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1. 发明授权

US09398902B2 Vessel closure device 有权
标题翻译：容器关闭装置
公开(公告)号：US09398902B2
公开(公告)日：2016-07-26
申请号：US13497708
申请日：2010-09-20
申请人： Ram H. Paul, Jr. , Brian L. Bates , Cleon Stanley
发明人： Ram H. Paul, Jr. , Brian L. Bates , Cleon Stanley
IPC分类号： A61B17/128 , A61B17/122 , A61B17/00 , A61B17/29 , A61B17/14 , A61B17/30
CPC分类号： A61B17/0057 , A61B17/29 , A61B2017/0034 , A61B2017/00473 , A61B2017/00575 , A61B2017/2905 , A61B2017/2931 , A61B2017/303
摘要： A device and system for closure of an opening formed in a body vessel includes a bioabsorbable grasping member and locking member. The grasping member includes grasping lingers that are radially collapsible to the closed positions by movement of the locking member over the fingers. A distal portion of the fingers is configured to grasp an outer wall portion of the body vessel surrounding the opening when the fingers are in the open position. Movement of the locking member can cause the fingers to at least substantially close the vessel opening. Structural features on the fingers and/or locking member can inhibit proximal or distal movement of the locking member when in a locking position. A detachable arm can be coupled to the grasping member to facilitate placement of the grasping member. A sheath can fit over the detachable arm and be configured to move the locking member over the fingers.
摘要翻译：用于封闭形成在体容器中的开口的装置和系统包括生物可吸收的抓持构件和锁定构件。抓持构件包括通过锁定构件通过手指的移动而径向可折叠到关闭位置的抓握件。手指的远端部分构造成当手指处于打开位置时抓住围绕开口的身体血管的外壁部分。锁定构件的运动可导致手指至少基本上关闭容器开口。手指和/或锁定构件上的结构特征可以在锁定位置时阻止锁定构件的近端或远端运动。可拆卸臂可以联接到抓握构件以便于抓握构件的放置。护套可以装配在可拆卸臂上方并且被配置成使锁定构件移动超过手指。

2. 发明授权

US09289581B2 Blood perfusion device 有权
标题翻译：血液灌注装置
公开(公告)号：US09289581B2
公开(公告)日：2016-03-22
申请号：US12721323
申请日：2010-03-10
申请人： Mark A. Magnuson , Ram H. Paul, Jr.
发明人： Mark A. Magnuson , Ram H. Paul, Jr.
IPC分类号： A61F2/82 , A61M29/02 , A61M25/00 , A61M25/01
CPC分类号： A61M29/02 , A61M2025/0024 , A61M2025/0096 , A61M2025/0188
摘要： Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve or graft material. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device may have a proximal non-expanding portion and a distal self-expanding support structure. The self-expanding support structure can expand radially outward to urge the graft material to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.
摘要翻译：提供医疗装置以及治疗和制造这种装置的方法，用于在体内血管局部施用血管治疗。医疗装置包括可扩张管状框架和套筒或移植材料。医疗装置可用于局部递送用于撕裂体血管的体内容器或填塞物中的治疗剂，同时允许灌注植入的医疗装置的远端的流体或血液流。医疗装置的管状框架可以具有近端非扩张部分和远端自扩张支撑结构。自膨胀支撑结构可以径向向外扩张以促使移植材料接触身体血管的壁。在扩展构型中，当套管抵靠身体血管壁时，该装置的一部分允许流体流动继续。

3. 发明授权

US08945170B2 Occluding device 有权
标题翻译：闭塞装置
公开(公告)号：US08945170B2
公开(公告)日：2015-02-03
申请号：US13059717
申请日：2009-08-18
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61M29/00 , C07D471/04 , A61B17/12
CPC分类号： A61B17/12177 , A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B17/1219 , A61B2017/12054 , C07D471/04
摘要： An occluding device is provided for occluding fluid flow through a lumen of a body vessel. The occluding device includes an expandable tubular body having a tubular wall defining a lumen formed therethrough. The tubular wall has a proximal end extending to a distal end along a longitudinal axis of the tubular body. A plurality of longitudinal slits is formed through the tubular wall to define a plurality of flexible strips bound by a proximal non-slit portion and a distal non-slit portion. A plurality of barbs is disposed on the flexible strips. The tubular body is configured to open radially to engage the barbs with the vessel wall defining an expanded state and to collapse along the longitudinal axis to draw the vessel wall radially inward defining a collapsed state. Occluding material is housed within the lumen of the tubular body and the occluding material is configured to move between a collapsed state and an expanded state with the tubular body.
摘要翻译：提供一种闭塞装置，用于阻塞通过体血管的内腔的流体流动。闭塞装置包括具有限定从其形成的内腔的管状壁的可扩张管状体。管状壁具有沿着管状体的纵向轴线延伸到远端的近端。通过管状壁形成多个纵向狭缝，以限定由近端非狭缝部分和远端非狭缝部分所限定的多个柔性条带。多个倒钩设置在柔性条上。管状体被构造成径向地开口以使倒钩与容器壁接合以限定扩张状态，并且沿着纵向轴线塌缩以将容器壁径向向内以限定收缩状态。封闭材料容纳在管状体的内腔内，并且阻塞材料构造成在管状体之间在收缩状态和膨胀状态之间移动。

4. 发明授权

US08932325B2 Devices and methods useful for sealing bodily openings 有权
标题翻译：用于密封身体开口的装置和方法
公开(公告)号：US08932325B2
公开(公告)日：2015-01-13
申请号：US13303707
申请日：2011-11-23
申请人： Cleon Stanley , Ram H. Paul, Jr. , Dennis Griffin , Sean Chambers
发明人： Cleon Stanley , Ram H. Paul, Jr. , Dennis Griffin , Sean Chambers
IPC分类号： A61B17/08 , A61B17/00 , A61B17/04 , A61B17/06
CPC分类号： A61B17/0057 , A61B2017/00407 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶形密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在与容器内部相适应的位置。

5. 发明授权

US08211165B1 Implantable device for placement in a vessel having a variable size 有权
标题翻译：用于放置在具有可变尺寸的容器中的可植入装置
公开(公告)号：US08211165B1
公开(公告)日：2012-07-03
申请号：US12350561
申请日：2009-01-08
申请人： Charles L. McIntosh , Sean D. Chambers , Ram H. Paul, Jr.
发明人： Charles L. McIntosh , Sean D. Chambers , Ram H. Paul, Jr.
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2250/0031 , A61F2250/0059
摘要： A device for implantation in a body vessel is provided. The device includes a frame that accommodates dynamic variation in the size of the vessel. At least one leaflet is attached to the frame. The leaflet is deformable between a first position allowing fluid flow in a first, antegrade direction and a second position restricting fluid flow in a second, retrograde direction. Methods for delivering the device to a body vessel and methods and kits for treating a subject using such a device are also provided.
摘要翻译：提供了用于植入体内容器的装置。该装置包括容纳容器尺寸的动态变化的框架。至少一个传单附在框架上。所述小叶可以在第一位置和第二位置之间变形，所述第一位置允许流体在第一顺行方向上流动，并且限制第二逆向方向上的流体流动。还提供了将装置输送到身体容器的方法以及用于使用这种装置治疗受试者的方法和试剂盒。

6. 发明申请

US20120116447A1 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 有权
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：US20120116447A1
公开(公告)日：2012-05-10
申请号：US13303707
申请日：2011-11-23
申请人： Cleon Stanley , Ram H. Paul, JR. , Dennis Griffin , Sean Chambers
发明人： Cleon Stanley , Ram H. Paul, JR. , Dennis Griffin , Sean Chambers
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00407 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶形密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在与容器内部的适当位置。

7. 发明授权

US08128682B2 Medical device with tensionably attached remodelable material 有权
标题翻译：具有可张力连接的可重塑材料的医疗装置
公开(公告)号：US08128682B2
公开(公告)日：2012-03-06
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodelable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当变弱的框架部分处于第一构型时，可重塑材料将框架从径向压缩构型扩展到径向扩张构型。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

8. 发明授权

US07921874B2 Flow variation valve assembly 有权
标题翻译：流量变化阀总成
公开(公告)号：US07921874B2
公开(公告)日：2011-04-12
申请号：US11272237
申请日：2005-11-10
申请人： Kurt J. Tekulve , Ram H. Paul, Jr. , Julie E. Urbanski
发明人： Kurt J. Tekulve , Ram H. Paul, Jr. , Julie E. Urbanski
IPC分类号： F16K15/14
CPC分类号： F16K15/147 , A61F2/04 , A61F2002/043 , A61M5/16881 , A61M39/22 , F16K15/148 , Y10T137/7847 , Y10T137/7882
摘要： A non-implantable valve assembly and a method for controlling flow rates in a medical device are provided. The valve assembly includes a valve member being dimensioned for reception at least partially within a lumen of the medical device. The valve member includes a flow regulator for controlling flow rates in a first direction having a first rate and a second direction having a second rate. The second rate is greater than the first rate.
摘要翻译：提供一种非植入式阀组件和用于控制医疗装置中的流速的方法。阀组件包括阀构件，其尺寸被设计成用于至少部分地接纳在医疗装置的内腔内。阀构件包括用于控制具有第一速率的第一方向的流量和具有第二速率的第二方向的流量调节器。第二个比率大于第一个比率。

9. 发明授权

US07798999B2 Adjustable length catheter 有权
标题翻译：可调长导管
公开(公告)号：US07798999B2
公开(公告)日：2010-09-21
申请号：US11758543
申请日：2007-06-05
申请人： Frances Kristen Bailey , Jessica L. Burke , Grant T. Hoffman , Ram H. Paul, Jr.
发明人： Frances Kristen Bailey , Jessica L. Burke , Grant T. Hoffman , Ram H. Paul, Jr.
IPC分类号： A61M5/178
CPC分类号： A61M25/0097 , A61M25/0029 , A61M2025/0031 , A61M2025/0034 , A61M2025/0037
摘要： An adjustable length catheter device, a kit and a method of providing the adjustable length catheter device to a patient are provided. The catheter device includes an elongate shaft having a proximal portion, a distal portion, a first lumen and a second lumen extending at least partially therethrough. The catheter device further includes a manifold operably connected to the shaft. The manifold is configured to longitudinally move along the shaft towards the distal portion for separating the proximal portion of the shaft into a first proximal shaft portion including the first lumen and a second proximal shaft portion including the second lumen.
摘要翻译：提供了一种可调节长度的导管装置，套件以及将可调节长度的导管装置提供给患者的方法。导管装置包括细长轴，其具有近端部分，远端部分，第一内腔和至少部分延伸穿过其中的第二内腔。导管装置还包括可操作地连接到轴的歧管。歧管被构造成沿着轴朝向远端部分纵向移动，用于将轴的近端部分分离成包括第一管腔的第一近侧轴部分和包括第二管腔的第二近侧轴部分。

10. 发明授权

US07717952B2 Artificial prostheses with preferred geometries 有权
标题翻译：具有优选几何形状的人造假体
公开(公告)号：US07717952B2
公开(公告)日：2010-05-18
申请号：US11586285
申请日：2006-10-25
申请人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
发明人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0039
摘要： Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.
摘要翻译：提供可植入的医疗装置，例如可植入后的支架和瓣膜，其具有某些优选的形状。优选地，可植入医疗装置的一部分可以限定具有优选几何形状的窦区。窦区可以具有本文所述的一种或多种优选的几何构型，例如减轻或预防体内血栓形成。医疗装置可以包括阀装置，例如位于窦区内的一个或多个瓣叶。可植入的医疗装置可以从身体容器内的导管输送，并且优选地可以从压缩构型扩展到径向扩张的构型。可植入的框架可以是自膨胀的或球囊的可膨胀的。医疗装置的一部分，例如可植入框架或瓣膜小叶，任选地涂覆有一种或多种生物活性材料。

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