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1. 发明授权

US09289581B2 Blood perfusion device 有权
标题翻译：血液灌注装置
公开(公告)号：US09289581B2
公开(公告)日：2016-03-22
申请号：US12721323
申请日：2010-03-10
申请人： Mark A. Magnuson , Ram H. Paul, Jr.
发明人： Mark A. Magnuson , Ram H. Paul, Jr.
IPC分类号： A61F2/82 , A61M29/02 , A61M25/00 , A61M25/01
CPC分类号： A61M29/02 , A61M2025/0024 , A61M2025/0096 , A61M2025/0188
摘要： Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve or graft material. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device may have a proximal non-expanding portion and a distal self-expanding support structure. The self-expanding support structure can expand radially outward to urge the graft material to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.
摘要翻译：提供医疗装置以及治疗和制造这种装置的方法，用于在体内血管局部施用血管治疗。医疗装置包括可扩张管状框架和套筒或移植材料。医疗装置可用于局部递送用于撕裂体血管的体内容器或填塞物中的治疗剂，同时允许灌注植入的医疗装置的远端的流体或血液流。医疗装置的管状框架可以具有近端非扩张部分和远端自扩张支撑结构。自膨胀支撑结构可以径向向外扩张以促使移植材料接触身体血管的壁。在扩展构型中，当套管抵靠身体血管壁时，该装置的一部分允许流体流动继续。

2. 发明授权

US09277904B2 Devices and methods useful for sealing bodily openings 有权
公开(公告)号：US09277904B2
公开(公告)日：2016-03-08
申请号：US13111338
申请日：2011-05-19
申请人： Ram H. Paul, Jr. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osborne , Sean Chambers
发明人： Ram H. Paul, Jr. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osborne , Sean Chambers
IPC分类号： A61B17/00 , A61B17/34 , A61B17/04 , A61B17/06
CPC分类号： A61B17/0057 , A61B17/3468 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

3. 发明授权

US08540760B2 Tubular devices having reversible components for deployment of endoluminal occluders and related methods and systems 有权
标题翻译：具有用于部署腔内封堵器的可逆组件的管状装置及相关方法和系统
公开(公告)号：US08540760B2
公开(公告)日：2013-09-24
申请号：US12164520
申请日：2008-06-30
申请人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/84
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12136 , A61B17/12181 , A61B17/1219 , A61B17/3468 , A61B2017/1205
摘要： Described are devices, methods, and systems useful for deploying one or more occlusive prostheses within the vasculature of a patient. Illustrative devices can include a deployment tube or sheath that contains an occlusive prosthesis, wherein a segment of the sheath is reversible by a user so as to deploy the prosthesis from the sheath lumen within a bodily lumen of a patient.
摘要翻译：描述了用于在患者的脉管系统内部署一个或多个闭塞假体的装置，方法和系统。示例性装置可以包括包含闭塞假体的展开管或护套，其中护套的一部分可由使用者逆转，以便将该假体从皮肤内腔部署到患者体内。

4. 发明授权

US08506583B2 Method for open surgical placement 有权
标题翻译：开放手术放置方法
公开(公告)号：US08506583B2
公开(公告)日：2013-08-13
申请号：US13593088
申请日：2012-08-23
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61B17/22
CPC分类号： A61F2/95 , A61F2/06 , A61F2/064 , A61F2002/8483 , A61F2002/9517
摘要： A method for open surgical repair of a damaged portion of an artery or vein. A tubular medical assembly may include one or more shaped members, such as microbarbs, configured to anchor into the tunica intima and the tunica media of the vessel wall, and not to the tunic adventitia and vasa vasorum. The medical assembly is delivered to the damaged vessel portion via a delivery device through an open air pathway, and forms a conduit between transected ends of the damaged vessel.
摘要翻译：一种用于开放性手术修复动脉或静脉损伤部分的方法。管状医疗组件可以包括一个或多个成形构件，例如微巴，构造成锚定到血管壁的内膜和中膜，而不是外套和血管充血。医疗组件经由输送装置通过开放空气通道输送到损坏的容器部分，并且在损坏的容器的横截面之间形成导管。

5. 发明授权

US08403979B2 Monocuspid prosthetic valve having a partial sinus 有权
标题翻译：具有部分窦的Monocuspid人工瓣膜
公开(公告)号：US08403979B2
公开(公告)日：2013-03-26
申请号：US12121453
申请日：2008-05-15
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054
摘要： The disclosure relates to an expandable valve prosthesis for regulating flow through a body vessel. The prosthesis comprises a frame configured to form a laterally asymmetric partial sinus and a valve member.
摘要翻译：本公开涉及一种用于调节通过身体血管的流动的可扩张瓣膜假体。假体包括构造成形成横向不对称的部分窦和瓣膜构件的框架。

6. 发明授权

US08313526B2 Valve frame 有权
标题翻译：阀框
公开(公告)号：US08313526B2
公开(公告)日：2012-11-20
申请号：US12273168
申请日：2008-11-18
申请人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul, Jr.
发明人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul, Jr.
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/24 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.
摘要翻译：本公开涉及用于假体植入式阀的支撑框架。支撑框架可以包括多个对称排列的互连的U形构件结构。优选的支撑框架是包围纵向轴线并且包括面向支撑框架的远端或近端的多个U形构件结构的管状结构。每个U形构件结构可以连接到面向相反纵向方向的单个纵向相邻的U形构件以及两个横向相邻的U形构件。

7. 发明授权

US07678144B2 Prosthetic valve with slanted leaflet design 有权
标题翻译：假体瓣带有倾斜小叶设计
公开(公告)号：US07678144B2
公开(公告)日：2010-03-16
申请号：US12019987
申请日：2008-01-25
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, Jr.
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, Jr.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet. The at least one semi-rigid leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one semi-rigid leaflet is slanted in a retrograde direction from the second portion to the first portion. The at least one flexible leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one flexible leaflet is slanted in a retrograde direction from the first portion to the second portion when at rest.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。至少一个半刚性小叶包括第一部分和第二部分，第一部分附接到框架，第二部分没有框架。至少一个半刚性小叶从第二部分向第一部分沿逆行方向倾斜。所述至少一个柔性小叶包括第一部分和第二部分，所述第一部分附接到所述框架并且所述第二部分没有所述框架。当静止时，至少一个柔性小叶在从第一部分到第二部分的逆行方向上倾斜。

8. 发明授权

US10226264B2 Apparatus and method for destruction of vascular thrombus 有权
公开(公告)号：US10226264B2
公开(公告)日：2019-03-12
申请号：US13555685
申请日：2012-07-23
申请人： Charles L. McIntosh , Ram H. Paul, Jr. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, Jr. , Grant T. Hoffman
发明人： Charles L. McIntosh , Ram H. Paul, Jr. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, Jr. , Grant T. Hoffman
IPC分类号： A61H1/00 , A61B17/22 , A61M25/10 , A61M37/00
摘要： A device for thrombolytic therapy is provided. The device includes an elongate catheter with a distal end portion and a proximal end portion and a first lumen extending through both distal and proximal end portions. The distal end portion of the catheter includes an echogenic tubular potion that defines or surrounds a portion of the first lumen. An expandable balloon coaxially surrounds the tubular portion. The tubular portion additionally includes a plurality of indentations defined upon an outer surface thereof.

9. 发明授权

US09192463B2 Blood perfusion device 有权
标题翻译：血液灌注装置
公开(公告)号：US09192463B2
公开(公告)日：2015-11-24
申请号：US13197511
申请日：2011-08-03
申请人： Ram H. Paul, Jr. , Richard A. Swift , Oliver Bach , Ralf Steiner
发明人： Ram H. Paul, Jr. , Richard A. Swift , Oliver Bach , Ralf Steiner
IPC分类号： A61F2/06 , A61F2/07 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2/915 , A61B17/11
CPC分类号： A61F2/07 , A61B2017/1107 , A61B2017/1132 , A61F2/06 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2250/0023 , A61F2250/0036 , A61F2250/0037
摘要： A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.
摘要翻译：灌注装置和用于修复身体血管损伤部分的输送系统。灌注装置可以包括可自膨胀的管状体，其具有近端部分，远端部分和中间部分。一个或多个串联的倒钩可以沿着中间部分周向设置。倒钩在将所述装置插入所述身体容器中时能够渗入所述血管壁的中膜和中膜，并且不会进入所述外膜。移植物可以与管状体相关联。移植物具有近端和远端，优选地沿管状体的腔壁完全延伸。移植物也可以在近端部分和远端部分沿管状体的外表面延伸。可以沿着中间部分施加可重塑的覆盖物。还提供用于灌注植入物的递送装置和递送灌注植入物的方法。

10. 发明授权

US09192362B2 Device and method for closure of vessel access site 有权
标题翻译：关闭船只进入现场的装置和方法
公开(公告)号：US09192362B2
公开(公告)日：2015-11-24
申请号：US13059157
申请日：2009-08-17
申请人： Ram H. Paul, Jr. , Brian L. Bates , Bradley L. Trembacki
发明人： Ram H. Paul, Jr. , Brian L. Bates , Bradley L. Trembacki
IPC分类号： A61B17/00 , A61B18/14 , A61B17/30 , A61B17/29
CPC分类号： A61B17/0057 , A61B18/1442 , A61B18/1445 , A61B18/1447 , A61B2017/00986 , A61B2017/2905 , A61B2017/2926 , A61B2017/2927 , A61B2017/301 , A61B2017/303 , A61B2017/305
摘要： A device for closure of an opening formed in a body vessel includes a grasping member and a sheath movable thereover. The grasping member comprises a tubular body having a plurality of grasping fingers extending from a distal end of the tubular body. The fingers radially extend from the tubular body at a first angle, and are collapsible therefrom to a second angle. The fingers have a distal tip configured for grasping an outer wall of the body vessel surrounding the vessel opening when the fingers are at the first angle. The sheath is slidable over the tubular body and at least a portion of the grasping fingers for collapsing the fingers from the first angle to the second angle, thereby causing the collapsed fingers to at least substantially close the opening.
摘要翻译：用于封闭形成在身体容器中的开口的装置包括抓握构件和可在其上移动的护套。抓持构件包括具有从管状体的远端延伸的多个抓取指状物的管状体。指状物从管状体以第一角度径向延伸，并且可从其收缩至第二角度。手指具有构造成当手指处于第一角度时抓住围绕容器开口的身体容器的外壁的远侧末端。护套可以在管状体上滑动并且至少一部分把持指状物用于将手指从第一角度折叠到第二角度，从而使折叠的手指至少基本上关闭开口。

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