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1. 发明申请

US20110308530A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 有权
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20110308530A1
公开(公告)日：2011-12-22
申请号：US13113946
申请日：2011-05-23
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F5/56
CPC分类号： A61F2/00 , A61F5/566 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body has first and second end portions and a medial portion. The implant body also includes a coupler configured to couple the end portions to one another such that the medial portion encircles targeted tissue. Methods of using such systems are also provided.
摘要翻译：一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。在一些实施例中，植入体具有第一和第二端部和中间部分。植入体还包括耦合器，其被配置为将端部部分彼此耦合，使得内侧部分围绕目标组织。还提供了使用这种系统的方法。

2. 发明授权

US09707122B2 Systems and methods for treatment of sleep apnea 有权
公开(公告)号：US09707122B2
公开(公告)日：2017-07-18
申请号：US13188385
申请日：2011-07-21
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A method of treating an airway disorder includes placing an implant in a patient's tongue, wherein the implant has first and second end portions that attach to tissue, and a tensioned medial portion between the first and second ends. The medial portion is configured to apply a pressure of less than a predetermined amount. Device systems associated with such methods are also provided.

3. 发明申请

US20110308529A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20110308529A1
公开(公告)日：2011-12-22
申请号：US13113933
申请日：2011-05-23
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F5/56
CPC分类号： A61F2/00 , A61F5/566 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body has a V-shape with first and second elongated legs configured for implantation in airway-interface tissue. The first and second elongated legs are configured to apply tensile forces to the tissue. Methods of using such systems are also provided.
摘要翻译：一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。在一些实施例中，植入物本体具有V形，其中第一和第二细长腿构造成用于植入气道界面组织中。第一和第二细长腿构造成对组织施加张力。还提供了使用这种系统的方法。

4. 发明授权

US09510922B2 Systems and methods for treatment of sleep apnea 有权
标题翻译：用于治疗睡眠呼吸暂停的系统和方法
公开(公告)号：US09510922B2
公开(公告)日：2016-12-06
申请号：US13113946
申请日：2011-05-23
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F2/00 , A61F5/56
CPC分类号： A61F2/00 , A61F5/566 , A61F2210/0004
摘要： An implant for treating an obstructive airway disorder includes an elongate implant body configured for implanting in airway-interface tissue. At least a portion of the elongate body carries a light transmission material for permitting light transmission therein. Systems and methods of treating an airway disorder including implanting an implant in an airway-interface tissue are also provided.
摘要翻译：用于治疗阻塞性气道障碍的植入物包括构造成用于植入气道界面组织中的细长植入体。细长体的至少一部分携带用于允许光透射的透光材料。还提供了治疗气道障碍的系统和方法，包括将植入物植入气道界面组织中。

5. 发明申请

US20120017919A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 有权
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20120017919A1
公开(公告)日：2012-01-26
申请号：US13188385
申请日：2011-07-21
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A method of treating an airway disorder includes placing an implant in a patient's tongue, wherein the implant has first and second end portions that attach to tissue, and a tensioned medial portion between the first and second ends. The medial portion is configured to apply a pressure of less than a predetermined amount. Device systems associated with such methods are also provided.
摘要翻译：治疗气道障碍的方法包括将植入物放置在患者舌头中，其中植入物具有连接到组织的第一和第二端部以及在第一和第二端之间的张紧的中间部分。内侧部分构造成施加小于预定量的压力。还提供了与这种方法相关联的设备系统。

6. 发明授权

US08733363B2 Systems and methods for treatment of sleep apnea 有权
标题翻译：用于治疗睡眠呼吸暂停的系统和方法
公开(公告)号：US08733363B2
公开(公告)日：2014-05-27
申请号：US13053059
申请日：2011-03-21
申请人： Edward M. Gillis , Andrew Poutiatine , John H. Shadduck , Csaba Truckai
发明人： Edward M. Gillis , Andrew Poutiatine , John H. Shadduck , Csaba Truckai
IPC分类号： A61F5/56 , A61F2/08
CPC分类号： A61F5/566 , A61F2/00 , A61F5/56 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body includes an adjustment element configured to allow in-situ adjustment of the implant body between first and second tensioning forces applied to the site. Methods of using such systems are also provided.
摘要翻译：一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。在一些实施例中，植入物主体包括调整元件，其被配置为允许植入物本体在施加到部位的第一和第二张力之间进行原位调整。还提供了使用这种系统的方法。

7. 发明申请

US20110226263A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 有权
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20110226263A1
公开(公告)日：2011-09-22
申请号：US13053059
申请日：2011-03-21
申请人： Edward M. Gillis , Andrew Poutiatine , John H. Shadduck , Csaba Truckai
发明人： Edward M. Gillis , Andrew Poutiatine , John H. Shadduck , Csaba Truckai
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F2/00 , A61F5/56 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body includes an adjustment element configured to allow in-situ adjustment of the implant body between first and second tensioning forces applied to the site. Methods of using such systems are also provided.
摘要翻译：一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。在一些实施例中，植入物主体包括调整元件，其被配置为允许植入物本体在施加到部位的第一和第二张力之间进行原位调整。还提供了使用这种系统的方法。

8. 发明申请

US20140007885A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20140007885A1
公开(公告)日：2014-01-09
申请号：US13935052
申请日：2013-07-03
申请人： Edward M. Gillis , Andrew Poutiatine , Paul J. Buscemi , John H. Shadduck
发明人： Edward M. Gillis , Andrew Poutiatine , Paul J. Buscemi , John H. Shadduck
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： Methods for treating sleep apnea. A method includes implanting at least first and second elongated implants in a tongue or soft palate of a patient, wherein each of the first and second implants is configured to have a first, expanded configuration and a second, contracted configuration, wherein implanting comprises implanting the first and second implants having their first, expanded configurations. The invention also provides systems for treating sleep apnea that can be used with the methods.
摘要翻译：睡眠呼吸暂停治疗方法一种方法包括将至少第一和第二细长植入物植入患者的舌或软腭中，其中第一和第二植入物中的每一个被配置为具有第一扩张构型和第二收缩构造，其中植入包括植入第一和第二植入物具有其第一，扩展的构型。本发明还提供了用于治疗可与该方法一起使用的睡眠呼吸暂停的系统。

9. 发明申请

US20140014116A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20140014116A1
公开(公告)日：2014-01-16
申请号：US13939107
申请日：2013-07-10
申请人： Edward M. Gillis , Andrew Poutiatine
发明人： Edward M. Gillis , Andrew Poutiatine
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A self-adjusting implant includes a first anchor configured to anchor to a first tissue location and apply a first tension force thereto; a second anchor configured to anchor to a second tissue location spaced apart from the first tissue location and apply a second tension to the second tissue location; a third anchor configured to anchor to a third tissue location spaced apart from and non-collinear with the first and the second tissue locations; a first tension-bearing segment spanning between the first and the third anchors, comprising a first deformable portion; and a second tension-bearing segment spanning between the second and the third anchors wherein the third anchor is configured to generally distribute a tension of the first tension-bearing segment with a tension of the second tension-bearing segment. The invention also includes methods for treating airway disorders that can be used with described implants.
摘要翻译：自调整植入物包括构造成锚定到第一组织位置并向其施加第一张力的第一锚固件; 第二锚固件，其构造成锚定到与所述第一组织位置间隔开的第二组织位置，并将第二张力施加到所述第二组织位置; 第三锚，其构造成锚定到与所述第一和第二组织位置间隔开并且与所述第一和第二组织位置非共线的第三组织位置; 横跨第一和第三锚固件之间的第一张力承载部分，包括第一可变形部分; 以及横跨在第二和第三锚固件之间的第二张力支承段，其中第三锚定构造成大体上分配第一张力承载段的张力与第二张力承载段的张力。本发明还包括用于治疗可以与所述种植体一起使用的气道障碍的方法。

10. 发明授权

US06835194B2 Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners 失效
标题翻译：通过输送芬太尼和芬太尼同系物治疗疼痛的植入式装置和方法
公开(公告)号：US06835194B2
公开(公告)日：2004-12-28
申请号：US10188325
申请日：2002-06-27
申请人： Randolph Mellus Johnson , Felix Theeuwes , Edward M. Gillis , Dana Litmanovitz , Barbara Laidlaw , James Brown , John Culwell , James A. Filice , Peter Wickman , Su-Il Yum , Andrew Poutiatine , John Dinka
发明人： Randolph Mellus Johnson , Felix Theeuwes , Edward M. Gillis , Dana Litmanovitz , Barbara Laidlaw , James Brown , John Culwell , James A. Filice , Peter Wickman , Su-Il Yum , Andrew Poutiatine , John Dinka
IPC分类号： A61K922
CPC分类号： A61F2/02 , A61F2250/0067 , A61K9/0004 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/168 , A61M5/16804 , A61M5/16881 , A61M31/002 , A61M2005/14264
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.
摘要翻译：本发明的特征在于用于治疗疼痛的装置和方法。药物递送装置是适于整个植入受试者的药物递送系统，并通过在持续的时间段内输送芬太尼或芬太尼（例如舒芬太尼）来提供疼痛缓解（例如，至少3天或更多 3天）。该装置包括限定容纳药物制剂的储存器的壳体，可操作地连接到壳体的泵，以促进药物从储存器移出并离开装置;以及热膨胀元件，其限定流动通路，该热膨胀元件包括热膨胀通道，以适应储层中配方的热膨胀。该装置还可以包括位于流动通道内的阀，以便在使用之前防止药物从储存器中移动。

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