer to selectively regulate the contact between the sample and a detection reagent. A method of use is also provided.
摘要翻译：本公开提供了用于检测液体样品中的微生物的制品。该制品包括微孔膜和阻挡层，以选择性地调节样品与检测试剂之间的接触。还提供了一种使用方法。

6. 发明申请

US20130230876A1 METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY 有权
标题翻译：检测生物活性的方法和组合物
公开(公告)号：US20130230876A1
公开(公告)日：2013-09-05
申请号：US13883620
申请日：2011-10-28
申请人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
发明人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/04
摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
摘要翻译：提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。第一指示剂可以包括具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再次吸收的9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。颗粒能够从水性液体中接收和保留第一生物衍生物。第一种生物衍生物可以指示微生物。组合物还可以包含胶凝剂。还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

7. 发明申请

US20130089923A1 DEVICE FOR RAPIDLY DETECTING MICROORGANISMS 有权
公开(公告)号：US20130089923A1
公开(公告)日：2013-04-11
申请号：US13703149
申请日：2011-06-27
申请人： Stephanie J. Moeller , Jimmie R. Baran, JR. , Jesse D. Miller , Neil Percy
发明人： Stephanie J. Moeller , Jimmie R. Baran, JR. , Jesse D. Miller , Neil Percy
IPC分类号： C12M1/00
CPC分类号： B01L9/52 , B82Y5/00 , C12M23/20 , C12M23/22 , C12M25/06 , C12M41/36 , C12Q1/06 , Y10T428/259
摘要： The disclosure includes: a coating composition, comprising a powdered cold-water-soluble gelling agent and surface-modified nanoparticles disposed in the powdered cold-water-soluble gelling agent; a coated film that includes a transparent film coated with the coating composition; and a device for growing microorganisms, including the coated film releasably attached to at least a portion of a body member that includes a self-supporting and water-proof substrate.

8. 发明授权

US09435739B2 Methods and compositions to detect a biological activity 有权
标题翻译：检测生物活性的方法和组合物
公开(公告)号：US09435739B2
公开(公告)日：2016-09-06
申请号：US13883620
申请日：2011-10-28
申请人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
发明人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
IPC分类号： C12Q1/44 , G01N21/64 , C12Q1/04
CPC分类号： G01N21/6486 , C12Q1/04
摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
摘要翻译：提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。第一指示剂可以包含具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再利用者，9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。颗粒能够从水性液体中接收和保留第一生物衍生物。第一种生物衍生物可以指示微生物。组合物还可以包含胶凝剂。还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

9. 发明申请

US20130316393A1 MICROBIAL DETECTION ARTICLE HAVING A WATER-ABSORBENT FILTER ASSEMBLY 有权
标题翻译：具有吸水过滤器组件的微生物检测文章
公开(公告)号：US20130316393A1
公开(公告)日：2013-11-28
申请号：US13809214
申请日：2011-12-27
申请人： Steven P. Swanson , Jesse D. Miller , Clinton P. Waller, JR. , Neil Percy , Jeffrey A. Lucas , Kannan Seshadri , Jerald K. Rasmussen , Douglas E. Weiss , James E. Aysta
发明人： Steven P. Swanson , Jesse D. Miller , Clinton P. Waller, JR. , Neil Percy , Jeffrey A. Lucas , Kannan Seshadri , Jerald K. Rasmussen , Douglas E. Weiss , James E. Aysta
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12M25/02 , C12M41/36 , C12Q1/24
摘要： A microbial detection article and methods of using the same, the article comprising: a base member comprising a self-supporting water impervious substrate with first and second generally opposed major surfaces; a filter assembly defining a filter assembly aperture therein, and having a composite filter body mounted across the filter assembly aperture; wherein the composite filter body comprises: a microporous membrane, and a water-absorbent layer in fluid communication with the microporous membrane; and a cover sheet.
摘要翻译：一种微生物检测制品及其使用方法，所述制品包括：基底构件，其包括具有第一和第二大致相对的主表面的自支撑防水基底; 过滤器组件，其中限定过滤器组件孔，并且具有穿过过滤器组件孔安装的复合过滤器主体; 其中所述复合过滤器主体包括：微多孔膜和与所述微多孔膜流体连通的吸水层; 和封面片。

10. 发明申请

US20120288888A1 MICROBIAL DETECTION ARTICLE 有权
标题翻译：微生物检测文章
公开(公告)号：US20120288888A1
公开(公告)日：2012-11-15
申请号：US13519284
申请日：2010-12-30
申请人： Jesse D. Miller , Stephanie J. Moeller , Kurt J. Halverson
发明人： Jesse D. Miller , Stephanie J. Moeller , Kurt J. Halverson
IPC分类号： C12M1/34 , G01N21/00 , C12Q1/04
CPC分类号： G01N33/56911 , C12M23/20 , C12M25/02 , C12M41/36 , C12Q1/04 , C12Q1/06 , G01N33/569
摘要： The disclosure provides an article for the detection of a microorganism in a liquid sample. The article comprises a microporous membrane and a barrier layer to selectively regulate the contact between the sample and a detection reagent. A method of use is also provided.
摘要翻译：本公开提供了用于检测液体样品中的微生物的制品。该制品包括微孔膜和阻挡层，以选择性地调节样品与检测试剂之间的接触。还提供了一种使用方法。

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